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KRIT1 (KRIT1 ankyrin repeat containing)

Gene

889

KRIT1 ankyrin repeat containing

KRIT1

CAM, CCM1

7q21.2

This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated prot

Show/Hide all(134)

SNP ID	Visualize variation	Clinical significance	Consequence
rs34358665	C>T	Conflicting-interpretations-of-pathogenicity, likely-benign, benign-likely-benign	Missense variant, coding sequence variant, 5 prime UTR variant
rs137853139	T>C	Pathogenic	Missense variant, coding sequence variant, 5 prime UTR variant
rs137853140	G>C	Pathogenic	Missense variant, intron variant, coding sequence variant
rs267607203	G>A,C	Pathogenic	Missense variant, coding sequence variant, stop gained
rs267607204	G>T	Pathogenic	Coding sequence variant, intron variant, stop gained
rs373763254	->T	Conflicting-interpretations-of-pathogenicity, likely-benign	Intron variant
rs374303823	C>G,T	Likely-pathogenic	Missense variant, coding sequence variant
rs374662170	G>A	Likely-pathogenic	Coding sequence variant, intron variant, stop gained
rs549591728	C>T	Pathogenic	Splice donor variant
rs757560062	->A	Pathogenic	Coding sequence variant, 5 prime UTR variant, frameshift variant
rs764960797	G>A,C,T	Pathogenic	Missense variant, synonymous variant, intron variant, coding sequence variant, stop gained
rs770594592	CTTTT>-	Likely-pathogenic	5 prime UTR variant, coding sequence variant, frameshift variant
rs771656368	G>A	Pathogenic	5 prime UTR variant, coding sequence variant, stop gained
rs779465895	G>A,C,T	Pathogenic	Intron variant
rs780114710	G>A,C	Likely-pathogenic	Coding sequence variant, stop gained, missense variant
rs866982998	G>A	Pathogenic	Coding sequence variant, stop gained, 5 prime UTR variant
rs886039400	ACTT>-	Pathogenic	5 prime UTR variant, coding sequence variant, frameshift variant
rs886039401	C>G,T	Likely-pathogenic, pathogenic	Splice donor variant
rs886039402	G>A	Pathogenic	Stop gained, coding sequence variant
rs886039571	T>C	Pathogenic	Splice acceptor variant
rs886039572	G>-	Pathogenic	Coding sequence variant, frameshift variant
rs886039659	G>A	Pathogenic	Stop gained, coding sequence variant
rs886041209	TTCT>-	Pathogenic	5 prime UTR variant, coding sequence variant, frameshift variant
rs886041415	AC>-	Pathogenic	Coding sequence variant, frameshift variant
rs886041557	TGTTTGTTTTCTT>-	Pathogenic	Coding sequence variant, frameshift variant
rs886041572	->A	Pathogenic	Coding sequence variant, frameshift variant
rs886043300	G>A	Pathogenic-likely-pathogenic, pathogenic	Stop gained, intron variant, coding sequence variant
rs965713946	T>C	Pathogenic	Splice acceptor variant
rs1041438637	T>C	Pathogenic	Intron variant
rs1057517752	AGTAATT>-	Pathogenic	Frameshift variant, coding sequence variant, intron variant
rs1057517753	GTTT>-	Pathogenic	Coding sequence variant, frameshift variant
rs1057517754	TTCTT>-	Pathogenic-likely-pathogenic	Coding sequence variant, frameshift variant
rs1057518665	CT>-	Likely-pathogenic	5 prime UTR variant, coding sequence variant, frameshift variant
rs1057521140	C>T	Conflicting-interpretations-of-pathogenicity	Missense variant, 5 prime UTR variant, coding sequence variant
rs1064793348	AT>-	Pathogenic	Coding sequence variant, frameshift variant
rs1180476377	GAGA>-,GA	Pathogenic	Coding sequence variant, frameshift variant
rs1326827713	->AATG	Pathogenic	Coding sequence variant, intron variant, frameshift variant
rs1331502949	G>A,C	Pathogenic	Stop gained, missense variant, coding sequence variant
rs1554489785	C>G,T	Likely-pathogenic	Splice acceptor variant
rs1554490317	TC>-	Pathogenic	Coding sequence variant, frameshift variant
rs1554502838	->G	Pathogenic	Coding sequence variant, frameshift variant
rs1554502927	->T	Pathogenic	Coding sequence variant, frameshift variant
rs1554503009	C>T	Pathogenic	Coding sequence variant, stop gained
rs1554503116	C>A	Pathogenic	Coding sequence variant, stop gained
rs1554503202	GA>-	Pathogenic	Coding sequence variant, frameshift variant
rs1554503702	T>A	Pathogenic	Coding sequence variant, stop gained
rs1554503705	->T	Pathogenic	Coding sequence variant, frameshift variant
rs1554504484	TC>-	Pathogenic	Coding sequence variant, stop gained
rs1554504519	CCATAGACTATTT>-	Pathogenic	Coding sequence variant, frameshift variant
rs1554512658	G>-	Pathogenic	Coding sequence variant, frameshift variant
rs1554512816	->C	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1554513061	G>A	Pathogenic	Coding sequence variant, stop gained
rs1554513070	C>A	Pathogenic	Splice acceptor variant
rs1554513911	G>A,T	Pathogenic, likely-pathogenic	Coding sequence variant, stop gained, missense variant
rs1554514380	TAC>-	Pathogenic	Splice acceptor variant, coding sequence variant, intron variant
rs1554518369	TT>-	Likely-pathogenic	Intron variant
rs1554518386	->T	Pathogenic	Coding sequence variant, frameshift variant
rs1554518541	C>-	Pathogenic	Coding sequence variant, frameshift variant
rs1554518750	T>-	Pathogenic	Coding sequence variant, frameshift variant
rs1554518783	C>T	Pathogenic	Coding sequence variant, stop gained, synonymous variant
rs1554518790	C>T	Likely-pathogenic	Splice acceptor variant
rs1554527032	->A	Likely-pathogenic	Coding sequence variant, intron variant, frameshift variant
rs1554527169	G>C	Pathogenic	Coding sequence variant, intron variant, stop gained
rs1554527779	C>T	Pathogenic	Coding sequence variant, stop gained
rs1554527817	G>C	Pathogenic	Coding sequence variant, stop gained
rs1554527919	C>A	Pathogenic	Coding sequence variant, missense variant
rs1554527922	C>G,T	Pathogenic, likely-pathogenic	Splice acceptor variant
rs1554527925	T>C	Pathogenic	Splice acceptor variant
rs1554528541	A>G	Pathogenic	Intron variant, splice donor variant
rs1554528662	G>C	Pathogenic	Coding sequence variant, stop gained, intron variant
rs1554529341	C>T	Pathogenic	Splice acceptor variant
rs1554539120	T>C	Pathogenic-likely-pathogenic, likely-pathogenic	Initiator codon variant, 5 prime UTR variant, missense variant
rs1563211361	T>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1563211627	G>A	Pathogenic	Coding sequence variant, stop gained
rs1563211839	->T	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1563212150	A>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1563239833	A>G	Likely-pathogenic	Splice donor variant
rs1563240592	G>A	Likely-pathogenic	Coding sequence variant, stop gained
rs1563240821	GTAGGAA>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1563242500	G>C	Pathogenic	Coding sequence variant, stop gained
rs1563242833	C>-	Pathogenic	Coding sequence variant, frameshift variant
rs1563242899	->A	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1563243016	T>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1563244596	ACTT>-	Pathogenic	Coding sequence variant, intron variant, splice donor variant
rs1563244618	C>T	Pathogenic	Intron variant
rs1563244629	T>G	Uncertain-significance, likely-pathogenic	Intron variant
rs1563244807	T>-	Pathogenic	Coding sequence variant, frameshift variant
rs1563245191	T>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1563245290	->T	Pathogenic	Coding sequence variant, frameshift variant
rs1563245596	A>T	Likely-pathogenic	Coding sequence variant, stop gained
rs1563263366	G>A	Pathogenic	Coding sequence variant, stop gained
rs1563263545	C>A	Likely-pathogenic	Coding sequence variant, stop gained
rs1563263604	->T	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1563263905	GT>-	Pathogenic	Coding sequence variant, frameshift variant
rs1563264033	->AG	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1563264113	T>G	Likely-pathogenic	Splice acceptor variant
rs1563265838	->T	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1563265959	C>T	Pathogenic	Coding sequence variant, stop gained
rs1563266147	T>-	Pathogenic	Coding sequence variant, frameshift variant
rs1563266163	G>A	Likely-pathogenic	Coding sequence variant, stop gained
rs1563266256	AGACG>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1563266277	->A	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1563266658	TTCAA>-	Pathogenic	Coding sequence variant, frameshift variant
rs1563266994	GAACT>TACA	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1563267100	C>T	Pathogenic	Splice acceptor variant
rs1563275256	CTTC>-	Pathogenic	Coding sequence variant, frameshift variant
rs1563275284	C>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1563275562	TGTTT>-	Pathogenic	Coding sequence variant, frameshift variant
rs1563279045	C>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1563301305	G>-	Likely-pathogenic	Coding sequence variant, frameshift variant, intron variant
rs1563301527	->GT	Likely-pathogenic	Coding sequence variant, frameshift variant, intron variant
rs1563301954	C>-	Likely-pathogenic	Coding sequence variant, frameshift variant, intron variant
rs1563302930	A>T	Likely-pathogenic	Splice donor variant
rs1563302941	C>T	Pathogenic	Splice donor variant
rs1563302951	T>-	Pathogenic	Coding sequence variant, frameshift variant
rs1563303222	ATTTG>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1563305064	C>T	Likely-pathogenic	Intron variant, splice donor variant
rs1563305269	G>C	Likely-pathogenic	Coding sequence variant, intron variant, stop gained
rs1563305588	->T	Pathogenic	Coding sequence variant, frameshift variant, intron variant
rs1563305648	G>-	Likely-pathogenic	Coding sequence variant, frameshift variant, intron variant
rs1563306485	G>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1563307239	C>T	Likely-pathogenic	Coding sequence variant, 5 prime UTR variant, stop gained
rs1563307254	C>T	Likely-pathogenic	Coding sequence variant, 5 prime UTR variant, stop gained
rs1563309967	TAGTATT>-	Likely-pathogenic	Coding sequence variant, 5 prime UTR variant, frameshift variant
rs1563313372	G>A	Pathogenic	Coding sequence variant, 5 prime UTR variant, stop gained
rs1563321624	->GG	Likely-pathogenic	Coding sequence variant, 5 prime UTR variant, frameshift variant
rs1584800138	->AGATTTT	Pathogenic	Coding sequence variant, frameshift variant
rs1584807148	G>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1584873058	T>A	Pathogenic	Stop gained, coding sequence variant
rs1584881309	T>-	Pathogenic	Coding sequence variant, frameshift variant
rs1584881660	C>A	Pathogenic	Stop gained, coding sequence variant
rs1584975743	->T	Pathogenic	Coding sequence variant, frameshift variant
rs1584976350	TATT>-	Pathogenic	Coding sequence variant, frameshift variant
rs1584981589	->A	Pathogenic	Intron variant, coding sequence variant, frameshift variant

Show/Hide all(218)

miRTarBase ID	miRNA	Experiments	Reference
MIRT440350	hsa-miR-21-5p	HITS-CLIP	22473208
MIRT440350	hsa-miR-21-5p	HITS-CLIP	22473208
MIRT1100899	hsa-miR-1185	CLIP-seq
MIRT1100900	hsa-miR-1257	CLIP-seq
MIRT1100901	hsa-miR-1272	CLIP-seq
MIRT1100902	hsa-miR-1283	CLIP-seq
MIRT1100903	hsa-miR-1297	CLIP-seq
MIRT1100904	hsa-miR-1322	CLIP-seq
MIRT1100905	hsa-miR-193a-5p	CLIP-seq
MIRT1100906	hsa-miR-21	CLIP-seq
MIRT1100907	hsa-miR-216a	CLIP-seq
MIRT1100908	hsa-miR-216b	CLIP-seq
MIRT1100909	hsa-miR-221	CLIP-seq
MIRT1100910	hsa-miR-222	CLIP-seq
MIRT1100911	hsa-miR-224	CLIP-seq
MIRT1100912	hsa-miR-23a	CLIP-seq
MIRT1100913	hsa-miR-23b	CLIP-seq
MIRT1100914	hsa-miR-23c	CLIP-seq
MIRT1100915	hsa-miR-26a	CLIP-seq
MIRT1100916	hsa-miR-26b	CLIP-seq
MIRT1100917	hsa-miR-3144-3p	CLIP-seq
MIRT1100918	hsa-miR-3163	CLIP-seq
MIRT1100919	hsa-miR-3180-5p	CLIP-seq
MIRT1100920	hsa-miR-329	CLIP-seq
MIRT1100921	hsa-miR-330-3p	CLIP-seq
MIRT1100922	hsa-miR-345	CLIP-seq
MIRT1100923	hsa-miR-3545-3p	CLIP-seq
MIRT1100924	hsa-miR-3605-5p	CLIP-seq
MIRT1100925	hsa-miR-362-3p	CLIP-seq
MIRT1100926	hsa-miR-365	CLIP-seq
MIRT1100927	hsa-miR-3663-5p	CLIP-seq
MIRT1100928	hsa-miR-3679-5p	CLIP-seq
MIRT1100929	hsa-miR-3686	CLIP-seq
MIRT1100930	hsa-miR-3922-5p	CLIP-seq
MIRT1100931	hsa-miR-3941	CLIP-seq
MIRT1100932	hsa-miR-409-3p	CLIP-seq
MIRT1100933	hsa-miR-410	CLIP-seq
MIRT1100934	hsa-miR-4457	CLIP-seq
MIRT1100935	hsa-miR-4465	CLIP-seq
MIRT1100936	hsa-miR-4477a	CLIP-seq
MIRT1100937	hsa-miR-4506	CLIP-seq
MIRT1100938	hsa-miR-4635	CLIP-seq
MIRT1100939	hsa-miR-466	CLIP-seq
MIRT1100940	hsa-miR-4670-3p	CLIP-seq
MIRT1100941	hsa-miR-4672	CLIP-seq
MIRT1100942	hsa-miR-4680-5p	CLIP-seq
MIRT1100943	hsa-miR-4693-3p	CLIP-seq
MIRT1100944	hsa-miR-4714-5p	CLIP-seq
MIRT1100945	hsa-miR-4753-5p	CLIP-seq
MIRT1100946	hsa-miR-4778-5p	CLIP-seq
MIRT1100947	hsa-miR-4803	CLIP-seq
MIRT1100948	hsa-miR-513b	CLIP-seq
MIRT1100949	hsa-miR-520a-5p	CLIP-seq
MIRT1100950	hsa-miR-520d-5p	CLIP-seq
MIRT1100951	hsa-miR-524-5p	CLIP-seq
MIRT1100952	hsa-miR-525-5p	CLIP-seq
MIRT1100953	hsa-miR-539	CLIP-seq
MIRT1100954	hsa-miR-548aa	CLIP-seq
MIRT1100955	hsa-miR-580	CLIP-seq
MIRT1100956	hsa-miR-590-5p	CLIP-seq
MIRT1100957	hsa-miR-603	CLIP-seq
MIRT1100958	hsa-miR-617	CLIP-seq
MIRT1100959	hsa-miR-656	CLIP-seq
MIRT1100960	hsa-miR-938	CLIP-seq
MIRT1100961	hsa-miR-944	CLIP-seq
MIRT1100962	hsa-miR-125a-3p	CLIP-seq
MIRT1100901	hsa-miR-1272	CLIP-seq
MIRT1100963	hsa-miR-1273g	CLIP-seq
MIRT1100964	hsa-miR-129-5p	CLIP-seq
MIRT1100903	hsa-miR-1297	CLIP-seq
MIRT1100965	hsa-miR-132	CLIP-seq
MIRT1100904	hsa-miR-1322	CLIP-seq
MIRT1100905	hsa-miR-193a-5p	CLIP-seq
MIRT1100966	hsa-miR-212	CLIP-seq
MIRT1100915	hsa-miR-26a	CLIP-seq
MIRT1100916	hsa-miR-26b	CLIP-seq
MIRT1100967	hsa-miR-299-3p	CLIP-seq
MIRT1100922	hsa-miR-345	CLIP-seq
MIRT1100968	hsa-miR-3658	CLIP-seq
MIRT1100969	hsa-miR-3671	CLIP-seq
MIRT1100970	hsa-miR-3921	CLIP-seq
MIRT1100971	hsa-miR-3934	CLIP-seq
MIRT1100972	hsa-miR-4272	CLIP-seq
MIRT1100973	hsa-miR-4454	CLIP-seq
MIRT1100935	hsa-miR-4465	CLIP-seq
MIRT1100974	hsa-miR-4491	CLIP-seq
MIRT1100937	hsa-miR-4506	CLIP-seq
MIRT1100975	hsa-miR-4653-5p	CLIP-seq
MIRT1100976	hsa-miR-4657	CLIP-seq
MIRT1100977	hsa-miR-4666-3p	CLIP-seq
MIRT1100944	hsa-miR-4714-5p	CLIP-seq
MIRT1100945	hsa-miR-4753-5p	CLIP-seq
MIRT1100978	hsa-miR-4762-5p	CLIP-seq
MIRT1100979	hsa-miR-4763-5p	CLIP-seq
MIRT1100980	hsa-miR-4766-5p	CLIP-seq
MIRT1100981	hsa-miR-4775	CLIP-seq
MIRT1100982	hsa-miR-488	CLIP-seq
MIRT1100983	hsa-miR-548a-5p	CLIP-seq
MIRT1100984	hsa-miR-548ab	CLIP-seq
MIRT1100985	hsa-miR-548ak	CLIP-seq
MIRT1100986	hsa-miR-548b-5p	CLIP-seq
MIRT1100987	hsa-miR-548c-5p	CLIP-seq
MIRT1100988	hsa-miR-548d-5p	CLIP-seq
MIRT1100989	hsa-miR-548h	CLIP-seq
MIRT1100990	hsa-miR-548i	CLIP-seq
MIRT1100991	hsa-miR-548j	CLIP-seq
MIRT1100992	hsa-miR-548w	CLIP-seq
MIRT1100993	hsa-miR-548y	CLIP-seq
MIRT1100994	hsa-miR-559	CLIP-seq
MIRT1100995	hsa-miR-579	CLIP-seq
MIRT1100996	hsa-miR-590-3p	CLIP-seq
MIRT1100997	hsa-miR-593	CLIP-seq
MIRT1100998	hsa-miR-607	CLIP-seq
MIRT1100958	hsa-miR-617	CLIP-seq
MIRT1100999	hsa-miR-764	CLIP-seq
MIRT1100961	hsa-miR-944	CLIP-seq
MIRT1100942	hsa-miR-4680-5p	CLIP-seq
MIRT2027488	hsa-miR-106a	CLIP-seq
MIRT2027489	hsa-miR-106b	CLIP-seq
MIRT2027490	hsa-miR-1287	CLIP-seq
MIRT2027491	hsa-miR-150	CLIP-seq
MIRT2027492	hsa-miR-17	CLIP-seq
MIRT2027493	hsa-miR-197	CLIP-seq
MIRT2027494	hsa-miR-20a	CLIP-seq
MIRT2027495	hsa-miR-20b	CLIP-seq
MIRT1100906	hsa-miR-21	CLIP-seq
MIRT2027496	hsa-miR-24	CLIP-seq
MIRT2027497	hsa-miR-302a	CLIP-seq
MIRT2027498	hsa-miR-302b	CLIP-seq
MIRT2027499	hsa-miR-302c	CLIP-seq
MIRT2027500	hsa-miR-302d	CLIP-seq
MIRT2027501	hsa-miR-302e	CLIP-seq
MIRT2027502	hsa-miR-3129-3p	CLIP-seq
MIRT2027503	hsa-miR-3135b	CLIP-seq
MIRT2027504	hsa-miR-3187-3p	CLIP-seq
MIRT1100927	hsa-miR-3663-5p	CLIP-seq
MIRT2027505	hsa-miR-3674	CLIP-seq
MIRT2027506	hsa-miR-372	CLIP-seq
MIRT2027507	hsa-miR-373	CLIP-seq
MIRT2027508	hsa-miR-3926	CLIP-seq
MIRT2027509	hsa-miR-423-3p	CLIP-seq
MIRT2027510	hsa-miR-4284	CLIP-seq
MIRT2027511	hsa-miR-4435	CLIP-seq
MIRT2027512	hsa-miR-4701-5p	CLIP-seq
MIRT2027513	hsa-miR-4716-5p	CLIP-seq
MIRT2027514	hsa-miR-4732-5p	CLIP-seq
MIRT2027515	hsa-miR-4755-3p	CLIP-seq
MIRT1100978	hsa-miR-4762-5p	CLIP-seq
MIRT2027516	hsa-miR-4781-3p	CLIP-seq
MIRT2027517	hsa-miR-4792	CLIP-seq
MIRT2027518	hsa-miR-5095	CLIP-seq
MIRT2027519	hsa-miR-5096	CLIP-seq
MIRT2027520	hsa-miR-512-3p	CLIP-seq
MIRT2027521	hsa-miR-519d	CLIP-seq
MIRT2027522	hsa-miR-520a-3p	CLIP-seq
MIRT2027523	hsa-miR-520b	CLIP-seq
MIRT2027524	hsa-miR-520c-3p	CLIP-seq
MIRT2027525	hsa-miR-520d-3p	CLIP-seq
MIRT2027526	hsa-miR-520e	CLIP-seq
MIRT2027527	hsa-miR-520g	CLIP-seq
MIRT2027528	hsa-miR-520h	CLIP-seq
MIRT1100983	hsa-miR-548a-5p	CLIP-seq
MIRT1100984	hsa-miR-548ab	CLIP-seq
MIRT1100985	hsa-miR-548ak	CLIP-seq
MIRT1100986	hsa-miR-548b-5p	CLIP-seq
MIRT1100987	hsa-miR-548c-5p	CLIP-seq
MIRT1100988	hsa-miR-548d-5p	CLIP-seq
MIRT1100989	hsa-miR-548h	CLIP-seq
MIRT1100990	hsa-miR-548i	CLIP-seq
MIRT1100991	hsa-miR-548j	CLIP-seq
MIRT2027529	hsa-miR-548n	CLIP-seq
MIRT2027530	hsa-miR-548s	CLIP-seq
MIRT1100992	hsa-miR-548w	CLIP-seq
MIRT1100993	hsa-miR-548y	CLIP-seq
MIRT1100994	hsa-miR-559	CLIP-seq
MIRT2027531	hsa-miR-588	CLIP-seq
MIRT1100956	hsa-miR-590-5p	CLIP-seq
MIRT2027532	hsa-miR-93	CLIP-seq
MIRT2027496	hsa-miR-24	CLIP-seq
MIRT2258816	hsa-miR-4258	CLIP-seq
MIRT2027510	hsa-miR-4284	CLIP-seq
MIRT1100973	hsa-miR-4454	CLIP-seq
MIRT2258817	hsa-miR-4707-3p	CLIP-seq
MIRT1100979	hsa-miR-4763-5p	CLIP-seq
MIRT1100942	hsa-miR-4680-5p	CLIP-seq
MIRT1100954	hsa-miR-548aa	CLIP-seq
MIRT2559495	hsa-miR-1343	CLIP-seq
MIRT2559496	hsa-miR-142-5p	CLIP-seq
MIRT2027496	hsa-miR-24	CLIP-seq
MIRT2559497	hsa-miR-3149	CLIP-seq
MIRT2559498	hsa-miR-320a	CLIP-seq
MIRT2559499	hsa-miR-320b	CLIP-seq
MIRT2559500	hsa-miR-320c	CLIP-seq
MIRT2559501	hsa-miR-320d	CLIP-seq
MIRT2559502	hsa-miR-340	CLIP-seq
MIRT2258816	hsa-miR-4258	CLIP-seq
MIRT2027510	hsa-miR-4284	CLIP-seq
MIRT2559503	hsa-miR-4429	CLIP-seq
MIRT2559504	hsa-miR-4503	CLIP-seq
MIRT2258817	hsa-miR-4707-3p	CLIP-seq
MIRT2559505	hsa-miR-4735-5p	CLIP-seq
MIRT1100981	hsa-miR-4775	CLIP-seq
MIRT1100996	hsa-miR-590-3p	CLIP-seq
MIRT2559506	hsa-miR-629	CLIP-seq
MIRT2559496	hsa-miR-142-5p	CLIP-seq
MIRT2027496	hsa-miR-24	CLIP-seq
MIRT2559498	hsa-miR-320a	CLIP-seq
MIRT2559499	hsa-miR-320b	CLIP-seq
MIRT2559500	hsa-miR-320c	CLIP-seq
MIRT2559501	hsa-miR-320d	CLIP-seq
MIRT2559502	hsa-miR-340	CLIP-seq
MIRT2258816	hsa-miR-4258	CLIP-seq
MIRT2027510	hsa-miR-4284	CLIP-seq
MIRT2559503	hsa-miR-4429	CLIP-seq
MIRT2258817	hsa-miR-4707-3p	CLIP-seq
MIRT2559505	hsa-miR-4735-5p	CLIP-seq
MIRT1100981	hsa-miR-4775	CLIP-seq
MIRT1100996	hsa-miR-590-3p	CLIP-seq

Show/Hide all(18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001525	Process	Angiogenesis	IEA
GO:0001937	Process	Negative regulation of endothelial cell proliferation	IMP	20616044
GO:0005515	Function	Protein binding	IPI	16037064, 17657516, 17916086, 20332120, 23007647, 25525273, 25814554, 25910212, 26780829, 27027284, 32296183
GO:0005546	Function	Phosphatidylinositol-4,5-bisphosphate binding	IDA	17916086
GO:0005615	Component	Extracellular space	HDA	22664934
GO:0005737	Component	Cytoplasm	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IDA	17916086
GO:0005911	Component	Cell-cell junction	IDA	20332120, 23007647
GO:0007264	Process	Small GTPase mediated signal transduction	TAS	9285558
GO:0008017	Function	Microtubule binding	IDA	17916086
GO:0010596	Process	Negative regulation of endothelial cell migration	IMP	20616044
GO:0016525	Process	Negative regulation of angiogenesis	IMP	20616044
GO:0030695	Function	GTPase regulator activity	TAS	9285558
GO:0045454	Process	Cell redox homeostasis	IMP	20668652
GO:0050790	Process	Regulation of catalytic activity	IEA
GO:2000114	Process	Regulation of establishment of cell polarity	IMP	20332120
GO:2000352	Process	Negative regulation of endothelial cell apoptotic process	IMP	20616044

MIM	HGNC	e!Ensembl
604214	1573	ENSG00000001631

Protein

UniProt ID

O00522

Protein name

Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein)

Protein function

Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity (By similarity). Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sp

PDB

3U7D , 4DX8 , 4DXA , 4HDO , 4HDQ , 4JIF , 4TKN , 5D68 , 6OQ3 , 6OQ4 , 6UZK , 8SU8 , 8T09 , 8T7V

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16705	NUDIX_5	22 → 198	NUDIX, or N-terminal NPxY motif-rich, region of KRIT	Domain
PF00023	Ank	320 → 352	Ankyrin repeat	Repeat
PF00373	FERM_M	517 → 640	FERM central domain	Domain

Sequence

MGNPENIEDAYVAVIRPKNTASLNSREYRAKSYEILLHEVPIEGQKKKRKKVLLETKLQG
NSEITQGILDYVVETTKPISPANQGIRGKRVVLMKKFPLDGEKMGREASLFIVPSVVKDN
TKYTYTPGCPIFYCLQDIMRVCSESSTHFATLTARMLIALDKWLDERHAQSHFIPALFRP
SPLERIKTNVINPAYATESGQTENSLHMGYSALEIKSKMLALEKADTCIYNPLFGSDLQY
TNRVDKVVINPYFGLGAPDYSKIQIPKQEKWQRSMSSVTEDKERQWVDDFPLHRSACEGD
SELLSRLLSERFSVNQLDSDHWAPIHYACWYGKVEATRILLEKGKCNPNLLNGQLSSPLH
FAAGGGHAEIVQILLNHPETDRHITDQQGRSPLNICEENKQNNWEEAAKLLKEAINKPYE
KVRIYRMDGSYRSVELKHGNNTTVQQIMEGMRLSQETQQYFTIWICSENLSLQLKPYHKP
LQHVRDWPEILAELTNLDPQRETPQLFLRRDVRLPLEVEKQIEDPLAILILFDEARYNLL
KGFYTAPDAKLITLASLLLQIVYGNYESKKHKQGFLNEENLKSIVPVTKLKSKAPHWTNR
ILHEYKNLSTSEGVSKEMHHLQRMFLQNCWEIPTYGAAFFTGQIFTKASPSNHKVIPVYV
GVNIKGLHLLNMETKALLISLKYGCFMWQLGDTDTCFQIHSMENKMSFIVHTKQAGLVVK
LLMKLNGQLMPTERNS

Sequence length

736

Interactions

View interactions

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