KCNK2 (potassium two pore domain channel subfamily K member 2)

Gene

• Entrez ID: 3776
• Gene name: Potassium two pore domain channel subfamily K member 2
• Gene symbol: KCNK2
• Synonyms: K2p2.1, TPKC1, TREK, TREK-1, TREK1, hTREK-1c, hTREK-1e
• Chromosome: 1
• Chromosome location: 1q41
• Summary: This gene encodes one of the members of the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers that create a channel that leaks potassium out of the cell to control resting membrane pote

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022916	hsa-miR-124-3p	Microarray	18668037
MIRT642058	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT642057	hsa-miR-3682-3p	HITS-CLIP	23824327
MIRT642054	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT642055	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT642059	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT642057	hsa-miR-3682-3p	HITS-CLIP	23824327
MIRT642056	hsa-miR-4284	HITS-CLIP	23824327
MIRT642054	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT642055	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT642059	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT642058	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT642057	hsa-miR-3682-3p	HITS-CLIP	23824327
MIRT642056	hsa-miR-4284	HITS-CLIP	23824327
MIRT642054	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT642055	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT739499	hsa-miR-4760-5p	HITS-CLIP	27418678
MIRT739499	hsa-miR-4760-5p	HITS-CLIP	27418678
MIRT739499	hsa-miR-4760-5p	HITS-CLIP	27418678
MIRT642058	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT642057	hsa-miR-3682-3p	HITS-CLIP	23824327
MIRT642054	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT642055	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT642059	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT642057	hsa-miR-3682-3p	HITS-CLIP	23824327
MIRT642056	hsa-miR-4284	HITS-CLIP	23824327
MIRT642054	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT642055	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT642059	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT642058	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT642057	hsa-miR-3682-3p	HITS-CLIP	23824327
MIRT642056	hsa-miR-4284	HITS-CLIP	23824327
MIRT642054	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT642055	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT1081832	hsa-miR-4659a-3p	CLIP-seq
MIRT1081833	hsa-miR-4659b-3p	CLIP-seq
MIRT1081834	hsa-miR-1184	CLIP-seq
MIRT1081835	hsa-miR-1205	CLIP-seq
MIRT1081836	hsa-miR-3130-3p	CLIP-seq
MIRT1081837	hsa-miR-3158-5p	CLIP-seq
MIRT1081838	hsa-miR-4768-5p	CLIP-seq
MIRT1081839	hsa-miR-4793-3p	CLIP-seq
MIRT2020297	hsa-miR-132	CLIP-seq
MIRT2020298	hsa-miR-212	CLIP-seq
MIRT2020299	hsa-miR-4328	CLIP-seq
MIRT2020300	hsa-miR-452	CLIP-seq
MIRT2020301	hsa-miR-4676-3p	CLIP-seq
MIRT2442288	hsa-miR-331-5p	CLIP-seq
MIRT2442289	hsa-miR-3647-3p	CLIP-seq
MIRT2442290	hsa-miR-4282	CLIP-seq
MIRT2442291	hsa-miR-513a-3p	CLIP-seq
MIRT2555416	hsa-miR-1224-3p	CLIP-seq
MIRT2555417	hsa-miR-1260	CLIP-seq
MIRT2555418	hsa-miR-1260b	CLIP-seq
MIRT2555419	hsa-miR-1263	CLIP-seq
MIRT2555420	hsa-miR-1273e	CLIP-seq
MIRT2555421	hsa-miR-1280	CLIP-seq
MIRT2555422	hsa-miR-1285	CLIP-seq
MIRT2020297	hsa-miR-132	CLIP-seq
MIRT2555423	hsa-miR-1324	CLIP-seq
MIRT2020298	hsa-miR-212	CLIP-seq
MIRT2555424	hsa-miR-224	CLIP-seq
MIRT2555425	hsa-miR-2909	CLIP-seq
MIRT2555426	hsa-miR-3125	CLIP-seq
MIRT2555427	hsa-miR-3126-3p	CLIP-seq
MIRT2555428	hsa-miR-3128	CLIP-seq
MIRT1081836	hsa-miR-3130-3p	CLIP-seq
MIRT2555429	hsa-miR-3153	CLIP-seq
MIRT2555430	hsa-miR-3162-5p	CLIP-seq
MIRT2555431	hsa-miR-3183	CLIP-seq
MIRT2555432	hsa-miR-3184	CLIP-seq
MIRT2555433	hsa-miR-3187-5p	CLIP-seq
MIRT2555434	hsa-miR-320e	CLIP-seq
MIRT2442288	hsa-miR-331-5p	CLIP-seq
MIRT2555435	hsa-miR-3613-3p	CLIP-seq
MIRT2442289	hsa-miR-3647-3p	CLIP-seq
MIRT2555436	hsa-miR-3655	CLIP-seq
MIRT2555437	hsa-miR-3671	CLIP-seq
MIRT2555438	hsa-miR-378g	CLIP-seq
MIRT2555439	hsa-miR-3910	CLIP-seq
MIRT2555440	hsa-miR-3916	CLIP-seq
MIRT2555441	hsa-miR-3942-3p	CLIP-seq
MIRT2555442	hsa-miR-410	CLIP-seq
MIRT2555443	hsa-miR-423-5p	CLIP-seq
MIRT2555444	hsa-miR-4252	CLIP-seq
MIRT2555445	hsa-miR-4257	CLIP-seq
MIRT2442290	hsa-miR-4282	CLIP-seq
MIRT2555446	hsa-miR-4311	CLIP-seq
MIRT2020299	hsa-miR-4328	CLIP-seq
MIRT2555447	hsa-miR-4436b-5p	CLIP-seq
MIRT2555448	hsa-miR-4470	CLIP-seq
MIRT2555449	hsa-miR-4486	CLIP-seq
MIRT2555450	hsa-miR-450b-5p	CLIP-seq
MIRT2555451	hsa-miR-4711-5p	CLIP-seq
MIRT2555452	hsa-miR-4715-3p	CLIP-seq
MIRT2555453	hsa-miR-4720-5p	CLIP-seq
MIRT2555454	hsa-miR-4723-3p	CLIP-seq
MIRT1081839	hsa-miR-4793-3p	CLIP-seq
MIRT2555455	hsa-miR-4799-3p	CLIP-seq
MIRT2555456	hsa-miR-485-3p	CLIP-seq
MIRT2555457	hsa-miR-499-3p	CLIP-seq
MIRT2555458	hsa-miR-499a-3p	CLIP-seq
MIRT2555459	hsa-miR-510	CLIP-seq
MIRT2555460	hsa-miR-512-5p	CLIP-seq
MIRT2442291	hsa-miR-513a-3p	CLIP-seq
MIRT2555461	hsa-miR-532-3p	CLIP-seq
MIRT2555462	hsa-miR-548a-5p	CLIP-seq
MIRT2555463	hsa-miR-548ab	CLIP-seq
MIRT2555464	hsa-miR-548ak	CLIP-seq
MIRT2555465	hsa-miR-548an	CLIP-seq
MIRT2555466	hsa-miR-548b-5p	CLIP-seq
MIRT2555467	hsa-miR-548c-5p	CLIP-seq
MIRT2555468	hsa-miR-548d-5p	CLIP-seq
MIRT2555469	hsa-miR-548h	CLIP-seq
MIRT2555470	hsa-miR-548i	CLIP-seq
MIRT2555471	hsa-miR-548j	CLIP-seq
MIRT2555472	hsa-miR-548n	CLIP-seq
MIRT2555473	hsa-miR-548w	CLIP-seq
MIRT2555474	hsa-miR-548y	CLIP-seq
MIRT2555475	hsa-miR-559	CLIP-seq
MIRT2555476	hsa-miR-570	CLIP-seq
MIRT2555477	hsa-miR-578	CLIP-seq
MIRT2555478	hsa-miR-612	CLIP-seq
MIRT2555479	hsa-miR-616	CLIP-seq
MIRT2555480	hsa-miR-622	CLIP-seq
MIRT2555416	hsa-miR-1224-3p	CLIP-seq
MIRT2555417	hsa-miR-1260	CLIP-seq
MIRT2555418	hsa-miR-1260b	CLIP-seq
MIRT2555420	hsa-miR-1273e	CLIP-seq
MIRT2555421	hsa-miR-1280	CLIP-seq
MIRT2555422	hsa-miR-1285	CLIP-seq
MIRT2020297	hsa-miR-132	CLIP-seq
MIRT2555423	hsa-miR-1324	CLIP-seq
MIRT2020298	hsa-miR-212	CLIP-seq
MIRT2555424	hsa-miR-224	CLIP-seq
MIRT2555426	hsa-miR-3125	CLIP-seq
MIRT2555427	hsa-miR-3126-3p	CLIP-seq
MIRT2555428	hsa-miR-3128	CLIP-seq
MIRT2555429	hsa-miR-3153	CLIP-seq
MIRT2555430	hsa-miR-3162-5p	CLIP-seq
MIRT2555431	hsa-miR-3183	CLIP-seq
MIRT2555433	hsa-miR-3187-5p	CLIP-seq
MIRT2442288	hsa-miR-331-5p	CLIP-seq
MIRT2555435	hsa-miR-3613-3p	CLIP-seq
MIRT2442289	hsa-miR-3647-3p	CLIP-seq
MIRT2555436	hsa-miR-3655	CLIP-seq
MIRT2555438	hsa-miR-378g	CLIP-seq
MIRT2555439	hsa-miR-3910	CLIP-seq
MIRT2555440	hsa-miR-3916	CLIP-seq
MIRT2555441	hsa-miR-3942-3p	CLIP-seq
MIRT2555442	hsa-miR-410	CLIP-seq
MIRT2555444	hsa-miR-4252	CLIP-seq
MIRT2442290	hsa-miR-4282	CLIP-seq
MIRT2555446	hsa-miR-4311	CLIP-seq
MIRT2555448	hsa-miR-4470	CLIP-seq
MIRT2555449	hsa-miR-4486	CLIP-seq
MIRT2555451	hsa-miR-4711-5p	CLIP-seq
MIRT2555452	hsa-miR-4715-3p	CLIP-seq
MIRT2555453	hsa-miR-4720-5p	CLIP-seq
MIRT2555454	hsa-miR-4723-3p	CLIP-seq
MIRT2555455	hsa-miR-4799-3p	CLIP-seq
MIRT2442291	hsa-miR-513a-3p	CLIP-seq
MIRT2683240	hsa-miR-520d-5p	CLIP-seq
MIRT2683241	hsa-miR-524-5p	CLIP-seq
MIRT2555461	hsa-miR-532-3p	CLIP-seq
MIRT2555462	hsa-miR-548a-5p	CLIP-seq
MIRT2555463	hsa-miR-548ab	CLIP-seq
MIRT2555464	hsa-miR-548ak	CLIP-seq
MIRT2555465	hsa-miR-548an	CLIP-seq
MIRT2555466	hsa-miR-548b-5p	CLIP-seq
MIRT2555467	hsa-miR-548c-5p	CLIP-seq
MIRT2555468	hsa-miR-548d-5p	CLIP-seq
MIRT2555469	hsa-miR-548h	CLIP-seq
MIRT2555470	hsa-miR-548i	CLIP-seq
MIRT2555471	hsa-miR-548j	CLIP-seq
MIRT2555472	hsa-miR-548n	CLIP-seq
MIRT2555473	hsa-miR-548w	CLIP-seq
MIRT2555474	hsa-miR-548y	CLIP-seq
MIRT2555475	hsa-miR-559	CLIP-seq
MIRT2555476	hsa-miR-570	CLIP-seq
MIRT2555477	hsa-miR-578	CLIP-seq
MIRT2555478	hsa-miR-612	CLIP-seq
MIRT2555479	hsa-miR-616	CLIP-seq
MIRT2555480	hsa-miR-622	CLIP-seq
MIRT2555432	hsa-miR-3184	CLIP-seq
MIRT2555443	hsa-miR-423-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003231	Process	Cardiac ventricle development	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007613	Process	Memory	IEA
GO:0008076	Component	Voltage-gated potassium channel complex	IEA
GO:0009612	Process	Response to mechanical stimulus	IEA
GO:0009986	Component	Cell surface	IEA
GO:0010942	Process	Positive regulation of cell death	IEA
GO:0015271	Function	Outward rectifier potassium channel activity	IBA	21873635
GO:0015271	Function	Outward rectifier potassium channel activity	ISS
GO:0016324	Component	Apical plasma membrane	IEA
GO:0022841	Function	Potassium ion leak channel activity	IBA	21873635
GO:0022841	Function	Potassium ion leak channel activity	ISS
GO:0030322	Process	Stabilization of membrane potential	IBA	21873635
GO:0043025	Component	Neuronal cell body	IEA
GO:0044305	Component	Calyx of Held	IEA
GO:0048678	Process	Response to axon injury	IEA
GO:0060044	Process	Negative regulation of cardiac muscle cell proliferation	IEA
GO:0071456	Process	Cellular response to hypoxia	IEA
GO:0071805	Process	Potassium ion transmembrane transport	IBA	21873635
GO:0071805	Process	Potassium ion transmembrane transport	ISS
GO:0090102	Process	Cochlea development	IEA
GO:0097449	Component	Astrocyte projection	IEA
GO:1900039	Process	Positive regulation of cellular response to hypoxia	IEA
GO:2000279	Process	Negative regulation of DNA biosynthetic process	IEA

Other IDs

• MIM: 603219
• HGNC: 6277
• e!Ensembl: ENSG00000082482

Protein

• UniProt ID: O95069
• Protein name: Potassium channel subfamily K member 2 (Outward rectifying potassium channel protein TREK-1) (TREK-1 K(+) channel subunit) (Two pore domain potassium channel TREK1) (Two pore potassium channel TPKC1) (K2P2.1)
• Protein function: K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate.
• PDB: 4TWK
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07885	Ion_trans_2	117 → 197	Ion channel	Family
  PF07885	Ion_trans_2	233 → 313	Ion channel	Family

• Sequence:

  MLPSASRERPGYRAGVAAPDLLDPKSAAQNSKPRLSFSTKPTVLASRVESDTTINVMKWK
  TVSTIFLVVVLYLIIGATVFKALEQPHEISQRTTIVIQKQTFISQHSCVNSTELDELIQQ
  IVAAINAGIIPLGNTSNQISHWDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIYALL
  GIPLFGFLLAGVGDQLGTIFGKGIAKVEDTFIKWNVSQTKIRIISTIIFILFGCVLFVAL
  PAIIFKHIEGWSALDAIYFVVITLTTIGFGDYVAGGSDIEYLDFYKPVVWFWILVGLAYF
  AAVLSMIGDWLRVISKKTKEEVGEFRAHAAEWTANVTAEFKETRRRLSVEIYDKFQRATS
  IKRKLSAELAGNHNQELTPCRRTLSVNHLTSERDVLPPLLKTESIYLNGLTPHCAGEEIA
  VIENIK

• Sequence length: 426