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IRS2 (insulin receptor substrate 2)

Gene

8660

Insulin receptor substrate 2

IRS2

IRS-2

13q34

This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstr

Show/Hide all(2)

SNP ID	Visualize variation	Clinical significance	Consequence
rs1805097	C>G,T	Risk-factor	Coding sequence variant, missense variant
rs137852740	G>A,C	Risk-factor	Missense variant, synonymous variant, coding sequence variant

Show/Hide all(529)

miRTarBase ID	miRNA	Experiments	Reference
MIRT003808	hsa-miR-7-5p	Reporter assay, Western blot	18483236
MIRT006332	hsa-miR-145-5p	Luciferase reporter assay	22431718
MIRT006332	hsa-miR-145-5p	Luciferase reporter assay	22431718
MIRT006332	hsa-miR-145-5p	Luciferase reporter assay	22431718
MIRT006332	hsa-miR-145-5p	Luciferase reporter assay	22431718
MIRT006332	hsa-miR-145-5p	Luciferase reporter assay	22431718
MIRT006332	hsa-miR-145-5p	Luciferase reporter assay	22431718
MIRT006332	hsa-miR-145-5p	Luciferase reporter assay	22431718
MIRT006332	hsa-miR-145-5p	Luciferase reporter assay	22431718
MIRT006332	hsa-miR-145-5p	Luciferase reporter assay	22431718
MIRT007355	hsa-miR-33a-5p	Immunofluorescence, Luciferase reporter assay, Western blot	23547260
MIRT007355	hsa-miR-33a-5p	Immunofluorescence, Luciferase reporter assay, Western blot	23547260
MIRT016052	hsa-miR-374b-5p	Sequencing	20371350
MIRT003808	hsa-miR-7-5p	Reporter assay;Western blot	18483236
MIRT027863	hsa-miR-98-5p	Microarray	19088304
MIRT052219	hsa-let-7b-5p	CLASH	23622248
MIRT051561	hsa-let-7e-5p	CLASH	23622248
MIRT041990	hsa-miR-484	CLASH	23622248
MIRT437827	hsa-miR-135a-5p	Luciferase reporter assay	23579070
MIRT437827	hsa-miR-135a-5p	Luciferase reporter assay	23579070
MIRT437827	hsa-miR-135a-5p	Luciferase reporter assay	23579070
MIRT437827	hsa-miR-135a-5p	Luciferase reporter assay	23579070
MIRT052219	hsa-let-7b-5p	Flow, Luciferase reporter assay, qRT-PCR, Western blot	24810113
MIRT052219	hsa-let-7b-5p	Flow, Luciferase reporter assay, qRT-PCR, Western blot	24810113
MIRT052219	hsa-let-7b-5p	Flow, Luciferase reporter assay, qRT-PCR, Western blot	24810113
MIRT052219	hsa-let-7b-5p	Flow, Luciferase reporter assay, qRT-PCR, Western blot	24810113
MIRT248936	hsa-miR-4501	HITS-CLIP	23313552
MIRT702681	hsa-miR-4793-5p	HITS-CLIP	23313552
MIRT702680	hsa-miR-3607-5p	HITS-CLIP	23313552
MIRT702679	hsa-miR-146a-3p	HITS-CLIP	23313552
MIRT702678	hsa-miR-301a-5p	HITS-CLIP	23313552
MIRT702677	hsa-miR-301b-5p	HITS-CLIP	23313552
MIRT702675	hsa-miR-3921	HITS-CLIP	23313552
MIRT702676	hsa-miR-4653-5p	HITS-CLIP	23313552
MIRT702674	hsa-miR-6730-3p	HITS-CLIP	23313552
MIRT702673	hsa-miR-3660	HITS-CLIP	23313552
MIRT702672	hsa-miR-4526	HITS-CLIP	23313552
MIRT702671	hsa-miR-6719-3p	HITS-CLIP	23313552
MIRT702670	hsa-miR-4299	HITS-CLIP	23313552
MIRT702669	hsa-miR-3913-3p	HITS-CLIP	23313552
MIRT702668	hsa-miR-4504	HITS-CLIP	23313552
MIRT702667	hsa-miR-542-3p	HITS-CLIP	23313552
MIRT702666	hsa-miR-489-3p	HITS-CLIP	23313552
MIRT732366	hsa-miR-338-3p	Luciferase reporter assay, qRT-PCR, Western blot	28123847
MIRT732366	hsa-miR-338-3p	Luciferase reporter assay, qRT-PCR, Western blot	28123847
MIRT735563	hsa-miR-181d-5p	ELISA, Luciferase reporter assay, qRT-PCR, Western blotting	34155619
MIRT051561	hsa-let-7e-5p	qRT-PCR	32710190
MIRT248936	hsa-miR-4501	HITS-CLIP	23313552
MIRT702681	hsa-miR-4793-5p	HITS-CLIP	23313552
MIRT702680	hsa-miR-3607-5p	HITS-CLIP	23313552
MIRT702679	hsa-miR-146a-3p	HITS-CLIP	23313552
MIRT702678	hsa-miR-301a-5p	HITS-CLIP	23313552
MIRT702677	hsa-miR-301b-5p	HITS-CLIP	23313552
MIRT702675	hsa-miR-3921	HITS-CLIP	23313552
MIRT702676	hsa-miR-4653-5p	HITS-CLIP	23313552
MIRT702674	hsa-miR-6730-3p	HITS-CLIP	23313552
MIRT702673	hsa-miR-3660	HITS-CLIP	23313552
MIRT702672	hsa-miR-4526	HITS-CLIP	23313552
MIRT702671	hsa-miR-6719-3p	HITS-CLIP	23313552
MIRT702670	hsa-miR-4299	HITS-CLIP	23313552
MIRT702669	hsa-miR-3913-3p	HITS-CLIP	23313552
MIRT702668	hsa-miR-4504	HITS-CLIP	23313552
MIRT702667	hsa-miR-542-3p	HITS-CLIP	23313552
MIRT702666	hsa-miR-489-3p	HITS-CLIP	23313552
MIRT1072121	hsa-let-7a	CLIP-seq
MIRT1072122	hsa-let-7b	CLIP-seq
MIRT1072123	hsa-let-7c	CLIP-seq
MIRT1072124	hsa-let-7d	CLIP-seq
MIRT1072125	hsa-let-7e	CLIP-seq
MIRT1072126	hsa-let-7f	CLIP-seq
MIRT1072127	hsa-let-7g	CLIP-seq
MIRT1072128	hsa-let-7i	CLIP-seq
MIRT1072129	hsa-miR-103a	CLIP-seq
MIRT1072130	hsa-miR-107	CLIP-seq
MIRT1072131	hsa-miR-1208	CLIP-seq
MIRT1072132	hsa-miR-126	CLIP-seq
MIRT1072133	hsa-miR-141	CLIP-seq
MIRT1072134	hsa-miR-145	CLIP-seq
MIRT1072135	hsa-miR-15a	CLIP-seq
MIRT1072136	hsa-miR-15b	CLIP-seq
MIRT1072137	hsa-miR-16	CLIP-seq
MIRT1072138	hsa-miR-181a	CLIP-seq
MIRT1072139	hsa-miR-181b	CLIP-seq
MIRT1072140	hsa-miR-181c	CLIP-seq
MIRT1072141	hsa-miR-181d	CLIP-seq
MIRT1072142	hsa-miR-188-3p	CLIP-seq
MIRT1072143	hsa-miR-1909	CLIP-seq
MIRT1072144	hsa-miR-1910	CLIP-seq
MIRT1072145	hsa-miR-1914	CLIP-seq
MIRT1072146	hsa-miR-195	CLIP-seq
MIRT1072147	hsa-miR-200a	CLIP-seq
MIRT1072148	hsa-miR-202	CLIP-seq
MIRT1072149	hsa-miR-2052	CLIP-seq
MIRT1072150	hsa-miR-2114	CLIP-seq
MIRT1072151	hsa-miR-223	CLIP-seq
MIRT1072152	hsa-miR-224	CLIP-seq
MIRT1072153	hsa-miR-23a	CLIP-seq
MIRT1072154	hsa-miR-23b	CLIP-seq
MIRT1072155	hsa-miR-23c	CLIP-seq
MIRT1072156	hsa-miR-3065-3p	CLIP-seq
MIRT1072157	hsa-miR-3117-3p	CLIP-seq
MIRT1072158	hsa-miR-3127-5p	CLIP-seq
MIRT1072159	hsa-miR-3143	CLIP-seq
MIRT1072160	hsa-miR-3169	CLIP-seq
MIRT1072161	hsa-miR-3177-5p	CLIP-seq
MIRT1072162	hsa-miR-3190	CLIP-seq
MIRT1072163	hsa-miR-3200-3p	CLIP-seq
MIRT1072164	hsa-miR-330-3p	CLIP-seq
MIRT1072165	hsa-miR-3545-3p	CLIP-seq
MIRT1072166	hsa-miR-3649	CLIP-seq
MIRT1072167	hsa-miR-3659	CLIP-seq
MIRT1072168	hsa-miR-3667-5p	CLIP-seq
MIRT1072169	hsa-miR-369-3p	CLIP-seq
MIRT1072170	hsa-miR-374a	CLIP-seq
MIRT1072171	hsa-miR-374b	CLIP-seq
MIRT1072172	hsa-miR-378g	CLIP-seq
MIRT1072173	hsa-miR-3910	CLIP-seq
MIRT1072174	hsa-miR-3925-3p	CLIP-seq
MIRT1072175	hsa-miR-3973	CLIP-seq
MIRT1072176	hsa-miR-3977	CLIP-seq
MIRT1072177	hsa-miR-409-5p	CLIP-seq
MIRT1072178	hsa-miR-423-3p	CLIP-seq
MIRT1072179	hsa-miR-424	CLIP-seq
MIRT1072180	hsa-miR-4258	CLIP-seq
MIRT1072181	hsa-miR-4262	CLIP-seq
MIRT1072182	hsa-miR-4269	CLIP-seq
MIRT1072183	hsa-miR-4270	CLIP-seq
MIRT1072184	hsa-miR-4272	CLIP-seq
MIRT1072185	hsa-miR-4291	CLIP-seq
MIRT1072186	hsa-miR-431	CLIP-seq
MIRT1072187	hsa-miR-4318	CLIP-seq
MIRT1072188	hsa-miR-4419a	CLIP-seq
MIRT1072189	hsa-miR-4437	CLIP-seq
MIRT1072190	hsa-miR-4441	CLIP-seq
MIRT1072191	hsa-miR-4458	CLIP-seq
MIRT1072192	hsa-miR-4459	CLIP-seq
MIRT1072193	hsa-miR-4461	CLIP-seq
MIRT1072194	hsa-miR-4468	CLIP-seq
MIRT1072195	hsa-miR-4477b	CLIP-seq
MIRT1072196	hsa-miR-4489	CLIP-seq
MIRT1072197	hsa-miR-4500	CLIP-seq
MIRT1072198	hsa-miR-4509	CLIP-seq
MIRT1072199	hsa-miR-4510	CLIP-seq
MIRT1072200	hsa-miR-4514	CLIP-seq
MIRT1072201	hsa-miR-452	CLIP-seq
MIRT1072202	hsa-miR-4530	CLIP-seq
MIRT1072203	hsa-miR-455-3p	CLIP-seq
MIRT1072204	hsa-miR-4648	CLIP-seq
MIRT1072205	hsa-miR-4653-3p	CLIP-seq
MIRT1072206	hsa-miR-4654	CLIP-seq
MIRT1072207	hsa-miR-4658	CLIP-seq
MIRT1072208	hsa-miR-4666-3p	CLIP-seq
MIRT1072209	hsa-miR-4674	CLIP-seq
MIRT1072210	hsa-miR-4676-3p	CLIP-seq
MIRT1072211	hsa-miR-4676-5p	CLIP-seq
MIRT1072212	hsa-miR-4683	CLIP-seq
MIRT1072213	hsa-miR-4692	CLIP-seq
MIRT1072214	hsa-miR-4697-3p	CLIP-seq
MIRT1072215	hsa-miR-4698	CLIP-seq
MIRT1072216	hsa-miR-4700-3p	CLIP-seq
MIRT1072217	hsa-miR-4723-5p	CLIP-seq
MIRT1072218	hsa-miR-4724-3p	CLIP-seq
MIRT1072219	hsa-miR-4733-5p	CLIP-seq
MIRT1072220	hsa-miR-4742-5p	CLIP-seq
MIRT1072221	hsa-miR-4744	CLIP-seq
MIRT1072222	hsa-miR-4758-5p	CLIP-seq
MIRT1072223	hsa-miR-4759	CLIP-seq
MIRT1072224	hsa-miR-4769-5p	CLIP-seq
MIRT1072225	hsa-miR-4795-3p	CLIP-seq
MIRT1072226	hsa-miR-4799-5p	CLIP-seq
MIRT1072227	hsa-miR-4800-3p	CLIP-seq
MIRT1072228	hsa-miR-487b	CLIP-seq
MIRT1072229	hsa-miR-497	CLIP-seq
MIRT1072230	hsa-miR-511	CLIP-seq
MIRT1072231	hsa-miR-513a-3p	CLIP-seq
MIRT1072232	hsa-miR-520d-5p	CLIP-seq
MIRT1072233	hsa-miR-520g	CLIP-seq
MIRT1072234	hsa-miR-520h	CLIP-seq
MIRT1072235	hsa-miR-524-5p	CLIP-seq
MIRT1072236	hsa-miR-539	CLIP-seq
MIRT1072237	hsa-miR-548ag	CLIP-seq
MIRT1072238	hsa-miR-548ai	CLIP-seq
MIRT1072239	hsa-miR-548an	CLIP-seq
MIRT1072240	hsa-miR-554	CLIP-seq
MIRT1072241	hsa-miR-561	CLIP-seq
MIRT1072242	hsa-miR-570	CLIP-seq
MIRT1072243	hsa-miR-574-5p	CLIP-seq
MIRT1072244	hsa-miR-575	CLIP-seq
MIRT1072245	hsa-miR-580	CLIP-seq
MIRT1072246	hsa-miR-619	CLIP-seq
MIRT1072247	hsa-miR-637	CLIP-seq
MIRT1072248	hsa-miR-660	CLIP-seq
MIRT1072249	hsa-miR-7	CLIP-seq
MIRT1072250	hsa-miR-766	CLIP-seq
MIRT1072251	hsa-miR-935	CLIP-seq
MIRT1072252	hsa-miR-944	CLIP-seq
MIRT1072253	hsa-miR-98	CLIP-seq
MIRT1072121	hsa-let-7a	CLIP-seq
MIRT1072122	hsa-let-7b	CLIP-seq
MIRT1072123	hsa-let-7c	CLIP-seq
MIRT1072124	hsa-let-7d	CLIP-seq
MIRT1072125	hsa-let-7e	CLIP-seq
MIRT1072126	hsa-let-7f	CLIP-seq
MIRT1072127	hsa-let-7g	CLIP-seq
MIRT1072128	hsa-let-7i	CLIP-seq
MIRT1550210	hsa-miR-1253	CLIP-seq
MIRT1072148	hsa-miR-202	CLIP-seq
MIRT1072149	hsa-miR-2052	CLIP-seq
MIRT1072157	hsa-miR-3117-3p	CLIP-seq
MIRT1072160	hsa-miR-3169	CLIP-seq
MIRT1072167	hsa-miR-3659	CLIP-seq
MIRT1072187	hsa-miR-4318	CLIP-seq
MIRT1072191	hsa-miR-4458	CLIP-seq
MIRT1072197	hsa-miR-4500	CLIP-seq
MIRT1072207	hsa-miR-4658	CLIP-seq
MIRT1072211	hsa-miR-4676-5p	CLIP-seq
MIRT1072222	hsa-miR-4758-5p	CLIP-seq
MIRT1072223	hsa-miR-4759	CLIP-seq
MIRT1072243	hsa-miR-574-5p	CLIP-seq
MIRT1072244	hsa-miR-575	CLIP-seq
MIRT1072253	hsa-miR-98	CLIP-seq
MIRT1072131	hsa-miR-1208	CLIP-seq
MIRT2017816	hsa-miR-1290	CLIP-seq
MIRT1072133	hsa-miR-141	CLIP-seq
MIRT1072138	hsa-miR-181a	CLIP-seq
MIRT1072139	hsa-miR-181b	CLIP-seq
MIRT1072140	hsa-miR-181c	CLIP-seq
MIRT1072141	hsa-miR-181d	CLIP-seq
MIRT1072145	hsa-miR-1914	CLIP-seq
MIRT1072147	hsa-miR-200a	CLIP-seq
MIRT2017817	hsa-miR-214	CLIP-seq
MIRT1072152	hsa-miR-224	CLIP-seq
MIRT2017818	hsa-miR-30a	CLIP-seq
MIRT2017819	hsa-miR-30b	CLIP-seq
MIRT2017820	hsa-miR-30c	CLIP-seq
MIRT2017821	hsa-miR-30d	CLIP-seq
MIRT2017822	hsa-miR-30e	CLIP-seq
MIRT2017823	hsa-miR-3138	CLIP-seq
MIRT1072159	hsa-miR-3143	CLIP-seq
MIRT2017824	hsa-miR-3171	CLIP-seq
MIRT1072161	hsa-miR-3177-5p	CLIP-seq
MIRT1072162	hsa-miR-3190	CLIP-seq
MIRT2017825	hsa-miR-323b-3p	CLIP-seq
MIRT2017826	hsa-miR-331-5p	CLIP-seq
MIRT2017827	hsa-miR-3611	CLIP-seq
MIRT2017828	hsa-miR-3619-5p	CLIP-seq
MIRT1072168	hsa-miR-3667-5p	CLIP-seq
MIRT2017829	hsa-miR-3911	CLIP-seq
MIRT1072177	hsa-miR-409-5p	CLIP-seq
MIRT1072181	hsa-miR-4262	CLIP-seq
MIRT1072182	hsa-miR-4269	CLIP-seq
MIRT1072184	hsa-miR-4272	CLIP-seq
MIRT1072185	hsa-miR-4291	CLIP-seq
MIRT2017830	hsa-miR-4328	CLIP-seq
MIRT1072192	hsa-miR-4459	CLIP-seq
MIRT2017831	hsa-miR-4477a	CLIP-seq
MIRT1072195	hsa-miR-4477b	CLIP-seq
MIRT1072196	hsa-miR-4489	CLIP-seq
MIRT1072200	hsa-miR-4514	CLIP-seq
MIRT2017832	hsa-miR-451b	CLIP-seq
MIRT1072201	hsa-miR-452	CLIP-seq
MIRT1072204	hsa-miR-4648	CLIP-seq
MIRT1072206	hsa-miR-4654	CLIP-seq
MIRT1072210	hsa-miR-4676-3p	CLIP-seq
MIRT2017833	hsa-miR-4679	CLIP-seq
MIRT1072212	hsa-miR-4683	CLIP-seq
MIRT1072213	hsa-miR-4692	CLIP-seq
MIRT1072215	hsa-miR-4698	CLIP-seq
MIRT1072216	hsa-miR-4700-3p	CLIP-seq
MIRT2017834	hsa-miR-4735-5p	CLIP-seq
MIRT1072220	hsa-miR-4742-5p	CLIP-seq
MIRT2017835	hsa-miR-4753-5p	CLIP-seq
MIRT1072224	hsa-miR-4769-5p	CLIP-seq
MIRT2017836	hsa-miR-4775	CLIP-seq
MIRT2017837	hsa-miR-4778-3p	CLIP-seq
MIRT2017838	hsa-miR-4793-3p	CLIP-seq
MIRT2017839	hsa-miR-4800-5p	CLIP-seq
MIRT2017840	hsa-miR-501-3p	CLIP-seq
MIRT2017841	hsa-miR-502-3p	CLIP-seq
MIRT1072231	hsa-miR-513a-3p	CLIP-seq
MIRT1072232	hsa-miR-520d-5p	CLIP-seq
MIRT1072235	hsa-miR-524-5p	CLIP-seq
MIRT2017842	hsa-miR-543	CLIP-seq
MIRT1072237	hsa-miR-548ag	CLIP-seq
MIRT1072238	hsa-miR-548ai	CLIP-seq
MIRT2017843	hsa-miR-548n	CLIP-seq
MIRT1072241	hsa-miR-561	CLIP-seq
MIRT1072242	hsa-miR-570	CLIP-seq
MIRT1072245	hsa-miR-580	CLIP-seq
MIRT2017844	hsa-miR-590-3p	CLIP-seq
MIRT2017845	hsa-miR-646	CLIP-seq
MIRT2017846	hsa-miR-659	CLIP-seq
MIRT1072249	hsa-miR-7	CLIP-seq
MIRT2017847	hsa-miR-761	CLIP-seq
MIRT2017848	hsa-miR-890	CLIP-seq
MIRT2017849	hsa-miR-922	CLIP-seq
MIRT1072144	hsa-miR-1910	CLIP-seq
MIRT2249653	hsa-miR-203	CLIP-seq
MIRT2249654	hsa-miR-2113	CLIP-seq
MIRT1072151	hsa-miR-223	CLIP-seq
MIRT1072161	hsa-miR-3177-5p	CLIP-seq
MIRT1072162	hsa-miR-3190	CLIP-seq
MIRT2017827	hsa-miR-3611	CLIP-seq
MIRT1072167	hsa-miR-3659	CLIP-seq
MIRT1072175	hsa-miR-3973	CLIP-seq
MIRT1072188	hsa-miR-4419a	CLIP-seq
MIRT1072193	hsa-miR-4461	CLIP-seq
MIRT1072194	hsa-miR-4468	CLIP-seq
MIRT2017831	hsa-miR-4477a	CLIP-seq
MIRT1072199	hsa-miR-4510	CLIP-seq
MIRT2017832	hsa-miR-451b	CLIP-seq
MIRT1072203	hsa-miR-455-3p	CLIP-seq
MIRT2249655	hsa-miR-4639-3p	CLIP-seq
MIRT1072207	hsa-miR-4658	CLIP-seq
MIRT1072211	hsa-miR-4676-5p	CLIP-seq
MIRT1072214	hsa-miR-4697-3p	CLIP-seq
MIRT1072216	hsa-miR-4700-3p	CLIP-seq
MIRT1072219	hsa-miR-4733-5p	CLIP-seq
MIRT1072233	hsa-miR-520g	CLIP-seq
MIRT1072234	hsa-miR-520h	CLIP-seq
MIRT1072236	hsa-miR-539	CLIP-seq
MIRT2017842	hsa-miR-543	CLIP-seq
MIRT1072241	hsa-miR-561	CLIP-seq
MIRT1072243	hsa-miR-574-5p	CLIP-seq
MIRT1072244	hsa-miR-575	CLIP-seq
MIRT1072245	hsa-miR-580	CLIP-seq
MIRT1072249	hsa-miR-7	CLIP-seq
MIRT2249656	hsa-miR-758	CLIP-seq
MIRT2389472	hsa-miR-1264	CLIP-seq
MIRT1072135	hsa-miR-15a	CLIP-seq
MIRT1072136	hsa-miR-15b	CLIP-seq
MIRT1072137	hsa-miR-16	CLIP-seq
MIRT1072146	hsa-miR-195	CLIP-seq
MIRT2389473	hsa-miR-3655	CLIP-seq
MIRT1072174	hsa-miR-3925-3p	CLIP-seq
MIRT1072179	hsa-miR-424	CLIP-seq
MIRT1072202	hsa-miR-4530	CLIP-seq
MIRT1072229	hsa-miR-497	CLIP-seq
MIRT1072249	hsa-miR-7	CLIP-seq
MIRT1072250	hsa-miR-766	CLIP-seq
MIRT1072121	hsa-let-7a	CLIP-seq
MIRT1072122	hsa-let-7b	CLIP-seq
MIRT1072123	hsa-let-7c	CLIP-seq
MIRT1072124	hsa-let-7d	CLIP-seq
MIRT1072125	hsa-let-7e	CLIP-seq
MIRT1072126	hsa-let-7f	CLIP-seq
MIRT1072127	hsa-let-7g	CLIP-seq
MIRT1072128	hsa-let-7i	CLIP-seq
MIRT1072131	hsa-miR-1208	CLIP-seq
MIRT2430088	hsa-miR-1273e	CLIP-seq
MIRT1072133	hsa-miR-141	CLIP-seq
MIRT2430089	hsa-miR-192	CLIP-seq
MIRT1072147	hsa-miR-200a	CLIP-seq
MIRT2430090	hsa-miR-200b	CLIP-seq
MIRT2430091	hsa-miR-200c	CLIP-seq
MIRT1072148	hsa-miR-202	CLIP-seq
MIRT1072149	hsa-miR-2052	CLIP-seq
MIRT2430092	hsa-miR-215	CLIP-seq
MIRT2430093	hsa-miR-3064-3p	CLIP-seq
MIRT1072156	hsa-miR-3065-3p	CLIP-seq
MIRT2017818	hsa-miR-30a	CLIP-seq
MIRT2017819	hsa-miR-30b	CLIP-seq
MIRT2017820	hsa-miR-30c	CLIP-seq
MIRT2017821	hsa-miR-30d	CLIP-seq
MIRT2017822	hsa-miR-30e	CLIP-seq
MIRT1072157	hsa-miR-3117-3p	CLIP-seq
MIRT1072159	hsa-miR-3143	CLIP-seq
MIRT1072160	hsa-miR-3169	CLIP-seq
MIRT2430094	hsa-miR-3173-3p	CLIP-seq
MIRT2430095	hsa-miR-320e	CLIP-seq
MIRT2430096	hsa-miR-33a	CLIP-seq
MIRT2430097	hsa-miR-33b	CLIP-seq
MIRT2430098	hsa-miR-3607-3p	CLIP-seq
MIRT2017827	hsa-miR-3611	CLIP-seq
MIRT2430099	hsa-miR-3616-3p	CLIP-seq
MIRT2389473	hsa-miR-3655	CLIP-seq
MIRT1072167	hsa-miR-3659	CLIP-seq
MIRT2430100	hsa-miR-3686	CLIP-seq
MIRT2430101	hsa-miR-3942-3p	CLIP-seq
MIRT2430102	hsa-miR-4267	CLIP-seq
MIRT2430103	hsa-miR-429	CLIP-seq
MIRT1072185	hsa-miR-4291	CLIP-seq
MIRT1072186	hsa-miR-431	CLIP-seq
MIRT1072187	hsa-miR-4318	CLIP-seq
MIRT2430104	hsa-miR-4428	CLIP-seq
MIRT1072191	hsa-miR-4458	CLIP-seq
MIRT1072195	hsa-miR-4477b	CLIP-seq
MIRT1072197	hsa-miR-4500	CLIP-seq
MIRT2430105	hsa-miR-4503	CLIP-seq
MIRT1072198	hsa-miR-4509	CLIP-seq
MIRT2430106	hsa-miR-450b-5p	CLIP-seq
MIRT1072201	hsa-miR-452	CLIP-seq
MIRT2430107	hsa-miR-4528	CLIP-seq
MIRT1072207	hsa-miR-4658	CLIP-seq
MIRT1072208	hsa-miR-4666-3p	CLIP-seq
MIRT1072210	hsa-miR-4676-3p	CLIP-seq
MIRT2430108	hsa-miR-4724-5p	CLIP-seq
MIRT2430109	hsa-miR-4729	CLIP-seq
MIRT1072221	hsa-miR-4744	CLIP-seq
MIRT1072222	hsa-miR-4758-5p	CLIP-seq
MIRT1072223	hsa-miR-4759	CLIP-seq
MIRT2430110	hsa-miR-4761-3p	CLIP-seq
MIRT2430111	hsa-miR-4766-3p	CLIP-seq
MIRT2430112	hsa-miR-4774-5p	CLIP-seq
MIRT2430113	hsa-miR-4778-5p	CLIP-seq
MIRT2430114	hsa-miR-4779	CLIP-seq
MIRT2430115	hsa-miR-4789-5p	CLIP-seq
MIRT1072226	hsa-miR-4799-5p	CLIP-seq
MIRT2430116	hsa-miR-4803	CLIP-seq
MIRT2430117	hsa-miR-507	CLIP-seq
MIRT1072230	hsa-miR-511	CLIP-seq
MIRT2017842	hsa-miR-543	CLIP-seq
MIRT2430118	hsa-miR-548p	CLIP-seq
MIRT2430119	hsa-miR-557	CLIP-seq
MIRT1072241	hsa-miR-561	CLIP-seq
MIRT1072242	hsa-miR-570	CLIP-seq
MIRT1072243	hsa-miR-574-5p	CLIP-seq
MIRT2430120	hsa-miR-603	CLIP-seq
MIRT2017846	hsa-miR-659	CLIP-seq
MIRT1072249	hsa-miR-7	CLIP-seq
MIRT1072253	hsa-miR-98	CLIP-seq
MIRT2437913	hsa-miR-1305	CLIP-seq
MIRT2017825	hsa-miR-323b-3p	CLIP-seq
MIRT2437914	hsa-miR-582-5p	CLIP-seq
MIRT2437915	hsa-miR-607	CLIP-seq
MIRT2017816	hsa-miR-1290	CLIP-seq
MIRT2430089	hsa-miR-192	CLIP-seq
MIRT2430090	hsa-miR-200b	CLIP-seq
MIRT2430091	hsa-miR-200c	CLIP-seq
MIRT2430092	hsa-miR-215	CLIP-seq
MIRT2553103	hsa-miR-2278	CLIP-seq
MIRT2430093	hsa-miR-3064-3p	CLIP-seq
MIRT2553104	hsa-miR-3121-3p	CLIP-seq
MIRT1072158	hsa-miR-3127-5p	CLIP-seq
MIRT1072159	hsa-miR-3143	CLIP-seq
MIRT2017824	hsa-miR-3171	CLIP-seq
MIRT2553105	hsa-miR-3200-5p	CLIP-seq
MIRT2389473	hsa-miR-3655	CLIP-seq
MIRT1072173	hsa-miR-3910	CLIP-seq
MIRT2430101	hsa-miR-3942-3p	CLIP-seq
MIRT1072177	hsa-miR-409-5p	CLIP-seq
MIRT2430102	hsa-miR-4267	CLIP-seq
MIRT1072183	hsa-miR-4270	CLIP-seq
MIRT2430103	hsa-miR-429	CLIP-seq
MIRT2553106	hsa-miR-4303	CLIP-seq
MIRT2553107	hsa-miR-4433	CLIP-seq
MIRT1072190	hsa-miR-4441	CLIP-seq
MIRT1072192	hsa-miR-4459	CLIP-seq
MIRT1072194	hsa-miR-4468	CLIP-seq
MIRT2430107	hsa-miR-4528	CLIP-seq
MIRT2017833	hsa-miR-4679	CLIP-seq
MIRT2430108	hsa-miR-4724-5p	CLIP-seq
MIRT2553108	hsa-miR-4768-3p	CLIP-seq
MIRT2430112	hsa-miR-4774-5p	CLIP-seq
MIRT2430116	hsa-miR-4803	CLIP-seq
MIRT2017840	hsa-miR-501-3p	CLIP-seq
MIRT2017841	hsa-miR-502-3p	CLIP-seq
MIRT2017842	hsa-miR-543	CLIP-seq
MIRT2553109	hsa-miR-548a-5p	CLIP-seq
MIRT2553110	hsa-miR-548aa	CLIP-seq
MIRT2553111	hsa-miR-548ab	CLIP-seq
MIRT2553112	hsa-miR-548ak	CLIP-seq
MIRT1072239	hsa-miR-548an	CLIP-seq
MIRT2553113	hsa-miR-548b-5p	CLIP-seq
MIRT2553114	hsa-miR-548c-3p	CLIP-seq
MIRT2553115	hsa-miR-548c-5p	CLIP-seq
MIRT2553116	hsa-miR-548d-5p	CLIP-seq
MIRT2553117	hsa-miR-548h	CLIP-seq
MIRT2553118	hsa-miR-548i	CLIP-seq
MIRT2553119	hsa-miR-548j	CLIP-seq
MIRT2017843	hsa-miR-548n	CLIP-seq
MIRT2553120	hsa-miR-548w	CLIP-seq
MIRT2553121	hsa-miR-548y	CLIP-seq
MIRT2553122	hsa-miR-559	CLIP-seq
MIRT2553123	hsa-miR-568	CLIP-seq
MIRT1072242	hsa-miR-570	CLIP-seq
MIRT2430120	hsa-miR-603	CLIP-seq
MIRT2017846	hsa-miR-659	CLIP-seq
MIRT2553124	hsa-miR-802	CLIP-seq
MIRT2017816	hsa-miR-1290	CLIP-seq
MIRT2430089	hsa-miR-192	CLIP-seq
MIRT2430090	hsa-miR-200b	CLIP-seq
MIRT2430091	hsa-miR-200c	CLIP-seq
MIRT2430092	hsa-miR-215	CLIP-seq
MIRT2553103	hsa-miR-2278	CLIP-seq
MIRT2430093	hsa-miR-3064-3p	CLIP-seq
MIRT2553104	hsa-miR-3121-3p	CLIP-seq
MIRT1072159	hsa-miR-3143	CLIP-seq
MIRT2017824	hsa-miR-3171	CLIP-seq
MIRT2553105	hsa-miR-3200-5p	CLIP-seq
MIRT2389473	hsa-miR-3655	CLIP-seq
MIRT1072173	hsa-miR-3910	CLIP-seq
MIRT2430101	hsa-miR-3942-3p	CLIP-seq
MIRT1072177	hsa-miR-409-5p	CLIP-seq
MIRT2430102	hsa-miR-4267	CLIP-seq
MIRT2430103	hsa-miR-429	CLIP-seq
MIRT2553106	hsa-miR-4303	CLIP-seq
MIRT2553107	hsa-miR-4433	CLIP-seq
MIRT1072192	hsa-miR-4459	CLIP-seq
MIRT1072194	hsa-miR-4468	CLIP-seq
MIRT2430107	hsa-miR-4528	CLIP-seq
MIRT2017833	hsa-miR-4679	CLIP-seq
MIRT2430108	hsa-miR-4724-5p	CLIP-seq
MIRT2553108	hsa-miR-4768-3p	CLIP-seq
MIRT2430112	hsa-miR-4774-5p	CLIP-seq
MIRT2430116	hsa-miR-4803	CLIP-seq
MIRT2017840	hsa-miR-501-3p	CLIP-seq
MIRT2017841	hsa-miR-502-3p	CLIP-seq
MIRT2017842	hsa-miR-543	CLIP-seq
MIRT2553109	hsa-miR-548a-5p	CLIP-seq
MIRT2553110	hsa-miR-548aa	CLIP-seq
MIRT2553111	hsa-miR-548ab	CLIP-seq
MIRT2553112	hsa-miR-548ak	CLIP-seq
MIRT1072239	hsa-miR-548an	CLIP-seq
MIRT2553113	hsa-miR-548b-5p	CLIP-seq
MIRT2553114	hsa-miR-548c-3p	CLIP-seq
MIRT2553115	hsa-miR-548c-5p	CLIP-seq
MIRT2553116	hsa-miR-548d-5p	CLIP-seq
MIRT2553117	hsa-miR-548h	CLIP-seq
MIRT2553118	hsa-miR-548i	CLIP-seq
MIRT2553119	hsa-miR-548j	CLIP-seq
MIRT2017843	hsa-miR-548n	CLIP-seq
MIRT2553120	hsa-miR-548w	CLIP-seq
MIRT2553121	hsa-miR-548y	CLIP-seq
MIRT2553122	hsa-miR-559	CLIP-seq
MIRT2553123	hsa-miR-568	CLIP-seq
MIRT1072242	hsa-miR-570	CLIP-seq
MIRT2430120	hsa-miR-603	CLIP-seq
MIRT2017846	hsa-miR-659	CLIP-seq

Transcription factors

Show/Hide all(9)

Transcription factor	Regulation	Reference
DLX5	Activation	21045156
EIF2AK2	Unknown	20685959
FOXO1	Unknown	20685959
NFIC	Activation	19755487
PGR	Unknown	14534541
SP1	Activation	19755487
SP1	Unknown	19875459
SREBF1	Repression	15881188;16091421
ZNF148	Unknown	19875459

Show/Hide all(43)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000165	Process	MAPK cascade	TAS
GO:0002053	Process	Positive regulation of mesenchymal cell proliferation	IEA
GO:0002903	Process	Negative regulation of B cell apoptotic process	ISS
GO:0005158	Function	Insulin receptor binding	IBA	21873635
GO:0005515	Function	Protein binding	IPI	15161933, 17901049, 21241768, 23617393, 26496610, 28514442
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	TAS
GO:0006006	Process	Glucose metabolic process	TAS	9495343
GO:0007165	Process	Signal transduction	TAS	7675087
GO:0007411	Process	Axon guidance	TAS
GO:0007420	Process	Brain development	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	NAS	17925406
GO:0008286	Process	Insulin receptor signaling pathway	IBA	21873635
GO:0008286	Process	Insulin receptor signaling pathway	ISS
GO:0009749	Process	Response to glucose	ISS
GO:0010748	Process	Negative regulation of long-chain fatty acid import across plasma membrane	IMP	16814735
GO:0010907	Process	Positive regulation of glucose metabolic process	IMP	16814735
GO:0014068	Process	Positive regulation of phosphatidylinositol 3-kinase signaling	TAS
GO:0019216	Process	Regulation of lipid metabolic process	TAS	16814735
GO:0019901	Function	Protein kinase binding	IEA
GO:0019903	Function	Protein phosphatase binding	IEA
GO:0019904	Function	Protein domain specific binding	IEA
GO:0030335	Process	Positive regulation of cell migration	IEA
GO:0030879	Process	Mammary gland development	IEA
GO:0030890	Process	Positive regulation of B cell proliferation	ISS
GO:0032000	Process	Positive regulation of fatty acid beta-oxidation	IMP	16814735
GO:0032024	Process	Positive regulation of insulin secretion	ISS
GO:0032869	Process	Cellular response to insulin stimulus	IMP	16814735
GO:0032991	Component	Protein-containing complex	IEA
GO:0033673	Process	Negative regulation of kinase activity	ISS
GO:0038111	Process	Interleukin-7-mediated signaling pathway	TAS
GO:0043548	Function	Phosphatidylinositol 3-kinase binding	IBA	21873635
GO:0045725	Process	Positive regulation of glycogen biosynthetic process	IMP	16814735
GO:0045725	Process	Positive regulation of glycogen biosynthetic process	NAS	17925406
GO:0046326	Process	Positive regulation of glucose import	IMP	16814735
GO:0046579	Process	Positive regulation of Ras protein signal transduction	TAS
GO:0048015	Process	Phosphatidylinositol-mediated signaling	TAS
GO:0051897	Process	Positive regulation of protein kinase B signaling	TAS
GO:0055088	Process	Lipid homeostasis	TAS	16814735
GO:0071333	Process	Cellular response to glucose stimulus	IEA
GO:0071889	Function	14-3-3 protein binding	IEA

MIM	HGNC	e!Ensembl
600797	6126	ENSG00000185950

Protein

UniProt ID

Q9Y4H2

Protein name

Insulin receptor substrate 2 (IRS-2)

Protein function

Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). Plays therefore an important role in de

PDB

3FQW , 3FQX

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00169	PH	31 → 144	PH domain	Domain
PF02174	IRS	194 → 296	PTB domain (IRS-1 type)	Domain

Sequence

MASPPRHGPPGPASGDGPNLNNNNNNNNHSVRKCGYLRKQKHGHKRFFVLRGPGAGGDEA
TAGGGSAPQPPRLEYYESEKKWRSKAGAPKRVIALDCCLNINKRADAKHKYLIALYTKDE
YFAVAAENEQEQEGWYRALTDLVSEGRAAAGDAPPAAAPAASCSASLPGALGGSAGAAGA
EDSYGLVAPATAAYREVWQVNLKPKGLGQSKNLTGVYRLCLSARTIGFVKLNCEQPSVTL
QLMNIRRCGHSDSFFFIEVGRSAVTGPGELWMQADDSVVAQNIHETILEAMKALKELFEF
RPRSKSQSSGSSATHPISVPGARRHHHLVNLPPSQTGLVRRSRTDSLAATPPAAKCSSCR
VRTASEGDGGAAAGAAAAGARPVSVAGSPLSPGPVRAPLSRSHTLSGGCGGRGSKVALLP
AGGALQHSRSMSMPVAHSPPAATSPGSLSSSSGHGSGSYPPPPGPHPPLPHPLHHGPGQR
PSSGSASASGSPSDPGFMSLDEYGSSPGDLRAFCSHRSNTPESIAETPPARDGGGGGEFY
GYMTMDRPLSHCGRSYRRVSGDAAQDLDRGLRKRTYSLTTPARQRPVPQPSSASLDEYTL
MRATFSGSAGRLCPSCPASSPKVAYHPYPEDYGDIEIGSHRSSSSNLGADDGYMPMTPGA
ALAGSGSGSCRSDDYMPMSPASVSAPKQILQPRAAAAAAAAVPSAGPAGPAPTSAAGRTF
PASGGGYKASSPAESSPEDSGYMRMWCGSKLSMEHADGKLLPNGDYLNVSPSDAVTTGTP
PDFFSAALHPGGEPLRGVPGCCYSSLPRSYKAPYTCGGDSDQYVLMSSPVGRILEEERLE
PQATPGPSQAASAFGAGPTQPPHPVVPSPVRPSGGRPEGFLGQRGRAVRPTRLSLEGLPS
LPSMHEYPLPPEPKSPGEYINIDFGEPGARLSPPAPPLLASAASSSSLLSASSPASSLGS
GTPGTSSDSRQRSPLSDYMNLDFSSPKSPKPGAPSGHPVGSLDGLLSPEASSPYPPLPPR
PSASPSSSLQPPPPPPAPGELYRLPPASAVATAQGPGAASSLSSDTGDNGDYTEMAFGVA
ATPPQPIAAPPKPEAARVASPTSGVKRLSLMEQVSGVEAFLQASQPPDPHRGAKVIRADP
QGGRRRHSSETFSSTTTVTPVSPSFAHNPKRHNSASVENVSLRKSSEGGVGVGPGGGDEP
PTSPRQLQPAPPLAPQGRPWTPGQPGGLVGCPGSGGSPMRRETSAGFQNGLNYIAIDVRE
EPGLPPQPQPPPPPLPQPGDKSSWGRTRSLGGLISAVGVGSTGGGCGGPGPGALPPANTY
ASIDFLSHHLKEATIVKE

Sequence length

1338

Interactions

View interactions

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