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IRS1 (insulin receptor substrate 1)

Gene

Insulin receptor substrate 1

IRS1

HIRS-1

2

2q36.3

This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009]

Show/Hide all(3)

SNP ID	Visualize variation	Clinical significance	Consequence
rs1801278	C>G,T	Risk-factor	Coding sequence variant, missense variant
rs104893642	G>A,C	Pathogenic	Coding sequence variant, missense variant
rs1259467443	ACC>-	Pathogenic	Coding sequence variant, inframe deletion

Show/Hide all(82)

miRTarBase ID	miRNA	Experiments	Reference
MIRT000731	hsa-miR-145-5p	Luciferase reporter assay, Northern blot, qRT-PCR, Western blot, Reporter assay;Other	17827156
MIRT000731	hsa-miR-145-5p	qRT-PCR, Western blot	19391107
MIRT000731	hsa-miR-145-5p	Luciferase reporter assay	22431718
MIRT000731	hsa-miR-145-5p	Luciferase reporter assay, Western blot	23201159
MIRT000731	hsa-miR-145-5p	Flow, Luciferase reporter assay, qRT-PCR, Western blot	24690171
MIRT000731	hsa-miR-145-5p	qRT-PCR, Western blot	19439999
MIRT000731	hsa-miR-145-5p	Luciferase reporter assay, qRT-PCR, Western blot	23714355
MIRT000731	hsa-miR-145-5p	qRT-PCR, In situ hybridization, Western blot	25477374
MIRT003807	hsa-miR-7-5p	Western blot	18483236
MIRT004355	hsa-miR-126-3p	qRT-PCR, Luciferase reporter assay, Western blot	18834857
MIRT004355	hsa-miR-126-3p	Luciferase reporter assay	21464990
MIRT004355	hsa-miR-126-3p	Luciferase reporter assay, Northern blot, qRT-PCR, Western blot	23603512
MIRT004355	hsa-miR-126-3p	Luciferase reporter assay, qRT-PCR, Western blot	23893300
MIRT004355	hsa-miR-126-3p	Luciferase reporter assay	26893711
MIRT004355	hsa-miR-126-3p	Luciferase reporter assay, qRT-PCR, Western blot	26617742
MIRT004355	hsa-miR-126-3p	Microarray, qRT-PCR, Western blot	27119351
MIRT006859	hsa-miR-148a-3p	Luciferase reporter assay, Western blot	22935141
MIRT006860	hsa-miR-152-3p	Luciferase reporter assay, Western blot	22935141
MIRT437910	hsa-miR-105-5p	Luciferase reporter assay, Western blot	25280563
MIRT442208	hsa-miR-4480	PAR-CLIP	22100165
MIRT442210	hsa-miR-4311	PAR-CLIP	22100165
MIRT542213	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT542213	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT542214	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT542214	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT542214	hsa-miR-4789-5p	HITS-CLIP	27418678
MIRT542215	hsa-miR-3941	PAR-CLIP	21572407
MIRT542215	hsa-miR-3941	HITS-CLIP	24906430
MIRT542215	hsa-miR-3941	HITS-CLIP	23824327
MIRT542215	hsa-miR-3941	HITS-CLIP	27418678
MIRT542216	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT542216	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT542217	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT542217	hsa-miR-511-3p	HITS-CLIP	23824327
MIRT542218	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT542218	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT542218	hsa-miR-5011-5p	HITS-CLIP	27418678
MIRT542219	hsa-miR-4789-3p	PAR-CLIP	21572407
MIRT542219	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT542219	hsa-miR-4789-3p	HITS-CLIP	27418678
MIRT542220	hsa-miR-5580-3p	PAR-CLIP	21572407
MIRT542220	hsa-miR-5580-3p	HITS-CLIP	23824327
MIRT542221	hsa-miR-603	PAR-CLIP	21572407
MIRT542221	hsa-miR-603	HITS-CLIP	24906430
MIRT542221	hsa-miR-603	HITS-CLIP	23824327
MIRT542221	hsa-miR-603	HITS-CLIP	27418678
MIRT542222	hsa-miR-362-3p	PAR-CLIP	21572407
MIRT542222	hsa-miR-362-3p	HITS-CLIP	24906430
MIRT542222	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT542222	hsa-miR-362-3p	HITS-CLIP	27418678
MIRT542223	hsa-miR-8485	PAR-CLIP	21572407
MIRT542223	hsa-miR-8485	HITS-CLIP	24906430
MIRT542223	hsa-miR-8485	HITS-CLIP	23824327
MIRT542223	hsa-miR-8485	HITS-CLIP	27418678
MIRT542224	hsa-miR-329-3p	PAR-CLIP	21572407
MIRT542224	hsa-miR-329-3p	HITS-CLIP	24906430
MIRT542224	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT542224	hsa-miR-329-3p	HITS-CLIP	27418678
MIRT544956	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT544956	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT544956	hsa-miR-190a-3p	HITS-CLIP	27418678
MIRT556913	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT623572	hsa-miR-1185-2-3p	HITS-CLIP	23824327
MIRT623572	hsa-miR-1185-2-3p	HITS-CLIP	27418678
MIRT623573	hsa-miR-1185-1-3p	HITS-CLIP	23824327
MIRT623573	hsa-miR-1185-1-3p	HITS-CLIP	27418678
MIRT623574	hsa-let-7f-2-3p	HITS-CLIP	23824327
MIRT623574	hsa-let-7f-2-3p	HITS-CLIP	27418678
MIRT623575	hsa-miR-7157-5p	HITS-CLIP	23824327
MIRT623576	hsa-miR-4310	HITS-CLIP	23824327
MIRT623577	hsa-miR-3120-3p	HITS-CLIP	23824327
MIRT667814	hsa-miR-4777-3p	HITS-CLIP	23824327
MIRT711049	hsa-miR-892c-3p	HITS-CLIP	19536157
MIRT711050	hsa-miR-4676-3p	HITS-CLIP	19536157
MIRT711051	hsa-miR-452-5p	HITS-CLIP	19536157
MIRT711052	hsa-miR-429	HITS-CLIP	19536157
MIRT711053	hsa-miR-200c-3p	HITS-CLIP	19536157
MIRT711054	hsa-miR-200b-3p	HITS-CLIP	19536157
MIRT732116	hsa-miR-1225-5p	Immunofluorescence, Immunohistochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	26684358
MIRT734527	hsa-miR-144-3p	Luciferase reporter assay, qRT-PCR, Western blot	27069535
MIRT735025	hsa-miR-628-5p	Luciferase reporter assay	27766036
MIRT735485	hsa-miR-384	Luciferase reporter assay, qRT-PCR, Western blot	27542674

Show/Hide all(52)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000165	Process	MAPK cascade	TAS
GO:0001784	Function	Phosphotyrosine residue binding	IPI	20624904
GO:0005068	Function	Transmembrane receptor protein tyrosine kinase adaptor activity	ISS
GO:0005080	Function	Protein kinase C binding	ISS
GO:0005158	Function	Insulin receptor binding	IBA	21873635
GO:0005158	Function	Insulin receptor binding	IPI	7493946, 7537849
GO:0005159	Function	Insulin-like growth factor receptor binding	IPI	7541045
GO:0005515	Function	Protein binding	IPI	7513703, 7542742, 7559478, 7680095, 7680644, 7935368, 8382612, 8388384, 9295312, 11018022, 11403293, 11416002, 11694516, 14632132, 16230374, 16273093, 16582879, 18498745, 18952604, 23643389, 23770097, 24008843, 25814554
GO:0005634	Component	Nucleus	ISS
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	ISS
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	TAS
GO:0005899	Component	Insulin receptor complex	ISS
GO:0005901	Component	Caveola	IDA	15182363
GO:0007165	Process	Signal transduction	TAS	1311924
GO:0008284	Process	Positive regulation of cell population proliferation	NAS	17925406
GO:0008286	Process	Insulin receptor signaling pathway	IBA	21873635
GO:0008286	Process	Insulin receptor signaling pathway	IDA	16516141, 23401856
GO:0008286	Process	Insulin receptor signaling pathway	IMP	16814735
GO:0008286	Process	Insulin receptor signaling pathway	IPI	7537849, 7559478
GO:0010907	Process	Positive regulation of glucose metabolic process	IMP	16814735
GO:0014065	Process	Phosphatidylinositol 3-kinase signaling	IDA	7782332
GO:0030159	Function	Signaling receptor complex adaptor activity	IDA	7493946
GO:0032000	Process	Positive regulation of fatty acid beta-oxidation	IMP	16814735
GO:0032868	Process	Response to insulin	IDA	16516141
GO:0032869	Process	Cellular response to insulin stimulus	IMP	16814735
GO:0038111	Process	Interleukin-7-mediated signaling pathway	TAS
GO:0042169	Function	SH2 domain binding	ISS
GO:0042593	Process	Glucose homeostasis	TAS	16814735
GO:0043231	Component	Intracellular membrane-bounded organelle	ISS
GO:0043434	Process	Response to peptide hormone	ISS
GO:0043548	Function	Phosphatidylinositol 3-kinase binding	IBA	21873635
GO:0043548	Function	Phosphatidylinositol 3-kinase binding	IPI	7782332, 16043515
GO:0043548	Function	Phosphatidylinositol 3-kinase binding	ISS
GO:0043552	Process	Positive regulation of phosphatidylinositol 3-kinase activity	ISS
GO:0045725	Process	Positive regulation of glycogen biosynthetic process	IMP	16814735
GO:0045725	Process	Positive regulation of glycogen biosynthetic process	NAS	17925406
GO:0046326	Process	Positive regulation of glucose import	IDA	7493946
GO:0046326	Process	Positive regulation of glucose import	IMP	16814735
GO:0046627	Process	Negative regulation of insulin receptor signaling pathway	ISS
GO:0046628	Process	Positive regulation of insulin receptor signaling pathway	IDA	7493946
GO:0046628	Process	Positive regulation of insulin receptor signaling pathway	ISS
GO:0046676	Process	Negative regulation of insulin secretion	IDA	15572028
GO:0048009	Process	Insulin-like growth factor receptor signaling pathway	IPI	7541045
GO:0048015	Process	Phosphatidylinositol-mediated signaling	TAS
GO:0051897	Process	Positive regulation of protein kinase B signaling	TAS
GO:0071398	Process	Cellular response to fatty acid	ISS

MIM	HGNC	e!Ensembl
147545	6125	ENSG00000169047

Protein

UniProt ID

Protein name

Insulin receptor substrate 1 (IRS-1)

Protein function

May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).

PDB

1IRS , 1K3A , 1QQG , 2Z8C , 5U1M , 6BNT

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00169	PH	7 → 114	PH domain	Domain
PF02174	IRS	160 → 262	PTB domain (IRS-1 type)	Domain

Sequence

MASPPESDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP
KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGH
HDGAAALGAGGGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLI
GIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQV
DDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLT
RRSRTESITATSPASMVGGKPGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHR
GSARLHPPLNHSRSIPMPASRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSP
SDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGPSTLTAPN
GHYILSRGGNGHRCTPGTGLGTSPALAGDEAASAADLDNRFRKRTHSAGTSPTITHQKTP
SQSSVASIEEYTEMMPAYPPGGGSGGRLPGHRHSAFVPTRSYPEEGLEMHPLERRGGHHR
PDSSTLHTDDGYMPMSPGVAPVPSGRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPN
GYMMMSPSGGCSPDIGGGPSSSSSSSNAVPSGTSYGKLWTNGVGGHHSHVLPHPKPPVES
SGGKLLPCTGDYMNMSPVGDSNTSSPSDCYYGPEDPQHKPVLSYYSLPRSFKHTQRPGEP
EEGARHQHLRLSTSSGRLLYAATADDSSSSTSSDSLGGGYCGARLEPSLPHPHHQVLQPH
LPRKVDTAAQTNSRLARPTRLSLGDPKASTLPRAREQQQQQQPLLHPPEPKSPGEYVNIE
FGSDQSGYLSGPVAFHSSPSVRCPSQLQPAPREEETGTEEYMKMDLGPGRRAAWQESTGV
EMGRLGPAPPGAASICRPTRAVPSSRGDYMTMQMSCPRQSYVDTSPAAPVSYADMRTGIA
AEEVSLPRATMAAASSSSAASASPTGPQGAAELAAHSSLLGGPQGPGGMSAFTRVNLSPN
RNQSAKVIRADPQGCRRRHSSETFSSTPSATRVGNTVPFGAGAAVGGGGGSSSSSEDVKR
HSSASFENVWLRPGELGGAPKEPAKLCGAAGGLENGLNYIDLDLVKDFKQCPQECTPEPQ
PPPPPPPHQPLGSGESSSTRRSSEDLSAYASISFQKQPEDRQ

Sequence length

1242

Interactions

View interactions

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