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IRAK1 (interleukin 1 receptor associated kinase 1)

Gene

3654

Interleukin 1 receptor associated kinase 1

IRAK1

IRAK, pelle

Xq28

This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation

Show/Hide all(349)

miRTarBase ID	miRNA	Experiments	Reference
MIRT000712	hsa-miR-146a-5p	Western blot, Northern blot	18504431
MIRT000712	hsa-miR-146a-5p	Luciferase reporter assay, Western blot	20061417
MIRT000712	hsa-miR-146a-5p	qRT-PCR	18759964
MIRT000712	hsa-miR-146a-5p	qRT-PCR, Western blot, Immunofluorescence	19918258
MIRT005395	hsa-miR-146b-5p	Luciferase reporter assay, Microarray, Northern blot, qRT-PCR	16885212
MIRT005395	hsa-miR-146b-5p	Luciferase reporter assay, Microarray, Northern blot, qRT-PCR	16885212
MIRT005395	hsa-miR-146b-5p	Luciferase reporter assay, Microarray, Northern blot, qRT-PCR	16885212
MIRT005395	hsa-miR-146b-5p	Luciferase reporter assay, Microarray, Northern blot, qRT-PCR	16885212
MIRT000712	hsa-miR-146a-5p	Luciferase reporter assay, Microarray, Northern blot, qRT-PCR	16885212
MIRT000712	hsa-miR-146a-5p	Luciferase reporter assay, Microarray, Northern blot, qRT-PCR	16885212
MIRT000712	hsa-miR-146a-5p	Luciferase reporter assay, Microarray, Northern blot, qRT-PCR	16885212
MIRT000712	hsa-miR-146a-5p	Luciferase reporter assay, Microarray, Northern blot, qRT-PCR	16885212
MIRT000712	hsa-miR-146a-5p	ELISA, Luciferase reporter assay, Northern blot, qRT-PCR, Western blot	20542134
MIRT000712	hsa-miR-146a-5p	ELISA, Luciferase reporter assay, Northern blot, qRT-PCR, Western blot	20542134
MIRT000712	hsa-miR-146a-5p	qRT-PCR, Western blot	21178010
MIRT000712	hsa-miR-146a-5p	Luciferase reporter assay, Western blot	21632853
MIRT000712	hsa-miR-146a-5p	Luciferase reporter assay, Western blot	21632853
MIRT000712	hsa-miR-146a-5p	Luciferase reporter assay, Western blot	21632853
MIRT000712	hsa-miR-146a-5p	Luciferase reporter assay	22593544
MIRT000712	hsa-miR-146a-5p	Western blot	20110513
MIRT024479	hsa-miR-215-5p	Microarray	19074876
MIRT026216	hsa-miR-192-5p	Microarray	19074876
MIRT051021	hsa-miR-17-5p	CLASH	23622248
MIRT049357	hsa-miR-92a-3p	CLASH	23622248
MIRT046662	hsa-miR-222-3p	CLASH	23622248
MIRT045847	hsa-miR-132-3p	CLASH	23622248
MIRT043810	hsa-miR-328-3p	CLASH	23622248
MIRT042485	hsa-miR-423-3p	CLASH	23622248
MIRT041223	hsa-miR-193b-3p	CLASH	23622248
MIRT038891	hsa-miR-93-3p	CLASH	23622248
MIRT038255	hsa-miR-330-5p	CLASH	23622248
MIRT037612	hsa-miR-744-5p	CLASH	23622248
MIRT036505	hsa-miR-1226-3p	CLASH	23622248
MIRT005395	hsa-miR-146b-5p	Luciferase reporter assay, qRT-PCR, Western blot	23680172
MIRT000712	hsa-miR-146a-5p	Luciferase reporter assay, qRT-PCR, Western blot	23680172
MIRT000712	hsa-miR-146a-5p	In situ hybridization, Luciferase reporter assay, qRT-PCR, Western blot	22992343
MIRT000712	hsa-miR-146a-5p	In situ hybridization, Luciferase reporter assay, qRT-PCR, Western blot	22992343
MIRT000712	hsa-miR-146a-5p	In situ hybridization, Luciferase reporter assay, qRT-PCR, Western blot	22992343
MIRT000712	hsa-miR-146a-5p	In situ hybridization, Luciferase reporter assay, qRT-PCR, Western blot	22992343
MIRT000712	hsa-miR-146a-5p	In situ hybridization, Luciferase reporter assay, qRT-PCR, Western blot	22992343
MIRT000712	hsa-miR-146a-5p	In situ hybridization, Luciferase reporter assay, qRT-PCR, Western blot	22992343
MIRT000712	hsa-miR-146a-5p	qRT-PCR, Western blot	23018031
MIRT054357	hsa-miR-21-5p	Chip, ELISA, Flow cytometry, Luciferase reporter assay, QRTPCR, Western blot	23633945
MIRT000712	hsa-miR-146a-5p	QRTPCR, Western blot	24867582
MIRT000712	hsa-miR-146a-5p	Microarray, Western blot	23952003
MIRT000712	hsa-miR-146a-5p	Luciferase reporter assay	24107356
MIRT000712	hsa-miR-146a-5p	Microarray, Western blot	23952003
MIRT000712	hsa-miR-146a-5p	Luciferase reporter assay	24107356
MIRT440429	hsa-miR-142-3p	HITS-CLIP	22473208
MIRT440429	hsa-miR-142-3p	HITS-CLIP	22473208
MIRT000712	hsa-miR-146a-5p	Luciferase reporter assay	25623956
MIRT000712	hsa-miR-146a-5p	Luciferase reporter assay, qRT-PCR, Western blot	26151128
MIRT000712	hsa-miR-146a-5p	ELISA, Immunohistochemistry, qRT-PCR, Western blot	27636999
MIRT000712	hsa-miR-146a-5p	qRT-PCR, Western blot	25889446
MIRT000712	hsa-miR-146a-5p	ELISA, EMSA, Microarray, qRT-PCR, Western blot	27922090
MIRT734683	hsa-miR-146b-3p	Luciferase reporter assay	25771167
MIRT000712	hsa-miR-146a-5p	qRT-PCR, Western blot	25805648
MIRT005395	hsa-miR-146b-5p	Luciferase reporter assay, qRT-PCR, Western blot	27533309
MIRT000712	hsa-miR-146a-5p	ChIP-seq, ELISA, qRT-PCR	34203452
MIRT000712	hsa-miR-146a-5p	Immunofluorescence, qRT-PCR	32210951
MIRT733241	hsa-miR-146a-3p	Immunocytochemistry (ICC), Mass spectrometry, qRT-PCR, Western blotting	33968923
MIRT733241	hsa-miR-146a-3p	ELISA, qRT-PCR	33430976
MIRT734331	hsa-miR-143-3p	ELISA, qRT-PCR	33430976
MIRT734681	hsa-miR-21-3p	Microarray, ELISA	31727077
MIRT733241	hsa-miR-146a-3p	Microarray, ELISA	31727077
MIRT734683	hsa-miR-146b-3p	Microarray, ELISA	31727077
MIRT735163	hsa-miR-192-3p	Luciferase reporter assay, Western blotting, qRT-PCR, ELISA	32668391
MIRT000712	hsa-miR-146a-5p	qRT-PCR	31739406
MIRT733241	hsa-miR-146a-3p	Western blotting, qRT-PCR, Flow cytometry, ELISA	32117283
MIRT736424	hsa-miR-491-3p	qRT-PCR, Flow cytometry	33679688
MIRT000712	hsa-miR-146a-5p	Luciferase reporter assay, Western blotting, qRT-PCR	32935891
MIRT000712	hsa-miR-146a-5p	Luciferase reporter assay, Western blotting, qRT-PCR, Immunohistochemistry (IHC), Immunofluorescence	37391426
MIRT000712	hsa-miR-146a-5p	qRT-PCR, Flow cytometry	35799283
MIRT000712	hsa-miR-146a-5p	Luciferase reporter assay, Western blotting, qRT-PCR	35777802
MIRT000712	hsa-miR-146a-5p	Luciferase reporter assay	36175984
MIRT1070321	hsa-miR-1207-3p	CLIP-seq
MIRT1070322	hsa-miR-1208	CLIP-seq
MIRT1070323	hsa-miR-134	CLIP-seq
MIRT1070324	hsa-miR-140-3p	CLIP-seq
MIRT1070325	hsa-miR-1587	CLIP-seq
MIRT1070326	hsa-miR-1914	CLIP-seq
MIRT1070327	hsa-miR-221	CLIP-seq
MIRT1070328	hsa-miR-222	CLIP-seq
MIRT1070329	hsa-miR-2355-5p	CLIP-seq
MIRT1070330	hsa-miR-3118	CLIP-seq
MIRT1070331	hsa-miR-3157-5p	CLIP-seq
MIRT1070332	hsa-miR-3164	CLIP-seq
MIRT1070333	hsa-miR-34b	CLIP-seq
MIRT1070334	hsa-miR-3607-5p	CLIP-seq
MIRT1070335	hsa-miR-3611	CLIP-seq
MIRT1070336	hsa-miR-3617	CLIP-seq
MIRT1070337	hsa-miR-3646	CLIP-seq
MIRT1070338	hsa-miR-3649	CLIP-seq
MIRT1070339	hsa-miR-3689a-5p	CLIP-seq
MIRT1070340	hsa-miR-3689b	CLIP-seq
MIRT1070341	hsa-miR-3689e	CLIP-seq
MIRT1070342	hsa-miR-3689f	CLIP-seq
MIRT1070343	hsa-miR-3690	CLIP-seq
MIRT1070344	hsa-miR-378g	CLIP-seq
MIRT1070345	hsa-miR-3977	CLIP-seq
MIRT1070346	hsa-miR-4253	CLIP-seq
MIRT1070347	hsa-miR-4492	CLIP-seq
MIRT1070348	hsa-miR-4498	CLIP-seq
MIRT1070349	hsa-miR-4530	CLIP-seq
MIRT1070350	hsa-miR-4656	CLIP-seq
MIRT1070351	hsa-miR-4666-5p	CLIP-seq
MIRT1070352	hsa-miR-4675	CLIP-seq
MIRT1070353	hsa-miR-4741	CLIP-seq
MIRT1070354	hsa-miR-4786-3p	CLIP-seq
MIRT1070355	hsa-miR-4798-3p	CLIP-seq
MIRT1070356	hsa-miR-490-3p	CLIP-seq
MIRT1070357	hsa-miR-511	CLIP-seq
MIRT1070358	hsa-miR-548v	CLIP-seq
MIRT1070359	hsa-miR-556-3p	CLIP-seq
MIRT1070360	hsa-miR-558	CLIP-seq
MIRT1070361	hsa-miR-619	CLIP-seq
MIRT1070362	hsa-miR-641	CLIP-seq
MIRT1070363	hsa-miR-646	CLIP-seq
MIRT1070364	hsa-miR-648	CLIP-seq
MIRT1070365	hsa-miR-661	CLIP-seq
MIRT1070366	hsa-miR-762	CLIP-seq
MIRT1070367	hsa-miR-888	CLIP-seq
MIRT1070368	hsa-miR-106a	CLIP-seq
MIRT1070369	hsa-miR-106b	CLIP-seq
MIRT1070370	hsa-miR-1182	CLIP-seq
MIRT1070322	hsa-miR-1208	CLIP-seq
MIRT1070371	hsa-miR-122	CLIP-seq
MIRT1070372	hsa-miR-1229	CLIP-seq
MIRT1070373	hsa-miR-1231	CLIP-seq
MIRT1070374	hsa-miR-150	CLIP-seq
MIRT1070375	hsa-miR-17	CLIP-seq
MIRT1070376	hsa-miR-1915	CLIP-seq
MIRT1070377	hsa-miR-193a-5p	CLIP-seq
MIRT1070378	hsa-miR-1976	CLIP-seq
MIRT1070379	hsa-miR-20a	CLIP-seq
MIRT1070380	hsa-miR-20b	CLIP-seq
MIRT1070381	hsa-miR-302a	CLIP-seq
MIRT1070382	hsa-miR-302b	CLIP-seq
MIRT1070383	hsa-miR-302c	CLIP-seq
MIRT1070384	hsa-miR-302d	CLIP-seq
MIRT1070385	hsa-miR-302e	CLIP-seq
MIRT1070386	hsa-miR-3120-5p	CLIP-seq
MIRT1070387	hsa-miR-3135b	CLIP-seq
MIRT1070388	hsa-miR-3194-3p	CLIP-seq
MIRT1070389	hsa-miR-3652	CLIP-seq
MIRT1070390	hsa-miR-3672	CLIP-seq
MIRT1070391	hsa-miR-372	CLIP-seq
MIRT1070392	hsa-miR-373	CLIP-seq
MIRT1070393	hsa-miR-431	CLIP-seq
MIRT1070394	hsa-miR-4312	CLIP-seq
MIRT1070395	hsa-miR-4430	CLIP-seq
MIRT1070396	hsa-miR-4438	CLIP-seq
MIRT1070397	hsa-miR-4446-5p	CLIP-seq
MIRT1070398	hsa-miR-4666-3p	CLIP-seq
MIRT1070399	hsa-miR-4685-5p	CLIP-seq
MIRT1070400	hsa-miR-4722-3p	CLIP-seq
MIRT1070401	hsa-miR-4726-3p	CLIP-seq
MIRT1070402	hsa-miR-4731-5p	CLIP-seq
MIRT1070403	hsa-miR-4757-5p	CLIP-seq
MIRT1070404	hsa-miR-485-3p	CLIP-seq
MIRT1070405	hsa-miR-494	CLIP-seq
MIRT1070406	hsa-miR-5095	CLIP-seq
MIRT1070407	hsa-miR-512-3p	CLIP-seq
MIRT1070408	hsa-miR-519d	CLIP-seq
MIRT1070409	hsa-miR-520a-3p	CLIP-seq
MIRT1070410	hsa-miR-520b	CLIP-seq
MIRT1070411	hsa-miR-520c-3p	CLIP-seq
MIRT1070412	hsa-miR-520d-3p	CLIP-seq
MIRT1070413	hsa-miR-520e	CLIP-seq
MIRT1070414	hsa-miR-520g	CLIP-seq
MIRT1070415	hsa-miR-520h	CLIP-seq
MIRT1070416	hsa-miR-555	CLIP-seq
MIRT1070417	hsa-miR-600	CLIP-seq
MIRT1070418	hsa-miR-93	CLIP-seq
MIRT2017311	hsa-miR-1197	CLIP-seq
MIRT1070334	hsa-miR-3607-5p	CLIP-seq
MIRT1070336	hsa-miR-3617	CLIP-seq
MIRT1070339	hsa-miR-3689a-5p	CLIP-seq
MIRT1070340	hsa-miR-3689b	CLIP-seq
MIRT1070341	hsa-miR-3689e	CLIP-seq
MIRT1070342	hsa-miR-3689f	CLIP-seq
MIRT1070351	hsa-miR-4666-5p	CLIP-seq
MIRT1070404	hsa-miR-485-3p	CLIP-seq
MIRT1070362	hsa-miR-641	CLIP-seq
MIRT2017312	hsa-miR-146a	CLIP-seq
MIRT1070339	hsa-miR-3689a-5p	CLIP-seq
MIRT1070340	hsa-miR-3689b	CLIP-seq
MIRT1070341	hsa-miR-3689e	CLIP-seq
MIRT1070342	hsa-miR-3689f	CLIP-seq
MIRT1070346	hsa-miR-4253	CLIP-seq
MIRT1070351	hsa-miR-4666-5p	CLIP-seq
MIRT2017313	hsa-miR-589	CLIP-seq
MIRT1070365	hsa-miR-661	CLIP-seq
MIRT2249209	hsa-miR-1184	CLIP-seq
MIRT1070371	hsa-miR-122	CLIP-seq
MIRT1070374	hsa-miR-150	CLIP-seq
MIRT1070378	hsa-miR-1976	CLIP-seq
MIRT2249210	hsa-miR-3117-3p	CLIP-seq
MIRT1070387	hsa-miR-3135b	CLIP-seq
MIRT2249211	hsa-miR-3169	CLIP-seq
MIRT1070389	hsa-miR-3652	CLIP-seq
MIRT2249212	hsa-miR-3680	CLIP-seq
MIRT1070346	hsa-miR-4253	CLIP-seq
MIRT1070394	hsa-miR-4312	CLIP-seq
MIRT2249213	hsa-miR-4418	CLIP-seq
MIRT1070395	hsa-miR-4430	CLIP-seq
MIRT1070398	hsa-miR-4666-3p	CLIP-seq
MIRT1070400	hsa-miR-4722-3p	CLIP-seq
MIRT2249214	hsa-miR-4724-5p	CLIP-seq
MIRT2249215	hsa-miR-4740-5p	CLIP-seq
MIRT1070403	hsa-miR-4757-5p	CLIP-seq
MIRT2249216	hsa-miR-4759	CLIP-seq
MIRT1070404	hsa-miR-485-3p	CLIP-seq
MIRT2249217	hsa-miR-509-3-5p	CLIP-seq
MIRT2249218	hsa-miR-509-5p	CLIP-seq
MIRT1070407	hsa-miR-512-3p	CLIP-seq
MIRT1070323	hsa-miR-134	CLIP-seq
MIRT2389465	hsa-miR-149	CLIP-seq
MIRT1070376	hsa-miR-1915	CLIP-seq
MIRT1070330	hsa-miR-3118	CLIP-seq
MIRT1070332	hsa-miR-3164	CLIP-seq
MIRT2389466	hsa-miR-3661	CLIP-seq
MIRT1070397	hsa-miR-4446-5p	CLIP-seq
MIRT1070401	hsa-miR-4726-3p	CLIP-seq
MIRT1070355	hsa-miR-4798-3p	CLIP-seq
MIRT2389467	hsa-miR-631	CLIP-seq
MIRT1070364	hsa-miR-648	CLIP-seq
MIRT1070370	hsa-miR-1182	CLIP-seq
MIRT1070371	hsa-miR-122	CLIP-seq
MIRT1070377	hsa-miR-193a-5p	CLIP-seq
MIRT1070387	hsa-miR-3135b	CLIP-seq
MIRT1070388	hsa-miR-3194-3p	CLIP-seq
MIRT1070389	hsa-miR-3652	CLIP-seq
MIRT1070393	hsa-miR-431	CLIP-seq
MIRT1070395	hsa-miR-4430	CLIP-seq
MIRT1070405	hsa-miR-494	CLIP-seq
MIRT1070370	hsa-miR-1182	CLIP-seq
MIRT2249209	hsa-miR-1184	CLIP-seq
MIRT1070321	hsa-miR-1207-3p	CLIP-seq
MIRT1070371	hsa-miR-122	CLIP-seq
MIRT2552731	hsa-miR-1254	CLIP-seq
MIRT2552732	hsa-miR-1295	CLIP-seq
MIRT1070324	hsa-miR-140-3p	CLIP-seq
MIRT2552733	hsa-miR-148a	CLIP-seq
MIRT2552734	hsa-miR-148b	CLIP-seq
MIRT2389465	hsa-miR-149	CLIP-seq
MIRT1070374	hsa-miR-150	CLIP-seq
MIRT2552735	hsa-miR-152	CLIP-seq
MIRT1070376	hsa-miR-1915	CLIP-seq
MIRT1070377	hsa-miR-193a-5p	CLIP-seq
MIRT2552736	hsa-miR-1972	CLIP-seq
MIRT1070329	hsa-miR-2355-5p	CLIP-seq
MIRT2552737	hsa-miR-2467-5p	CLIP-seq
MIRT2552738	hsa-miR-2861	CLIP-seq
MIRT2552739	hsa-miR-3064-3p	CLIP-seq
MIRT2552740	hsa-miR-3116	CLIP-seq
MIRT1070387	hsa-miR-3135b	CLIP-seq
MIRT1070331	hsa-miR-3157-5p	CLIP-seq
MIRT2552741	hsa-miR-3188	CLIP-seq
MIRT1070388	hsa-miR-3194-3p	CLIP-seq
MIRT1070337	hsa-miR-3646	CLIP-seq
MIRT1070338	hsa-miR-3649	CLIP-seq
MIRT1070389	hsa-miR-3652	CLIP-seq
MIRT2389466	hsa-miR-3661	CLIP-seq
MIRT2249212	hsa-miR-3680	CLIP-seq
MIRT2552742	hsa-miR-3929	CLIP-seq
MIRT2552743	hsa-miR-3975	CLIP-seq
MIRT2552744	hsa-miR-4267	CLIP-seq
MIRT2552745	hsa-miR-4293	CLIP-seq
MIRT1070393	hsa-miR-431	CLIP-seq
MIRT2552746	hsa-miR-4327	CLIP-seq
MIRT2249213	hsa-miR-4418	CLIP-seq
MIRT2552747	hsa-miR-4419b	CLIP-seq
MIRT1070395	hsa-miR-4430	CLIP-seq
MIRT2552748	hsa-miR-4474-3p	CLIP-seq
MIRT2552749	hsa-miR-4478	CLIP-seq
MIRT1070349	hsa-miR-4530	CLIP-seq
MIRT2552750	hsa-miR-4649-3p	CLIP-seq
MIRT2552751	hsa-miR-4663	CLIP-seq
MIRT1070398	hsa-miR-4666-3p	CLIP-seq
MIRT2552752	hsa-miR-4671-5p	CLIP-seq
MIRT2552753	hsa-miR-4717-5p	CLIP-seq
MIRT2552754	hsa-miR-4755-3p	CLIP-seq
MIRT1070403	hsa-miR-4757-5p	CLIP-seq
MIRT1070404	hsa-miR-485-3p	CLIP-seq
MIRT2552755	hsa-miR-485-5p	CLIP-seq
MIRT1070405	hsa-miR-494	CLIP-seq
MIRT2249217	hsa-miR-509-3-5p	CLIP-seq
MIRT2249218	hsa-miR-509-5p	CLIP-seq
MIRT2552756	hsa-miR-515-3p	CLIP-seq
MIRT2552757	hsa-miR-519e	CLIP-seq
MIRT2552758	hsa-miR-544b	CLIP-seq
MIRT2552759	hsa-miR-550a	CLIP-seq
MIRT2552760	hsa-miR-566	CLIP-seq
MIRT2389467	hsa-miR-631	CLIP-seq
MIRT1070363	hsa-miR-646	CLIP-seq
MIRT1070365	hsa-miR-661	CLIP-seq
MIRT2552761	hsa-miR-663b	CLIP-seq
MIRT1070370	hsa-miR-1182	CLIP-seq
MIRT2249209	hsa-miR-1184	CLIP-seq
MIRT1070371	hsa-miR-122	CLIP-seq
MIRT2552731	hsa-miR-1254	CLIP-seq
MIRT2552733	hsa-miR-148a	CLIP-seq
MIRT2552734	hsa-miR-148b	CLIP-seq
MIRT2389465	hsa-miR-149	CLIP-seq
MIRT1070374	hsa-miR-150	CLIP-seq
MIRT2552735	hsa-miR-152	CLIP-seq
MIRT1070376	hsa-miR-1915	CLIP-seq
MIRT1070377	hsa-miR-193a-5p	CLIP-seq
MIRT2552737	hsa-miR-2467-5p	CLIP-seq
MIRT2552738	hsa-miR-2861	CLIP-seq
MIRT2552739	hsa-miR-3064-3p	CLIP-seq
MIRT2552740	hsa-miR-3116	CLIP-seq
MIRT1070387	hsa-miR-3135b	CLIP-seq
MIRT1070331	hsa-miR-3157-5p	CLIP-seq
MIRT2552741	hsa-miR-3188	CLIP-seq
MIRT1070388	hsa-miR-3194-3p	CLIP-seq
MIRT1070337	hsa-miR-3646	CLIP-seq
MIRT1070389	hsa-miR-3652	CLIP-seq
MIRT2389466	hsa-miR-3661	CLIP-seq
MIRT2249212	hsa-miR-3680	CLIP-seq
MIRT2552742	hsa-miR-3929	CLIP-seq
MIRT2552743	hsa-miR-3975	CLIP-seq
MIRT2552745	hsa-miR-4293	CLIP-seq
MIRT1070393	hsa-miR-431	CLIP-seq
MIRT2552746	hsa-miR-4327	CLIP-seq
MIRT2249213	hsa-miR-4418	CLIP-seq
MIRT2552747	hsa-miR-4419b	CLIP-seq
MIRT1070395	hsa-miR-4430	CLIP-seq
MIRT2552748	hsa-miR-4474-3p	CLIP-seq
MIRT2552749	hsa-miR-4478	CLIP-seq
MIRT2552750	hsa-miR-4649-3p	CLIP-seq
MIRT2552751	hsa-miR-4663	CLIP-seq
MIRT1070398	hsa-miR-4666-3p	CLIP-seq
MIRT2552752	hsa-miR-4671-5p	CLIP-seq
MIRT1070403	hsa-miR-4757-5p	CLIP-seq
MIRT1070404	hsa-miR-485-3p	CLIP-seq
MIRT2552755	hsa-miR-485-5p	CLIP-seq
MIRT1070405	hsa-miR-494	CLIP-seq
MIRT2249217	hsa-miR-509-3-5p	CLIP-seq
MIRT2249218	hsa-miR-509-5p	CLIP-seq
MIRT2552756	hsa-miR-515-3p	CLIP-seq
MIRT2552757	hsa-miR-519e	CLIP-seq
MIRT2552758	hsa-miR-544b	CLIP-seq
MIRT2552759	hsa-miR-550a	CLIP-seq
MIRT2552760	hsa-miR-566	CLIP-seq
MIRT2389467	hsa-miR-631	CLIP-seq
MIRT1070365	hsa-miR-661	CLIP-seq
MIRT2552761	hsa-miR-663b	CLIP-seq

Show/Hide all(66)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000187	Process	Activation of MAPK activity	TAS
GO:0001959	Process	Regulation of cytokine-mediated signaling pathway	IMP	10383454
GO:0002224	Process	Toll-like receptor signaling pathway	TAS
GO:0002755	Process	MyD88-dependent toll-like receptor signaling pathway	TAS	10383454
GO:0004672	Function	Protein kinase activity	IBA	21873635
GO:0004672	Function	Protein kinase activity	IDA	12054681
GO:0004672	Function	Protein kinase activity	TAS
GO:0004674	Function	Protein serine/threonine kinase activity	EXP	11960013
GO:0004674	Function	Protein serine/threonine kinase activity	IBA	21873635
GO:0004704	Function	NF-kappaB-inducing kinase activity	TAS	8599092
GO:0005515	Function	Protein binding	IPI	10854325, 11397809, 11518704, 12242293, 12496252, 12860405, 12874243, 12925853, 16203735, 16884718, 17567694, 19081057, 19264966, 21743479, 21903422, 22037600, 28436939, 29883609
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005811	Component	Lipid droplet	ISS
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	TAS
GO:0006468	Process	Protein phosphorylation	TAS	8599092
GO:0007250	Process	Activation of NF-kappaB-inducing kinase activity	IDA	11397809
GO:0007254	Process	JNK cascade	TAS
GO:0007568	Process	Aging	IEA
GO:0010008	Component	Endosome membrane	TAS
GO:0016032	Process	Viral process	IEA
GO:0016301	Function	Kinase activity	IDA	12054681
GO:0019221	Process	Cytokine-mediated signaling pathway	IBA	21873635
GO:0031072	Function	Heat shock protein binding	IEA
GO:0031663	Process	Lipopolysaccharide-mediated signaling pathway	IMP	10383454
GO:0032088	Process	Negative regulation of NF-kappaB transcription factor activity	IMP	10383454
GO:0032481	Process	Positive regulation of type I interferon production	IMP	23633945
GO:0032496	Process	Response to lipopolysaccharide	IMP	10383454
GO:0032991	Component	Protein-containing complex	IDA	10854325
GO:0034134	Process	Toll-like receptor 2 signaling pathway	IBA	21873635
GO:0034134	Process	Toll-like receptor 2 signaling pathway	IMP	10383454
GO:0034142	Process	Toll-like receptor 4 signaling pathway	IBA	21873635
GO:0034162	Process	Toll-like receptor 9 signaling pathway	TAS
GO:0034605	Process	Cellular response to heat	IEA
GO:0035556	Process	Intracellular signal transduction	IBA	21873635
GO:0042802	Function	Identical protein binding	IPI	11397809
GO:0042803	Function	Protein homodimerization activity	IPI	10383454
GO:0043066	Process	Negative regulation of apoptotic process	TAS
GO:0043123	Process	Positive regulation of I-kappaB kinase/NF-kappaB signaling	IBA	21873635
GO:0043123	Process	Positive regulation of I-kappaB kinase/NF-kappaB signaling	IMP	22158417
GO:0043123	Process	Positive regulation of I-kappaB kinase/NF-kappaB signaling	TAS
GO:0043406	Process	Positive regulation of MAP kinase activity	IBA	21873635
GO:0045087	Process	Innate immune response	IBA	21873635
GO:0046777	Process	Protein autophosphorylation	IDA	10383454, 12054681
GO:0046982	Function	Protein heterodimerization activity	IPI	10383454
GO:0048661	Process	Positive regulation of smooth muscle cell proliferation	IEA
GO:0051092	Process	Positive regulation of NF-kappaB transcription factor activity	IBA	21873635
GO:0051092	Process	Positive regulation of NF-kappaB transcription factor activity	IDA	10383454
GO:0051092	Process	Positive regulation of NF-kappaB transcription factor activity	TAS
GO:0060337	Process	Type I interferon signaling pathway	IMP	23633945
GO:0070423	Process	Nucleotide-binding oligomerization domain containing signaling pathway	TAS
GO:0070498	Process	Interleukin-1-mediated signaling pathway	IBA	21873635
GO:0070498	Process	Interleukin-1-mediated signaling pathway	IMP	10383454
GO:0070498	Process	Interleukin-1-mediated signaling pathway	TAS
GO:0070555	Process	Response to interleukin-1	IMP	10383454
GO:0071222	Process	Cellular response to lipopolysaccharide	IBA	21873635
GO:0071456	Process	Cellular response to hypoxia	IEA
GO:0106310	Function	Protein serine kinase activity	IEA
GO:0106311	Function	Protein threonine kinase activity	IEA
GO:1901224	Process	Positive regulation of NIK/NF-kappaB signaling	IMP	25515214
GO:1904996	Process	Positive regulation of leukocyte adhesion to vascular endothelial cell	IMP	25515214

MIM	HGNC	e!Ensembl
300283	6112	ENSG00000184216

Protein

UniProt ID

P51617

Protein name

Interleukin-1 receptor-associated kinase 1 (IRAK-1) (EC 2.7.11.1)

Protein function

Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling

PDB

6BFN

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00531	Death	27 → 103	Death domain	Domain
PF00069	Pkinase	212 → 517	Protein kinase domain	Domain

Sequence

MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCE
RSGQRTASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTAPRPSS
IPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTK
PGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKR
LKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRL
HCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFG
LARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAG
QRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDP
RPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQVYERLEKLQAVVAGVPGHSEAASCIPP
SPQENSYVSSTGRAHSGAAPWQPLAAPSGASAQAAEQLQRGPNQPVESDESLGGLSAALR
SWHLTPSCPLDPAPLREAGCPQGDTAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQI
IINPARQKMVQKLALYEDGALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQS

Sequence length

712

Interactions

View interactions

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