IL17RC (interleukin 17 receptor C)

Gene

• Entrez ID: 84818
• Gene name: Interleukin 17 receptor C
• Gene symbol: IL17RC
• Synonyms: CANDF9, IL17-RL, IL17RL
• Chromosome: 3
• Chromosome location: 3p25.3|3p25.3-p24.1
• Summary: This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs559955121	C>T	Likely-pathogenic	Coding sequence variant, stop gained, non coding transcript variant
rs773852926	C>T	Pathogenic	Non coding transcript variant, coding sequence variant, stop gained
rs1057518751	C>T	Pathogenic	Stop gained, non coding transcript variant, coding sequence variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT028962	hsa-miR-26b-5p	Microarray	19088304
MIRT052327	hsa-let-7b-5p	CLASH	23622248
MIRT050548	hsa-miR-20a-5p	CLASH	23622248
MIRT036625	hsa-miR-940	CLASH	23622248
MIRT036625	hsa-miR-940	CLASH	23622248

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005102	Function	Signaling receptor binding	IEA
GO:0005515	Function	Protein binding	IPI	24120361, 28827714
GO:0005886	Component	Plasma membrane	TAS
GO:0006954	Process	Inflammatory response	IEA
GO:0009986	Component	Cell surface	IEA
GO:0016021	Component	Integral component of membrane	IEA
GO:0030368	Function	Interleukin-17 receptor activity	IBA	21873635
GO:0030368	Function	Interleukin-17 receptor activity	IDA	17911633
GO:0032755	Process	Positive regulation of interleukin-6 production	IEA
GO:0050832	Process	Defense response to fungus	IEA
GO:0071621	Process	Granulocyte chemotaxis	IEA
GO:0097400	Process	Interleukin-17-mediated signaling pathway	TAS
GO:1900017	Process	Positive regulation of cytokine production involved in inflammatory response	IEA

Other IDs

• MIM: 610925
• HGNC: 18358
• e!Ensembl: ENSG00000163702

Protein

• UniProt ID: Q8NAC3
• Protein name: Interleukin-17 receptor C (IL-17 receptor C) (IL-17RC) (Interleukin-17 receptor homolog) (IL17Rhom) (Interleukin-17 receptor-like protein) (IL-17RL) (ZcytoR14)
• Protein function: Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity (By similarity). Receptor for IL17A and IL17F, major effector cytokines of inn
• PDB: 6HG4, 6HG9, 6HGA, 7UWN, 7ZAN
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15037	IL17_R_N	142 → 530	Interleukin-17 receptor extracellular region	Family
  PF08357	SEFIR	584 → 737	SEFIR domain	Family

• Sequence:

  MPVPWFLLSLALGRSPVVLSLERLVGPQDATHCSPVSLEPWGDEERLRVQFLAQQSLSLA
  PVTAATARTALSGLSGADGRREERGRGKSWVCLSLGGSGNTEPQKKGLSCRLWDSDILCL
  PGDIVPAPGPVLAPTHLQTELVLRCQKETDCDLCLRVAVHLAVHGHWEEPEDEEKFGGAA
  DSGVEEPRNASLQAQVVLSFQAYPTARCVLLEVQVPAALVQFGQSVGSVVYDCFEAALGS
  EVRIWSYTQPRYEKELNHTQQLPDCRGLEVWNSIPSCWALPWLNVSADGDNVHLVLNVSE
  EQHFGLSLYWNQVQGPPKPRWHKNLTGPQIITLNHTDLVPCLCIQVWPLEPDSVRTNICP
  FREDPRAHQNLWQAARLQLLTLQSWLLDAPCSLPAEAALCWRAPGGDPCQPLVPPLSWEN
  VTVDKVLEFPLLKGHPNLCVQVNSSEKLQLQECLWADSLGPLKDDVLLLETRGPQDNRSL
  CALEPSGCTSLPSKASTRAARLGEYLLQDLQSGQCLQLWDDDLGALWACPMDKYIHKRWA
  LVWLACLLFAAALSLILLLKKDHAKGWLRLLKQDVRSGAAARGRAALLLYSADDSGFERL
  VGALASALCQLPLRVAVDLWSRRELSAQGPVAWFHAQRRQTLQEGGVVVLLFSPGAVALC
  SEWLQDGVSGPGAHGPHDAFRASLSCVLPDFLQGRAPGSYVGACFDRLLHPDAVPALFRT
  VPVFTLPSQLPDFLGALQQPRAPRSGRLQERAEQVSRALQPALDSYFHPPGTPAPGRGVG
  PGAGPGAGDGT

• Sequence length: 791