Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
23765 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Interleukin 17 receptor A |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
IL17RA |
SynonymsGene synonyms aliases
|
CANDF5, CD217, CDw217, IL-17RA, IL17R, IMD51, hIL-17R |
ChromosomeChromosome number
|
22 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
22q11.1 |
SummarySummary of gene provided in NCBI Entrez Gene.
|
Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A |
SNPsSNP information provided by dbSNP.
|
SNP ID |
Visualize variation |
Clinical significance |
Consequence |
rs201128237 |
T>C |
Likely-pathogenic |
Splice donor variant |
rs387906913 |
C>T |
Pathogenic |
Stop gained, coding sequence variant |
rs778624945 |
C>A,T |
Pathogenic |
Synonymous variant, coding sequence variant, stop gained |
rs1057518744 |
->GGAGATGGTGGAGAGCA |
Pathogenic |
Frameshift variant, coding sequence variant |
rs1057518745 |
C>G,T |
Pathogenic |
Coding sequence variant, stop gained, missense variant |
rs1057518746 |
C>- |
Pathogenic |
Frameshift variant, coding sequence variant |
rs1057518747 |
CCAGA>- |
Pathogenic |
Frameshift variant, coding sequence variant |
rs1057519079 |
G>A |
Pathogenic |
Coding sequence variant, missense variant |
rs1601340933 |
->ACCT |
Pathogenic |
Coding sequence variant, frameshift variant |
|
miRNAmiRNA information provided by mirtarbase database.
|
|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
|
|
Protein
|
UniProt ID |
Q96F46 |
Protein name |
Interleukin-17 receptor A (IL-17 receptor A) (IL-17RA) (CDw217) (CD antigen CD217) |
Protein function |
Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (Pub |
PDB |
3JVF
,
4HSA
,
4NUX
,
5N9B
,
5NAN
,
7UWL
,
7UWM
,
7UWN
,
7ZAN
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF16556 |
IL17R_fnIII_D1 |
48 → 198 |
Interleukin-17 receptor, fibronectin-III-like domain 1 |
Domain |
PF16578 |
IL17R_fnIII_D2 |
199 → 303 |
|
Domain |
PF08357 |
SEFIR |
378 → 536 |
SEFIR domain |
Family |
|
Sequence |
|
Sequence length |
866 |
Interactions |
View interactions |