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IL10 (interleukin 10)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3586
Gene nameGene Name - the full gene name approved by the HGNC.
Interleukin 10
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
IL10
SynonymsGene synonyms aliases
CSIF, GVHDS, IL-10, IL10A, TGIF
ChromosomeChromosome number
1
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q32.1
SummarySummary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT005082 hsa-miR-106a-5p Luciferase reporter assay, qRT-PCR 19307576
MIRT054365 hsa-let-7c-5p Luciferase reporter assay, qRT-PCR 22835429
MIRT054365 hsa-let-7c-5p Luciferase reporter assay, qRT-PCR 22835429
MIRT731372 hsa-miR-194-5p Luciferase reporter assay, Microarray, qRT-PCR 26147452
MIRT731372 hsa-miR-194-5p Luciferase reporter assay, Microarray, qRT-PCR 26147452
Transcription factors
Transcription factor Regulation Reference
ATF1 Activation 10540320
CEBPA Unknown 12219016
CEBPB Unknown 12493739
CREB1 Activation 10540320;22140263
CREB1 Unknown 17202341
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001818 Process Negative regulation of cytokine production IDA 1940799
GO:0001819 Process Positive regulation of cytokine production IDA 10443688
GO:0001938 Process Positive regulation of endothelial cell proliferation IEA
GO:0002237 Process Response to molecule of bacterial origin IDA 17449476
GO:0002639 Process Positive regulation of immunoglobulin production IGI 22962438
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P22301
Protein name Interleukin-10 (IL-10) (Cytokine synthesis inhibitory factor) (CSIF)
Protein function Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric rec
PDB 1ILK , 1INR , 1J7V , 1LK3 , 1Y6K , 2H24 , 2ILK , 6X93 , 8SVE
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00726 IL10
5 174
Interleukin 10
Domain
Sequence
Sequence length 178
Interactions View interactions

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