IKBKE (inhibitor of nuclear factor kappa B kinase subunit epsilon)

Gene

• Entrez ID: 9641
• Gene name: Inhibitor of nuclear factor kappa B kinase subunit epsilon
• Gene symbol: IKBKE
• Synonyms: IKK-E, IKK-i, IKKE, IKKI
• Chromosome: 1
• Chromosome location: 1q32.1
• Summary: IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT003484	hsa-miR-155-5p	qRT-PCR, Western blot	18753206
MIRT003484	hsa-miR-155-5p	Luciferase reporter assay	19177201
MIRT003484	hsa-miR-155-5p	Review	20026422
MIRT006572	hsa-miR-296-5p	Luciferase reporter assay	22114321
MIRT006572	hsa-miR-296-5p	Luciferase reporter assay	22114321
MIRT003484	hsa-miR-155-5p	Proteomics	20584899
MIRT022344	hsa-miR-124-3p	Microarray	18668037
MIRT003484	hsa-miR-155-5p	Luciferase reporter assay, Western blot	24151514
MIRT003484	hsa-miR-155-5p	Luciferase reporter assay, Western blot	24151514
MIRT003484	hsa-miR-155-5p	Immunofluorescence, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	26934326
MIRT003484	hsa-miR-155-5p	Immunofluorescence, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	26934326
MIRT003484	hsa-miR-155-5p	Immunofluorescence, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	26934326
MIRT003484	hsa-miR-155-5p	Immunofluorescence, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	26934326
MIRT003484	hsa-miR-155-5p	Immunofluorescence, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	26934326
MIRT003484	hsa-miR-155-5p	Immunofluorescence, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	26934326
MIRT003484	hsa-miR-155-5p	Immunofluorescence, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	26934326
MIRT003484	hsa-miR-155-5p	Immunofluorescence, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	26934326
MIRT1063065	hsa-miR-155	CLIP-seq
MIRT1063066	hsa-miR-2682	CLIP-seq
MIRT1063067	hsa-miR-3190	CLIP-seq
MIRT1063068	hsa-miR-3202	CLIP-seq
MIRT1063069	hsa-miR-34a	CLIP-seq
MIRT1063070	hsa-miR-34c-5p	CLIP-seq
MIRT1063071	hsa-miR-3714	CLIP-seq
MIRT1063072	hsa-miR-449a	CLIP-seq
MIRT1063073	hsa-miR-449b	CLIP-seq
MIRT1063074	hsa-miR-449c	CLIP-seq
MIRT1063075	hsa-miR-4533	CLIP-seq
MIRT1063076	hsa-miR-4717-5p	CLIP-seq
MIRT1063077	hsa-miR-4729	CLIP-seq
MIRT1063078	hsa-miR-4753-5p	CLIP-seq
MIRT1063079	hsa-miR-548ag	CLIP-seq
MIRT1063080	hsa-miR-548ai	CLIP-seq
MIRT1063081	hsa-miR-548an	CLIP-seq
MIRT1063065	hsa-miR-155	CLIP-seq
MIRT1063066	hsa-miR-2682	CLIP-seq
MIRT1063067	hsa-miR-3190	CLIP-seq
MIRT1063068	hsa-miR-3202	CLIP-seq
MIRT1063069	hsa-miR-34a	CLIP-seq
MIRT1063070	hsa-miR-34c-5p	CLIP-seq
MIRT1063071	hsa-miR-3714	CLIP-seq
MIRT1063072	hsa-miR-449a	CLIP-seq
MIRT1063073	hsa-miR-449b	CLIP-seq
MIRT1063074	hsa-miR-449c	CLIP-seq
MIRT1063075	hsa-miR-4533	CLIP-seq
MIRT1063079	hsa-miR-548ag	CLIP-seq
MIRT1063080	hsa-miR-548ai	CLIP-seq
MIRT1063081	hsa-miR-548an	CLIP-seq
MIRT2247226	hsa-miR-4459	CLIP-seq
MIRT2451670	hsa-miR-1976	CLIP-seq
MIRT2451671	hsa-miR-3183	CLIP-seq
MIRT2247226	hsa-miR-4459	CLIP-seq
MIRT2451672	hsa-miR-4695-5p	CLIP-seq
MIRT2451673	hsa-miR-4723-3p	CLIP-seq
MIRT2451674	hsa-miR-665	CLIP-seq
MIRT2550643	hsa-miR-1252	CLIP-seq
MIRT2550644	hsa-miR-1282	CLIP-seq
MIRT2550645	hsa-miR-1321	CLIP-seq
MIRT2550646	hsa-miR-146b-3p	CLIP-seq
MIRT2550647	hsa-miR-185	CLIP-seq
MIRT2550648	hsa-miR-1915	CLIP-seq
MIRT2550649	hsa-miR-192	CLIP-seq
MIRT2550650	hsa-miR-193a-3p	CLIP-seq
MIRT2550651	hsa-miR-193b	CLIP-seq
MIRT2451670	hsa-miR-1976	CLIP-seq
MIRT2550652	hsa-miR-2110	CLIP-seq
MIRT2550653	hsa-miR-215	CLIP-seq
MIRT2550654	hsa-miR-24	CLIP-seq
MIRT2550655	hsa-miR-2467-5p	CLIP-seq
MIRT2550656	hsa-miR-3125	CLIP-seq
MIRT2550657	hsa-miR-3133	CLIP-seq
MIRT2550658	hsa-miR-3162-5p	CLIP-seq
MIRT2550659	hsa-miR-3173-5p	CLIP-seq
MIRT2550660	hsa-miR-3176	CLIP-seq
MIRT2451671	hsa-miR-3183	CLIP-seq
MIRT2550661	hsa-miR-3187-3p	CLIP-seq
MIRT2550662	hsa-miR-3188	CLIP-seq
MIRT2550663	hsa-miR-337-3p	CLIP-seq
MIRT1063069	hsa-miR-34a	CLIP-seq
MIRT1063070	hsa-miR-34c-5p	CLIP-seq
MIRT2550664	hsa-miR-3916	CLIP-seq
MIRT2550665	hsa-miR-3922-3p	CLIP-seq
MIRT2550666	hsa-miR-3975	CLIP-seq
MIRT2550667	hsa-miR-421	CLIP-seq
MIRT2550668	hsa-miR-4264	CLIP-seq
MIRT2550669	hsa-miR-4271	CLIP-seq
MIRT2550670	hsa-miR-4292	CLIP-seq
MIRT2550671	hsa-miR-4306	CLIP-seq
MIRT2550672	hsa-miR-4423-5p	CLIP-seq
MIRT2550673	hsa-miR-4435	CLIP-seq
MIRT2550674	hsa-miR-4457	CLIP-seq
MIRT2247226	hsa-miR-4459	CLIP-seq
MIRT2550675	hsa-miR-4476	CLIP-seq
MIRT1063072	hsa-miR-449a	CLIP-seq
MIRT1063073	hsa-miR-449b	CLIP-seq
MIRT1063075	hsa-miR-4533	CLIP-seq
MIRT2550676	hsa-miR-4635	CLIP-seq
MIRT2550677	hsa-miR-4644	CLIP-seq
MIRT2550678	hsa-miR-4649-3p	CLIP-seq
MIRT2550679	hsa-miR-4667-5p	CLIP-seq
MIRT2550680	hsa-miR-4679	CLIP-seq
MIRT2451672	hsa-miR-4695-5p	CLIP-seq
MIRT2550681	hsa-miR-4700-5p	CLIP-seq
MIRT2550682	hsa-miR-4701-5p	CLIP-seq
MIRT2550683	hsa-miR-4704-3p	CLIP-seq
MIRT2550684	hsa-miR-4709-3p	CLIP-seq
MIRT2451673	hsa-miR-4723-3p	CLIP-seq
MIRT2550685	hsa-miR-4725-3p	CLIP-seq
MIRT2550686	hsa-miR-4725-5p	CLIP-seq
MIRT2550687	hsa-miR-4726-3p	CLIP-seq
MIRT2550688	hsa-miR-4739	CLIP-seq
MIRT2550689	hsa-miR-4756-5p	CLIP-seq
MIRT2550690	hsa-miR-4773	CLIP-seq
MIRT2550691	hsa-miR-4781-3p	CLIP-seq
MIRT2550692	hsa-miR-485-5p	CLIP-seq
MIRT2550693	hsa-miR-504	CLIP-seq
MIRT2550694	hsa-miR-513b	CLIP-seq
MIRT2550695	hsa-miR-513c	CLIP-seq
MIRT2550696	hsa-miR-514b-5p	CLIP-seq
MIRT2550697	hsa-miR-544b	CLIP-seq
MIRT2550698	hsa-miR-548s	CLIP-seq
MIRT2550699	hsa-miR-588	CLIP-seq
MIRT2550700	hsa-miR-604	CLIP-seq
MIRT2550701	hsa-miR-647	CLIP-seq
MIRT2550702	hsa-miR-660	CLIP-seq
MIRT2451674	hsa-miR-665	CLIP-seq
MIRT2550703	hsa-miR-7	CLIP-seq
MIRT2550704	hsa-miR-874	CLIP-seq
MIRT2682708	hsa-miR-1207-3p	CLIP-seq
MIRT2550643	hsa-miR-1252	CLIP-seq
MIRT2682709	hsa-miR-128	CLIP-seq
MIRT2550644	hsa-miR-1282	CLIP-seq
MIRT2550646	hsa-miR-146b-3p	CLIP-seq
MIRT2550647	hsa-miR-185	CLIP-seq
MIRT2682710	hsa-miR-1910	CLIP-seq
MIRT2550648	hsa-miR-1915	CLIP-seq
MIRT2550649	hsa-miR-192	CLIP-seq
MIRT2550650	hsa-miR-193a-3p	CLIP-seq
MIRT2550651	hsa-miR-193b	CLIP-seq
MIRT2451670	hsa-miR-1976	CLIP-seq
MIRT2550652	hsa-miR-2110	CLIP-seq
MIRT2550653	hsa-miR-215	CLIP-seq
MIRT2550654	hsa-miR-24	CLIP-seq
MIRT2682711	hsa-miR-27a	CLIP-seq
MIRT2682712	hsa-miR-27b	CLIP-seq
MIRT2682713	hsa-miR-3064-5p	CLIP-seq
MIRT2550656	hsa-miR-3125	CLIP-seq
MIRT2682714	hsa-miR-3135b	CLIP-seq
MIRT2550659	hsa-miR-3173-5p	CLIP-seq
MIRT2550660	hsa-miR-3176	CLIP-seq
MIRT2451671	hsa-miR-3183	CLIP-seq
MIRT2550661	hsa-miR-3187-3p	CLIP-seq
MIRT2550664	hsa-miR-3916	CLIP-seq
MIRT2550665	hsa-miR-3922-3p	CLIP-seq
MIRT2550667	hsa-miR-421	CLIP-seq
MIRT2550668	hsa-miR-4264	CLIP-seq
MIRT2550669	hsa-miR-4271	CLIP-seq
MIRT2550670	hsa-miR-4292	CLIP-seq
MIRT2550671	hsa-miR-4306	CLIP-seq
MIRT2550673	hsa-miR-4435	CLIP-seq
MIRT2550674	hsa-miR-4457	CLIP-seq
MIRT2247226	hsa-miR-4459	CLIP-seq
MIRT2550675	hsa-miR-4476	CLIP-seq
MIRT1063075	hsa-miR-4533	CLIP-seq
MIRT2550676	hsa-miR-4635	CLIP-seq
MIRT2550677	hsa-miR-4644	CLIP-seq
MIRT2550679	hsa-miR-4667-5p	CLIP-seq
MIRT2550680	hsa-miR-4679	CLIP-seq
MIRT2451672	hsa-miR-4695-5p	CLIP-seq
MIRT2550681	hsa-miR-4700-5p	CLIP-seq
MIRT2550682	hsa-miR-4701-5p	CLIP-seq
MIRT2550683	hsa-miR-4704-3p	CLIP-seq
MIRT2550684	hsa-miR-4709-3p	CLIP-seq
MIRT2451673	hsa-miR-4723-3p	CLIP-seq
MIRT2550685	hsa-miR-4725-3p	CLIP-seq
MIRT2550686	hsa-miR-4725-5p	CLIP-seq
MIRT2550687	hsa-miR-4726-3p	CLIP-seq
MIRT2550693	hsa-miR-504	CLIP-seq
MIRT2550694	hsa-miR-513b	CLIP-seq
MIRT2550695	hsa-miR-513c	CLIP-seq
MIRT2550696	hsa-miR-514b-5p	CLIP-seq
MIRT2550698	hsa-miR-548s	CLIP-seq
MIRT2550699	hsa-miR-588	CLIP-seq
MIRT2550700	hsa-miR-604	CLIP-seq
MIRT2550701	hsa-miR-647	CLIP-seq
MIRT2550702	hsa-miR-660	CLIP-seq
MIRT2451674	hsa-miR-665	CLIP-seq
MIRT2550703	hsa-miR-7	CLIP-seq
MIRT2550704	hsa-miR-874	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
STAT3	Activation	22330135
ZNF382	Repression	20682794

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004672	Function	Protein kinase activity	TAS
GO:0004674	Function	Protein serine/threonine kinase activity	IBA	21873635
GO:0004704	Function	NF-kappaB-inducing kinase activity	IDA	10882136
GO:0005515	Function	Protein binding	IPI	14743216, 16177806, 16281057, 17568778, 17599067, 17600090, 18636086, 18636090, 19153231, 20188669, 20657822, 21212807, 21903422, 21931555, 22939624, 23096996, 24706939, 25036637, 25852190, 27980081, 28011935, 29251827, 32814053
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IDA	20188669
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	20188669, 24882218
GO:0005829	Component	Cytosol	TAS
GO:0006468	Process	Protein phosphorylation	IDA	10882136, 20188669, 24882218
GO:0006955	Process	Immune response	NAS	10421793
GO:0007252	Process	I-kappaB phosphorylation	IEA
GO:0008384	Function	IkappaB kinase activity	IEA
GO:0008630	Process	Intrinsic apoptotic signaling pathway in response to DNA damage	IMP	20188669
GO:0010008	Component	Endosome membrane	TAS
GO:0010884	Process	Positive regulation of lipid storage	ISS
GO:0016032	Process	Viral process	IEA
GO:0016605	Component	PML body	IDA	20188669
GO:0018105	Process	Peptidyl-serine phosphorylation	IBA	21873635
GO:0019903	Function	Protein phosphatase binding	ISS
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	24882218
GO:0031966	Component	Mitochondrial membrane	IMP	16876765
GO:0032480	Process	Negative regulation of type I interferon production	TAS
GO:0034340	Process	Response to type I interferon	IEA
GO:0035456	Process	Response to interferon-beta	IMP	24882218
GO:0035666	Process	TRIF-dependent toll-like receptor signaling pathway	TAS
GO:0036435	Function	K48-linked polyubiquitin modification-dependent protein binding	IMP	24882218
GO:0038061	Process	NIK/NF-kappaB signaling	IEA
GO:0042802	Function	Identical protein binding	IPI	24882218
GO:0043123	Process	Positive regulation of I-kappaB kinase/NF-kappaB signaling	IEP	12761501
GO:0060340	Process	Positive regulation of type I interferon-mediated signaling pathway	IEA
GO:0070530	Function	K63-linked polyubiquitin modification-dependent protein binding	IMP	24882218
GO:0098586	Process	Cellular response to virus	IEA

Other IDs

• MIM: 605048
• HGNC: 14552
• e!Ensembl: ENSG00000263528

Protein

• UniProt ID: Q14164
• Protein name: Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i)
• Protein function: Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interle
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00069	Pkinase	9 → 301	Protein kinase domain	Domain
  PF18396	TBK1_ULD	308 → 393	TANK binding kinase 1 ubiquitin-like domain	Domain
  PF18394	TBK1_CCD1	400 → 646	TANK-binding kinase 1 coiled-coil domain 1	Coiled-coil

• Sequence:

  MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLR
  KLNHQNIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVV
  AGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYL
  HPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTE
  KPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGFDQFFA
  ETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQEYLFEGHLCV
  LEPSVSAQHIAHTTASSPLTLFSTAIPKGLAFRDPALDVPKFVPKVDLQADYNTAKGVLG
  AGYQALRLARALLDGQELMFRGLHWVMEVLQATCRRTLEVARTSLLYLSSSLGTERFSSV
  AGTPEIQELKAAAELRSRLRTLAEVLSRCSQNITETQESLSSLNRELVKSRDQVHEDRSI
  QQIQCCLDKMNFIYKQFKKSRMRPGLGYNEEQIHKLDKVNFSHLAKRLLQVFQEECVQKY
  QASLVTHGKRMRVVHETRNHLRLVGCSVAACNTEAQGVQESLSKLLEELSHQLLQDRAKG
  AQASPPPIAPYPSPTRKDLLLHMQELCEGMKLLASDLLDNNRIIERLNRVPAPPDV

• Sequence length: 716