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IKBKB (inhibitor of nuclear factor kappa B kinase subunit beta)

Gene

3551

Inhibitor of nuclear factor kappa B kinase subunit beta

IKBKB

IKK-2, IKK-beta, IKK2, IKKB, IMD15, IMD15A, IMD15B, NFKBIKB

8p11.21

The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variant

Show/Hide all(3)

SNP ID	Visualize variation	Clinical significance	Consequence
rs200296680	C>T	Pathogenic	Stop gained, non coding transcript variant, 5 prime UTR variant, coding sequence variant
rs886041036	->G	Pathogenic	Frameshift variant, non coding transcript variant, coding sequence variant
rs1563340753	G>A	Pathogenic	Coding sequence variant, intron variant, missense variant, 5 prime UTR variant, non coding transcript variant

Show/Hide all(200)

miRTarBase ID	miRNA	Experiments	Reference
MIRT003828	hsa-miR-199a-5p	Reporter assay, Western blot	18408758
MIRT003828	hsa-miR-199a-5p	GFP reporter assay, Luciferase reporter assay, qRT-PCR	18408758
MIRT003828	hsa-miR-199a-5p	GFP reporter assay, Luciferase reporter assay, qRT-PCR	18408758
MIRT003828	hsa-miR-199a-5p	GFP reporter assay, Luciferase reporter assay, qRT-PCR	18408758
MIRT003828	hsa-miR-199a-5p	Luciferase reporter assay	18408758
MIRT004030	hsa-miR-218-5p	Luciferase reporter assay, qRT-PCR, Western blot	20933503
MIRT004030	hsa-miR-218-5p	Luciferase reporter assay, qRT-PCR, Western blot	20933503
MIRT004030	hsa-miR-218-5p	Luciferase reporter assay, qRT-PCR, Western blot	20933503
MIRT004030	hsa-miR-218-5p	Luciferase reporter assay, qRT-PCR, Western blot	20933503
MIRT006884	hsa-miR-200c-3p	Luciferase reporter assay, Western blot	22569286
MIRT018148	hsa-miR-335-5p	Microarray	18185580
MIRT043610	hsa-miR-151a-3p	CLASH	23622248
MIRT054428	hsa-miR-503-5p	Immunohistochemistry, In situ hybridization, Luciferase reporter assay, qRT-PCR, Western blot	24550137
MIRT438803	hsa-miR-451a	5.0	23740840
MIRT438803	hsa-miR-451a	5.0	23740840
MIRT006884	hsa-miR-200c-3p	Luciferase reporter assay	24755559
MIRT006884	hsa-miR-200c-3p	Luciferase reporter assay	24755559
MIRT438803	hsa-miR-451a	5.0	23740840
MIRT438803	hsa-miR-451a	5.0	23740840
MIRT006884	hsa-miR-200c-3p	Luciferase reporter assay	24755559
MIRT006884	hsa-miR-200c-3p	Luciferase reporter assay	24755559
MIRT732818	hsa-miR-214-3p	Immunofluorescence, Luciferase reporter assay, qRT-PCR, Western blotting	33714889
MIRT1062986	hsa-miR-129-3p	CLIP-seq
MIRT1062987	hsa-miR-938	CLIP-seq
MIRT1062988	hsa-miR-1185	CLIP-seq
MIRT1062989	hsa-miR-1323	CLIP-seq
MIRT1062990	hsa-miR-2392	CLIP-seq
MIRT1062991	hsa-miR-3065-5p	CLIP-seq
MIRT1062992	hsa-miR-3125	CLIP-seq
MIRT1062993	hsa-miR-3605-5p	CLIP-seq
MIRT1062994	hsa-miR-3622a-3p	CLIP-seq
MIRT1062995	hsa-miR-3622b-3p	CLIP-seq
MIRT1062996	hsa-miR-3675-5p	CLIP-seq
MIRT1062997	hsa-miR-3679-5p	CLIP-seq
MIRT1062998	hsa-miR-3916	CLIP-seq
MIRT1062999	hsa-miR-4640-5p	CLIP-seq
MIRT1063000	hsa-miR-4726-5p	CLIP-seq
MIRT1063001	hsa-miR-4755-3p	CLIP-seq
MIRT1063002	hsa-miR-515-5p	CLIP-seq
MIRT1063003	hsa-miR-548o	CLIP-seq
MIRT1063004	hsa-miR-942	CLIP-seq
MIRT1063005	hsa-miR-106a	CLIP-seq
MIRT1063006	hsa-miR-106b	CLIP-seq
MIRT1063007	hsa-miR-1229	CLIP-seq
MIRT1063008	hsa-miR-17	CLIP-seq
MIRT1063009	hsa-miR-20a	CLIP-seq
MIRT1063010	hsa-miR-20b	CLIP-seq
MIRT1063011	hsa-miR-2116	CLIP-seq
MIRT1063012	hsa-miR-3120-5p	CLIP-seq
MIRT1063013	hsa-miR-3145-5p	CLIP-seq
MIRT1063014	hsa-miR-3607-3p	CLIP-seq
MIRT1063015	hsa-miR-3609	CLIP-seq
MIRT1063016	hsa-miR-3648	CLIP-seq
MIRT1063017	hsa-miR-3941	CLIP-seq
MIRT1063018	hsa-miR-4255	CLIP-seq
MIRT1063019	hsa-miR-4266	CLIP-seq
MIRT1063020	hsa-miR-4323	CLIP-seq
MIRT1063021	hsa-miR-4434	CLIP-seq
MIRT1063022	hsa-miR-4514	CLIP-seq
MIRT1063023	hsa-miR-4516	CLIP-seq
MIRT1063024	hsa-miR-4645-5p	CLIP-seq
MIRT1063025	hsa-miR-466	CLIP-seq
MIRT1063026	hsa-miR-4672	CLIP-seq
MIRT1063027	hsa-miR-4673	CLIP-seq
MIRT1063028	hsa-miR-4677-5p	CLIP-seq
MIRT1063029	hsa-miR-4692	CLIP-seq
MIRT1063030	hsa-miR-4731-3p	CLIP-seq
MIRT1063001	hsa-miR-4755-3p	CLIP-seq
MIRT1063031	hsa-miR-4758-3p	CLIP-seq
MIRT1063032	hsa-miR-4796-3p	CLIP-seq
MIRT1063033	hsa-miR-4801	CLIP-seq
MIRT1063034	hsa-miR-508-5p	CLIP-seq
MIRT1063035	hsa-miR-519d	CLIP-seq
MIRT1063036	hsa-miR-548ah	CLIP-seq
MIRT1063037	hsa-miR-548g	CLIP-seq
MIRT1063038	hsa-miR-600	CLIP-seq
MIRT1063039	hsa-miR-651	CLIP-seq
MIRT1063040	hsa-miR-93	CLIP-seq
MIRT1063005	hsa-miR-106a	CLIP-seq
MIRT1063006	hsa-miR-106b	CLIP-seq
MIRT1063041	hsa-miR-1270	CLIP-seq
MIRT1063008	hsa-miR-17	CLIP-seq
MIRT1063042	hsa-miR-185	CLIP-seq
MIRT1063009	hsa-miR-20a	CLIP-seq
MIRT1063010	hsa-miR-20b	CLIP-seq
MIRT1063043	hsa-miR-2278	CLIP-seq
MIRT1063014	hsa-miR-3607-3p	CLIP-seq
MIRT1063015	hsa-miR-3609	CLIP-seq
MIRT1063044	hsa-miR-3918	CLIP-seq
MIRT1063045	hsa-miR-3973	CLIP-seq
MIRT1063046	hsa-miR-4270	CLIP-seq
MIRT1063047	hsa-miR-4306	CLIP-seq
MIRT1063048	hsa-miR-4438	CLIP-seq
MIRT1063049	hsa-miR-4441	CLIP-seq
MIRT1063050	hsa-miR-4512	CLIP-seq
MIRT1063051	hsa-miR-4531	CLIP-seq
MIRT1063052	hsa-miR-4644	CLIP-seq
MIRT1063053	hsa-miR-4722-5p	CLIP-seq
MIRT1063030	hsa-miR-4731-3p	CLIP-seq
MIRT1063054	hsa-miR-4768-3p	CLIP-seq
MIRT1063032	hsa-miR-4796-3p	CLIP-seq
MIRT1063033	hsa-miR-4801	CLIP-seq
MIRT1063035	hsa-miR-519d	CLIP-seq
MIRT1063055	hsa-miR-548ac	CLIP-seq
MIRT1063056	hsa-miR-548ae	CLIP-seq
MIRT1063036	hsa-miR-548ah	CLIP-seq
MIRT1063057	hsa-miR-548aj	CLIP-seq
MIRT1063058	hsa-miR-548am	CLIP-seq
MIRT1063059	hsa-miR-548d-3p	CLIP-seq
MIRT1063060	hsa-miR-548x	CLIP-seq
MIRT1063061	hsa-miR-548z	CLIP-seq
MIRT1063062	hsa-miR-583	CLIP-seq
MIRT1063063	hsa-miR-590-3p	CLIP-seq
MIRT1063064	hsa-miR-620	CLIP-seq
MIRT1063040	hsa-miR-93	CLIP-seq
MIRT2014892	hsa-miR-22	CLIP-seq
MIRT2014893	hsa-miR-2467-3p	CLIP-seq
MIRT2014894	hsa-miR-28-5p	CLIP-seq
MIRT1062992	hsa-miR-3125	CLIP-seq
MIRT2014895	hsa-miR-3139	CLIP-seq
MIRT1062998	hsa-miR-3916	CLIP-seq
MIRT2014896	hsa-miR-4476	CLIP-seq
MIRT2014897	hsa-miR-4533	CLIP-seq
MIRT1062999	hsa-miR-4640-5p	CLIP-seq
MIRT2014898	hsa-miR-4659a-5p	CLIP-seq
MIRT2014899	hsa-miR-4659b-5p	CLIP-seq
MIRT1063000	hsa-miR-4726-5p	CLIP-seq
MIRT2014900	hsa-miR-4769-3p	CLIP-seq
MIRT2014901	hsa-miR-558	CLIP-seq
MIRT2014902	hsa-miR-708	CLIP-seq
MIRT2247171	hsa-miR-103a	CLIP-seq
MIRT2247172	hsa-miR-107	CLIP-seq
MIRT2247173	hsa-miR-146b-3p	CLIP-seq
MIRT2247174	hsa-miR-148a	CLIP-seq
MIRT2247175	hsa-miR-148b	CLIP-seq
MIRT2247176	hsa-miR-152	CLIP-seq
MIRT2247177	hsa-miR-15a	CLIP-seq
MIRT2247178	hsa-miR-15b	CLIP-seq
MIRT2247179	hsa-miR-16	CLIP-seq
MIRT2247180	hsa-miR-1825	CLIP-seq
MIRT2247181	hsa-miR-1913	CLIP-seq
MIRT2247182	hsa-miR-195	CLIP-seq
MIRT2247183	hsa-miR-199b-5p	CLIP-seq
MIRT2247184	hsa-miR-214	CLIP-seq
MIRT1062992	hsa-miR-3125	CLIP-seq
MIRT2247185	hsa-miR-3166	CLIP-seq
MIRT2247186	hsa-miR-3173-5p	CLIP-seq
MIRT2247187	hsa-miR-3195	CLIP-seq
MIRT2247188	hsa-miR-324-3p	CLIP-seq
MIRT2247189	hsa-miR-331-3p	CLIP-seq
MIRT2247190	hsa-miR-34a	CLIP-seq
MIRT2247191	hsa-miR-34c-5p	CLIP-seq
MIRT2247192	hsa-miR-3607-5p	CLIP-seq
MIRT2247193	hsa-miR-3619-5p	CLIP-seq
MIRT2247194	hsa-miR-371b-3p	CLIP-seq
MIRT2247195	hsa-miR-3914	CLIP-seq
MIRT1062998	hsa-miR-3916	CLIP-seq
MIRT2247196	hsa-miR-3917	CLIP-seq
MIRT2247197	hsa-miR-3925-3p	CLIP-seq
MIRT2247198	hsa-miR-3944-5p	CLIP-seq
MIRT2247199	hsa-miR-423-3p	CLIP-seq
MIRT2247200	hsa-miR-424	CLIP-seq
MIRT2247201	hsa-miR-4292	CLIP-seq
MIRT2247202	hsa-miR-4302	CLIP-seq
MIRT1063048	hsa-miR-4438	CLIP-seq
MIRT2247203	hsa-miR-449a	CLIP-seq
MIRT2247204	hsa-miR-449b	CLIP-seq
MIRT2247205	hsa-miR-4519	CLIP-seq
MIRT2247206	hsa-miR-4522	CLIP-seq
MIRT2247207	hsa-miR-4524	CLIP-seq
MIRT2247208	hsa-miR-4529-5p	CLIP-seq
MIRT1062999	hsa-miR-4640-5p	CLIP-seq
MIRT2247209	hsa-miR-4677-3p	CLIP-seq
MIRT2247210	hsa-miR-4707-5p	CLIP-seq
MIRT1063000	hsa-miR-4726-5p	CLIP-seq
MIRT2247211	hsa-miR-4751	CLIP-seq
MIRT2247212	hsa-miR-4766-5p	CLIP-seq
MIRT2247213	hsa-miR-4771	CLIP-seq
MIRT2247214	hsa-miR-4802-5p	CLIP-seq
MIRT2247215	hsa-miR-497	CLIP-seq
MIRT2247216	hsa-miR-503	CLIP-seq
MIRT2247217	hsa-miR-518e	CLIP-seq
MIRT2247218	hsa-miR-524-3p	CLIP-seq
MIRT2247219	hsa-miR-525-3p	CLIP-seq
MIRT1063063	hsa-miR-590-3p	CLIP-seq
MIRT2247220	hsa-miR-646	CLIP-seq
MIRT2247221	hsa-miR-648	CLIP-seq
MIRT2247222	hsa-miR-761	CLIP-seq
MIRT2247223	hsa-miR-765	CLIP-seq
MIRT2247224	hsa-miR-873	CLIP-seq
MIRT2247225	hsa-miR-874	CLIP-seq
MIRT1063024	hsa-miR-4645-5p	CLIP-seq
MIRT1063027	hsa-miR-4673	CLIP-seq
MIRT2451668	hsa-miR-1234	CLIP-seq
MIRT2451669	hsa-miR-3189-5p	CLIP-seq
MIRT1063020	hsa-miR-4323	CLIP-seq
MIRT1063022	hsa-miR-4514	CLIP-seq
MIRT1063024	hsa-miR-4645-5p	CLIP-seq
MIRT1063027	hsa-miR-4673	CLIP-seq
MIRT1063029	hsa-miR-4692	CLIP-seq

Show/Hide all(65)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002223	Process	Stimulatory C-type lectin receptor signaling pathway	TAS
GO:0002479	Process	Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	TAS
GO:0002756	Process	MyD88-independent toll-like receptor signaling pathway	TAS
GO:0004672	Function	Protein kinase activity	IDA	20434986
GO:0004674	Function	Protein serine/threonine kinase activity	EXP	18692471, 23613522
GO:0004674	Function	Protein serine/threonine kinase activity	IBA	21873635
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	15084260, 25326418, 25636800
GO:0004674	Function	Protein serine/threonine kinase activity	TAS
GO:0005515	Function	Protein binding	IPI	9520446, 9751060, 10521409, 10733566, 11297557, 11971985, 12482991, 12486103, 12842894, 14743216, 15084260, 15389287, 15601829, 15749833, 16126728, 16129692, 16286467, 16319058, 16365431, 16938294, 17568778, 17693255, 17939994, 18198944, 18266467, 18462684, 18930133, 19196987, 19345
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006468	Process	Protein phosphorylation	IDA	15084260, 20434986
GO:0006468	Process	Protein phosphorylation	NAS	9346484
GO:0006954	Process	Inflammatory response	TAS	18626576
GO:0007249	Process	I-kappaB kinase/NF-kappaB signaling	IMP	15383541, 25816133
GO:0007249	Process	I-kappaB kinase/NF-kappaB signaling	TAS	18626576
GO:0007252	Process	I-kappaB phosphorylation	IEA
GO:0008384	Function	IkappaB kinase activity	IBA	21873635
GO:0008384	Function	IkappaB kinase activity	TAS	18626576
GO:0008385	Component	IkappaB kinase complex	IBA	21873635
GO:0008385	Component	IkappaB kinase complex	TAS	18626576
GO:0009615	Process	Response to virus	TAS	18626576
GO:0009898	Component	Cytoplasmic side of plasma membrane	ISS
GO:0010803	Process	Regulation of tumor necrosis factor-mediated signaling pathway	TAS
GO:0016032	Process	Viral process	IEA
GO:0018105	Process	Peptidyl-serine phosphorylation	IBA	21873635
GO:0018105	Process	Peptidyl-serine phosphorylation	IDA	21399639, 25326418
GO:0019901	Function	Protein kinase binding	IPI	12492477
GO:0030866	Process	Cortical actin cytoskeleton organization	IMP	25816133
GO:0033209	Process	Tumor necrosis factor-mediated signaling pathway	IBA	21873635
GO:0033209	Process	Tumor necrosis factor-mediated signaling pathway	IMP	15084260, 25816133
GO:0035509	Process	Negative regulation of myosin-light-chain-phosphatase activity	IMP	25816133
GO:0035631	Component	CD40 receptor complex	ISS
GO:0035666	Process	TRIF-dependent toll-like receptor signaling pathway	TAS
GO:0038095	Process	Fc-epsilon receptor signaling pathway	TAS
GO:0042325	Process	Regulation of phosphorylation	IDA	26212789
GO:0042802	Function	Identical protein binding	IPI	16319058, 21423167, 23776406
GO:0042803	Function	Protein homodimerization activity	IDA	23091055
GO:0043066	Process	Negative regulation of apoptotic process	TAS
GO:0043123	Process	Positive regulation of I-kappaB kinase/NF-kappaB signaling	IMP	30337470
GO:0043123	Process	Positive regulation of I-kappaB kinase/NF-kappaB signaling	TAS
GO:0045087	Process	Innate immune response	TAS	18626576
GO:0045121	Component	Membrane raft	IEA
GO:0045893	Process	Positive regulation of transcription, DNA-templated	NAS	9346484, 9346485, 9813230
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA	21873635
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	23091055, 23453807
GO:0046982	Function	Protein heterodimerization activity	IDA	23091055
GO:0050852	Process	T cell receptor signaling pathway	TAS
GO:0051092	Process	Positive regulation of NF-kappaB transcription factor activity	IBA	21873635
GO:0051092	Process	Positive regulation of NF-kappaB transcription factor activity	IDA	15790681
GO:0051092	Process	Positive regulation of NF-kappaB transcription factor activity	TAS	18626576
GO:0051403	Process	Stress-activated MAPK cascade	TAS
GO:0070498	Process	Interleukin-1-mediated signaling pathway	IMP	25816133
GO:0070498	Process	Interleukin-1-mediated signaling pathway	TAS
GO:0071356	Process	Cellular response to tumor necrosis factor	IDA	23091055
GO:0072659	Process	Protein localization to plasma membrane	IMP	25816133
GO:0097110	Function	Scaffold protein binding	IDA	23776175
GO:0106310	Function	Protein serine kinase activity	IEA
GO:0106311	Function	Protein threonine kinase activity	IEA
GO:1903140	Process	Regulation of establishment of endothelial barrier	IMP	25816133
GO:1903347	Process	Negative regulation of bicellular tight junction assembly	IMP	25816133
GO:1990459	Function	Transferrin receptor binding	IPI	23016877

MIM	HGNC	e!Ensembl
603258	5960	ENSG00000104365

Protein

UniProt ID

O14920

Protein name

Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBK

Protein function

Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:20434986, PubMed:20

PDB

3BRT , 3BRV , 4E3C , 4KIK , 8OMV

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	15 → 297	Protein kinase domain	Domain
PF18397	IKBKB_SDD	389 → 663	IQBAL scaffold dimerization domain	Domain
PF12179	IKKbetaNEMObind	706 → 742	I-kappa-kinase-beta NEMO binding domain	Domain

Sequence

MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL
EIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG
AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCT
SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
VDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCF
KALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLA
LIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRN
LAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLK
AKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMAL
QTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQS
FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKI
ACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVAEAHNLCTLLE
NAIQDTVREQDQSFTALDWSWLQTEEEEHSCLEQAS

Sequence length

756

Interactions

View interactions

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