IFNA2 (interferon alpha 2)

Gene

• Entrez ID: 3440
• Gene name: Interferon alpha 2
• Gene symbol: IFNA2
• Synonyms: IFN-alpha-2, IFN-alphaA, IFNA, IFNA2B, leIF A
• Chromosome: 9
• Chromosome location: 9p21.3
• Summary: This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded cytokine is a member of the type I interferon family that is produced in response to viral infection as a key part of the innate immune response with potent antiviral, antiproliferative and immunomodulatory properties. This cytokine, like other type I interferons, binds a plasma membrane receptor made of IFNAR1 and IFNAR2 that is ubiquitously expressed, and thus is able to act on virtually all body cells. The encoded protein is effective in reducing the symptoms and duration of the common cold and in treating many types of cancer, including some hematological malignancies and solid tumors. A deficiency of type I interferon in the blood is thought to be a hallmark of severe COVID-19 and may provide a rationale for a combined therapeutic approach. [provided by RefSeq, Aug 2020]

Transcription factors

Transcription factor	Regulation	Reference
IRF7	Activation	17236232

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002250	Process	Adaptive immune response	IBA	21873635
GO:0002286	Process	T cell activation involved in immune response	IBA	21873635
GO:0002323	Process	Natural killer cell activation involved in immune response	IBA	21873635
GO:0005125	Function	Cytokine activity	IBA	21873635
GO:0005132	Function	Type I interferon receptor binding	IBA	21873635
GO:0005515	Function	Protein binding	IPI	7759950, 21854986, 32296183
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0006915	Process	Apoptotic process	TAS	10477584
GO:0006954	Process	Inflammatory response	TAS	10477584
GO:0006959	Process	Humoral immune response	IBA	21873635
GO:0007166	Process	Cell surface receptor signaling pathway	TAS	6158094
GO:0007267	Process	Cell-cell signaling	TAS	10477584
GO:0007596	Process	Blood coagulation	TAS
GO:0010629	Process	Negative regulation of gene expression	IDA	20554961
GO:0019221	Process	Cytokine-mediated signaling pathway	IBA	21873635
GO:0030183	Process	B cell differentiation	IBA	21873635
GO:0032696	Process	Negative regulation of interleukin-13 production	IDA	20554961
GO:0032714	Process	Negative regulation of interleukin-5 production	IDA	20554961
GO:0033141	Process	Positive regulation of peptidyl-serine phosphorylation of STAT protein	IBA	21873635
GO:0042100	Process	B cell proliferation	IBA	21873635
GO:0042327	Process	Positive regulation of phosphorylation	IMP	17275127
GO:0042531	Process	Positive regulation of tyrosine phosphorylation of STAT protein	IDA	22783022
GO:0043330	Process	Response to exogenous dsRNA	IBA	21873635
GO:0045581	Process	Negative regulation of T cell differentiation	IDA	20554961
GO:0045892	Process	Negative regulation of transcription, DNA-templated	IDA	20554961
GO:0045893	Process	Positive regulation of transcription, DNA-templated	IMP	17275127
GO:0046597	Process	Negative regulation of viral entry into host cell	IDA	22783022
GO:0051607	Process	Defense response to virus	IDA	22783022
GO:0060337	Process	Type I interferon signaling pathway	TAS
GO:0062023	Component	Collagen-containing extracellular matrix	HDA	28675934
GO:0062023	Component	Collagen-containing extracellular matrix	HDA	28327460
GO:2000552	Process	Negative regulation of T-helper 2 cell cytokine production	IDA	20554961

Other IDs

• MIM: 147562
• HGNC: 5423
• e!Ensembl: ENSG00000188379

Protein

• UniProt ID: P01563
• Protein name: Interferon alpha-2 (IFN-alpha-2) (Interferon alpha-A) (LeIF A)
• Protein function: Produced by macrophages, IFN-alpha have antiviral activities.
• PDB: 1ITF, 1RH2, 2HIE, 2HYM, 2KZ1, 2LAG, 2LMS, 3S9D, 3SE3, 4YPG, 4Z5R
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00143	Interferon	26 → 184	Interferon alpha/beta domain	Domain

• Sequence:

  MALTFALLVALLVLSCKSSCSVGCDLPQTHSLGSRRTLMLLAQMRKISLFSCLKDRHDFG
  FPQEEFGNQFQKAETIPVLHEMIQQIFNLFSTKDSSAAWDETLLDKFYTELYQQLNDLEA
  CVIQGVGVTETPLMKEDSILAVRKYFQRITLYLKEKKYSPCAWEVVRAEIMRSFSLSTNL
  QESLRSKE

• Sequence length: 188