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HRAS (HRas proto-oncogene, GTPase)

Gene

3265

HRas proto-oncogene, GTPase

HRAS

C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, RASH1, p21ras

11p15.5

This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and the

Show/Hide all(95)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004471	hsa-let-7a-5p	Luciferase reporter assay	18083101
MIRT005644	hsa-miR-143-3p	Luciferase reporter assay, Northern blot, qRT-PCR	21276449
MIRT005880	hsa-miR-181a-5p	Luciferase reporter assay, qRT-PCR, Western blot	21167132
MIRT005880	hsa-miR-181a-5p	Luciferase reporter assay, qRT-PCR, Western blot	21167132
MIRT004471	hsa-let-7a-5p	Immunoblot, qRT-PCR, Western blot	21252116
MIRT006057	hsa-let-7b-5p	Immunoblot, qRT-PCR, Western blot	21252116
MIRT004471	hsa-let-7a-5p	Immunoblot, qRT-PCR, Western blot	21252116
MIRT006057	hsa-let-7b-5p	Immunoblot, qRT-PCR, Western blot	21252116
MIRT004471	hsa-let-7a-5p	Immunoblot, qRT-PCR, Western blot	21252116
MIRT006057	hsa-let-7b-5p	Immunoblot, qRT-PCR, Western blot	21252116
MIRT006548	hsa-miR-181d-5p	FACS, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	22207524
MIRT006548	hsa-miR-181d-5p	FACS, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	22207524
MIRT006548	hsa-miR-181d-5p	FACS, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	22207524
MIRT006548	hsa-miR-181d-5p	FACS, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	22207524
MIRT005880	hsa-miR-181a-5p	Reporter assay	21167132
MIRT040422	hsa-miR-615-3p	CLASH	23622248
MIRT438681	hsa-miR-663a	Luciferase reporter assay, qRT-PCR, Western blot	23953123
MIRT438494	hsa-miR-139-5p	Luciferase reporter assay	24158791
MIRT004471	hsa-let-7a-5p	Luciferase reporter assay	24092860
MIRT438681	hsa-miR-663a	Luciferase reporter assay, qRT-PCR, Western blot	23953123
MIRT438494	hsa-miR-139-5p	Luciferase reporter assay	24158791
MIRT004471	hsa-let-7a-5p	Luciferase reporter assay	24092860
MIRT005644	hsa-miR-143-3p	qRT-PCR, In situ hybridization, Western blot	25477374
MIRT733425	hsa-miR-1184	Immunohistochemistry (IHC), Immunoprecipitaion (IP), Luciferase reporter assay, qRT-PCR	34234808
MIRT733513	hsa-miR-1200	Microarray	34164896
MIRT1054553	hsa-miR-1207-5p	CLIP-seq
MIRT1054554	hsa-miR-1256	CLIP-seq
MIRT1054555	hsa-miR-1268	CLIP-seq
MIRT1054556	hsa-miR-1321	CLIP-seq
MIRT1054557	hsa-miR-1908	CLIP-seq
MIRT1054558	hsa-miR-1909	CLIP-seq
MIRT1054559	hsa-miR-1972	CLIP-seq
MIRT1054560	hsa-miR-3122	CLIP-seq
MIRT1054561	hsa-miR-3170	CLIP-seq
MIRT1054562	hsa-miR-3180	CLIP-seq
MIRT1054563	hsa-miR-3180-3p	CLIP-seq
MIRT1054564	hsa-miR-3196	CLIP-seq
MIRT1054565	hsa-miR-3913-5p	CLIP-seq
MIRT1054566	hsa-miR-4300	CLIP-seq
MIRT1054567	hsa-miR-4446-3p	CLIP-seq
MIRT1054568	hsa-miR-4492	CLIP-seq
MIRT1054569	hsa-miR-4498	CLIP-seq
MIRT1054570	hsa-miR-4505	CLIP-seq
MIRT1054571	hsa-miR-450b-3p	CLIP-seq
MIRT1054572	hsa-miR-4632	CLIP-seq
MIRT1054573	hsa-miR-4633-3p	CLIP-seq
MIRT1054574	hsa-miR-4664-3p	CLIP-seq
MIRT1054575	hsa-miR-4706	CLIP-seq
MIRT1054576	hsa-miR-4731-5p	CLIP-seq
MIRT1054577	hsa-miR-4739	CLIP-seq
MIRT1054578	hsa-miR-4749-5p	CLIP-seq
MIRT1054579	hsa-miR-4756-5p	CLIP-seq
MIRT1054580	hsa-miR-4763-3p	CLIP-seq
MIRT1054581	hsa-miR-4768-3p	CLIP-seq
MIRT1054582	hsa-miR-485-5p	CLIP-seq
MIRT1054583	hsa-miR-541	CLIP-seq
MIRT1054584	hsa-miR-585	CLIP-seq
MIRT1054585	hsa-miR-610	CLIP-seq
MIRT1054586	hsa-miR-622	CLIP-seq
MIRT1054587	hsa-miR-628-5p	CLIP-seq
MIRT1054588	hsa-miR-663	CLIP-seq
MIRT1054589	hsa-miR-665	CLIP-seq
MIRT1054590	hsa-miR-762	CLIP-seq
MIRT1054591	hsa-miR-769-3p	CLIP-seq
MIRT1054592	hsa-miR-920	CLIP-seq
MIRT1054593	hsa-miR-939	CLIP-seq
MIRT1054594	hsa-miR-3074-5p	CLIP-seq
MIRT1054595	hsa-miR-3130-3p	CLIP-seq
MIRT1054596	hsa-miR-324-5p	CLIP-seq
MIRT1054597	hsa-miR-3667-3p	CLIP-seq
MIRT1054598	hsa-miR-4324	CLIP-seq
MIRT1054599	hsa-miR-4691-5p	CLIP-seq
MIRT1054600	hsa-miR-4716-5p	CLIP-seq
MIRT1054601	hsa-miR-4793-3p	CLIP-seq
MIRT1054602	hsa-miR-544b	CLIP-seq
MIRT1054554	hsa-miR-1256	CLIP-seq
MIRT1054561	hsa-miR-3170	CLIP-seq
MIRT2244707	hsa-miR-3192	CLIP-seq
MIRT2244708	hsa-miR-3689a-3p	CLIP-seq
MIRT2244709	hsa-miR-3689c	CLIP-seq
MIRT1054566	hsa-miR-4300	CLIP-seq
MIRT2244710	hsa-miR-4308	CLIP-seq
MIRT1054567	hsa-miR-4446-3p	CLIP-seq
MIRT1054568	hsa-miR-4492	CLIP-seq
MIRT1054569	hsa-miR-4498	CLIP-seq
MIRT1054570	hsa-miR-4505	CLIP-seq
MIRT1054573	hsa-miR-4633-3p	CLIP-seq
MIRT1054574	hsa-miR-4664-3p	CLIP-seq
MIRT2244711	hsa-miR-4728-5p	CLIP-seq
MIRT1054576	hsa-miR-4731-5p	CLIP-seq
MIRT1054585	hsa-miR-610	CLIP-seq
MIRT2244712	hsa-miR-661	CLIP-seq
MIRT1054590	hsa-miR-762	CLIP-seq
MIRT1054592	hsa-miR-920	CLIP-seq
MIRT1054593	hsa-miR-939	CLIP-seq

Transcription factors

Show/Hide all(5)

Transcription factor	Regulation	Reference
BTG2	Repression	20197462
MAZ	Activation	21931711
SP1	Activation	21931711
SP1	Unknown	3012774
TP53	Unknown	11127813

Show/Hide all(70)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0000165	Process	MAPK cascade	TAS
GO:0001889	Process	Liver development	IEA
GO:0001934	Process	Positive regulation of protein phosphorylation	IDA	22065586
GO:0002223	Process	Stimulatory C-type lectin receptor signaling pathway	TAS
GO:0003924	Function	GTPase activity	IBA	21873635
GO:0003924	Function	GTPase activity	IDA	9178006
GO:0003924	Function	GTPase activity	IMP	9230043
GO:0005515	Function	Protein binding	IPI	2122974, 8332187, 8670882, 9144171, 9447984, 9488663, 9690470, 10369681, 10608844, 11022048, 11335720, 11598133, 11857081, 11980706, 12620389, 12628188, 14500341, 14724641, 15507210, 15886098, 16316996, 16698549, 16810318, 17084389, 17540175, 18073111, 18273062, 18454158, 18596699, 1
GO:0005525	Function	GTP binding	IBA	21873635
GO:0005525	Function	GTP binding	IDA	14500341, 17260967
GO:0005525	Function	GTP binding	IMP	9230043
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	TAS	10842192
GO:0005794	Component	Golgi apparatus	IDA	14500341, 21968647
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA	14500341, 17724343, 21968647
GO:0005886	Component	Plasma membrane	TAS
GO:0006897	Process	Endocytosis	IEA
GO:0006935	Process	Chemotaxis	TAS	10848592
GO:0007050	Process	Cell cycle arrest	IDA	9054499
GO:0007050	Process	Cell cycle arrest	IMP	9765203
GO:0007165	Process	Signal transduction	NAS	8607982
GO:0007166	Process	Cell surface receptor signaling pathway	TAS	9020890
GO:0007265	Process	Ras protein signal transduction	IBA	21873635
GO:0007265	Process	Ras protein signal transduction	IDA	23027131
GO:0007265	Process	Ras protein signal transduction	TAS
GO:0008022	Function	Protein C-terminus binding	IPI	9219684
GO:0008284	Process	Positive regulation of cell population proliferation	IDA	9765203
GO:0008285	Process	Negative regulation of cell population proliferation	IDA	9054499
GO:0009887	Process	Animal organ morphogenesis	TAS	10848592
GO:0010629	Process	Negative regulation of gene expression	IDA	23027131
GO:0010863	Process	Positive regulation of phospholipase C activity	IDA	11022048
GO:0019003	Function	GDP binding	IBA	21873635
GO:0019003	Function	GDP binding	IMP	8142349, 9230043
GO:0030335	Process	Positive regulation of cell migration	IDA	23027131
GO:0032729	Process	Positive regulation of interferon-gamma production	IEA
GO:0034260	Process	Negative regulation of GTPase activity	IDA	23027131
GO:0035900	Process	Response to isolation stress	IEA
GO:0042088	Process	T-helper 1 type immune response	IEA
GO:0042832	Process	Defense response to protozoan	IEA
GO:0043406	Process	Positive regulation of MAP kinase activity	IDA	23027131
GO:0043410	Process	Positive regulation of MAPK cascade	IDA	9765203
GO:0043524	Process	Negative regulation of neuron apoptotic process	IEA
GO:0043547	Process	Positive regulation of GTPase activity	IDA	23027131
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0045740	Process	Positive regulation of DNA replication	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	22065586, 23027131
GO:0046330	Process	Positive regulation of JNK cascade	IDA	22065586
GO:0046579	Process	Positive regulation of Ras protein signal transduction	IEA
GO:0048013	Process	Ephrin receptor signaling pathway	TAS
GO:0048169	Process	Regulation of long-term neuronal synaptic plasticity	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0050679	Process	Positive regulation of epithelial cell proliferation	IMP	20154697
GO:0050852	Process	T cell receptor signaling pathway	IEA
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IDA	22065586
GO:0071480	Process	Cellular response to gamma radiation	IDA	16213212
GO:0090303	Process	Positive regulation of wound healing	IDA	23027131
GO:0090314	Process	Positive regulation of protein targeting to membrane	IMP	11022048
GO:0090398	Process	Cellular senescence	IBA	21873635
GO:0090398	Process	Cellular senescence	IDA	9054499
GO:0097193	Process	Intrinsic apoptotic signaling pathway	IEA
GO:0098696	Process	Regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IDA	12202034
GO:0098696	Process	Regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IMP	12202034
GO:0098978	Component	Glutamatergic synapse	IDA	12202034
GO:0098978	Component	Glutamatergic synapse	IMP	12202034
GO:1900029	Process	Positive regulation of ruffle assembly	IDA	23027131
GO:2000251	Process	Positive regulation of actin cytoskeleton reorganization	IDA	23027131
GO:2000630	Process	Positive regulation of miRNA metabolic process	IDA	23027131

MIM	HGNC	e!Ensembl
190020	5173	ENSG00000174775

Protein

UniProt ID

P01112

Protein name

GTPase HRas (EC 3.6.5.2) (H-Ras-1) (Ha-Ras) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed]

Protein function

Involved in the activation of Ras protein signal transduction (PubMed:22821884). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:12740440, PubMed:14500341, PubMed:9020151). {ECO:0000269|PubMed:12740440, ECO:0000269|PubMed

PDB

121P , 1AA9 , 1AGP , 1BKD , 1CLU , 1CRP , 1CRQ , 1CRR , 1CTQ , 1GNP , 1GNQ , 1GNR , 1HE8 , 1IAQ , 1IOZ , 1JAH , 1JAI , 1K8R , 1LF0 , 1LF5 , 1LFD , 1NVU , 1NVV , 1NVW , 1NVX , 1P2S , 1P2T , 1P2U , 1P2V , 1PLJ , 1PLK , 1PLL , 1Q21 , 1QRA , 1RVD , 1WQ1 , 1XCM , 1XD2 , 1XJ0 , 1ZVQ , 1ZW6 , 221P , 2C5L , 2CE2 , 2CL0 , 2CL6 , 2CL7 , 2CLC , 2CLD , 2EVW , 2LCF

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00071	Ras	5 → 165	Ras family	Domain

Sequence

MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDL
AARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPG
CMSCKCVLS

Sequence length

189

Interactions

View interactions

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