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GSK3B (glycogen synthase kinase 3 beta)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2932
Gene nameGene Name - the full gene name approved by the HGNC.
Glycogen synthase kinase 3 beta
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
GSK3B
SynonymsGene synonyms aliases
-
ChromosomeChromosome number
3
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3q13.33
SummarySummary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction,
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT004676 hsa-miR-26a-5p Luciferase reporter assay, Microarray, qRT-PCR, Western blot 20525681
MIRT006753 hsa-miR-29b-3p Luciferase reporter assay 21501592
MIRT006753 hsa-miR-29b-3p Luciferase reporter assay 21501592
MIRT021044 hsa-miR-155-5p Proteomics 19289835
MIRT049345 hsa-miR-92a-3p CLASH 23622248
Transcription factors
Transcription factor Regulation Reference
CDX2 Unknown 24501326
CREB1 Unknown 11579131
NFKB1 Unknown 11579131
TFCP2 Unknown 16973241
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001085 Function RNA polymerase II transcription factor binding IPI 20864106
GO:0001837 Process Epithelial to mesenchymal transition IMP 15448698
GO:0001954 Process Positive regulation of cell-matrix adhesion IMP 18156211
GO:0002020 Function Protease binding IPI 25118933
GO:0002039 Function P53 binding IDA 14744935
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P49841
Protein name Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1)
Protein function Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase
PDB 1GNG , 1H8F , 1I09 , 1J1B , 1J1C , 1O6K , 1O6L , 1O9U , 1PYX , 1Q3D , 1Q3W , 1Q41 , 1Q4L , 1Q5K , 1R0E , 1UV5 , 2JDO , 2JDR , 2JLD , 2O5K , 2OW3 , 2UW9 , 2X39 , 2XH5 , 3CQU , 3CQW , 3DU8 , 3E87 , 3E88 , 3E8D , 3F7Z , 3F88 , 3GB2 , 3I4B , 3L1S , 3M1S , 3MV5 , 3OW4 , 3PUP , 3Q3B , 3QKK , 3QKL , 3SAY , 3SD0 , 3ZDI , 3ZRK , 3ZRL , 3ZRM , 4ACC , 4ACD , 4ACG
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase
56 340
Protein kinase domain
Domain
Sequence
Sequence length 420
Interactions View interactions

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