GPC5 (glypican 5)

Gene

• Entrez ID: 2262
• Gene name: Glypican 5
• Gene symbol: GPC5
• Synonyms: -
• Chromosome: 13
• Chromosome location: 13q31.3
• Summary: Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. [provided by RefSeq, Jul 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT438314	hsa-miR-217	Luciferase reporter assay, Northern blot, qRT-PCR, Western blot	26098560
MIRT449560	hsa-miR-190b	PAR-CLIP	22100165
MIRT449561	hsa-miR-190a-5p	PAR-CLIP	22100165
MIRT449562	hsa-miR-20a-3p	PAR-CLIP	22100165
MIRT449563	hsa-miR-186-5p	PAR-CLIP	22100165
MIRT449564	hsa-miR-3133	PAR-CLIP	22100165
MIRT449565	hsa-miR-5582-3p	PAR-CLIP	22100165
MIRT449566	hsa-miR-548x-3p	PAR-CLIP	22100165
MIRT449566	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT449567	hsa-miR-548j-3p	PAR-CLIP	22100165
MIRT449567	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT449568	hsa-miR-548aq-3p	PAR-CLIP	22100165
MIRT449568	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT449569	hsa-miR-548am-3p	PAR-CLIP	22100165
MIRT449569	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT449570	hsa-miR-548aj-3p	PAR-CLIP	22100165
MIRT449570	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT449571	hsa-miR-548ah-3p	PAR-CLIP	22100165
MIRT449571	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT449572	hsa-miR-548ae-3p	PAR-CLIP	22100165
MIRT449572	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT625750	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT625751	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT625752	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT625753	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT625754	hsa-miR-4469	HITS-CLIP	23824327
MIRT625755	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT625756	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT625757	hsa-miR-5193	HITS-CLIP	23824327
MIRT625758	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT625759	hsa-miR-1470	HITS-CLIP	23824327
MIRT657695	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT657696	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT657697	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT657698	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT657699	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT657700	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT657701	hsa-miR-4637	HITS-CLIP	23824327
MIRT657702	hsa-miR-548z	HITS-CLIP	23824327
MIRT657703	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT657704	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT657705	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT657706	hsa-miR-548ac	HITS-CLIP	23824327
MIRT732315	hsa-miR-297	Luciferase reporter assay, qRT-PCR, Western blot	27554041

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001523	Process	Retinoid metabolic process	TAS
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IEA
GO:0005796	Component	Golgi lumen	TAS
GO:0005886	Component	Plasma membrane	TAS
GO:0006024	Process	Glycosaminoglycan biosynthetic process	TAS
GO:0006027	Process	Glycosaminoglycan catabolic process	TAS
GO:0009986	Component	Cell surface	IBA	21873635
GO:0016021	Component	Integral component of membrane	TAS	7657705
GO:0016477	Process	Cell migration	IBA	21873635
GO:0043202	Component	Lysosomal lumen	TAS
GO:0046658	Component	Anchored component of plasma membrane	IEA
GO:0062023	Component	Collagen-containing extracellular matrix	IEA
GO:0090263	Process	Positive regulation of canonical Wnt signaling pathway	IBA	21873635
GO:1905475	Process	Regulation of protein localization to membrane	IBA	21873635

Other IDs

• MIM: 602446
• HGNC: 4453
• e!Ensembl: ENSG00000179399

Protein

• UniProt ID: P78333
• Protein name: Glypican-5 [Cleaved into: Secreted glypican-5]
• Protein function: Cell surface proteoglycan that bears heparan sulfate.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01153	Glypican	12 → 570	Glypican	Family

• Sequence:

  MDAQTWPVGFRCLLLLALVGSARSEGVQTCEEVRKLFQWRLLGAVRGLPDSPRAGPDLQV
  CISKKPTCCTRKMEERYQIAARQDMQQFLQTSSSTLKFLISRNAAAFQETLETLIKQAEN
  YTSILFCSTYRNMALEAAASVQEFFTDVGLYLFGADVNPEEFVNRFFDSLFPLVYNHLIN
  PGVTDSSLEYSECIRMARRDVSPFGNIPQRVMGQMGRSLLPSRTFLQALNLGIEVINTTD
  YLHFSKECSRALLKMQYCPHCQGLALTKPCMGYCLNVMRGCLAHMAELNPHWHAYIRSLE
  ELSDAMHGTYDIGHVLLNFHLLVNDAVLQAHLNGQKLLEQVNRICGRPVRTPTQSPRCSF
  DQSKEKHGMKTTTRNSEETLANRRKEFINSLRLYRSFYGGLADQLCANELAAADGLPCWN
  GEDIVKSYTQRVVGNGIKAQSGNPEVKVKGIDPVINQIIDKLKHVVQLLQGRSPKPDKWE
  LLQLGSGGGMVEQVSGDCDDEDGCGGSGSGEVKRTLKITDWMPDDMNFSDVKQIHQTDTG
  STLDTTGAGCAVATESMTFTLISVVMLLPGIW

• Sequence length: 572