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GPC4 (glypican 4)
Gene
Gene SNPs Other IDs
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2239
Gene nameGene Name - the full gene name approved by the HGNC.
Glypican 4
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
GPC4
SynonymsGene synonyms aliases
K-glypican, KPTS
ChromosomeChromosome number
X
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
Xq26.2
SummarySummary of gene provided in NCBI Entrez Gene.
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3` end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome. [provided by RefSeq, Jul 2008]
SNPsSNP information provided by dbSNP.
Gene SNPs Other IDs
SNP ID Visualize variation Clinical significance Consequence
rs1556022641 G>A Pathogenic Stop gained, coding sequence variant
rs1556022644 C>A Pathogenic Stop gained, coding sequence variant
rs1556022962 C>T Likely-pathogenic Missense variant, coding sequence variant
rs1556025980 ->T Pathogenic Frameshift variant, coding sequence variant
rs1556028269 C>- Pathogenic Frameshift variant, coding sequence variant
miRNAmiRNA information provided by mirtarbase database.
Gene SNPs Other IDs
miRTarBase ID miRNA Experiments Reference
MIRT006768 hsa-miR-125a-3p Luciferase reporter assay 22644326
MIRT021567 hsa-miR-142-3p Microarray 17612493
MIRT024432 hsa-miR-215-5p Microarray 19074876
MIRT026559 hsa-miR-192-5p Microarray 19074876
MIRT029649 hsa-miR-26b-5p Microarray 19088304
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs Other IDs
GO ID Ontology Definition Evidence Reference
GO:0001523 Process Retinoid metabolic process TAS
GO:0005515 Function Protein binding IPI 32296183
GO:0005634 Component Nucleus HDA 21630459
GO:0005796 Component Golgi lumen TAS
GO:0005886 Component Plasma membrane TAS
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs Other IDs
MIM
HGNC
e!Ensembl
Protein
Gene SNPs Other IDs
UniProt ID O75487
Protein name Glypican-4 (K-glypican) [Cleaved into: Secreted glypican-4]
Protein function Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system (By similarity).
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01153 Glypican
9 → 553
Glypican
 Family
Sequence
Sequence length 556
Interactions View interactions

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