GPC2 (glypican 2)

Gene

• Entrez ID: 221914
• Gene name: Glypican 2
• Gene symbol: GPC2
• Synonyms: -
• Chromosome: 7
• Chromosome location: 7q22.1

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001523	Process	Retinoid metabolic process	TAS
GO:0005515	Function	Protein binding	IPI	29162697
GO:0005615	Component	Extracellular space	IEA
GO:0005783	Component	Endoplasmic reticulum	IDA
GO:0005796	Component	Golgi lumen	TAS
GO:0005886	Component	Plasma membrane	TAS
GO:0006024	Process	Glycosaminoglycan biosynthetic process	TAS
GO:0006027	Process	Glycosaminoglycan catabolic process	TAS
GO:0007224	Process	Smoothened signaling pathway	IBA	21873635
GO:0009966	Process	Regulation of signal transduction	IEA
GO:0009986	Component	Cell surface	IBA	21873635
GO:0010976	Process	Positive regulation of neuron projection development	ISS
GO:0016477	Process	Cell migration	IBA	21873635
GO:0030182	Process	Neuron differentiation	IEA
GO:0043202	Component	Lysosomal lumen	TAS
GO:0045202	Component	Synapse	IBA	21873635
GO:0046658	Component	Anchored component of plasma membrane	IEA
GO:0062023	Component	Collagen-containing extracellular matrix	IEA
GO:1905475	Process	Regulation of protein localization to membrane	IBA	21873635

Other IDs

• MIM: 618446
• HGNC: 4450
• e!Ensembl: ENSG00000213420

Protein

• UniProt ID: Q8N158
• Protein name: Glypican-2 [Cleaved into: Secreted glypican-2]
• Protein function: Cell surface proteoglycan that bears heparan sulfate. May fulfill a function related to the motile behaviors of developing neurons (By similarity).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01153	Glypican	11 → 566	Glypican	Family

• Sequence:

  MSALRPLLLLLLPLCPGPGPGPGSEAKVTRSCAETRQVLGARGYSLNLIPPALISGEHLR
  VCPQEYTCCSSETEQRLIRETEATFRGLVEDSGSFLVHTLAARHRKFDEFFLEMLSVAQH
  SLTQLFSHSYGRLYAQHALIFNGLFSRLRDFYGESGEGLDDTLADFWAQLLERVFPLLHP
  QYSFPPDYLLCLSRLASSTDGSLQPFGDSPRRLRLQITRTLVAARAFVQGLETGRNVVSE
  ALKVPVSEGCSQALMRLIGCPLCRGVPSLMPCQGFCLNVVRGCLSSRGLEPDWGNYLDGL
  LILADKLQGPFSFELTAESIGVKISEGLMYLQENSAKVSAQVFQECGPPDPVPARNRRAP
  PPREEAGRLWSMVTEEERPTTAAGTNLHRLVWELRERLARMRGFWARLSLTVCGDSRMAA
  DASLEAAPCWTGAGRGRYLPPVVGGSPAEQVNNPELKVDASGPDVPTRRRRLQLRAATAR
  MKTAALGHDLDGQDADEDASGSGGGQQYADDWMAGAVAPPARPPRPPYPPRRDGSGGKGG
  GGSARYNQGRSRSGGASIGFHTQTILILSLSALALLGPR

• Sequence length: 579