GPC2 (glypican 2)

Gene

• Entrez ID: 221914
• Gene name: Glypican 2
• Gene symbol: GPC2
• Synonyms: -
• Chromosome: 7
• Chromosome location: 7q22.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1028565	hsa-miR-1207-3p	CLIP-seq
MIRT1028566	hsa-miR-146b-3p	CLIP-seq
MIRT1028567	hsa-miR-205	CLIP-seq
MIRT1028568	hsa-miR-2355-5p	CLIP-seq
MIRT1028569	hsa-miR-3127-3p	CLIP-seq
MIRT1028570	hsa-miR-3144-3p	CLIP-seq
MIRT1028571	hsa-miR-3146	CLIP-seq
MIRT1028572	hsa-miR-3173-5p	CLIP-seq
MIRT1028573	hsa-miR-324-5p	CLIP-seq
MIRT1028574	hsa-miR-421	CLIP-seq
MIRT1028575	hsa-miR-4263	CLIP-seq
MIRT1028576	hsa-miR-4267	CLIP-seq
MIRT1028577	hsa-miR-4436b-3p	CLIP-seq
MIRT1028578	hsa-miR-4502	CLIP-seq
MIRT1028579	hsa-miR-4641	CLIP-seq
MIRT1028580	hsa-miR-4709-5p	CLIP-seq
MIRT1028581	hsa-miR-4721	CLIP-seq
MIRT1028582	hsa-miR-4724-3p	CLIP-seq
MIRT1028583	hsa-miR-4761-3p	CLIP-seq
MIRT1028584	hsa-miR-874	CLIP-seq
MIRT1028585	hsa-miR-875-5p	CLIP-seq
MIRT2005156	hsa-miR-4684-5p	CLIP-seq
MIRT1028568	hsa-miR-2355-5p	CLIP-seq
MIRT1028569	hsa-miR-3127-3p	CLIP-seq
MIRT2388609	hsa-miR-4431	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001523	Process	Retinoid metabolic process	TAS
GO:0005515	Function	Protein binding	IPI	29162697
GO:0005615	Component	Extracellular space	IEA
GO:0005783	Component	Endoplasmic reticulum	IDA
GO:0005796	Component	Golgi lumen	TAS
GO:0005886	Component	Plasma membrane	TAS
GO:0006024	Process	Glycosaminoglycan biosynthetic process	TAS
GO:0006027	Process	Glycosaminoglycan catabolic process	TAS
GO:0007224	Process	Smoothened signaling pathway	IBA	21873635
GO:0009966	Process	Regulation of signal transduction	IEA
GO:0009986	Component	Cell surface	IBA	21873635
GO:0010976	Process	Positive regulation of neuron projection development	ISS
GO:0016477	Process	Cell migration	IBA	21873635
GO:0030182	Process	Neuron differentiation	IEA
GO:0043202	Component	Lysosomal lumen	TAS
GO:0045202	Component	Synapse	IBA	21873635
GO:0046658	Component	Anchored component of plasma membrane	IEA
GO:0062023	Component	Collagen-containing extracellular matrix	IEA
GO:1905475	Process	Regulation of protein localization to membrane	IBA	21873635

Other IDs

• MIM: 618446
• HGNC: 4450
• e!Ensembl: ENSG00000213420

Protein

• UniProt ID: Q8N158
• Protein name: Glypican-2 [Cleaved into: Secreted glypican-2]
• Protein function: Cell surface proteoglycan that bears heparan sulfate. May fulfill a function related to the motile behaviors of developing neurons (By similarity).
• PDB: 6WJL, 7T62
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01153	Glypican	11 → 566	Glypican	Family

• Sequence:

  MSALRPLLLLLLPLCPGPGPGPGSEAKVTRSCAETRQVLGARGYSLNLIPPALISGEHLR
  VCPQEYTCCSSETEQRLIRETEATFRGLVEDSGSFLVHTLAARHRKFDEFFLEMLSVAQH
  SLTQLFSHSYGRLYAQHALIFNGLFSRLRDFYGESGEGLDDTLADFWAQLLERVFPLLHP
  QYSFPPDYLLCLSRLASSTDGSLQPFGDSPRRLRLQITRTLVAARAFVQGLETGRNVVSE
  ALKVPVSEGCSQALMRLIGCPLCRGVPSLMPCQGFCLNVVRGCLSSRGLEPDWGNYLDGL
  LILADKLQGPFSFELTAESIGVKISEGLMYLQENSAKVSAQVFQECGPPDPVPARNRRAP
  PPREEAGRLWSMVTEEERPTTAAGTNLHRLVWELRERLARMRGFWARLSLTVCGDSRMAA
  DASLEAAPCWTGAGRGRYLPPVVGGSPAEQVNNPELKVDASGPDVPTRRRRLQLRAATAR
  MKTAALGHDLDGQDADEDASGSGGGQQYADDWMAGAVAPPARPPRPPYPPRRDGSGGKGG
  GGSARYNQGRSRSGGASIGFHTQTILILSLSALALLGPR

• Sequence length: 579