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GPC1 (glypican 1)

Gene

2817

Glypican 1

GPC1

glypican

2q37.3

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protei

Show/Hide all(181)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022703	hsa-miR-124-3p	Microarray	18668037
MIRT023811	hsa-miR-1-3p	Proteomics;Microarray	18668037
MIRT054857	hsa-miR-149-5p	Luciferase reporter assay, qRT-PCR, Western blot	24463821
MIRT054858	hsa-miR-149-3p	Luciferase reporter assay, qRT-PCR, Western blot	24463821
MIRT054858	hsa-miR-149-3p	qRT-PCR, Western blot, MTT	28233416
MIRT734395	hsa-miR-125b-5p	Luciferase reporter assay, Western blotting	32435510
MIRT1028528	hsa-miR-1226	CLIP-seq
MIRT1028529	hsa-miR-1271	CLIP-seq
MIRT1028530	hsa-miR-15a	CLIP-seq
MIRT1028531	hsa-miR-15b	CLIP-seq
MIRT1028532	hsa-miR-16	CLIP-seq
MIRT1028533	hsa-miR-182	CLIP-seq
MIRT1028534	hsa-miR-1910	CLIP-seq
MIRT1028535	hsa-miR-195	CLIP-seq
MIRT1028536	hsa-miR-223	CLIP-seq
MIRT1028537	hsa-miR-298	CLIP-seq
MIRT1028538	hsa-miR-3133	CLIP-seq
MIRT1028539	hsa-miR-330-3p	CLIP-seq
MIRT1028540	hsa-miR-338-3p	CLIP-seq
MIRT1028541	hsa-miR-3613-5p	CLIP-seq
MIRT1028542	hsa-miR-3689a-3p	CLIP-seq
MIRT1028543	hsa-miR-3689c	CLIP-seq
MIRT1028544	hsa-miR-371b-5p	CLIP-seq
MIRT1028545	hsa-miR-424	CLIP-seq
MIRT1028546	hsa-miR-4459	CLIP-seq
MIRT1028547	hsa-miR-4494	CLIP-seq
MIRT1028548	hsa-miR-4530	CLIP-seq
MIRT1028549	hsa-miR-4648	CLIP-seq
MIRT1028550	hsa-miR-4654	CLIP-seq
MIRT1028551	hsa-miR-4667-3p	CLIP-seq
MIRT1028552	hsa-miR-4691-5p	CLIP-seq
MIRT1028553	hsa-miR-4697-3p	CLIP-seq
MIRT1028554	hsa-miR-4728-5p	CLIP-seq
MIRT1028555	hsa-miR-4733-3p	CLIP-seq
MIRT1028556	hsa-miR-4765	CLIP-seq
MIRT1028557	hsa-miR-4769-5p	CLIP-seq
MIRT1028558	hsa-miR-497	CLIP-seq
MIRT1028559	hsa-miR-499a-5p	CLIP-seq
MIRT1028560	hsa-miR-542-3p	CLIP-seq
MIRT1028561	hsa-miR-766	CLIP-seq
MIRT1028562	hsa-miR-888	CLIP-seq
MIRT1028563	hsa-miR-922	CLIP-seq
MIRT1028564	hsa-miR-96	CLIP-seq
MIRT1921627	hsa-miR-1205	CLIP-seq
MIRT1921628	hsa-miR-1286	CLIP-seq
MIRT1921629	hsa-miR-3691-3p	CLIP-seq
MIRT1921630	hsa-miR-4722-5p	CLIP-seq
MIRT1921627	hsa-miR-1205	CLIP-seq
MIRT1921628	hsa-miR-1286	CLIP-seq
MIRT1921629	hsa-miR-3691-3p	CLIP-seq
MIRT1921630	hsa-miR-4722-5p	CLIP-seq
MIRT2005101	hsa-miR-1197	CLIP-seq
MIRT1921627	hsa-miR-1205	CLIP-seq
MIRT2005102	hsa-miR-1207-5p	CLIP-seq
MIRT2005103	hsa-miR-1266	CLIP-seq
MIRT1921628	hsa-miR-1286	CLIP-seq
MIRT2005104	hsa-miR-1291	CLIP-seq
MIRT2005105	hsa-miR-136	CLIP-seq
MIRT2005106	hsa-miR-146b-3p	CLIP-seq
MIRT2005107	hsa-miR-1470	CLIP-seq
MIRT1028534	hsa-miR-1910	CLIP-seq
MIRT2005108	hsa-miR-1913	CLIP-seq
MIRT2005109	hsa-miR-214	CLIP-seq
MIRT2005110	hsa-miR-22	CLIP-seq
MIRT2005111	hsa-miR-296-5p	CLIP-seq
MIRT1028537	hsa-miR-298	CLIP-seq
MIRT2005112	hsa-miR-3064-5p	CLIP-seq
MIRT2005113	hsa-miR-3115	CLIP-seq
MIRT2005114	hsa-miR-3117-5p	CLIP-seq
MIRT2005115	hsa-miR-3127-3p	CLIP-seq
MIRT2005116	hsa-miR-3144-5p	CLIP-seq
MIRT2005117	hsa-miR-3173-5p	CLIP-seq
MIRT2005118	hsa-miR-3187-3p	CLIP-seq
MIRT2005119	hsa-miR-324-3p	CLIP-seq
MIRT1028540	hsa-miR-338-3p	CLIP-seq
MIRT2005120	hsa-miR-3591-3p	CLIP-seq
MIRT2005121	hsa-miR-361-3p	CLIP-seq
MIRT2005122	hsa-miR-3619-5p	CLIP-seq
MIRT2005123	hsa-miR-3649	CLIP-seq
MIRT2005124	hsa-miR-3675-5p	CLIP-seq
MIRT1028542	hsa-miR-3689a-3p	CLIP-seq
MIRT1028543	hsa-miR-3689c	CLIP-seq
MIRT1921629	hsa-miR-3691-3p	CLIP-seq
MIRT2005125	hsa-miR-3918	CLIP-seq
MIRT2005126	hsa-miR-4252	CLIP-seq
MIRT2005127	hsa-miR-4290	CLIP-seq
MIRT2005128	hsa-miR-4313	CLIP-seq
MIRT2005129	hsa-miR-4435	CLIP-seq
MIRT2005130	hsa-miR-4436a	CLIP-seq
MIRT2005131	hsa-miR-4447	CLIP-seq
MIRT1028546	hsa-miR-4459	CLIP-seq
MIRT2005132	hsa-miR-4472	CLIP-seq
MIRT2005133	hsa-miR-4476	CLIP-seq
MIRT2005134	hsa-miR-4518	CLIP-seq
MIRT1028548	hsa-miR-4530	CLIP-seq
MIRT2005135	hsa-miR-4533	CLIP-seq
MIRT2005136	hsa-miR-4650-5p	CLIP-seq
MIRT2005137	hsa-miR-4651	CLIP-seq
MIRT1028551	hsa-miR-4667-3p	CLIP-seq
MIRT2005138	hsa-miR-4671-5p	CLIP-seq
MIRT2005139	hsa-miR-4690-5p	CLIP-seq
MIRT1028552	hsa-miR-4691-5p	CLIP-seq
MIRT2005140	hsa-miR-4701-5p	CLIP-seq
MIRT1921630	hsa-miR-4722-5p	CLIP-seq
MIRT1028554	hsa-miR-4728-5p	CLIP-seq
MIRT2005141	hsa-miR-4732-3p	CLIP-seq
MIRT2005142	hsa-miR-4736	CLIP-seq
MIRT2005143	hsa-miR-4752	CLIP-seq
MIRT2005144	hsa-miR-4763-3p	CLIP-seq
MIRT2005145	hsa-miR-4795-3p	CLIP-seq
MIRT2005146	hsa-miR-485-3p	CLIP-seq
MIRT2005147	hsa-miR-548s	CLIP-seq
MIRT2005148	hsa-miR-566	CLIP-seq
MIRT2005149	hsa-miR-588	CLIP-seq
MIRT2005150	hsa-miR-608	CLIP-seq
MIRT2005151	hsa-miR-626	CLIP-seq
MIRT2005152	hsa-miR-661	CLIP-seq
MIRT2005153	hsa-miR-761	CLIP-seq
MIRT2005154	hsa-miR-765	CLIP-seq
MIRT1028561	hsa-miR-766	CLIP-seq
MIRT2005155	hsa-miR-874	CLIP-seq
MIRT1028563	hsa-miR-922	CLIP-seq
MIRT2005101	hsa-miR-1197	CLIP-seq
MIRT2237785	hsa-miR-1207-3p	CLIP-seq
MIRT2005103	hsa-miR-1266	CLIP-seq
MIRT2237786	hsa-miR-1321	CLIP-seq
MIRT2005106	hsa-miR-146b-3p	CLIP-seq
MIRT1028534	hsa-miR-1910	CLIP-seq
MIRT2005109	hsa-miR-214	CLIP-seq
MIRT2005114	hsa-miR-3117-5p	CLIP-seq
MIRT2237787	hsa-miR-3127-5p	CLIP-seq
MIRT2005116	hsa-miR-3144-5p	CLIP-seq
MIRT2005117	hsa-miR-3173-5p	CLIP-seq
MIRT2005118	hsa-miR-3187-3p	CLIP-seq
MIRT2005122	hsa-miR-3619-5p	CLIP-seq
MIRT2005123	hsa-miR-3649	CLIP-seq
MIRT2237788	hsa-miR-3689d	CLIP-seq
MIRT2005125	hsa-miR-3918	CLIP-seq
MIRT2005126	hsa-miR-4252	CLIP-seq
MIRT2237789	hsa-miR-4270	CLIP-seq
MIRT2005129	hsa-miR-4435	CLIP-seq
MIRT2237790	hsa-miR-4441	CLIP-seq
MIRT2237791	hsa-miR-4446-3p	CLIP-seq
MIRT2005131	hsa-miR-4447	CLIP-seq
MIRT1028546	hsa-miR-4459	CLIP-seq
MIRT2005132	hsa-miR-4472	CLIP-seq
MIRT2005134	hsa-miR-4518	CLIP-seq
MIRT2005139	hsa-miR-4690-5p	CLIP-seq
MIRT2005140	hsa-miR-4701-5p	CLIP-seq
MIRT1028554	hsa-miR-4728-5p	CLIP-seq
MIRT2237792	hsa-miR-4731-5p	CLIP-seq
MIRT2005141	hsa-miR-4732-3p	CLIP-seq
MIRT2237793	hsa-miR-4739	CLIP-seq
MIRT2005143	hsa-miR-4752	CLIP-seq
MIRT2237794	hsa-miR-4756-5p	CLIP-seq
MIRT2237795	hsa-miR-4779	CLIP-seq
MIRT2237796	hsa-miR-486-3p	CLIP-seq
MIRT2237797	hsa-miR-510	CLIP-seq
MIRT2005147	hsa-miR-548s	CLIP-seq
MIRT2005149	hsa-miR-588	CLIP-seq
MIRT2005153	hsa-miR-761	CLIP-seq
MIRT2005154	hsa-miR-765	CLIP-seq
MIRT2005155	hsa-miR-874	CLIP-seq
MIRT2237798	hsa-miR-885-3p	CLIP-seq
MIRT2005104	hsa-miR-1291	CLIP-seq
MIRT2541829	hsa-miR-1915	CLIP-seq
MIRT2541830	hsa-miR-2355-5p	CLIP-seq
MIRT2005120	hsa-miR-3591-3p	CLIP-seq
MIRT2005125	hsa-miR-3918	CLIP-seq
MIRT2541831	hsa-miR-4685-5p	CLIP-seq
MIRT2005103	hsa-miR-1266	CLIP-seq
MIRT2005109	hsa-miR-214	CLIP-seq
MIRT2005122	hsa-miR-3619-5p	CLIP-seq
MIRT2681895	hsa-miR-3664-3p	CLIP-seq
MIRT2681896	hsa-miR-3907	CLIP-seq
MIRT2681897	hsa-miR-4291	CLIP-seq
MIRT2005134	hsa-miR-4518	CLIP-seq
MIRT2681898	hsa-miR-4519	CLIP-seq
MIRT2005151	hsa-miR-626	CLIP-seq
MIRT2005153	hsa-miR-761	CLIP-seq
MIRT1028563	hsa-miR-922	CLIP-seq

Show/Hide all(35)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001523	Process	Retinoid metabolic process	TAS
GO:0005507	Function	Copper ion binding	IDA	12732622
GO:0005576	Component	Extracellular region	HDA	27068509
GO:0005615	Component	Extracellular space	TAS	2148568
GO:0005654	Component	Nucleoplasm	IDA
GO:0005768	Component	Endosome	IEA
GO:0005796	Component	Golgi lumen	TAS
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	TAS
GO:0006024	Process	Glycosaminoglycan biosynthetic process	TAS
GO:0006027	Process	Glycosaminoglycan catabolic process	TAS
GO:0007411	Process	Axon guidance	TAS
GO:0009986	Component	Cell surface	IBA	21873635
GO:0014037	Process	Schwann cell differentiation	ISS
GO:0016477	Process	Cell migration	IBA	21873635
GO:0017134	Function	Fibroblast growth factor binding	IBA	21873635
GO:0017134	Function	Fibroblast growth factor binding	ISS
GO:0030200	Process	Heparan sulfate proteoglycan catabolic process	IDA	12732622
GO:0031012	Component	Extracellular matrix	ISS
GO:0031226	Component	Intrinsic component of plasma membrane	TAS	2148568
GO:0032288	Process	Myelin assembly	ISS
GO:0040037	Process	Negative regulation of fibroblast growth factor receptor signaling pathway	IBA	21873635
GO:0040037	Process	Negative regulation of fibroblast growth factor receptor signaling pathway	ISS
GO:0043202	Component	Lysosomal lumen	TAS
GO:0043236	Function	Laminin binding	ISS
GO:0045121	Component	Membrane raft	IDA	12732622
GO:0045121	Component	Membrane raft	ISS
GO:0045202	Component	Synapse	IBA	21873635
GO:0046658	Component	Anchored component of plasma membrane	IEA
GO:0050900	Process	Leukocyte migration	TAS
GO:0062023	Component	Collagen-containing extracellular matrix	HDA	27559042
GO:0070062	Component	Extracellular exosome	HDA	19199708
GO:1905475	Process	Regulation of protein localization to membrane	IBA	21873635
GO:2001016	Process	Positive regulation of skeletal muscle cell differentiation	ISS

MIM	HGNC	e!Ensembl
600395	4449	ENSG00000063660

Protein

UniProt ID

P35052

Protein name

Glypican-1 [Cleaved into: Secreted glypican-1]

Protein function

Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of pr

PDB

4ACR , 4AD7 , 4BWE , 4YWT

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01153	Glypican	11 → 555	Glypican	Family

Sequence

MELRARGWWLLCAAAALVACARGDPASKSRSCGEVRQIYGAKGFSLSDVPQAEISGEHLR
ICPQGYTCCTSEMEENLANRSHAELETALRDSSRVLQAMLATQLRSFDDHFQHLLNDSER
TLQATFPGAFGELYTQNARAFRDLYSELRLYYRGANLHLEETLAEFWARLLERLFKQLHP
QLLLPDDYLDCLGKQAEALRPFGEAPRELRLRATRAFVAARSFVQGLGVASDVVRKVAQV
PLGPECSRAVMKLVYCAHCLGVPGARPCPDYCRNVLKGCLANQADLDAEWRNLLDSMVLI
TDKFWGTSGVESVIGSVHTWLAEAINALQDNRDTLTAKVIQGCGNPKVNPQGPGPEEKRR
RGKLAPRERPPSGTLEKLVSEAKAQLRDVQDFWISLPGTLCSEKMALSTASDDRCWNGMA
RGRYLPEVMGDGLANQINNPEVEVDITKPDMTIRQQIMQLKIMTNRLRSAYNGNDVDFQD
ASDDGSGSGSGDGCLDDLCSRKVSRKSSSSRTPLTHALPGLSEQEGQKTSAASCPQPPTF
LLPLLLFLALTVARPRWR

Sequence length

558

Interactions

View interactions

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