GNAQ (G protein subunit alpha q)

Gene

• Entrez ID: 2776
• Gene name: G protein subunit alpha q
• Gene symbol: GNAQ
• Synonyms: CMAL, CMC1, G-ALPHA-q, GAQ, SWS
• Chromosome: 9
• Chromosome location: 9q21.2
• Summary: This locus encodes a guanine nucleotide-binding protein. The encoded protein, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospolipase C-beta. Mutations at this locus have been associated with problems

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs121913492	T>A,C,G	Likely-pathogenic, pathogenic	Coding sequence variant, missense variant
rs397514698	C>T	Pathogenic	Missense variant, coding sequence variant
rs1057519853	TG>AA	Likely-pathogenic	Coding sequence variant, missense variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT021640	hsa-miR-142-3p	Microarray	17612493
MIRT021961	hsa-miR-128-3p	Microarray	17612493
MIRT030765	hsa-miR-21-5p	Microarray	18591254
MIRT612954	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT612953	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT612952	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT612951	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT612950	hsa-miR-5579-3p	HITS-CLIP	23824327
MIRT614979	hsa-miR-3130-3p	HITS-CLIP	23824327
MIRT614978	hsa-miR-767-5p	HITS-CLIP	23824327
MIRT614977	hsa-miR-6885-3p	HITS-CLIP	23824327
MIRT614976	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT612954	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT612953	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT612952	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT612951	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT612950	hsa-miR-5579-3p	HITS-CLIP	23824327
MIRT562279	hsa-miR-92a-3p	PAR-CLIP	20371350
MIRT562278	hsa-miR-25-3p	PAR-CLIP	20371350
MIRT562277	hsa-miR-32-5p	PAR-CLIP	20371350
MIRT562276	hsa-miR-92b-3p	PAR-CLIP	20371350
MIRT562275	hsa-miR-367-3p	PAR-CLIP	20371350
MIRT562274	hsa-miR-363-3p	PAR-CLIP	20371350
MIRT562272	hsa-miR-5589-3p	PAR-CLIP	20371350
MIRT562273	hsa-miR-653-5p	PAR-CLIP	20371350
MIRT614976	hsa-miR-129-5p	PAR-CLIP	26701625
MIRT614976	hsa-miR-129-5p	PAR-CLIP	26701625
MIRT614976	hsa-miR-129-5p	PAR-CLIP	26701625
MIRT614976	hsa-miR-129-5p	PAR-CLIP	26701625
MIRT614976	hsa-miR-129-5p	PAR-CLIP	26701625
MIRT614976	hsa-miR-129-5p	PAR-CLIP	26701625
MIRT614976	hsa-miR-129-5p	PAR-CLIP	26701625
MIRT614979	hsa-miR-3130-3p	PAR-CLIP	26701625
MIRT614979	hsa-miR-3130-3p	PAR-CLIP	26701625
MIRT614979	hsa-miR-3130-3p	PAR-CLIP	26701625
MIRT614979	hsa-miR-3130-3p	PAR-CLIP	26701625
MIRT614979	hsa-miR-3130-3p	PAR-CLIP	26701625
MIRT614979	hsa-miR-3130-3p	PAR-CLIP	26701625
MIRT614979	hsa-miR-3130-3p	PAR-CLIP	26701625
MIRT614979	hsa-miR-3130-3p	PAR-CLIP	26701625
MIRT614977	hsa-miR-6885-3p	PAR-CLIP	26701625
MIRT614977	hsa-miR-6885-3p	PAR-CLIP	26701625
MIRT614977	hsa-miR-6885-3p	PAR-CLIP	26701625
MIRT614977	hsa-miR-6885-3p	PAR-CLIP	26701625
MIRT614977	hsa-miR-6885-3p	PAR-CLIP	26701625
MIRT614977	hsa-miR-6885-3p	PAR-CLIP	26701625
MIRT614977	hsa-miR-6885-3p	PAR-CLIP	26701625
MIRT614977	hsa-miR-6885-3p	PAR-CLIP	26701625
MIRT614978	hsa-miR-767-5p	PAR-CLIP	26701625
MIRT614978	hsa-miR-767-5p	PAR-CLIP	26701625
MIRT614978	hsa-miR-767-5p	PAR-CLIP	26701625
MIRT614978	hsa-miR-767-5p	PAR-CLIP	26701625
MIRT614978	hsa-miR-767-5p	PAR-CLIP	26701625
MIRT614978	hsa-miR-767-5p	PAR-CLIP	26701625
MIRT614978	hsa-miR-767-5p	PAR-CLIP	26701625
MIRT614978	hsa-miR-767-5p	PAR-CLIP	26701625
MIRT614976	hsa-miR-129-5p	HITS-CLIP	27418678
MIRT614976	hsa-miR-129-5p	HITS-CLIP	27418678
MIRT614976	hsa-miR-129-5p	HITS-CLIP	27418678
MIRT614976	hsa-miR-129-5p	HITS-CLIP	27418678
MIRT614979	hsa-miR-3130-3p	HITS-CLIP	27418678
MIRT614979	hsa-miR-3130-3p	HITS-CLIP	27418678
MIRT614979	hsa-miR-3130-3p	HITS-CLIP	27418678
MIRT614979	hsa-miR-3130-3p	HITS-CLIP	27418678
MIRT614977	hsa-miR-6885-3p	HITS-CLIP	27418678
MIRT614977	hsa-miR-6885-3p	HITS-CLIP	27418678
MIRT614977	hsa-miR-6885-3p	HITS-CLIP	27418678
MIRT614977	hsa-miR-6885-3p	HITS-CLIP	27418678
MIRT614978	hsa-miR-767-5p	HITS-CLIP	27418678
MIRT614978	hsa-miR-767-5p	HITS-CLIP	27418678
MIRT614978	hsa-miR-767-5p	HITS-CLIP	27418678
MIRT614978	hsa-miR-767-5p	HITS-CLIP	27418678
MIRT614976	hsa-miR-129-5p	HITS-CLIP	28735896
MIRT614979	hsa-miR-3130-3p	HITS-CLIP	28735896
MIRT614977	hsa-miR-6885-3p	HITS-CLIP	28735896
MIRT614978	hsa-miR-767-5p	HITS-CLIP	28735896
MIRT612954	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT612953	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT612952	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT612951	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT612950	hsa-miR-5579-3p	HITS-CLIP	23824327
MIRT614979	hsa-miR-3130-3p	HITS-CLIP	23824327
MIRT614978	hsa-miR-767-5p	HITS-CLIP	23824327
MIRT614977	hsa-miR-6885-3p	HITS-CLIP	23824327
MIRT614976	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT612954	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT612953	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT612952	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT612951	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT612950	hsa-miR-5579-3p	HITS-CLIP	23824327
MIRT562279	hsa-miR-92a-3p	PAR-CLIP	20371350
MIRT562278	hsa-miR-25-3p	PAR-CLIP	20371350
MIRT562277	hsa-miR-32-5p	PAR-CLIP	20371350
MIRT562276	hsa-miR-92b-3p	PAR-CLIP	20371350
MIRT562275	hsa-miR-367-3p	PAR-CLIP	20371350
MIRT562274	hsa-miR-363-3p	PAR-CLIP	20371350
MIRT562272	hsa-miR-5589-3p	PAR-CLIP	20371350
MIRT562273	hsa-miR-653-5p	PAR-CLIP	20371350
MIRT1023536	hsa-miR-1207-5p	CLIP-seq
MIRT1023537	hsa-miR-1271	CLIP-seq
MIRT1023538	hsa-miR-1321	CLIP-seq
MIRT1023539	hsa-miR-15a	CLIP-seq
MIRT1023540	hsa-miR-15b	CLIP-seq
MIRT1023541	hsa-miR-16	CLIP-seq
MIRT1023542	hsa-miR-182	CLIP-seq
MIRT1023543	hsa-miR-195	CLIP-seq
MIRT1023544	hsa-miR-202	CLIP-seq
MIRT1023545	hsa-miR-2114	CLIP-seq
MIRT1023546	hsa-miR-30a	CLIP-seq
MIRT1023547	hsa-miR-30b	CLIP-seq
MIRT1023548	hsa-miR-30c	CLIP-seq
MIRT1023549	hsa-miR-30d	CLIP-seq
MIRT1023550	hsa-miR-30e	CLIP-seq
MIRT1023551	hsa-miR-3117-5p	CLIP-seq
MIRT1023552	hsa-miR-3125	CLIP-seq
MIRT1023553	hsa-miR-3132	CLIP-seq
MIRT1023554	hsa-miR-3136-5p	CLIP-seq
MIRT1023555	hsa-miR-3141	CLIP-seq
MIRT1023556	hsa-miR-3152-5p	CLIP-seq
MIRT1023557	hsa-miR-3163	CLIP-seq
MIRT1023558	hsa-miR-3199	CLIP-seq
MIRT1023559	hsa-miR-3202	CLIP-seq
MIRT1023560	hsa-miR-342-3p	CLIP-seq
MIRT1023561	hsa-miR-3651	CLIP-seq
MIRT1023562	hsa-miR-3653	CLIP-seq
MIRT1023563	hsa-miR-3656	CLIP-seq
MIRT1023564	hsa-miR-377	CLIP-seq
MIRT1023565	hsa-miR-3916	CLIP-seq
MIRT1023566	hsa-miR-3976	CLIP-seq
MIRT1023567	hsa-miR-424	CLIP-seq
MIRT1023568	hsa-miR-425	CLIP-seq
MIRT1023569	hsa-miR-4251	CLIP-seq
MIRT1023570	hsa-miR-4291	CLIP-seq
MIRT1023571	hsa-miR-4310	CLIP-seq
MIRT1023572	hsa-miR-4314	CLIP-seq
MIRT1023573	hsa-miR-4321	CLIP-seq
MIRT1023574	hsa-miR-4419a	CLIP-seq
MIRT1023575	hsa-miR-4433	CLIP-seq
MIRT1023576	hsa-miR-4436b-3p	CLIP-seq
MIRT1023577	hsa-miR-4439	CLIP-seq
MIRT1023578	hsa-miR-4457	CLIP-seq
MIRT1023579	hsa-miR-4459	CLIP-seq
MIRT1023580	hsa-miR-4510	CLIP-seq
MIRT1023581	hsa-miR-4513	CLIP-seq
MIRT1023582	hsa-miR-4524	CLIP-seq
MIRT1023583	hsa-miR-4662a-3p	CLIP-seq
MIRT1023584	hsa-miR-4714-3p	CLIP-seq
MIRT1023585	hsa-miR-4731-5p	CLIP-seq
MIRT1023586	hsa-miR-4733-3p	CLIP-seq
MIRT1023587	hsa-miR-4739	CLIP-seq
MIRT1023588	hsa-miR-4747-5p	CLIP-seq
MIRT1023589	hsa-miR-4756-5p	CLIP-seq
MIRT1023590	hsa-miR-4763-3p	CLIP-seq
MIRT1023591	hsa-miR-4768-3p	CLIP-seq
MIRT1023592	hsa-miR-4774-3p	CLIP-seq
MIRT1023593	hsa-miR-4779	CLIP-seq
MIRT1023594	hsa-miR-4781-5p	CLIP-seq
MIRT1023595	hsa-miR-4789-3p	CLIP-seq
MIRT1023596	hsa-miR-4797-5p	CLIP-seq
MIRT1023597	hsa-miR-493	CLIP-seq
MIRT1023598	hsa-miR-497	CLIP-seq
MIRT1023599	hsa-miR-503	CLIP-seq
MIRT1023600	hsa-miR-513b	CLIP-seq
MIRT1023601	hsa-miR-514	CLIP-seq
MIRT1023602	hsa-miR-514b-3p	CLIP-seq
MIRT1023603	hsa-miR-548ag	CLIP-seq
MIRT1023604	hsa-miR-548ai	CLIP-seq
MIRT1023605	hsa-miR-548al	CLIP-seq
MIRT1023606	hsa-miR-574-3p	CLIP-seq
MIRT1023607	hsa-miR-579	CLIP-seq
MIRT1023608	hsa-miR-580	CLIP-seq
MIRT1023609	hsa-miR-581	CLIP-seq
MIRT1023610	hsa-miR-624	CLIP-seq
MIRT1023611	hsa-miR-642a	CLIP-seq
MIRT1023612	hsa-miR-646	CLIP-seq
MIRT1023613	hsa-miR-664	CLIP-seq
MIRT1023614	hsa-miR-665	CLIP-seq
MIRT1023615	hsa-miR-96	CLIP-seq
MIRT2003534	hsa-miR-1204	CLIP-seq
MIRT1023536	hsa-miR-1207-5p	CLIP-seq
MIRT2003535	hsa-miR-1267	CLIP-seq
MIRT1023537	hsa-miR-1271	CLIP-seq
MIRT2003536	hsa-miR-135a	CLIP-seq
MIRT2003537	hsa-miR-135b	CLIP-seq
MIRT1023542	hsa-miR-182	CLIP-seq
MIRT1023551	hsa-miR-3117-5p	CLIP-seq
MIRT1023555	hsa-miR-3141	CLIP-seq
MIRT1023559	hsa-miR-3202	CLIP-seq
MIRT2003538	hsa-miR-3609	CLIP-seq
MIRT2003539	hsa-miR-3921	CLIP-seq
MIRT2003540	hsa-miR-3945	CLIP-seq
MIRT2003541	hsa-miR-4253	CLIP-seq
MIRT2003542	hsa-miR-4303	CLIP-seq
MIRT1023576	hsa-miR-4436b-3p	CLIP-seq
MIRT2003543	hsa-miR-448	CLIP-seq
MIRT2003544	hsa-miR-455-3p	CLIP-seq
MIRT2003545	hsa-miR-4642	CLIP-seq
MIRT2003546	hsa-miR-4653-5p	CLIP-seq
MIRT1023588	hsa-miR-4747-5p	CLIP-seq
MIRT2003547	hsa-miR-4760-5p	CLIP-seq
MIRT1023590	hsa-miR-4763-3p	CLIP-seq
MIRT2003548	hsa-miR-4768-5p	CLIP-seq
MIRT1023595	hsa-miR-4789-3p	CLIP-seq
MIRT2003549	hsa-miR-491-3p	CLIP-seq
MIRT1023597	hsa-miR-493	CLIP-seq
MIRT2003550	hsa-miR-520g	CLIP-seq
MIRT2003551	hsa-miR-520h	CLIP-seq
MIRT2003552	hsa-miR-548ah	CLIP-seq
MIRT1023615	hsa-miR-96	CLIP-seq
MIRT1023536	hsa-miR-1207-5p	CLIP-seq
MIRT2003535	hsa-miR-1267	CLIP-seq
MIRT1023537	hsa-miR-1271	CLIP-seq
MIRT2236342	hsa-miR-144	CLIP-seq
MIRT1023539	hsa-miR-15a	CLIP-seq
MIRT1023540	hsa-miR-15b	CLIP-seq
MIRT1023541	hsa-miR-16	CLIP-seq
MIRT1023542	hsa-miR-182	CLIP-seq
MIRT2236343	hsa-miR-1914	CLIP-seq
MIRT1023543	hsa-miR-195	CLIP-seq
MIRT2236344	hsa-miR-2276	CLIP-seq
MIRT1023553	hsa-miR-3132	CLIP-seq
MIRT1023555	hsa-miR-3141	CLIP-seq
MIRT1023559	hsa-miR-3202	CLIP-seq
MIRT2003538	hsa-miR-3609	CLIP-seq
MIRT2236345	hsa-miR-3612	CLIP-seq
MIRT1023561	hsa-miR-3651	CLIP-seq
MIRT1023563	hsa-miR-3656	CLIP-seq
MIRT1023567	hsa-miR-424	CLIP-seq
MIRT2236346	hsa-miR-4266	CLIP-seq
MIRT2236347	hsa-miR-4297	CLIP-seq
MIRT1023572	hsa-miR-4314	CLIP-seq
MIRT1023576	hsa-miR-4436b-3p	CLIP-seq
MIRT1023582	hsa-miR-4524	CLIP-seq
MIRT2003544	hsa-miR-455-3p	CLIP-seq
MIRT2003545	hsa-miR-4642	CLIP-seq
MIRT2236348	hsa-miR-4645-3p	CLIP-seq
MIRT2236349	hsa-miR-4695-5p	CLIP-seq
MIRT2236350	hsa-miR-4711-3p	CLIP-seq
MIRT2236351	hsa-miR-4722-3p	CLIP-seq
MIRT1023586	hsa-miR-4733-3p	CLIP-seq
MIRT1023588	hsa-miR-4747-5p	CLIP-seq
MIRT1023590	hsa-miR-4763-3p	CLIP-seq
MIRT2236352	hsa-miR-4772-3p	CLIP-seq
MIRT1023593	hsa-miR-4779	CLIP-seq
MIRT2236353	hsa-miR-488	CLIP-seq
MIRT1023598	hsa-miR-497	CLIP-seq
MIRT1023599	hsa-miR-503	CLIP-seq
MIRT2236354	hsa-miR-511	CLIP-seq
MIRT2003550	hsa-miR-520g	CLIP-seq
MIRT2003551	hsa-miR-520h	CLIP-seq
MIRT2003552	hsa-miR-548ah	CLIP-seq
MIRT2236355	hsa-miR-640	CLIP-seq
MIRT1023612	hsa-miR-646	CLIP-seq
MIRT2236356	hsa-miR-650	CLIP-seq
MIRT1023615	hsa-miR-96	CLIP-seq
MIRT1023559	hsa-miR-3202	CLIP-seq
MIRT1023561	hsa-miR-3651	CLIP-seq
MIRT1023564	hsa-miR-377	CLIP-seq
MIRT1023576	hsa-miR-4436b-3p	CLIP-seq
MIRT1023586	hsa-miR-4733-3p	CLIP-seq
MIRT1023588	hsa-miR-4747-5p	CLIP-seq
MIRT1023596	hsa-miR-4797-5p	CLIP-seq
MIRT1023605	hsa-miR-548al	CLIP-seq
MIRT1023614	hsa-miR-665	CLIP-seq
MIRT2236342	hsa-miR-144	CLIP-seq
MIRT2540086	hsa-miR-1537	CLIP-seq
MIRT1023551	hsa-miR-3117-5p	CLIP-seq
MIRT1023552	hsa-miR-3125	CLIP-seq
MIRT1023556	hsa-miR-3152-5p	CLIP-seq
MIRT2540087	hsa-miR-330-3p	CLIP-seq
MIRT2003538	hsa-miR-3609	CLIP-seq
MIRT2540088	hsa-miR-3692	CLIP-seq
MIRT2540089	hsa-miR-3713	CLIP-seq
MIRT1023564	hsa-miR-377	CLIP-seq
MIRT1023565	hsa-miR-3916	CLIP-seq
MIRT2003540	hsa-miR-3945	CLIP-seq
MIRT1023566	hsa-miR-3976	CLIP-seq
MIRT2003541	hsa-miR-4253	CLIP-seq
MIRT1023578	hsa-miR-4457	CLIP-seq
MIRT2003544	hsa-miR-455-3p	CLIP-seq
MIRT2236348	hsa-miR-4645-3p	CLIP-seq
MIRT1023583	hsa-miR-4662a-3p	CLIP-seq
MIRT2003547	hsa-miR-4760-5p	CLIP-seq
MIRT1023592	hsa-miR-4774-3p	CLIP-seq
MIRT1023596	hsa-miR-4797-5p	CLIP-seq
MIRT2003549	hsa-miR-491-3p	CLIP-seq
MIRT1023600	hsa-miR-513b	CLIP-seq
MIRT2003550	hsa-miR-520g	CLIP-seq
MIRT2003551	hsa-miR-520h	CLIP-seq
MIRT2540090	hsa-miR-548aa	CLIP-seq
MIRT2003552	hsa-miR-548ah	CLIP-seq
MIRT1023605	hsa-miR-548al	CLIP-seq
MIRT1023608	hsa-miR-580	CLIP-seq
MIRT1023610	hsa-miR-624	CLIP-seq
MIRT1023614	hsa-miR-665	CLIP-seq
MIRT2236342	hsa-miR-144	CLIP-seq
MIRT1023551	hsa-miR-3117-5p	CLIP-seq
MIRT2540087	hsa-miR-330-3p	CLIP-seq
MIRT2003538	hsa-miR-3609	CLIP-seq
MIRT2540089	hsa-miR-3713	CLIP-seq
MIRT1023564	hsa-miR-377	CLIP-seq
MIRT2003540	hsa-miR-3945	CLIP-seq
MIRT2003541	hsa-miR-4253	CLIP-seq
MIRT1023578	hsa-miR-4457	CLIP-seq
MIRT2003544	hsa-miR-455-3p	CLIP-seq
MIRT2236348	hsa-miR-4645-3p	CLIP-seq
MIRT2003547	hsa-miR-4760-5p	CLIP-seq
MIRT1023596	hsa-miR-4797-5p	CLIP-seq
MIRT2003549	hsa-miR-491-3p	CLIP-seq
MIRT1023600	hsa-miR-513b	CLIP-seq
MIRT2003550	hsa-miR-520g	CLIP-seq
MIRT2003551	hsa-miR-520h	CLIP-seq
MIRT2003552	hsa-miR-548ah	CLIP-seq
MIRT1023605	hsa-miR-548al	CLIP-seq
MIRT1023608	hsa-miR-580	CLIP-seq
MIRT1023614	hsa-miR-665	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001508	Process	Action potential	IBA	21873635
GO:0001664	Function	G protein-coupled receptor binding	IBA	21873635
GO:0001750	Component	Photoreceptor outer segment	ISS
GO:0003924	Function	GTPase activity	IBA	21873635
GO:0005096	Function	GTPase activator activity	IBA	21873635
GO:0005096	Function	GTPase activator activity	IDA	15611106
GO:0005515	Function	Protein binding	IPI	18672896, 18772143, 22056876, 22750945, 23353685, 23994616, 27265506
GO:0005525	Function	GTP binding	IEA
GO:0005737	Component	Cytoplasm	TAS	9175863
GO:0005765	Component	Lysosomal membrane	HDA	17897319
GO:0005794	Component	Golgi apparatus	IEA
GO:0005834	Component	Heterotrimeric G-protein complex	IBA	21873635
GO:0005886	Component	Plasma membrane	TAS
GO:0006469	Process	Negative regulation of protein kinase activity	IMP	20399743
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007188	Process	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA	21873635
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA	21873635
GO:0007202	Process	Activation of phospholipase C activity	TAS	8825633
GO:0007213	Process	G protein-coupled acetylcholine receptor signaling pathway	ISS
GO:0007215	Process	Glutamate receptor signaling pathway	IBA	21873635
GO:0007596	Process	Blood coagulation	TAS	9238049
GO:0007603	Process	Phototransduction, visible light	ISS
GO:0009649	Process	Entrainment of circadian clock	ISS
GO:0030168	Process	Platelet activation	TAS
GO:0031683	Function	G-protein beta/gamma-subunit complex binding	IBA	21873635
GO:0031826	Function	Type 2A serotonin receptor binding	IBA	21873635
GO:0031965	Component	Nuclear membrane	IEA
GO:0043547	Process	Positive regulation of GTPase activity	IEA
GO:0045202	Component	Synapse	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0050821	Process	Protein stabilization	IMP	20399743
GO:0060828	Process	Regulation of canonical Wnt signaling pathway	IMP	20399743
GO:0070062	Component	Extracellular exosome	HDA	19056867, 19199708, 23533145

Other IDs

• MIM: 600998
• HGNC: 4390
• e!Ensembl: ENSG00000156052

Protein

• UniProt ID: P50148
• Protein name: Guanine nucleotide-binding protein G(q) subunit alpha (EC 3.6.5.-) (Guanine nucleotide-binding protein alpha-q)
• Protein function: Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:37991948). The alpha chain contains the guanine nucleotide binding site and alterna
• PDB: 6VU5, 7EZM, 7F6G, 7F6H, 7F6I, 7F8W, 7W3Z, 7W40, 7XOW, 8G59, 8IA7, 8IYS, 8J9N, 8JPB, 8JPC, 8JPE, 8SZG, 8UQN, 8UQO, 8XGO, 8XGS, 8Y52, 8ZJD, 8ZJE, 9K27
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00503	G-alpha	19 → 348	G-protein alpha subunit	Domain

• Sequence:

  MTLESIMACCLSEEAKEARRINDEIERQLRRDKRDARRELKLLLLGTGESGKSTFIKQMR
  IIHGSGYSDEDKRGFTKLVYQNIFTAMQAMIRAMDTLKIPYKYEHNKAHAQLVREVDVEK
  VSAFENPYVDAIKSLWNDPGIQECYDRRREYQLSDSTKYYLNDLDRVADPAYLPTQQDVL
  RVRVPTTGIIEYPFDLQSVIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLV
  ESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEEKIMYSHLVDYFPEYDGPQR
  DAQAAREFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV

• Sequence length: 359