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GNAI3 (G protein subunit alpha i3)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2773
Gene nameGene Name - the full gene name approved by the HGNC.
G protein subunit alpha i3
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
GNAI3
SynonymsGene synonyms aliases
87U6, ARCND1, ARCODS, HG1A
ChromosomeChromosome number
1
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p13.3
SummarySummary of gene provided in NCBI Entrez Gene.
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling pathways. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes an alpha subunit and belongs to the G-alph
SNPsSNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs387907178 G>A,C Pathogenic Coding sequence variant, missense variant
rs397514768 C>A Pathogenic Coding sequence variant, missense variant
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT002679 hsa-miR-124-3p Microarray 15685193
MIRT002679 hsa-miR-124-3p Microarray;Other 15685193
MIRT023926 hsa-miR-1-3p Proteomics;Microarray 18668037
MIRT025197 hsa-miR-181a-5p Sequencing 20371350
MIRT445890 hsa-miR-3691-3p PAR-CLIP 22100165
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IDA 12642577
GO:0001664 Function G protein-coupled receptor binding IBA 21873635
GO:0003924 Function GTPase activity IBA 21873635
GO:0003924 Function GTPase activity IDA 19478087
GO:0005515 Function Protein binding IPI 18434541, 21988832, 25416956, 26126266, 27621449, 28514442, 30194280, 32296183
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P08754
Protein name Guanine nucleotide-binding protein G(i) subunit alpha-3 (G(i) alpha-3)
Protein function Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates
PDB 2IHB , 2ODE , 2V4Z , 4G5O , 4G5R , 4G5S , 7E9H , 7KH0 , 7RA3 , 7RGP , 7T10 , 7T11 , 7X6I , 8GVX , 8JD6 , 8K9L , 8OY1 , 8SZH , 8SZI , 8WGB , 9AVL
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00503 G-alpha
13 343
G-protein alpha subunit
Domain
Sequence
Sequence length 354
Interactions View interactions

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