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GNAI2 (G protein subunit alpha i2)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2771
Gene nameGene Name - the full gene name approved by the HGNC.
G protein subunit alpha i2
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
GNAI2
SynonymsGene synonyms aliases
GIP, GNAI2B, HG1C, H_LUCA15.1, H_LUCA16.1
ChromosomeChromosome number
3
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3p21.31
SummarySummary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of adenylate cyclase. Several transcript
SNPsSNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs137853226 C>G,T Pathogenic Missense variant, coding sequence variant
rs137853227 G>A Pathogenic Missense variant, coding sequence variant
rs137853228 T>A Pathogenic Missense variant, coding sequence variant
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT003274 hsa-miR-30d-5p Western blot 20054866
MIRT003274 hsa-miR-30d-5p Western blot 20054866
MIRT003274 hsa-miR-30d-5p Western blot 20054866
MIRT003274 hsa-miR-30d-5p Western blot 20054866
MIRT005181 hsa-miR-30a-5p pSILAC 18668040
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001664 Function G protein-coupled receptor binding IBA 21873635
GO:0001973 Process G protein-coupled adenosine receptor signaling pathway IBA 21873635
GO:0003924 Function GTPase activity IBA 21873635
GO:0005515 Function Protein binding IPI 16189514, 16782902, 18599439, 23773523, 25241761, 25416956, 32296183
GO:0005525 Function GTP binding IEA
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P04899
Protein name Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein)
Protein function Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in respon
PDB 6D9H , 7F8V , 7LD3 , 7LD4 , 7WV9 , 7WVV , 7WVW , 7WVX , 7WVY , 7XXI , 7YJ4 , 7YK6 , 7YK7 , 8K6M , 8K6N , 8K6O , 8KGG , 8THK , 8THL , 8Y45 , 8ZSJ , 8ZSP , 8ZSS , 8ZSV
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00503 G-alpha
13 344
G-protein alpha subunit
Domain
Sequence
Sequence length 355
Interactions View interactions

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