GLUD2 (glutamate dehydrogenase 2)

Gene

• Entrez ID: 2747
• Gene name: Glutamate dehydrogenase 2
• Gene symbol: GLUD2
• Synonyms: GDH2, GLUDP1
• Chromosome: X
• Chromosome location: Xq24
• Summary: The protein encoded by this gene is localized to the mitochondrion and acts as a homohexamer to recycle glutamate during neurotransmission. The encoded enzyme catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate. This gene is intronless.[provided by RefSeq, Jan 2010]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT036419	hsa-miR-1226-3p	CLASH	23622248
MIRT710734	hsa-miR-3161	HITS-CLIP	19536157
MIRT710735	hsa-miR-1257	HITS-CLIP	19536157
MIRT710736	hsa-miR-187-5p	HITS-CLIP	19536157
MIRT710737	hsa-miR-4738-3p	HITS-CLIP	19536157
MIRT710738	hsa-miR-3646	HITS-CLIP	19536157
MIRT710739	hsa-miR-1283	HITS-CLIP	19536157
MIRT725494	hsa-miR-653-5p	HITS-CLIP	19536157
MIRT725495	hsa-miR-4790-3p	HITS-CLIP	19536157
MIRT725496	hsa-miR-580-3p	HITS-CLIP	19536157
MIRT725497	hsa-miR-885-5p	HITS-CLIP	19536157
MIRT725498	hsa-miR-7151-5p	HITS-CLIP	19536157

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004352	Function	Glutamate dehydrogenase (NAD+) activity	IBA	21873635
GO:0004352	Function	Glutamate dehydrogenase (NAD+) activity	IDA	8207021, 15578726
GO:0004353	Function	Glutamate dehydrogenase [NAD(P)+] activity	IDA	11032875
GO:0005525	Function	GTP binding	IDA	11032875
GO:0005739	Component	Mitochondrion	IBA	21873635
GO:0005739	Component	Mitochondrion	IDA	18688271
GO:0005759	Component	Mitochondrial matrix	IEA
GO:0005829	Component	Cytosol	IDA	18688271
GO:0006536	Process	Glutamate metabolic process	IDA	8207021
GO:0006537	Process	Glutamate biosynthetic process	IDA	11032875
GO:0006538	Process	Glutamate catabolic process	IBA	21873635
GO:0006538	Process	Glutamate catabolic process	IDA	11032875
GO:0043531	Function	ADP binding	IDA	12742085
GO:0070728	Function	Leucine binding	IDA	12742085

Other IDs

• MIM: 300144
• HGNC: 4336
• e!Ensembl: ENSG00000182890

Protein

• UniProt ID: P49448
• Protein name: Glutamate dehydrogenase 2, mitochondrial (GDH 2) (EC 1.4.1.3)
• Protein function: Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission.
• PDB: 6G2U
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02812	ELFV_dehydrog_N	112 → 242	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain	Domain
  PF00208	ELFV_dehydrog	263 → 463	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase	Domain

• Sequence:

  MYRYLAKALLPSRAGPAALGSAANHSAALLGRGRGQPAAASQPGLALAARRHYSELVADR
  EDDPNFFKMVEGFFDRGASIVEDKLVKDLRTQESEEQKRNRVRGILRIIKPCNHVLSLSF
  PIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFG
  GAKAGVKINPKNYTENELEKITRRFTMELAKKGFIGPGVDVPAPDMNTGEREMSWIADTY
  ASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGFR
  DKTFVVQGFGNVGLHSMRYLHRFGAKCIAVGESDGSIWNPDGIDPKELEDFKLQHGSILG
  FPKAKPYEGSILEVDCDILIPAATEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLER
  NILVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLLSVQESLERKFGK
  HGGTIPIVPTAEFQDSISGASEKDIVHSALAYTMERSARQIMHTAMKYNLGLDLRTAAYV
  NAIEKVFKVYSEAGVTFT

• Sequence length: 558