G6PC2 (glucose-6-phosphatase catalytic subunit 2)

Gene

• Entrez ID: 57818
• Gene name: Glucose-6-phosphatase catalytic subunit 2
• Gene symbol: G6PC2
• Synonyms: IGRP
• Chromosome: 2
• Chromosome location: 2q31.1
• Summary: This gene encodes an enzyme belonging to the glucose-6-phosphatase catalytic subunit family. These enzymes are part of a multicomponent integral membrane system that catalyzes the hydrolysis of glucose-6-phosphate, the terminal step in gluconeogenic and g

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT440599	hsa-miR-377-5p	HITS-CLIP	24374217
MIRT440598	hsa-miR-409-3p	HITS-CLIP	24374217
MIRT440599	hsa-miR-377-5p	HITS-CLIP	24374217
MIRT440598	hsa-miR-409-3p	HITS-CLIP	24374217
MIRT1008910	hsa-miR-1228	CLIP-seq
MIRT1008911	hsa-miR-1285	CLIP-seq
MIRT1008912	hsa-miR-1321	CLIP-seq
MIRT1008913	hsa-miR-147	CLIP-seq
MIRT1008914	hsa-miR-203	CLIP-seq
MIRT1008915	hsa-miR-224	CLIP-seq
MIRT1008916	hsa-miR-297	CLIP-seq
MIRT1008917	hsa-miR-3150b-3p	CLIP-seq
MIRT1008918	hsa-miR-3151	CLIP-seq
MIRT1008919	hsa-miR-3187-5p	CLIP-seq
MIRT1008920	hsa-miR-3189-3p	CLIP-seq
MIRT1008921	hsa-miR-323-5p	CLIP-seq
MIRT1008922	hsa-miR-3622b-5p	CLIP-seq
MIRT1008923	hsa-miR-362-5p	CLIP-seq
MIRT1008924	hsa-miR-371b-5p	CLIP-seq
MIRT1008925	hsa-miR-3911	CLIP-seq
MIRT1008926	hsa-miR-3929	CLIP-seq
MIRT1008927	hsa-miR-3940-5p	CLIP-seq
MIRT1008928	hsa-miR-4419a	CLIP-seq
MIRT1008929	hsa-miR-4419b	CLIP-seq
MIRT1008930	hsa-miR-4433	CLIP-seq
MIRT1008931	hsa-miR-4447	CLIP-seq
MIRT1008932	hsa-miR-4472	CLIP-seq
MIRT1008933	hsa-miR-4478	CLIP-seq
MIRT1008934	hsa-miR-4507	CLIP-seq
MIRT1008935	hsa-miR-4510	CLIP-seq
MIRT1008936	hsa-miR-4645-5p	CLIP-seq
MIRT1008937	hsa-miR-4662a-5p	CLIP-seq
MIRT1008938	hsa-miR-4668-3p	CLIP-seq
MIRT1008939	hsa-miR-4673	CLIP-seq
MIRT1008940	hsa-miR-4676-5p	CLIP-seq
MIRT1008941	hsa-miR-4689	CLIP-seq
MIRT1008942	hsa-miR-4698	CLIP-seq
MIRT1008943	hsa-miR-4735-5p	CLIP-seq
MIRT1008944	hsa-miR-4739	CLIP-seq
MIRT1008945	hsa-miR-4755-3p	CLIP-seq
MIRT1008946	hsa-miR-4756-5p	CLIP-seq
MIRT1008947	hsa-miR-4779	CLIP-seq
MIRT1008948	hsa-miR-4784	CLIP-seq
MIRT1008949	hsa-miR-491-5p	CLIP-seq
MIRT1008950	hsa-miR-500a	CLIP-seq
MIRT1008951	hsa-miR-500b	CLIP-seq
MIRT1008952	hsa-miR-567	CLIP-seq
MIRT1008953	hsa-miR-575	CLIP-seq
MIRT1008954	hsa-miR-576-5p	CLIP-seq
MIRT1008955	hsa-miR-579	CLIP-seq
MIRT1008956	hsa-miR-592	CLIP-seq
MIRT1008957	hsa-miR-597	CLIP-seq
MIRT1008958	hsa-miR-612	CLIP-seq
MIRT1008959	hsa-miR-644	CLIP-seq
MIRT1008960	hsa-miR-661	CLIP-seq
MIRT1008961	hsa-miR-665	CLIP-seq
MIRT1008962	hsa-miR-876-3p	CLIP-seq
MIRT1998939	hsa-miR-1289	CLIP-seq
MIRT1998940	hsa-miR-3198	CLIP-seq
MIRT1998941	hsa-miR-4294	CLIP-seq
MIRT1998942	hsa-miR-4309	CLIP-seq
MIRT1998943	hsa-miR-502-5p	CLIP-seq
MIRT1998944	hsa-miR-539	CLIP-seq
MIRT1008923	hsa-miR-362-5p	CLIP-seq
MIRT1008924	hsa-miR-371b-5p	CLIP-seq
MIRT1008938	hsa-miR-4668-3p	CLIP-seq
MIRT1008942	hsa-miR-4698	CLIP-seq
MIRT1008950	hsa-miR-500a	CLIP-seq
MIRT1008951	hsa-miR-500b	CLIP-seq
MIRT2449978	hsa-miR-548p	CLIP-seq
MIRT1008923	hsa-miR-362-5p	CLIP-seq
MIRT1008924	hsa-miR-371b-5p	CLIP-seq
MIRT1008938	hsa-miR-4668-3p	CLIP-seq
MIRT1008942	hsa-miR-4698	CLIP-seq
MIRT1008950	hsa-miR-500a	CLIP-seq
MIRT1008951	hsa-miR-500b	CLIP-seq
MIRT2449978	hsa-miR-548p	CLIP-seq
MIRT1008914	hsa-miR-203	CLIP-seq
MIRT1008923	hsa-miR-362-5p	CLIP-seq
MIRT2536240	hsa-miR-425	CLIP-seq
MIRT1008950	hsa-miR-500a	CLIP-seq
MIRT1008951	hsa-miR-500b	CLIP-seq
MIRT1008914	hsa-miR-203	CLIP-seq
MIRT1008923	hsa-miR-362-5p	CLIP-seq
MIRT2536240	hsa-miR-425	CLIP-seq
MIRT2681273	hsa-miR-4263	CLIP-seq
MIRT2681274	hsa-miR-4799-5p	CLIP-seq
MIRT1008950	hsa-miR-500a	CLIP-seq
MIRT1008951	hsa-miR-500b	CLIP-seq
MIRT1008954	hsa-miR-576-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004346	Function	Glucose-6-phosphatase activity	EXP	14722102
GO:0004346	Function	Glucose-6-phosphatase activity	IBA	21873635
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0006094	Process	Gluconeogenesis	IBA	21873635
GO:0006094	Process	Gluconeogenesis	IEA
GO:0006094	Process	Gluconeogenesis	TAS
GO:0016020	Component	Membrane	IBA	21873635
GO:0016021	Component	Integral component of membrane	IEA
GO:0016311	Process	Dephosphorylation	IEA
GO:0042593	Process	Glucose homeostasis	IMP	20668700
GO:0050796	Process	Regulation of insulin secretion	IMP	20668700
GO:0051156	Process	Glucose 6-phosphate metabolic process	IBA	21873635

Other IDs

• MIM: 608058
• HGNC: 28906
• e!Ensembl: ENSG00000152254

Protein

• UniProt ID: Q9NQR9
• Protein name: Glucose-6-phosphatase 2 (G-6-Pase 2) (G6Pase 2) (EC 3.1.3.9) (Islet-specific glucose-6-phosphatase catalytic subunit-related protein)
• Protein function: May hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis (By similarity).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01569	PAP2	53 → 197	PAP2 superfamily	Family

• Sequence:

  MDFLHRNGVLIIQHLQKDYRAYYTFLNFMSNVGDPRNIFFIYFPLCFQFNQTVGTKMIWV
  AVIGDWLNLIFKWILFGHRPYWWVQETQIYPNHSSPCLEQFPTTCETGPGSPSGHAMGAS
  CVWYVMVTAALSHTVCGMDKFSITLHRLTWSFLWSVFWLIQISVCISRVFIATHFPHQVI
  LGVIGGMLVAEAFEHTPGIQTASLGTYLKTNLFLFLFAVGFYLLLRVLNIDLLWSVPIAK
  KWCANPDWIHIDTTPFAGLVRNLGVLFGLGFAINSEMFLLSCRGGNNYTLSFRLLCALTS
  LTILQLYHFLQIPTHEEHLFYVLSFCKSASIPLTVVAFIPYSVHMLMKQSGKKSQ

• Sequence length: 355