FUT2 (fucosyltransferase 2 (H blood group))

Gene

• Entrez ID: 2524
• Gene name: Fucosyltransferase 2 (H blood group)
• Gene symbol: FUT2
• Synonyms: B12QTL1, SE, SEC2, Se2, sej
• Chromosome: 19
• Chromosome location: 19q13.33
• Summary: The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the soluble A and B antigen synthesis pathway. This gene is one of two encoding th

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT437485	hsa-miR-15b-5p	Luciferase reporter assay, qRT-PCR, Western blot	24122375
MIRT690897	hsa-miR-21-3p	HITS-CLIP	23313552
MIRT690896	hsa-miR-3591-3p	HITS-CLIP	23313552
MIRT690895	hsa-miR-383-3p	HITS-CLIP	23313552
MIRT690894	hsa-miR-5693	HITS-CLIP	23313552
MIRT690893	hsa-miR-7977	HITS-CLIP	23313552
MIRT690892	hsa-miR-30c-1-3p	HITS-CLIP	23313552
MIRT690891	hsa-miR-30c-2-3p	HITS-CLIP	23313552
MIRT690890	hsa-miR-6788-5p	HITS-CLIP	23313552
MIRT690889	hsa-miR-1273h-5p	HITS-CLIP	23313552
MIRT690888	hsa-miR-30b-3p	HITS-CLIP	23313552
MIRT690887	hsa-miR-3689a-3p	HITS-CLIP	23313552
MIRT690886	hsa-miR-3689b-3p	HITS-CLIP	23313552
MIRT690885	hsa-miR-3689c	HITS-CLIP	23313552
MIRT690884	hsa-miR-6779-5p	HITS-CLIP	23313552
MIRT690883	hsa-miR-6780a-5p	HITS-CLIP	23313552
MIRT690882	hsa-miR-450a-1-3p	HITS-CLIP	23313552
MIRT690881	hsa-miR-3122	HITS-CLIP	23313552
MIRT690880	hsa-miR-3913-5p	HITS-CLIP	23313552
MIRT690879	hsa-miR-887-5p	HITS-CLIP	23313552
MIRT690878	hsa-miR-6513-5p	HITS-CLIP	23313552
MIRT674211	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT674210	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT674209	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT674208	hsa-miR-940	HITS-CLIP	23824327
MIRT674207	hsa-miR-3929	HITS-CLIP	23824327
MIRT674206	hsa-miR-4419b	HITS-CLIP	23824327
MIRT674205	hsa-miR-4478	HITS-CLIP	23824327
MIRT674204	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT674203	hsa-miR-6746-5p	HITS-CLIP	23824327
MIRT674202	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT674201	hsa-miR-1827	HITS-CLIP	23824327
MIRT674200	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT674199	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT674198	hsa-miR-6771-5p	HITS-CLIP	23824327
MIRT674197	hsa-miR-665	HITS-CLIP	23824327
MIRT662037	hsa-miR-504-5p	HITS-CLIP	23824327
MIRT662036	hsa-miR-1245a	HITS-CLIP	23824327
MIRT662035	hsa-miR-8079	HITS-CLIP	23824327
MIRT662034	hsa-miR-3620-3p	HITS-CLIP	23824327
MIRT662033	hsa-miR-3176	HITS-CLIP	23824327
MIRT662032	hsa-miR-3922-3p	HITS-CLIP	23824327
MIRT662031	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT662030	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT662029	hsa-miR-640	HITS-CLIP	23824327
MIRT662028	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT690897	hsa-miR-21-3p	HITS-CLIP	23313552
MIRT690896	hsa-miR-3591-3p	HITS-CLIP	23313552
MIRT690895	hsa-miR-383-3p	HITS-CLIP	23313552
MIRT690894	hsa-miR-5693	HITS-CLIP	23313552
MIRT690893	hsa-miR-7977	HITS-CLIP	23313552
MIRT690892	hsa-miR-30c-1-3p	HITS-CLIP	23313552
MIRT690891	hsa-miR-30c-2-3p	HITS-CLIP	23313552
MIRT690890	hsa-miR-6788-5p	HITS-CLIP	23313552
MIRT690889	hsa-miR-1273h-5p	HITS-CLIP	23313552
MIRT690888	hsa-miR-30b-3p	HITS-CLIP	23313552
MIRT690887	hsa-miR-3689a-3p	HITS-CLIP	23313552
MIRT690886	hsa-miR-3689b-3p	HITS-CLIP	23313552
MIRT690885	hsa-miR-3689c	HITS-CLIP	23313552
MIRT690884	hsa-miR-6779-5p	HITS-CLIP	23313552
MIRT690883	hsa-miR-6780a-5p	HITS-CLIP	23313552
MIRT690882	hsa-miR-450a-1-3p	HITS-CLIP	23313552
MIRT690881	hsa-miR-3122	HITS-CLIP	23313552
MIRT690880	hsa-miR-3913-5p	HITS-CLIP	23313552
MIRT690879	hsa-miR-887-5p	HITS-CLIP	23313552
MIRT690878	hsa-miR-6513-5p	HITS-CLIP	23313552
MIRT674211	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT674210	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT674209	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT674208	hsa-miR-940	HITS-CLIP	23824327
MIRT674207	hsa-miR-3929	HITS-CLIP	23824327
MIRT674206	hsa-miR-4419b	HITS-CLIP	23824327
MIRT674205	hsa-miR-4478	HITS-CLIP	23824327
MIRT674204	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT674203	hsa-miR-6746-5p	HITS-CLIP	23824327
MIRT674202	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT674201	hsa-miR-1827	HITS-CLIP	23824327
MIRT674200	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT674199	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT674198	hsa-miR-6771-5p	HITS-CLIP	23824327
MIRT674197	hsa-miR-665	HITS-CLIP	23824327
MIRT662037	hsa-miR-504-5p	HITS-CLIP	23824327
MIRT662036	hsa-miR-1245a	HITS-CLIP	23824327
MIRT662035	hsa-miR-8079	HITS-CLIP	23824327
MIRT662034	hsa-miR-3620-3p	HITS-CLIP	23824327
MIRT662033	hsa-miR-3176	HITS-CLIP	23824327
MIRT662032	hsa-miR-3922-3p	HITS-CLIP	23824327
MIRT662031	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT662030	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT662029	hsa-miR-640	HITS-CLIP	23824327
MIRT662028	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT1006528	hsa-miR-1208	CLIP-seq
MIRT1006529	hsa-miR-1245	CLIP-seq
MIRT1006530	hsa-miR-136	CLIP-seq
MIRT1006531	hsa-miR-1972	CLIP-seq
MIRT1006532	hsa-miR-3152-5p	CLIP-seq
MIRT1006533	hsa-miR-3192	CLIP-seq
MIRT1006534	hsa-miR-3545-3p	CLIP-seq
MIRT1006535	hsa-miR-3672	CLIP-seq
MIRT1006536	hsa-miR-3934	CLIP-seq
MIRT1006537	hsa-miR-4252	CLIP-seq
MIRT1006538	hsa-miR-4293	CLIP-seq
MIRT1006539	hsa-miR-4476	CLIP-seq
MIRT1006540	hsa-miR-4635	CLIP-seq
MIRT1006541	hsa-miR-4680-5p	CLIP-seq
MIRT1006542	hsa-miR-4717-5p	CLIP-seq
MIRT1006543	hsa-miR-4728-5p	CLIP-seq
MIRT1006544	hsa-miR-4738-3p	CLIP-seq
MIRT1006545	hsa-miR-4740-3p	CLIP-seq
MIRT1006546	hsa-miR-4755-3p	CLIP-seq
MIRT1006547	hsa-miR-4786-5p	CLIP-seq
MIRT1006548	hsa-miR-485-5p	CLIP-seq
MIRT1006549	hsa-miR-490-3p	CLIP-seq
MIRT1006550	hsa-miR-5095	CLIP-seq
MIRT1006551	hsa-miR-5096	CLIP-seq
MIRT1006552	hsa-miR-552	CLIP-seq
MIRT1006553	hsa-miR-658	CLIP-seq
MIRT1006554	hsa-miR-767-5p	CLIP-seq
MIRT1006555	hsa-miR-769-5p	CLIP-seq
MIRT1006535	hsa-miR-3672	CLIP-seq
MIRT1006556	hsa-miR-4433	CLIP-seq
MIRT1006557	hsa-miR-4459	CLIP-seq
MIRT1006539	hsa-miR-4476	CLIP-seq
MIRT1006543	hsa-miR-4728-5p	CLIP-seq
MIRT1006547	hsa-miR-4786-5p	CLIP-seq
MIRT1006555	hsa-miR-769-5p	CLIP-seq
MIRT1998256	hsa-miR-3187-3p	CLIP-seq
MIRT1006533	hsa-miR-3192	CLIP-seq
MIRT1006534	hsa-miR-3545-3p	CLIP-seq
MIRT1998257	hsa-miR-4435	CLIP-seq
MIRT1006539	hsa-miR-4476	CLIP-seq
MIRT1006540	hsa-miR-4635	CLIP-seq
MIRT1006541	hsa-miR-4680-5p	CLIP-seq
MIRT1998258	hsa-miR-4701-5p	CLIP-seq
MIRT1998259	hsa-miR-4716-5p	CLIP-seq
MIRT1006543	hsa-miR-4728-5p	CLIP-seq
MIRT1006546	hsa-miR-4755-3p	CLIP-seq
MIRT1998260	hsa-miR-4781-3p	CLIP-seq
MIRT1006548	hsa-miR-485-5p	CLIP-seq
MIRT1006549	hsa-miR-490-3p	CLIP-seq
MIRT1998261	hsa-miR-548s	CLIP-seq
MIRT1998262	hsa-miR-588	CLIP-seq
MIRT1006553	hsa-miR-658	CLIP-seq
MIRT2231893	hsa-miR-122	CLIP-seq
MIRT2231894	hsa-miR-1281	CLIP-seq
MIRT2231895	hsa-miR-1289	CLIP-seq
MIRT2231896	hsa-miR-1297	CLIP-seq
MIRT2231897	hsa-miR-1343	CLIP-seq
MIRT2231898	hsa-miR-1912	CLIP-seq
MIRT2231899	hsa-miR-26a	CLIP-seq
MIRT2231900	hsa-miR-26b	CLIP-seq
MIRT1006532	hsa-miR-3152-5p	CLIP-seq
MIRT1006533	hsa-miR-3192	CLIP-seq
MIRT2231901	hsa-miR-3198	CLIP-seq
MIRT1006536	hsa-miR-3934	CLIP-seq
MIRT2231902	hsa-miR-3944-5p	CLIP-seq
MIRT2231903	hsa-miR-4294	CLIP-seq
MIRT2231904	hsa-miR-4309	CLIP-seq
MIRT2231905	hsa-miR-431	CLIP-seq
MIRT2231906	hsa-miR-4463	CLIP-seq
MIRT2231907	hsa-miR-4465	CLIP-seq
MIRT2231908	hsa-miR-4494	CLIP-seq
MIRT2231909	hsa-miR-4534	CLIP-seq
MIRT1006543	hsa-miR-4728-5p	CLIP-seq
MIRT1006545	hsa-miR-4740-3p	CLIP-seq
MIRT2231910	hsa-miR-4753-3p	CLIP-seq
MIRT1006546	hsa-miR-4755-3p	CLIP-seq
MIRT2231911	hsa-miR-4772-3p	CLIP-seq
MIRT1006548	hsa-miR-485-5p	CLIP-seq
MIRT1006549	hsa-miR-490-3p	CLIP-seq
MIRT2231912	hsa-miR-500a	CLIP-seq
MIRT1006550	hsa-miR-5095	CLIP-seq
MIRT1006551	hsa-miR-5096	CLIP-seq
MIRT1006552	hsa-miR-552	CLIP-seq
MIRT2231913	hsa-miR-592	CLIP-seq
MIRT2231914	hsa-miR-597	CLIP-seq
MIRT1006553	hsa-miR-658	CLIP-seq
MIRT1006554	hsa-miR-767-5p	CLIP-seq
MIRT2231915	hsa-miR-924	CLIP-seq
MIRT2231894	hsa-miR-1281	CLIP-seq
MIRT2231896	hsa-miR-1297	CLIP-seq
MIRT2231897	hsa-miR-1343	CLIP-seq
MIRT2231899	hsa-miR-26a	CLIP-seq
MIRT2231900	hsa-miR-26b	CLIP-seq
MIRT2449932	hsa-miR-3149	CLIP-seq
MIRT1006532	hsa-miR-3152-5p	CLIP-seq
MIRT2449933	hsa-miR-3619-3p	CLIP-seq
MIRT2449934	hsa-miR-3682-3p	CLIP-seq
MIRT2231907	hsa-miR-4465	CLIP-seq
MIRT1006539	hsa-miR-4476	CLIP-seq
MIRT1006543	hsa-miR-4728-5p	CLIP-seq
MIRT2449935	hsa-miR-4735-5p	CLIP-seq
MIRT1006545	hsa-miR-4740-3p	CLIP-seq
MIRT2231910	hsa-miR-4753-3p	CLIP-seq
MIRT2449936	hsa-miR-4775	CLIP-seq
MIRT2449937	hsa-miR-4794	CLIP-seq
MIRT2449938	hsa-miR-590-3p	CLIP-seq
MIRT2449939	hsa-miR-591	CLIP-seq
MIRT1006554	hsa-miR-767-5p	CLIP-seq
MIRT2231894	hsa-miR-1281	CLIP-seq
MIRT2535873	hsa-miR-1287	CLIP-seq
MIRT2231896	hsa-miR-1297	CLIP-seq
MIRT2231897	hsa-miR-1343	CLIP-seq
MIRT2231899	hsa-miR-26a	CLIP-seq
MIRT2231900	hsa-miR-26b	CLIP-seq
MIRT2449932	hsa-miR-3149	CLIP-seq
MIRT1006532	hsa-miR-3152-5p	CLIP-seq
MIRT1006533	hsa-miR-3192	CLIP-seq
MIRT2535874	hsa-miR-3607-5p	CLIP-seq
MIRT2535875	hsa-miR-3652	CLIP-seq
MIRT1006536	hsa-miR-3934	CLIP-seq
MIRT2535876	hsa-miR-4430	CLIP-seq
MIRT2231907	hsa-miR-4465	CLIP-seq
MIRT1006539	hsa-miR-4476	CLIP-seq
MIRT2535877	hsa-miR-4505	CLIP-seq
MIRT2535878	hsa-miR-4686	CLIP-seq
MIRT1006543	hsa-miR-4728-5p	CLIP-seq
MIRT2449935	hsa-miR-4735-5p	CLIP-seq
MIRT2231910	hsa-miR-4753-3p	CLIP-seq
MIRT2449936	hsa-miR-4775	CLIP-seq
MIRT2449937	hsa-miR-4794	CLIP-seq
MIRT1006548	hsa-miR-485-5p	CLIP-seq
MIRT1006549	hsa-miR-490-3p	CLIP-seq
MIRT1006550	hsa-miR-5095	CLIP-seq
MIRT1006552	hsa-miR-552	CLIP-seq
MIRT2449938	hsa-miR-590-3p	CLIP-seq
MIRT1006553	hsa-miR-658	CLIP-seq
MIRT1006554	hsa-miR-767-5p	CLIP-seq
MIRT2231894	hsa-miR-1281	CLIP-seq
MIRT2535873	hsa-miR-1287	CLIP-seq
MIRT2231896	hsa-miR-1297	CLIP-seq
MIRT2231897	hsa-miR-1343	CLIP-seq
MIRT2231899	hsa-miR-26a	CLIP-seq
MIRT2231900	hsa-miR-26b	CLIP-seq
MIRT2449932	hsa-miR-3149	CLIP-seq
MIRT1006532	hsa-miR-3152-5p	CLIP-seq
MIRT1006533	hsa-miR-3192	CLIP-seq
MIRT2535874	hsa-miR-3607-5p	CLIP-seq
MIRT2535875	hsa-miR-3652	CLIP-seq
MIRT1006536	hsa-miR-3934	CLIP-seq
MIRT2535876	hsa-miR-4430	CLIP-seq
MIRT2231907	hsa-miR-4465	CLIP-seq
MIRT1006539	hsa-miR-4476	CLIP-seq
MIRT2535877	hsa-miR-4505	CLIP-seq
MIRT2535878	hsa-miR-4686	CLIP-seq
MIRT1006543	hsa-miR-4728-5p	CLIP-seq
MIRT2449935	hsa-miR-4735-5p	CLIP-seq
MIRT1006545	hsa-miR-4740-3p	CLIP-seq
MIRT2231910	hsa-miR-4753-3p	CLIP-seq
MIRT2449936	hsa-miR-4775	CLIP-seq
MIRT2449937	hsa-miR-4794	CLIP-seq
MIRT1006548	hsa-miR-485-5p	CLIP-seq
MIRT1006549	hsa-miR-490-3p	CLIP-seq
MIRT1006550	hsa-miR-5095	CLIP-seq
MIRT1006552	hsa-miR-552	CLIP-seq
MIRT2449938	hsa-miR-590-3p	CLIP-seq
MIRT1006553	hsa-miR-658	CLIP-seq
MIRT1006554	hsa-miR-767-5p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
CDX2	Activation	22547830

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001936	Process	Regulation of endothelial cell proliferation	ISS
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005794	Component	Golgi apparatus	TAS	11698403
GO:0005975	Process	Carbohydrate metabolic process	TAS	7876235
GO:0006486	Process	Protein glycosylation	IBA	21873635
GO:0006486	Process	Protein glycosylation	IEA
GO:0006486	Process	Protein glycosylation	TAS	11698403
GO:0006664	Process	Glycolipid metabolic process	ISS
GO:0008107	Function	Galactoside 2-alpha-L-fucosyltransferase activity	IBA	21873635
GO:0008107	Function	Galactoside 2-alpha-L-fucosyltransferase activity	TAS	11698403
GO:0008417	Function	Fucosyltransferase activity	TAS	7876235
GO:0016021	Component	Integral component of membrane	IEA
GO:0030155	Process	Regulation of cell adhesion	ISS
GO:0031127	Function	Alpha-(1,2)-fucosyltransferase activity	ISS
GO:0032580	Component	Golgi cisterna membrane	IEA
GO:0036065	Process	Fucosylation	IBA	21873635
GO:0036065	Process	Fucosylation	ISS
GO:0042355	Process	L-fucose catabolic process	NAS	11698403
GO:0070062	Component	Extracellular exosome	HDA	19199708

Other IDs

• MIM: 182100
• HGNC: 4013
• e!Ensembl: ENSG00000176920

Protein

• UniProt ID: Q10981
• Protein name: Galactoside alpha-(1,2)-fucosyltransferase 2 (Alpha(1,2)FT 2) (Fucosyltransferase 2) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2) (SE2) (Secretor blood group alpha-2-fucosyltransferase) (Secretor factor) (Se) (Type 1 galactoside alpha-
• Protein function: Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose on both O- and N-linked glycans chains of cell surface glycoproteins and glycolipids and the resulting epitope regulates several processes
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01531	Glyco_transf_11	21 → 334	Glycosyl transferase family 11	Family

• Sequence:

  MLVVQMPFSFPMAHFILFVFTVSTIFHVQQRLAKIQAMWELPVQIPVLASTSKALGPSQL
  RGMWTINAIGRLGNQMGEYATLYALAKMNGRPAFIPAQMHSTLAPIFRITLPVLHSATAS
  RIPWQNYHLNDWMEEEYRHIPGEYVRFTGYPCSWTFYHHLRQEILQEFTLHDHVREEAQK
  FLRGLQVNGSRPGTFVGVHVRRGDYVHVMPKVWKGVVADRRYLQQALDWFRARYSSLIFV
  VTSNGMAWCRENIDTSHGDVVFAGDGIEGSPAKDFALLTQCNHTIMTIGTFGIWAAYLTG
  GDTIYLANYTLPDSPFLKIFKPEAAFLPEWTGIAADLSPLLKH

• Sequence length: 343