GeDiPNet: Comprehensive Gene Data - OMIM, HGNC, Ensembl, UniProt, GO, Transcription Factors & miRNA

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FER (FER tyrosine kinase)

Gene

2241

FER tyrosine kinase

FER

PPP1R74, TYK3, p94-Fer

5q21.3

The protein encoded by this gene is a member of the FPS/FES family of non-transmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. Alternative sp

Show/Hide all(131)

miRTarBase ID	miRNA	Experiments	Reference
MIRT051027	hsa-miR-17-5p	CLASH	23622248
MIRT050063	hsa-miR-26a-5p	CLASH	23622248
MIRT038279	hsa-miR-26a-2-3p	CLASH	23622248
MIRT626663	hsa-miR-582-3p	HITS-CLIP	23824327
MIRT626662	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT626661	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT626660	hsa-miR-4469	HITS-CLIP	23824327
MIRT626659	hsa-miR-4326	HITS-CLIP	23824327
MIRT626658	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT626657	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT626656	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT626655	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT626654	hsa-miR-33a-5p	HITS-CLIP	23824327
MIRT626653	hsa-miR-33b-5p	HITS-CLIP	23824327
MIRT626652	hsa-miR-218-1-3p	HITS-CLIP	23824327
MIRT626651	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT626650	hsa-miR-507	HITS-CLIP	23824327
MIRT626649	hsa-miR-557	HITS-CLIP	23824327
MIRT626648	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT626663	hsa-miR-582-3p	HITS-CLIP	23824327
MIRT648989	hsa-miR-4686	HITS-CLIP	23824327
MIRT626662	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT626661	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT626660	hsa-miR-4469	HITS-CLIP	23824327
MIRT648988	hsa-miR-93-3p	HITS-CLIP	23824327
MIRT648987	hsa-miR-3692-5p	HITS-CLIP	23824327
MIRT648986	hsa-miR-6882-3p	HITS-CLIP	23824327
MIRT626659	hsa-miR-4326	HITS-CLIP	23824327
MIRT626658	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT626657	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT626656	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT626655	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT648985	hsa-miR-6071	HITS-CLIP	23824327
MIRT626654	hsa-miR-33a-5p	HITS-CLIP	23824327
MIRT626653	hsa-miR-33b-5p	HITS-CLIP	23824327
MIRT626652	hsa-miR-218-1-3p	HITS-CLIP	23824327
MIRT626651	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT626650	hsa-miR-507	HITS-CLIP	23824327
MIRT626649	hsa-miR-557	HITS-CLIP	23824327
MIRT626648	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT626663	hsa-miR-582-3p	HITS-CLIP	23824327
MIRT626662	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT626661	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT626660	hsa-miR-4469	HITS-CLIP	23824327
MIRT626659	hsa-miR-4326	HITS-CLIP	23824327
MIRT626658	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT626657	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT626656	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT626655	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT626654	hsa-miR-33a-5p	HITS-CLIP	23824327
MIRT626653	hsa-miR-33b-5p	HITS-CLIP	23824327
MIRT626652	hsa-miR-218-1-3p	HITS-CLIP	23824327
MIRT626651	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT626650	hsa-miR-507	HITS-CLIP	23824327
MIRT626649	hsa-miR-557	HITS-CLIP	23824327
MIRT626648	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT447435	hsa-miR-1277-5p	PAR-CLIP	22100165
MIRT447434	hsa-miR-5011-5p	PAR-CLIP	22100165
MIRT447433	hsa-miR-4635	PAR-CLIP	22100165
MIRT447432	hsa-miR-190a-3p	PAR-CLIP	22100165
MIRT447431	hsa-miR-5585-3p	PAR-CLIP	22100165
MIRT447436	hsa-miR-6507-5p	PAR-CLIP	22100165
MIRT447435	hsa-miR-1277-5p	PAR-CLIP	22100165
MIRT447434	hsa-miR-5011-5p	PAR-CLIP	22100165
MIRT447433	hsa-miR-4635	PAR-CLIP	22100165
MIRT447432	hsa-miR-190a-3p	PAR-CLIP	22100165
MIRT447431	hsa-miR-5585-3p	PAR-CLIP	22100165
MIRT626663	hsa-miR-582-3p	HITS-CLIP	23824327
MIRT626662	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT626661	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT626660	hsa-miR-4469	HITS-CLIP	23824327
MIRT626659	hsa-miR-4326	HITS-CLIP	23824327
MIRT626658	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT626657	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT626656	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT626655	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT626654	hsa-miR-33a-5p	HITS-CLIP	23824327
MIRT626653	hsa-miR-33b-5p	HITS-CLIP	23824327
MIRT626652	hsa-miR-218-1-3p	HITS-CLIP	23824327
MIRT626651	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT626650	hsa-miR-507	HITS-CLIP	23824327
MIRT626649	hsa-miR-557	HITS-CLIP	23824327
MIRT626648	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT626663	hsa-miR-582-3p	HITS-CLIP	23824327
MIRT648989	hsa-miR-4686	HITS-CLIP	23824327
MIRT626662	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT626661	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT626660	hsa-miR-4469	HITS-CLIP	23824327
MIRT648988	hsa-miR-93-3p	HITS-CLIP	23824327
MIRT648987	hsa-miR-3692-5p	HITS-CLIP	23824327
MIRT648986	hsa-miR-6882-3p	HITS-CLIP	23824327
MIRT626659	hsa-miR-4326	HITS-CLIP	23824327
MIRT626658	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT626657	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT626656	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT626655	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT648985	hsa-miR-6071	HITS-CLIP	23824327
MIRT626654	hsa-miR-33a-5p	HITS-CLIP	23824327
MIRT626653	hsa-miR-33b-5p	HITS-CLIP	23824327
MIRT626652	hsa-miR-218-1-3p	HITS-CLIP	23824327
MIRT626651	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT626650	hsa-miR-507	HITS-CLIP	23824327
MIRT626649	hsa-miR-557	HITS-CLIP	23824327
MIRT626648	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT626663	hsa-miR-582-3p	HITS-CLIP	23824327
MIRT626662	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT626661	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT626660	hsa-miR-4469	HITS-CLIP	23824327
MIRT626659	hsa-miR-4326	HITS-CLIP	23824327
MIRT626658	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT626657	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT626656	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT626655	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT626654	hsa-miR-33a-5p	HITS-CLIP	23824327
MIRT626653	hsa-miR-33b-5p	HITS-CLIP	23824327
MIRT626652	hsa-miR-218-1-3p	HITS-CLIP	23824327
MIRT626651	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT626650	hsa-miR-507	HITS-CLIP	23824327
MIRT626649	hsa-miR-557	HITS-CLIP	23824327
MIRT626648	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT447435	hsa-miR-1277-5p	PAR-CLIP	22100165
MIRT447434	hsa-miR-5011-5p	PAR-CLIP	22100165
MIRT447433	hsa-miR-4635	PAR-CLIP	22100165
MIRT447432	hsa-miR-190a-3p	PAR-CLIP	22100165
MIRT447431	hsa-miR-5585-3p	PAR-CLIP	22100165
MIRT447436	hsa-miR-6507-5p	PAR-CLIP	22100165
MIRT447435	hsa-miR-1277-5p	PAR-CLIP	22100165
MIRT447434	hsa-miR-5011-5p	PAR-CLIP	22100165
MIRT447433	hsa-miR-4635	PAR-CLIP	22100165
MIRT447432	hsa-miR-190a-3p	PAR-CLIP	22100165
MIRT447431	hsa-miR-5585-3p	PAR-CLIP	22100165

Show/Hide all(63)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000226	Process	Microtubule cytoskeleton organization	IMP	12972546
GO:0000785	Component	Chromatin	IDA	1990274
GO:0001932	Process	Regulation of protein phosphorylation	ISS
GO:0004713	Function	Protein tyrosine kinase activity	IBA	21873635
GO:0004713	Function	Protein tyrosine kinase activity	TAS	2725517
GO:0004715	Function	Non-membrane spanning protein tyrosine kinase activity	IBA	21873635
GO:0004715	Function	Non-membrane spanning protein tyrosine kinase activity	IDA	12972546, 19738202
GO:0005102	Function	Signaling receptor binding	IBA	21873635
GO:0005154	Function	Epidermal growth factor receptor binding	IDA	21518868
GO:0005515	Function	Protein binding	IPI	15226396, 25036637
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IDA	19147545
GO:0005737	Component	Cytoplasm	IDA	1990274
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005938	Component	Cell cortex	IEA
GO:0006468	Process	Protein phosphorylation	TAS	2725517
GO:0006935	Process	Chemotaxis	IBA	21873635
GO:0007155	Process	Cell adhesion	IBA	21873635
GO:0007169	Process	Transmembrane receptor protein tyrosine kinase signaling pathway	IBA	21873635
GO:0007260	Process	Tyrosine phosphorylation of STAT protein	IDA	19147545
GO:0008157	Function	Protein phosphatase 1 binding	IEA
GO:0008283	Process	Cell population proliferation	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IMP	25540073
GO:0008284	Process	Positive regulation of cell population proliferation	TAS	20111072
GO:0008289	Function	Lipid binding	IDA	19738202
GO:0010591	Process	Regulation of lamellipodium assembly	IDA	19738202
GO:0010762	Process	Regulation of fibroblast migration	IEA
GO:0015629	Component	Actin cytoskeleton	IDA	19738202
GO:0015630	Component	Microtubule cytoskeleton	IDA	12972546
GO:0018108	Process	Peptidyl-tyrosine phosphorylation	IDA	12972546, 19738202
GO:0019221	Process	Cytokine-mediated signaling pathway	IMP	9722593
GO:0030027	Component	Lamellipodium	IDA	19738202
GO:0030054	Component	Cell junction	IDA	12972546
GO:0030154	Process	Cell differentiation	IBA	21873635
GO:0030335	Process	Positive regulation of cell migration	IMP	19738202
GO:0030838	Process	Positive regulation of actin filament polymerization	IMP	19738202
GO:0031234	Component	Extrinsic component of cytoplasmic side of plasma membrane	IBA	21873635
GO:0031234	Component	Extrinsic component of cytoplasmic side of plasma membrane	IDA	19738202
GO:0031532	Process	Actin cytoskeleton reorganization	ISS
GO:0032496	Process	Response to lipopolysaccharide	ISS
GO:0032869	Process	Cellular response to insulin stimulus	ISS
GO:0033007	Process	Negative regulation of mast cell activation involved in immune response	ISS
GO:0034446	Process	Substrate adhesion-dependent cell spreading	ISS
GO:0034614	Process	Cellular response to reactive oxygen species	ISS
GO:0035426	Process	Extracellular matrix-cell signaling	ISS
GO:0035556	Process	Intracellular signal transduction	TAS	2209086
GO:0036006	Process	Cellular response to macrophage colony-stimulating factor stimulus	IMP	9722593
GO:0036119	Process	Response to platelet-derived growth factor	ISS
GO:0038028	Process	Insulin receptor signaling pathway via phosphatidylinositol 3-kinase	ISS
GO:0038095	Process	Fc-epsilon receptor signaling pathway	IBA	21873635
GO:0038095	Process	Fc-epsilon receptor signaling pathway	ISS
GO:0038109	Process	Kit signaling pathway	ISS
GO:0042058	Process	Regulation of epidermal growth factor receptor signaling pathway	IMP	21518868
GO:0043304	Process	Regulation of mast cell degranulation	IBA	21873635
GO:0044331	Process	Cell-cell adhesion mediated by cadherin	ISS
GO:0045087	Process	Innate immune response	IBA	21873635
GO:0046777	Process	Protein autophosphorylation	IDA	7623846
GO:0048008	Process	Platelet-derived growth factor receptor signaling pathway	ISS
GO:0048008	Process	Platelet-derived growth factor receptor signaling pathway	TAS	11994747
GO:0050904	Process	Diapedesis	ISS
GO:0051092	Process	Positive regulation of NF-kappaB transcription factor activity	IMP	21518868
GO:0070102	Process	Interleukin-6-mediated signaling pathway	IMP	19147545

MIM	HGNC	e!Ensembl
176942	3655	ENSG00000151422

Protein

UniProt ID

P16591

Protein name

Tyrosine-protein kinase Fer (EC 2.7.10.2) (Feline encephalitis virus-related kinase FER) (Fujinami poultry sarcoma/Feline sarcoma-related protein Fer) (Proto-oncogene c-Fer) (Tyrosine kinase 3) (p94-Fer)

Protein function

Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. A

PDB

2KK6 , 6KC4

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00611	FCH	10 → 87	Fes/CIP4, and EFC/F-BAR homology domain	Family
PF00017	SH2	460 → 531	SH2 domain	Domain
PF07714	PK_Tyr_Ser-Thr	563 → 814	Protein tyrosine and serine/threonine kinase	Domain

Sequence

MGFGSDLKNSHEAVLKLQDWELRLLETVKKFMALRIKSDKEYASTLQNLCNQVDKESTVQ
MNYVSNVSKSWLLMIQQTEQLSRIMKTHAEDLNSGPLHRLTMMIKDKQQVKKSYIGVHQQ
IEAEMIKVTKTELEKLKCSYRQLIKEMNSAKEKYKEALAKGKETEKAKERYDKATMKLHM
LHNQYVLALKGAQLHQNQYYDITLPLLLDSLQKMQEEMIKALKGIFDEYSQITSLVTEEI
VNVHKEIQMSVEQIDPSTEYNNFIDVHRTTAAKEQEIEFDTSLLEENENLQANEIMWNNL
TAESLQVMLKTLAEELMQTQQMLLNKEEAVLELEKRIEESSETCEKKSDIVLLLSQKQAL
EELKQSVQQLRCTEAKFSAQKELLEQKVQENDGKEPPPVVNYEEDARSVTSMERKERLSK
FESIRHSIAGIIRSPKSALGSSALSDMISISEKPLAEQDWYHGAIPRIEAQELLKKQGDF
LVRESHGKPGEYVLSVYSDGQRRHFIIQYVDNMYRFEGTGFSNIPQLIDHHYTTKQVITK
KSGVVLLNPIPKDKKWILSHEDVILGELLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQE
LKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQ
LVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLK
QIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMS
APQHCPEDISKIMMKCWDYKPENRPKFSELQKELTIIKRKLT

Sequence length

822

Interactions

View interactions

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