FASN (fatty acid synthase)

Gene

• Entrez ID: 2194
• Gene name: Fatty acid synthase
• Gene symbol: FASN
• Synonyms: FAS, OA-519, SDR27X1
• Chromosome: 17
• Chromosome location: 17q25.3
• Summary: The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this pro

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs145515446	G>A	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, missense variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT051341	hsa-miR-15a-5p	CLASH	23622248
MIRT050921	hsa-miR-17-5p	CLASH	23622248
MIRT050182	hsa-miR-26a-5p	CLASH	23622248
MIRT049363	hsa-miR-92a-3p	CLASH	23622248
MIRT048815	hsa-miR-93-5p	CLASH	23622248
MIRT048070	hsa-miR-197-3p	CLASH	23622248
MIRT047715	hsa-miR-10a-5p	CLASH	23622248
MIRT047454	hsa-miR-10b-5p	CLASH	23622248
MIRT046667	hsa-miR-222-3p	CLASH	23622248
MIRT046177	hsa-miR-27b-3p	CLASH	23622248
MIRT046177	hsa-miR-27b-3p	CLASH	23622248
MIRT044920	hsa-miR-186-5p	CLASH	23622248
MIRT044920	hsa-miR-186-5p	CLASH	23622248
MIRT043627	hsa-miR-326	CLASH	23622248
MIRT043627	hsa-miR-326	CLASH	23622248
MIRT043370	hsa-miR-331-3p	CLASH	23622248
MIRT042890	hsa-miR-324-3p	CLASH	23622248
MIRT042639	hsa-miR-423-3p	CLASH	23622248
MIRT041844	hsa-miR-484	CLASH	23622248
MIRT041844	hsa-miR-484	CLASH	23622248
MIRT041844	hsa-miR-484	CLASH	23622248
MIRT041844	hsa-miR-484	CLASH	23622248
MIRT041844	hsa-miR-484	CLASH	23622248
MIRT041353	hsa-miR-193b-3p	CLASH	23622248
MIRT041353	hsa-miR-193b-3p	CLASH	23622248
MIRT040657	hsa-miR-92b-3p	CLASH	23622248
MIRT039824	hsa-miR-615-3p	CLASH	23622248
MIRT039824	hsa-miR-615-3p	CLASH	23622248
MIRT039824	hsa-miR-615-3p	CLASH	23622248
MIRT039824	hsa-miR-615-3p	CLASH	23622248
MIRT038318	hsa-miR-130b-5p	CLASH	23622248
MIRT037647	hsa-miR-744-5p	CLASH	23622248
MIRT037647	hsa-miR-744-5p	CLASH	23622248
MIRT036832	hsa-miR-877-3p	CLASH	23622248
MIRT036557	hsa-miR-942-5p	CLASH	23622248
MIRT035891	hsa-miR-1303	CLASH	23622248
MIRT035847	hsa-miR-1268a	CLASH	23622248
MIRT035759	hsa-miR-2110	CLASH	23622248
MIRT053106	hsa-miR-424-5p	Luciferase reporter assay, Western blot	23599729
MIRT053228	hsa-miR-195-5p	Luciferase reporter assay, qRT-PCR, Western blot	23162665
MIRT054707	hsa-miR-1-3p	qRT-PCR, Western blot	24310399
MIRT658284	hsa-miR-6771-3p	HITS-CLIP	23824327
MIRT658283	hsa-miR-1264	HITS-CLIP	23824327
MIRT658282	hsa-miR-6861-5p	HITS-CLIP	23824327
MIRT658281	hsa-miR-6776-5p	HITS-CLIP	23824327
MIRT658280	hsa-miR-3182	HITS-CLIP	23824327
MIRT658279	hsa-miR-6740-3p	HITS-CLIP	23824327
MIRT658278	hsa-miR-4314	HITS-CLIP	23824327
MIRT658277	hsa-miR-4774-3p	HITS-CLIP	23824327
MIRT548285	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT548284	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT548283	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT548282	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT053106	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT051341	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT053228	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT548281	hsa-miR-4668-3p	PAR-CLIP	20371350
MIRT548280	hsa-miR-15b-3p	PAR-CLIP	20371350
MIRT548285	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT548284	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT548283	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT548282	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT053106	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT051341	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT053228	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT548281	hsa-miR-4668-3p	PAR-CLIP	20371350
MIRT548280	hsa-miR-15b-3p	PAR-CLIP	20371350
MIRT548285	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT548284	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT548283	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT548282	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT053106	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT051341	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT053228	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT548281	hsa-miR-4668-3p	PAR-CLIP	21572407
MIRT548280	hsa-miR-15b-3p	PAR-CLIP	21572407
MIRT756169	hsa-miR-532-5p	qRT-PCR, Western blot	25983556
MIRT047715	hsa-miR-10a-5p	Luciferase reporter assay, Western blotting, qRT-PCR	33128541
MIRT735807	hsa-miR-27a-3p	Luciferase reporter assay, Western blotting, qRT-PCR	32975270
MIRT658284	hsa-miR-6771-3p	HITS-CLIP	23824327
MIRT658283	hsa-miR-1264	HITS-CLIP	23824327
MIRT658282	hsa-miR-6861-5p	HITS-CLIP	23824327
MIRT658281	hsa-miR-6776-5p	HITS-CLIP	23824327
MIRT658280	hsa-miR-3182	HITS-CLIP	23824327
MIRT658279	hsa-miR-6740-3p	HITS-CLIP	23824327
MIRT658278	hsa-miR-4314	HITS-CLIP	23824327
MIRT658277	hsa-miR-4774-3p	HITS-CLIP	23824327
MIRT548285	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT548284	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT548283	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT548282	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT053106	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT051341	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT053228	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT548281	hsa-miR-4668-3p	PAR-CLIP	20371350
MIRT548280	hsa-miR-15b-3p	PAR-CLIP	20371350
MIRT548285	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT548284	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT548283	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT548282	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT053106	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT051341	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT053228	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT548281	hsa-miR-4668-3p	PAR-CLIP	20371350
MIRT548280	hsa-miR-15b-3p	PAR-CLIP	20371350
MIRT548285	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT548284	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT548283	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT548282	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT053106	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT051341	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT053228	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT548281	hsa-miR-4668-3p	PAR-CLIP	21572407
MIRT548280	hsa-miR-15b-3p	PAR-CLIP	21572407
MIRT756169	hsa-miR-532-5p	Luciferase reporter assay, Immunoprecipitaion (IP)	35499057
MIRT548285	hsa-miR-497-5p	Luciferase reporter assay, Western blotting, qRT-PCR	34789312
MIRT548285	hsa-miR-497-5p	Luciferase reporter assay, Western blotting, qRT-PCR	34789312
MIRT989500	hsa-miR-101	CLIP-seq
MIRT989501	hsa-miR-103a	CLIP-seq
MIRT989502	hsa-miR-107	CLIP-seq
MIRT989503	hsa-miR-1207-5p	CLIP-seq
MIRT989504	hsa-miR-1224-3p	CLIP-seq
MIRT989505	hsa-miR-1260	CLIP-seq
MIRT989506	hsa-miR-1260b	CLIP-seq
MIRT989507	hsa-miR-1270	CLIP-seq
MIRT989508	hsa-miR-1280	CLIP-seq
MIRT989509	hsa-miR-1286	CLIP-seq
MIRT989510	hsa-miR-1293	CLIP-seq
MIRT989511	hsa-miR-1302	CLIP-seq
MIRT989512	hsa-miR-144	CLIP-seq
MIRT989513	hsa-miR-147b	CLIP-seq
MIRT989514	hsa-miR-1539	CLIP-seq
MIRT989515	hsa-miR-15a	CLIP-seq
MIRT989516	hsa-miR-15b	CLIP-seq
MIRT989517	hsa-miR-16	CLIP-seq
MIRT989518	hsa-miR-195	CLIP-seq
MIRT989519	hsa-miR-198	CLIP-seq
MIRT989520	hsa-miR-2278	CLIP-seq
MIRT989521	hsa-miR-3065-3p	CLIP-seq
MIRT989522	hsa-miR-3074-5p	CLIP-seq
MIRT989523	hsa-miR-3136-3p	CLIP-seq
MIRT989524	hsa-miR-3138	CLIP-seq
MIRT989525	hsa-miR-3150b-3p	CLIP-seq
MIRT989526	hsa-miR-3177-5p	CLIP-seq
MIRT989527	hsa-miR-3193	CLIP-seq
MIRT989528	hsa-miR-3195	CLIP-seq
MIRT989529	hsa-miR-34a	CLIP-seq
MIRT989530	hsa-miR-34c-5p	CLIP-seq
MIRT989531	hsa-miR-3591-3p	CLIP-seq
MIRT989532	hsa-miR-3656	CLIP-seq
MIRT989533	hsa-miR-3657	CLIP-seq
MIRT989534	hsa-miR-3660	CLIP-seq
MIRT989535	hsa-miR-3687	CLIP-seq
MIRT989536	hsa-miR-3689a-3p	CLIP-seq
MIRT989537	hsa-miR-3689c	CLIP-seq
MIRT989538	hsa-miR-3908	CLIP-seq
MIRT989539	hsa-miR-3929	CLIP-seq
MIRT989540	hsa-miR-3945	CLIP-seq
MIRT989541	hsa-miR-3960	CLIP-seq
MIRT989542	hsa-miR-424	CLIP-seq
MIRT989543	hsa-miR-4265	CLIP-seq
MIRT989544	hsa-miR-4286	CLIP-seq
MIRT989545	hsa-miR-4294	CLIP-seq
MIRT989546	hsa-miR-4296	CLIP-seq
MIRT989547	hsa-miR-4298	CLIP-seq
MIRT989548	hsa-miR-4299	CLIP-seq
MIRT989549	hsa-miR-4310	CLIP-seq
MIRT989550	hsa-miR-4322	CLIP-seq
MIRT989551	hsa-miR-4419b	CLIP-seq
MIRT989552	hsa-miR-4436b-3p	CLIP-seq
MIRT989553	hsa-miR-4442	CLIP-seq
MIRT989554	hsa-miR-4455	CLIP-seq
MIRT989555	hsa-miR-4456	CLIP-seq
MIRT989556	hsa-miR-4467	CLIP-seq
MIRT989557	hsa-miR-4478	CLIP-seq
MIRT989558	hsa-miR-4483	CLIP-seq
MIRT989559	hsa-miR-4488	CLIP-seq
MIRT989560	hsa-miR-449a	CLIP-seq
MIRT989561	hsa-miR-449b	CLIP-seq
MIRT989562	hsa-miR-4520a-3p	CLIP-seq
MIRT989563	hsa-miR-4524	CLIP-seq
MIRT989564	hsa-miR-4526	CLIP-seq
MIRT989565	hsa-miR-4635	CLIP-seq
MIRT989566	hsa-miR-4645-3p	CLIP-seq
MIRT989567	hsa-miR-4648	CLIP-seq
MIRT989568	hsa-miR-4650-5p	CLIP-seq
MIRT989569	hsa-miR-4653-3p	CLIP-seq
MIRT989570	hsa-miR-4654	CLIP-seq
MIRT989571	hsa-miR-4660	CLIP-seq
MIRT989572	hsa-miR-4683	CLIP-seq
MIRT989573	hsa-miR-4684-5p	CLIP-seq
MIRT989574	hsa-miR-4687-3p	CLIP-seq
MIRT989575	hsa-miR-4689	CLIP-seq
MIRT989576	hsa-miR-4690-3p	CLIP-seq
MIRT989577	hsa-miR-4697-5p	CLIP-seq
MIRT989578	hsa-miR-4698	CLIP-seq
MIRT989579	hsa-miR-4706	CLIP-seq
MIRT989580	hsa-miR-4717-3p	CLIP-seq
MIRT989581	hsa-miR-4728-5p	CLIP-seq
MIRT989582	hsa-miR-4734	CLIP-seq
MIRT989583	hsa-miR-4736	CLIP-seq
MIRT989584	hsa-miR-4743	CLIP-seq
MIRT989585	hsa-miR-4749-5p	CLIP-seq
MIRT989586	hsa-miR-4763-3p	CLIP-seq
MIRT989587	hsa-miR-4767	CLIP-seq
MIRT989588	hsa-miR-4769-5p	CLIP-seq
MIRT989589	hsa-miR-4784	CLIP-seq
MIRT989590	hsa-miR-4787-5p	CLIP-seq
MIRT989591	hsa-miR-4802-3p	CLIP-seq
MIRT989592	hsa-miR-485-5p	CLIP-seq
MIRT989593	hsa-miR-495	CLIP-seq
MIRT989594	hsa-miR-497	CLIP-seq
MIRT989595	hsa-miR-503	CLIP-seq
MIRT989596	hsa-miR-512-5p	CLIP-seq
MIRT989597	hsa-miR-513a-3p	CLIP-seq
MIRT989598	hsa-miR-526b	CLIP-seq
MIRT989599	hsa-miR-544b	CLIP-seq
MIRT989600	hsa-miR-548q	CLIP-seq
MIRT989601	hsa-miR-564	CLIP-seq
MIRT989602	hsa-miR-571	CLIP-seq
MIRT989603	hsa-miR-578	CLIP-seq
MIRT989604	hsa-miR-582-5p	CLIP-seq
MIRT989605	hsa-miR-607	CLIP-seq
MIRT989606	hsa-miR-609	CLIP-seq
MIRT989607	hsa-miR-615-5p	CLIP-seq
MIRT989608	hsa-miR-620	CLIP-seq
MIRT989609	hsa-miR-634	CLIP-seq
MIRT989610	hsa-miR-637	CLIP-seq
MIRT989611	hsa-miR-646	CLIP-seq
MIRT989612	hsa-miR-661	CLIP-seq
MIRT989613	hsa-miR-711	CLIP-seq
MIRT989614	hsa-miR-744	CLIP-seq
MIRT989615	hsa-miR-759	CLIP-seq
MIRT989616	hsa-miR-924	CLIP-seq
MIRT989617	hsa-miR-935	CLIP-seq
MIRT989500	hsa-miR-101	CLIP-seq
MIRT989501	hsa-miR-103a	CLIP-seq
MIRT989502	hsa-miR-107	CLIP-seq
MIRT989503	hsa-miR-1207-5p	CLIP-seq
MIRT989504	hsa-miR-1224-3p	CLIP-seq
MIRT989505	hsa-miR-1260	CLIP-seq
MIRT989506	hsa-miR-1260b	CLIP-seq
MIRT1993284	hsa-miR-1262	CLIP-seq
MIRT989507	hsa-miR-1270	CLIP-seq
MIRT989508	hsa-miR-1280	CLIP-seq
MIRT989509	hsa-miR-1286	CLIP-seq
MIRT1993285	hsa-miR-1291	CLIP-seq
MIRT989510	hsa-miR-1293	CLIP-seq
MIRT989511	hsa-miR-1302	CLIP-seq
MIRT989512	hsa-miR-144	CLIP-seq
MIRT1993286	hsa-miR-146b-3p	CLIP-seq
MIRT989515	hsa-miR-15a	CLIP-seq
MIRT989516	hsa-miR-15b	CLIP-seq
MIRT989517	hsa-miR-16	CLIP-seq
MIRT1993287	hsa-miR-1908	CLIP-seq
MIRT1993288	hsa-miR-1909	CLIP-seq
MIRT1993289	hsa-miR-1914	CLIP-seq
MIRT989518	hsa-miR-195	CLIP-seq
MIRT989519	hsa-miR-198	CLIP-seq
MIRT1993290	hsa-miR-214	CLIP-seq
MIRT989520	hsa-miR-2278	CLIP-seq
MIRT1993291	hsa-miR-27a	CLIP-seq
MIRT1993292	hsa-miR-27b	CLIP-seq
MIRT989524	hsa-miR-3138	CLIP-seq
MIRT989525	hsa-miR-3150b-3p	CLIP-seq
MIRT989526	hsa-miR-3177-5p	CLIP-seq
MIRT1993293	hsa-miR-342-5p	CLIP-seq
MIRT989529	hsa-miR-34a	CLIP-seq
MIRT989530	hsa-miR-34c-5p	CLIP-seq
MIRT989531	hsa-miR-3591-3p	CLIP-seq
MIRT1993294	hsa-miR-3619-5p	CLIP-seq
MIRT1993295	hsa-miR-3646	CLIP-seq
MIRT989532	hsa-miR-3656	CLIP-seq
MIRT989533	hsa-miR-3657	CLIP-seq
MIRT989534	hsa-miR-3660	CLIP-seq
MIRT1993296	hsa-miR-3662	CLIP-seq
MIRT989535	hsa-miR-3687	CLIP-seq
MIRT989536	hsa-miR-3689a-3p	CLIP-seq
MIRT989537	hsa-miR-3689c	CLIP-seq
MIRT1993297	hsa-miR-3691-3p	CLIP-seq
MIRT989538	hsa-miR-3908	CLIP-seq
MIRT989539	hsa-miR-3929	CLIP-seq
MIRT1993298	hsa-miR-3944-5p	CLIP-seq
MIRT989541	hsa-miR-3960	CLIP-seq
MIRT1993299	hsa-miR-412	CLIP-seq
MIRT989542	hsa-miR-424	CLIP-seq
MIRT989543	hsa-miR-4265	CLIP-seq
MIRT989545	hsa-miR-4294	CLIP-seq
MIRT989546	hsa-miR-4296	CLIP-seq
MIRT989547	hsa-miR-4298	CLIP-seq
MIRT989548	hsa-miR-4299	CLIP-seq
MIRT989549	hsa-miR-4310	CLIP-seq
MIRT989550	hsa-miR-4322	CLIP-seq
MIRT989551	hsa-miR-4419b	CLIP-seq
MIRT1993300	hsa-miR-4433	CLIP-seq
MIRT989553	hsa-miR-4442	CLIP-seq
MIRT989554	hsa-miR-4455	CLIP-seq
MIRT989555	hsa-miR-4456	CLIP-seq
MIRT989556	hsa-miR-4467	CLIP-seq
MIRT989557	hsa-miR-4478	CLIP-seq
MIRT989558	hsa-miR-4483	CLIP-seq
MIRT989559	hsa-miR-4488	CLIP-seq
MIRT989560	hsa-miR-449a	CLIP-seq
MIRT989561	hsa-miR-449b	CLIP-seq
MIRT989562	hsa-miR-4520a-3p	CLIP-seq
MIRT989563	hsa-miR-4524	CLIP-seq
MIRT989564	hsa-miR-4526	CLIP-seq
MIRT1993301	hsa-miR-4530	CLIP-seq
MIRT989565	hsa-miR-4635	CLIP-seq
MIRT989566	hsa-miR-4645-3p	CLIP-seq
MIRT989567	hsa-miR-4648	CLIP-seq
MIRT989568	hsa-miR-4650-5p	CLIP-seq
MIRT1993302	hsa-miR-4651	CLIP-seq
MIRT989570	hsa-miR-4654	CLIP-seq
MIRT989571	hsa-miR-4660	CLIP-seq
MIRT1993303	hsa-miR-4664-5p	CLIP-seq
MIRT989572	hsa-miR-4683	CLIP-seq
MIRT989573	hsa-miR-4684-5p	CLIP-seq
MIRT989575	hsa-miR-4689	CLIP-seq
MIRT1993304	hsa-miR-4690-5p	CLIP-seq
MIRT989577	hsa-miR-4697-5p	CLIP-seq
MIRT989578	hsa-miR-4698	CLIP-seq
MIRT1993305	hsa-miR-4701-3p	CLIP-seq
MIRT1993306	hsa-miR-4707-3p	CLIP-seq
MIRT989580	hsa-miR-4717-3p	CLIP-seq
MIRT989581	hsa-miR-4728-5p	CLIP-seq
MIRT989583	hsa-miR-4736	CLIP-seq
MIRT989584	hsa-miR-4743	CLIP-seq
MIRT989586	hsa-miR-4763-3p	CLIP-seq
MIRT989588	hsa-miR-4769-5p	CLIP-seq
MIRT989589	hsa-miR-4784	CLIP-seq
MIRT989590	hsa-miR-4787-5p	CLIP-seq
MIRT989592	hsa-miR-485-5p	CLIP-seq
MIRT989593	hsa-miR-495	CLIP-seq
MIRT989594	hsa-miR-497	CLIP-seq
MIRT989595	hsa-miR-503	CLIP-seq
MIRT989597	hsa-miR-513a-3p	CLIP-seq
MIRT1993307	hsa-miR-513a-5p	CLIP-seq
MIRT1993308	hsa-miR-515-5p	CLIP-seq
MIRT989598	hsa-miR-526b	CLIP-seq
MIRT1993309	hsa-miR-542-5p	CLIP-seq
MIRT989599	hsa-miR-544b	CLIP-seq
MIRT1993310	hsa-miR-548c-3p	CLIP-seq
MIRT989600	hsa-miR-548q	CLIP-seq
MIRT1993311	hsa-miR-550a	CLIP-seq
MIRT989603	hsa-miR-578	CLIP-seq
MIRT989604	hsa-miR-582-5p	CLIP-seq
MIRT1993312	hsa-miR-604	CLIP-seq
MIRT989605	hsa-miR-607	CLIP-seq
MIRT1993313	hsa-miR-608	CLIP-seq
MIRT989606	hsa-miR-609	CLIP-seq
MIRT989607	hsa-miR-615-5p	CLIP-seq
MIRT989608	hsa-miR-620	CLIP-seq
MIRT989609	hsa-miR-634	CLIP-seq
MIRT989610	hsa-miR-637	CLIP-seq
MIRT1993314	hsa-miR-644	CLIP-seq
MIRT989611	hsa-miR-646	CLIP-seq
MIRT1993315	hsa-miR-647	CLIP-seq
MIRT989612	hsa-miR-661	CLIP-seq
MIRT1993316	hsa-miR-663	CLIP-seq
MIRT1993317	hsa-miR-663b	CLIP-seq
MIRT1993318	hsa-miR-665	CLIP-seq
MIRT989613	hsa-miR-711	CLIP-seq
MIRT989615	hsa-miR-759	CLIP-seq
MIRT1993319	hsa-miR-761	CLIP-seq
MIRT989616	hsa-miR-924	CLIP-seq
MIRT989617	hsa-miR-935	CLIP-seq
MIRT989500	hsa-miR-101	CLIP-seq
MIRT989501	hsa-miR-103a	CLIP-seq
MIRT989502	hsa-miR-107	CLIP-seq
MIRT989503	hsa-miR-1207-5p	CLIP-seq
MIRT989504	hsa-miR-1224-3p	CLIP-seq
MIRT989505	hsa-miR-1260	CLIP-seq
MIRT989506	hsa-miR-1260b	CLIP-seq
MIRT1993284	hsa-miR-1262	CLIP-seq
MIRT989508	hsa-miR-1280	CLIP-seq
MIRT989509	hsa-miR-1286	CLIP-seq
MIRT989510	hsa-miR-1293	CLIP-seq
MIRT989511	hsa-miR-1302	CLIP-seq
MIRT989512	hsa-miR-144	CLIP-seq
MIRT989514	hsa-miR-1539	CLIP-seq
MIRT989515	hsa-miR-15a	CLIP-seq
MIRT989516	hsa-miR-15b	CLIP-seq
MIRT989517	hsa-miR-16	CLIP-seq
MIRT1993287	hsa-miR-1908	CLIP-seq
MIRT1993288	hsa-miR-1909	CLIP-seq
MIRT1993289	hsa-miR-1914	CLIP-seq
MIRT989518	hsa-miR-195	CLIP-seq
MIRT989519	hsa-miR-198	CLIP-seq
MIRT1993290	hsa-miR-214	CLIP-seq
MIRT989520	hsa-miR-2278	CLIP-seq
MIRT1993291	hsa-miR-27a	CLIP-seq
MIRT1993292	hsa-miR-27b	CLIP-seq
MIRT989521	hsa-miR-3065-3p	CLIP-seq
MIRT989522	hsa-miR-3074-5p	CLIP-seq
MIRT989524	hsa-miR-3138	CLIP-seq
MIRT989525	hsa-miR-3150b-3p	CLIP-seq
MIRT989526	hsa-miR-3177-5p	CLIP-seq
MIRT989527	hsa-miR-3193	CLIP-seq
MIRT989528	hsa-miR-3195	CLIP-seq
MIRT1993293	hsa-miR-342-5p	CLIP-seq
MIRT989531	hsa-miR-3591-3p	CLIP-seq
MIRT1993294	hsa-miR-3619-5p	CLIP-seq
MIRT1993295	hsa-miR-3646	CLIP-seq
MIRT989532	hsa-miR-3656	CLIP-seq
MIRT989534	hsa-miR-3660	CLIP-seq
MIRT1993296	hsa-miR-3662	CLIP-seq
MIRT989535	hsa-miR-3687	CLIP-seq
MIRT989536	hsa-miR-3689a-3p	CLIP-seq
MIRT989537	hsa-miR-3689c	CLIP-seq
MIRT989538	hsa-miR-3908	CLIP-seq
MIRT989539	hsa-miR-3929	CLIP-seq
MIRT1993298	hsa-miR-3944-5p	CLIP-seq
MIRT989540	hsa-miR-3945	CLIP-seq
MIRT989541	hsa-miR-3960	CLIP-seq
MIRT1993299	hsa-miR-412	CLIP-seq
MIRT989542	hsa-miR-424	CLIP-seq
MIRT989543	hsa-miR-4265	CLIP-seq
MIRT989545	hsa-miR-4294	CLIP-seq
MIRT989546	hsa-miR-4296	CLIP-seq
MIRT989547	hsa-miR-4298	CLIP-seq
MIRT989549	hsa-miR-4310	CLIP-seq
MIRT989550	hsa-miR-4322	CLIP-seq
MIRT989551	hsa-miR-4419b	CLIP-seq
MIRT989552	hsa-miR-4436b-3p	CLIP-seq
MIRT989553	hsa-miR-4442	CLIP-seq
MIRT989556	hsa-miR-4467	CLIP-seq
MIRT989557	hsa-miR-4478	CLIP-seq
MIRT989558	hsa-miR-4483	CLIP-seq
MIRT989562	hsa-miR-4520a-3p	CLIP-seq
MIRT989564	hsa-miR-4526	CLIP-seq
MIRT1993301	hsa-miR-4530	CLIP-seq
MIRT989566	hsa-miR-4645-3p	CLIP-seq
MIRT989567	hsa-miR-4648	CLIP-seq
MIRT989568	hsa-miR-4650-5p	CLIP-seq
MIRT1993302	hsa-miR-4651	CLIP-seq
MIRT989569	hsa-miR-4653-3p	CLIP-seq
MIRT989570	hsa-miR-4654	CLIP-seq
MIRT1993303	hsa-miR-4664-5p	CLIP-seq
MIRT989573	hsa-miR-4684-5p	CLIP-seq
MIRT989575	hsa-miR-4689	CLIP-seq
MIRT989576	hsa-miR-4690-3p	CLIP-seq
MIRT1993304	hsa-miR-4690-5p	CLIP-seq
MIRT989578	hsa-miR-4698	CLIP-seq
MIRT1993305	hsa-miR-4701-3p	CLIP-seq
MIRT1993306	hsa-miR-4707-3p	CLIP-seq
MIRT989581	hsa-miR-4728-5p	CLIP-seq
MIRT989582	hsa-miR-4734	CLIP-seq
MIRT989583	hsa-miR-4736	CLIP-seq
MIRT989584	hsa-miR-4743	CLIP-seq
MIRT989586	hsa-miR-4763-3p	CLIP-seq
MIRT989587	hsa-miR-4767	CLIP-seq
MIRT989588	hsa-miR-4769-5p	CLIP-seq
MIRT989589	hsa-miR-4784	CLIP-seq
MIRT989590	hsa-miR-4787-5p	CLIP-seq
MIRT989591	hsa-miR-4802-3p	CLIP-seq
MIRT989592	hsa-miR-485-5p	CLIP-seq
MIRT989594	hsa-miR-497	CLIP-seq
MIRT989597	hsa-miR-513a-3p	CLIP-seq
MIRT1993307	hsa-miR-513a-5p	CLIP-seq
MIRT1993309	hsa-miR-542-5p	CLIP-seq
MIRT989599	hsa-miR-544b	CLIP-seq
MIRT1993310	hsa-miR-548c-3p	CLIP-seq
MIRT1993311	hsa-miR-550a	CLIP-seq
MIRT989601	hsa-miR-564	CLIP-seq
MIRT989602	hsa-miR-571	CLIP-seq
MIRT989604	hsa-miR-582-5p	CLIP-seq
MIRT1993312	hsa-miR-604	CLIP-seq
MIRT989605	hsa-miR-607	CLIP-seq
MIRT1993313	hsa-miR-608	CLIP-seq
MIRT989607	hsa-miR-615-5p	CLIP-seq
MIRT989609	hsa-miR-634	CLIP-seq
MIRT989610	hsa-miR-637	CLIP-seq
MIRT1993315	hsa-miR-647	CLIP-seq
MIRT989612	hsa-miR-661	CLIP-seq
MIRT1993316	hsa-miR-663	CLIP-seq
MIRT1993318	hsa-miR-665	CLIP-seq
MIRT1993319	hsa-miR-761	CLIP-seq
MIRT989616	hsa-miR-924	CLIP-seq
MIRT989617	hsa-miR-935	CLIP-seq
MIRT989504	hsa-miR-1224-3p	CLIP-seq
MIRT989505	hsa-miR-1260	CLIP-seq
MIRT989506	hsa-miR-1260b	CLIP-seq
MIRT989508	hsa-miR-1280	CLIP-seq
MIRT989509	hsa-miR-1286	CLIP-seq
MIRT989515	hsa-miR-15a	CLIP-seq
MIRT989516	hsa-miR-15b	CLIP-seq
MIRT989517	hsa-miR-16	CLIP-seq
MIRT989518	hsa-miR-195	CLIP-seq
MIRT989521	hsa-miR-3065-3p	CLIP-seq
MIRT989528	hsa-miR-3195	CLIP-seq
MIRT989535	hsa-miR-3687	CLIP-seq
MIRT989540	hsa-miR-3945	CLIP-seq
MIRT989542	hsa-miR-424	CLIP-seq
MIRT989552	hsa-miR-4436b-3p	CLIP-seq
MIRT989553	hsa-miR-4442	CLIP-seq
MIRT989584	hsa-miR-4743	CLIP-seq
MIRT989594	hsa-miR-497	CLIP-seq
MIRT989533	hsa-miR-3657	CLIP-seq
MIRT989548	hsa-miR-4299	CLIP-seq
MIRT989555	hsa-miR-4456	CLIP-seq
MIRT989571	hsa-miR-4660	CLIP-seq
MIRT989600	hsa-miR-548q	CLIP-seq
MIRT989533	hsa-miR-3657	CLIP-seq
MIRT989548	hsa-miR-4299	CLIP-seq
MIRT989555	hsa-miR-4456	CLIP-seq
MIRT989571	hsa-miR-4660	CLIP-seq
MIRT989600	hsa-miR-548q	CLIP-seq
MIRT989500	hsa-miR-101	CLIP-seq
MIRT989503	hsa-miR-1207-5p	CLIP-seq
MIRT989512	hsa-miR-144	CLIP-seq
MIRT989515	hsa-miR-15a	CLIP-seq
MIRT989516	hsa-miR-15b	CLIP-seq
MIRT989517	hsa-miR-16	CLIP-seq
MIRT989518	hsa-miR-195	CLIP-seq
MIRT989525	hsa-miR-3150b-3p	CLIP-seq
MIRT989531	hsa-miR-3591-3p	CLIP-seq
MIRT989542	hsa-miR-424	CLIP-seq
MIRT989545	hsa-miR-4294	CLIP-seq
MIRT989565	hsa-miR-4635	CLIP-seq
MIRT989566	hsa-miR-4645-3p	CLIP-seq
MIRT989569	hsa-miR-4653-3p	CLIP-seq
MIRT989575	hsa-miR-4689	CLIP-seq
MIRT989578	hsa-miR-4698	CLIP-seq
MIRT989583	hsa-miR-4736	CLIP-seq
MIRT989586	hsa-miR-4763-3p	CLIP-seq
MIRT989589	hsa-miR-4784	CLIP-seq
MIRT989591	hsa-miR-4802-3p	CLIP-seq
MIRT989593	hsa-miR-495	CLIP-seq
MIRT989594	hsa-miR-497	CLIP-seq
MIRT989597	hsa-miR-513a-3p	CLIP-seq
MIRT989598	hsa-miR-526b	CLIP-seq
MIRT989599	hsa-miR-544b	CLIP-seq
MIRT989602	hsa-miR-571	CLIP-seq
MIRT989603	hsa-miR-578	CLIP-seq
MIRT989604	hsa-miR-582-5p	CLIP-seq
MIRT989605	hsa-miR-607	CLIP-seq
MIRT989612	hsa-miR-661	CLIP-seq
MIRT989616	hsa-miR-924	CLIP-seq
MIRT989617	hsa-miR-935	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
KLF5	Activation	18774944
SREBF1	Unknown	10520861;11790787;17449569

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001649	Process	Osteoblast differentiation	HDA	16210410
GO:0002068	Process	Glandular epithelial cell development	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0004313	Function	[acyl-carrier-protein] S-acetyltransferase activity	IEA
GO:0004314	Function	[acyl-carrier-protein] S-malonyltransferase activity	IEA
GO:0004315	Function	3-oxoacyl-[acyl-carrier-protein] synthase activity	IEA
GO:0004316	Function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	IEA
GO:0004317	Function	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity	IEA
GO:0004320	Function	Oleoyl-[acyl-carrier-protein] hydrolase activity	IEA
GO:0005515	Function	Protein binding	IPI	18022563, 23427160, 25959826, 27478939, 32296183, 32814053
GO:0005794	Component	Golgi apparatus	IDA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA
GO:0006084	Process	Acetyl-CoA metabolic process	IEA
GO:0006631	Process	Fatty acid metabolic process	TAS	7835891
GO:0006633	Process	Fatty acid biosynthetic process	IEA
GO:0008611	Process	Ether lipid biosynthetic process	IEA
GO:0008659	Function	(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity	IEA
GO:0008693	Function	3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity	IEA
GO:0016020	Component	Membrane	HDA	16210410, 19946888
GO:0016295	Function	Myristoyl-[acyl-carrier-protein] hydrolase activity	IEA
GO:0016296	Function	Palmitoyl-[acyl-carrier-protein] hydrolase activity	IEA
GO:0030223	Process	Neutrophil differentiation	IEA
GO:0030224	Process	Monocyte differentiation	IEA
GO:0030879	Process	Mammary gland development	IEA
GO:0031177	Function	Phosphopantetheine binding	IEA
GO:0031325	Process	Positive regulation of cellular metabolic process	TAS
GO:0042470	Component	Melanosome	IEA
GO:0042587	Component	Glycogen granule	IEA
GO:0042802	Function	Identical protein binding	IEA
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0045540	Process	Regulation of cholesterol biosynthetic process	TAS
GO:0046949	Process	Fatty-acyl-CoA biosynthetic process	TAS
GO:0047117	Function	Enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity	IEA
GO:0047451	Function	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337, 23533145
GO:0071353	Process	Cellular response to interleukin-4	IEA
GO:0090557	Process	Establishment of endothelial intestinal barrier	IEA
GO:0102131	Function	3-oxo-glutaryl-[acp] methyl ester reductase activity	IEA
GO:0102132	Function	3-oxo-pimeloyl-[acp] methyl ester reductase activity	IEA

Other IDs

• MIM: 600212
• HGNC: 3594
• e!Ensembl: ENSG00000169710

Protein

• UniProt ID: P49327
• Protein name: Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoac
• Protein function: Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic ac
• PDB: 1XKT, 2CG5, 2JFD, 2JFK, 2PX6, 3HHD, 3TJM, 4PIV, 4W82, 4W9N, 4Z49, 5C37, 6NNA, 7MHD, 7MHE, 8EYI, 8EYK, 8G7X, 8GKC, 8VF7, 8VG4, 8VLE, 8VLO, 8VLP, 8VM0, 8VM5, 8VM6, 8VM7, 8VMC, 8VMD, 9B7Z, 9B80, 9MJ9
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00109	ketoacyl-synt	1 → 239	Beta-ketoacyl synthase, N-terminal domain	Domain
  PF02801	Ketoacyl-synt_C	243 → 360	Beta-ketoacyl synthase, C-terminal domain	Domain
  PF16197	KAsynt_C_assoc	362 → 472	Ketoacyl-synthetase C-terminal extension	Family
  PF00698	Acyl_transf_1	493 → 810	Acyl transferase domain	Domain
  PF14765	PS-DH	865 → 1108	Polyketide synthase dehydratase	Domain
  PF08242	Methyltransf_12	1243 → 1342	Methyltransferase domain	Domain
  PF00107	ADH_zinc_N	1679 → 1816	Zinc-binding dehydrogenase	Family
  PF08659	KR	1885 → 2065	KR domain	Family
  PF00550	PP-binding	2125 → 2192	Phosphopantetheine attachment site	Domain
  PF00975	Thioesterase	2242 → 2501	Thioesterase domain	Domain

• Sequence:

  MEEVVIAGMSGKLPESENLQEFWDNLIGGVDMVTDDDRRWKAGLYGLPRRSGKLKDLSRF
  DASFFGVHPKQAHTMDPQLRLLLEVTYEAIVDGGINPDSLRGTHTGVWVGVSGSETSEAL
  SRDPETLVGYSMVGCQRAMMANRLSFFFDFRGPSIALDTACSSSLMALQNAYQAIHSGQC
  PAAIVGGINVLLKPNTSVQFLRLGMLSPEGTCKAFDTAGNGYCRSEGVVAVLLTKKSLAR
  RVYATILNAGTNTDGFKEQGVTFPSGDIQEQLIRSLYQSAGVAPESFEYIEAHGTGTKVG
  DPQELNGITRALCATRQEPLLIGSTKSNMGHPEPASGLAALAKVLLSLEHGLWAPNLHFH
  SPNPEIPALLDGRLQVVDQPLPVRGGNVGINSFGFGGSNVHIILRPNTQPPPAPAPHATL
  PRLLRASGRTPEAVQKLLEQGLRHSQDLAFLSMLNDIAAVPATAMPFRGYAVLGGERGGP
  EVQQVPAGERPLWFICSGMGTQWRGMGLSLMRLDRFRDSILRSDEAVKPFGLKVSQLLLS
  TDESTFDDIVHSFVSLTAIQIGLIDLLSCMGLRPDGIVGHSLGEVACGYADGCLSQEEAV
  LAAYWRGQCIKEAHLPPGAMAAVGLSWEECKQRCPPGVVPACHNSKDTVTISGPQAPVFE
  FVEQLRKEGVFAKEVRTGGMAFHSYFMEAIAPPLLQELKKVIREPKPRSARWLSTSIPEA
  QWHSSLARTSSAEYNVNNLVSPVLFQEALWHVPEHAVVLEIAPHALLQAVLKRGLKPSCT
  IIPLMKKDHRDNLEFFLAGIGRLHLSGIDANPNALFPPVEFPAPRGTPLISPLIKWDHSL
  AWDVPAAEDFPNGSGSPSAAIYNIDTSSESPDHYLVDHTLDGRVLFPATGYLSIVWKTLA
  RALGLGVEQLPVVFEDVVLHQATILPKTGTVSLEVRLLEASRAFEVSENGNLVVSGKVYQ
  WDDPDPRLFDHPESPTPNPTEPLFLAQAEVYKELRLRGYDYGPHFQGILEASLEGDSGRL
  LWKDNWVSFMDTMLQMSILGSAKHGLYLPTRVTAIHIDPATHRQKLYTLQDKAQVADVVV
  SRWLRVTVAGGVHISGLHTESAPRRQQEQQVPILEKFCFTPHTEEGCLSERAALQEELQL
  CKGLVQALQTKVTQQGLKMVVPGLDGAQIPRDPSQQELPRLLSAACRLQLNGNLQLELAQ
  VLAQERPKLPEDPLLSGLLDSPALKACLDTAVENMPSLKMKVVEVLAGHGHLYSRIPGLL
  SPHPLLQLSYTATDRHPQALEAAQAELQQHDVAQGQWDPADPAPSALGSADLLVCNCAVA
  ALGDPASALSNMVAALREGGFLLLHTLLRGHPLGDIVAFLTSTEPQYGQGILSQDAWESL
  FSRVSLRLVGLKKSFYGSTLFLCRRPTPQDSPIFLPVDDTSFRWVESLKGILADEDSSRP
  VWLKAINCATSGVVGLVNCLRREPGGNRLRCVLLSNLSSTSHVPEVDPGSAELQKVLQGD
  LVMNVYRDGAWGAFRHFLLEEDKPEEPTAHAFVSTLTRGDLSSIRWVCSSLRHAQPTCPG
  AQLCTVYYASLNFRDIMLATGKLSPDAIPGKWTSQDSLLGMEFSGRDASGKRVMGLVPAK
  GLATSVLLSPDFLWDVPSNWTLEEAASVPVVYSTAYYALVVRGRVRPGETLLIHSGSGGV
  GQAAIAIALSLGCRVFTTVGSAEKRAYLQARFPQLDSTSFANSRDTSFEQHVLWHTGGKG
  VDLVLNSLAEEKLQASVRCLATHGRFLEIGKFDLSQNHPLGMAIFLKNVTFHGVLLDAFF
  NESSADWREVWALVQAGIRDGVVRPLKCTVFHGAQVEDAFRYMAQGKHIGKVVVQVLAEE
  PEAVLKGAKPKLMSAISKTFCPAHKSYIIAGGLGGFGLELAQWLIQRGVQKLVLTSRSGI
  RTGYQAKQVRRWRRQGVQVQVSTSNISSLEGARGLIAEAAQLGPVGGVFNLAVVLRDGLL
  ENQTPEFFQDVCKPKYSGTLNLDRVTREACPELDYFVVFSSVSCGRGNAGQSNYGFANSA
  MERICEKRRHEGLPGLAVQWGAIGDVGILVETMSTNDTIVSGTLPQRMASCLEVLDLFLN
  QPHMVLSSFVLAEKAAAYRDRDSQRDLVEAVAHILGIRDLAAVNLDSSLADLGLDSLMSV
  EVRQTLERELNLVLSVREVRQLTLRKLQELSSKADEASELACPTPKEDGLAQQQTQLNLR
  SLLVNPEGPTLMRLNSVQSSERPLFLVHPIEGSTTVFHSLASRLSIPTYGLQCTRAAPLD
  SIHSLAAYYIDCIRQVQPEGPYRVAGYSYGACVAFEMCSQLQAQQSPAPTHNSLFLFDGS
  PTYVLAYTQSYRAKLTPGCEAEAETEAICFFVQQFTDMEHNRVLEALLPLKGLEERVAAA
  VDLIIKSHQGLDRQELSFAARSFYYKLRAAEQYTPKAKYHGNVMLLRAKTGGAYGEDLGA
  DYNLSQVCDGKVSVHVIEGDHRTLLEGSGLESIISIIHSSLAEPRVSVREG

• Sequence length: 2511