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FAS (Fas cell surface death receptor)

Gene

355

Fas cell surface death receptor

FAS

ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6

10q23.31

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogen

Show/Hide all(41)

SNP ID	Visualize variation	Clinical significance	Consequence
rs28929498	A>T	Pathogenic	Missense variant, coding sequence variant, 3 prime UTR variant, non coding transcript variant
rs56006128	G>A	Conflicting-interpretations-of-pathogenicity, uncertain-significance, not-provided	Intron variant, coding sequence variant, missense variant, non coding transcript variant
rs121913076	A>C	Pathogenic	Non coding transcript variant, missense variant, 3 prime UTR variant, coding sequence variant
rs121913077	C>T	Pathogenic	Non coding transcript variant, stop gained, 3 prime UTR variant, coding sequence variant
rs121913078	C>T	Pathogenic	Intron variant, missense variant, non coding transcript variant, coding sequence variant
rs121913079	A>G	Pathogenic, uncertain-significance	Non coding transcript variant, missense variant, 3 prime UTR variant, coding sequence variant
rs121913080	G>C	Pathogenic, likely-pathogenic	Non coding transcript variant, missense variant, 3 prime UTR variant, coding sequence variant
rs121913081	C>T	Pathogenic	Non coding transcript variant, missense variant, 3 prime UTR variant, coding sequence variant
rs121913082	A>G	Pathogenic	Non coding transcript variant, missense variant, 3 prime UTR variant, coding sequence variant
rs121913083	A>G	Pathogenic	Intron variant, missense variant, non coding transcript variant, coding sequence variant
rs121913084	T>C	Pathogenic	Intron variant, missense variant, non coding transcript variant, coding sequence variant
rs121913085	G>C	Pathogenic	Non coding transcript variant, missense variant, 3 prime UTR variant, coding sequence variant
rs121913086	G>T	Pathogenic	Non coding transcript variant, missense variant, 3 prime UTR variant, coding sequence variant
rs267607122	T>A,C	Pathogenic	Splice donor variant, intron variant
rs483352683	T>A,C	Likely-pathogenic, uncertain-significance	Coding sequence variant, 3 prime UTR variant, non coding transcript variant, missense variant
rs606231361	G>-	Pathogenic	Coding sequence variant, intron variant, frameshift variant, non coding transcript variant
rs606231362	->T	Pathogenic	Intron variant, splice donor variant
rs606231363	A>C	Pathogenic	Intron variant, splice acceptor variant
rs606231364	G>A	Pathogenic	Coding sequence variant, non coding transcript variant, missense variant
rs606231365	->AAAATTCAAACTTCAGAAAT	Pathogenic	Coding sequence variant, frameshift variant, non coding transcript variant, 3 prime UTR variant
rs606231366	->T	Pathogenic	Coding sequence variant, frameshift variant, non coding transcript variant, 3 prime UTR variant
rs778993919	C>A,T	Pathogenic	Stop gained, coding sequence variant, non coding transcript variant, 3 prime UTR variant, synonymous variant
rs886039359	G>A	Pathogenic	Intron variant, splice donor variant
rs886039524	AT>-	Pathogenic	Non coding transcript variant, coding sequence variant, frameshift variant, 3 prime UTR variant
rs1085307626	G>-	Likely-pathogenic	Frameshift variant, non coding transcript variant, intron variant, coding sequence variant
rs1554851356	C>-	Pathogenic	Non coding transcript variant, intron variant, coding sequence variant, frameshift variant
rs1554851718	T>G	Likely-pathogenic	Non coding transcript variant, intron variant, missense variant, coding sequence variant
rs1554852090	A>-	Likely-pathogenic	Intron variant, frameshift variant, non coding transcript variant, stop gained, coding sequence variant
rs1554852244	->CATG	Pathogenic	Non coding transcript variant, frameshift variant, 3 prime UTR variant, coding sequence variant
rs1564686301	T>A	Pathogenic	Non coding transcript variant, stop gained, coding sequence variant
rs1564691414	A>G	Likely-pathogenic	Intron variant, splice acceptor variant
rs1564692984	T>-,TT	Likely-pathogenic	Non coding transcript variant, intron variant, coding sequence variant, frameshift variant
rs1564696849	G>A,T	Pathogenic, pathogenic-likely-pathogenic	Intron variant, splice donor variant
rs1564699214	A>-	Pathogenic	Non coding transcript variant, frameshift variant, 3 prime UTR variant, coding sequence variant
rs1589465172	C>-	Pathogenic	Frameshift variant, coding sequence variant, non coding transcript variant
rs1589465256	C>-	Likely-pathogenic	Frameshift variant, coding sequence variant, non coding transcript variant
rs1589478691	G>-	Pathogenic	Frameshift variant, coding sequence variant, intron variant, non coding transcript variant
rs1589485636	->TGAAAT	Pathogenic	Intron variant, splice donor variant
rs1589488463	G>A	Pathogenic	Splice acceptor variant, intron variant
rs1589488494	AG>-	Pathogenic	Frameshift variant, coding sequence variant, intron variant, non coding transcript variant
rs1589488640	G>A	Pathogenic	Intron variant, splice donor variant

Show/Hide all(358)

miRTarBase ID	miRNA	Experiments	Reference
MIRT005581	hsa-miR-146a-5p	Luciferase reporter assay, Western blot	20656888
MIRT006331	hsa-miR-106a-5p	Luciferase reporter assay	22431000
MIRT006331	hsa-miR-106a-5p	Luciferase reporter assay	22431000
MIRT006331	hsa-miR-106a-5p	Luciferase reporter assay	22431000
MIRT006331	hsa-miR-106a-5p	Luciferase reporter assay	22431000
MIRT006331	hsa-miR-106a-5p	Luciferase reporter assay	22431000
MIRT006331	hsa-miR-106a-5p	Luciferase reporter assay	22431000
MIRT016252	hsa-miR-504-5p	qRT-PCR	20542001
MIRT027598	hsa-miR-98-5p	Microarray	19088304
MIRT002421	hsa-miR-21-5p	Microarray	20048743
MIRT053338	hsa-miR-196b-5p	Immunohistochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	22353710
MIRT053338	hsa-miR-196b-5p	Immunohistochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	22353710
MIRT053381	hsa-miR-23a-3p	Flow, Luciferase reporter assay, Microarray, Western blot	23804233
MIRT005581	hsa-miR-146a-5p	Luciferase reporter assay	23645835
MIRT005581	hsa-miR-146a-5p	Luciferase reporter assay	23645835
MIRT438788	hsa-miR-17-5p	qRT-PCR	24955218
MIRT438788	hsa-miR-17-5p	qRT-PCR	24955218
MIRT438787	hsa-miR-106b-5p	qRT-PCR	24955218
MIRT438787	hsa-miR-106b-5p	qRT-PCR	24955218
MIRT438786	hsa-miR-18a-5p	qRT-PCR	24955218
MIRT438786	hsa-miR-18a-5p	qRT-PCR	24955218
MIRT438785	hsa-miR-92a-1-5p	qRT-PCR	24955218
MIRT438785	hsa-miR-92a-1-5p	qRT-PCR	24955218
MIRT438784	hsa-miR-92a-2-5p	qRT-PCR	24955218
MIRT438784	hsa-miR-92a-2-5p	qRT-PCR	24955218
MIRT005581	hsa-miR-146a-5p	Luciferase reporter assay	23645835
MIRT005581	hsa-miR-146a-5p	Luciferase reporter assay	23645835
MIRT438788	hsa-miR-17-5p	qRT-PCR	24955218
MIRT438788	hsa-miR-17-5p	qRT-PCR	24955218
MIRT438787	hsa-miR-106b-5p	qRT-PCR	24955218
MIRT438787	hsa-miR-106b-5p	qRT-PCR	24955218
MIRT438786	hsa-miR-18a-5p	qRT-PCR	24955218
MIRT438786	hsa-miR-18a-5p	qRT-PCR	24955218
MIRT438785	hsa-miR-92a-1-5p	qRT-PCR	24955218
MIRT438785	hsa-miR-92a-1-5p	qRT-PCR	24955218
MIRT438784	hsa-miR-92a-2-5p	qRT-PCR	24955218
MIRT438784	hsa-miR-92a-2-5p	qRT-PCR	24955218
MIRT127441	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT127442	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT731620	hsa-miR-133b	Luciferase reporter assay	26919791
MIRT731620	hsa-miR-133b	Luciferase reporter assay	26919791
MIRT006331	hsa-miR-106a-5p	Flow, Immunohistochemistry, In situ hybridization, Luciferase reporter assay, qRT-PCR, Western blot	27142596
MIRT006331	hsa-miR-106a-5p	Flow, Immunohistochemistry, In situ hybridization, Luciferase reporter assay, qRT-PCR, Western blot	27142596
MIRT053338	hsa-miR-196b-5p	Luciferase reporter assay, qRT-PCR, Western blot	25605245
MIRT053338	hsa-miR-196b-5p	Luciferase reporter assay, qRT-PCR, Western blot	25605245
MIRT005581	hsa-miR-146a-5p	Immunofluorescence, qRT-PCR	32210951
MIRT053338	hsa-miR-196b-5p	Western blotting, Immunohistochemistry (IHC), qRT-PCR, Flow cytometry, ELISA	32963220
MIRT735853	hsa-miR-141-3p	qRT-PCR, ELISA	32691634
MIRT989477	hsa-miR-1303	CLIP-seq
MIRT989478	hsa-miR-23a	CLIP-seq
MIRT989479	hsa-miR-23b	CLIP-seq
MIRT989480	hsa-miR-23c	CLIP-seq
MIRT989481	hsa-miR-3170	CLIP-seq
MIRT989482	hsa-miR-340	CLIP-seq
MIRT989483	hsa-miR-361-5p	CLIP-seq
MIRT989484	hsa-miR-3691-5p	CLIP-seq
MIRT989485	hsa-miR-374c	CLIP-seq
MIRT989486	hsa-miR-4257	CLIP-seq
MIRT989487	hsa-miR-4282	CLIP-seq
MIRT989488	hsa-miR-4293	CLIP-seq
MIRT989489	hsa-miR-4330	CLIP-seq
MIRT989490	hsa-miR-4481	CLIP-seq
MIRT989491	hsa-miR-4719	CLIP-seq
MIRT989492	hsa-miR-4745-5p	CLIP-seq
MIRT989493	hsa-miR-4752	CLIP-seq
MIRT989494	hsa-miR-561	CLIP-seq
MIRT989495	hsa-miR-596	CLIP-seq
MIRT989496	hsa-miR-655	CLIP-seq
MIRT989497	hsa-miR-759	CLIP-seq
MIRT989498	hsa-miR-877	CLIP-seq
MIRT1993275	hsa-miR-1912	CLIP-seq
MIRT1993276	hsa-miR-3130-5p	CLIP-seq
MIRT1993277	hsa-miR-4482	CLIP-seq
MIRT1993278	hsa-miR-4699-3p	CLIP-seq
MIRT1993279	hsa-miR-548aa	CLIP-seq
MIRT1993280	hsa-miR-548ac	CLIP-seq
MIRT1993281	hsa-miR-548d-3p	CLIP-seq
MIRT1993282	hsa-miR-548z	CLIP-seq
MIRT1993275	hsa-miR-1912	CLIP-seq
MIRT1993276	hsa-miR-3130-5p	CLIP-seq
MIRT2449478	hsa-miR-3163	CLIP-seq
MIRT2449479	hsa-miR-3646	CLIP-seq
MIRT2449480	hsa-miR-3662	CLIP-seq
MIRT1993277	hsa-miR-4482	CLIP-seq
MIRT2530912	hsa-miR-103b	CLIP-seq
MIRT2530913	hsa-miR-1206	CLIP-seq
MIRT2530914	hsa-miR-1225-5p	CLIP-seq
MIRT2530915	hsa-miR-1251	CLIP-seq
MIRT2530916	hsa-miR-1275	CLIP-seq
MIRT2530917	hsa-miR-1283	CLIP-seq
MIRT2530918	hsa-miR-1295	CLIP-seq
MIRT2530919	hsa-miR-129-5p	CLIP-seq
MIRT2530920	hsa-miR-1302	CLIP-seq
MIRT989477	hsa-miR-1303	CLIP-seq
MIRT2530921	hsa-miR-1305	CLIP-seq
MIRT2530922	hsa-miR-153	CLIP-seq
MIRT2530923	hsa-miR-181a	CLIP-seq
MIRT2530924	hsa-miR-181b	CLIP-seq
MIRT2530925	hsa-miR-181c	CLIP-seq
MIRT2530926	hsa-miR-181d	CLIP-seq
MIRT2530927	hsa-miR-185	CLIP-seq
MIRT1993275	hsa-miR-1912	CLIP-seq
MIRT2530928	hsa-miR-1976	CLIP-seq
MIRT2530929	hsa-miR-200b	CLIP-seq
MIRT2530930	hsa-miR-200c	CLIP-seq
MIRT2530931	hsa-miR-216b	CLIP-seq
MIRT2530932	hsa-miR-217	CLIP-seq
MIRT2530933	hsa-miR-2278	CLIP-seq
MIRT2530934	hsa-miR-28-3p	CLIP-seq
MIRT2530935	hsa-miR-29a	CLIP-seq
MIRT2530936	hsa-miR-29b	CLIP-seq
MIRT2530937	hsa-miR-29c	CLIP-seq
MIRT2530938	hsa-miR-302f	CLIP-seq
MIRT1993276	hsa-miR-3130-5p	CLIP-seq
MIRT2530939	hsa-miR-3140-3p	CLIP-seq
MIRT2530940	hsa-miR-3145-3p	CLIP-seq
MIRT2530941	hsa-miR-3148	CLIP-seq
MIRT2449478	hsa-miR-3163	CLIP-seq
MIRT2530942	hsa-miR-325	CLIP-seq
MIRT989482	hsa-miR-340	CLIP-seq
MIRT2530943	hsa-miR-342-5p	CLIP-seq
MIRT989483	hsa-miR-361-5p	CLIP-seq
MIRT2449479	hsa-miR-3646	CLIP-seq
MIRT2530944	hsa-miR-3653	CLIP-seq
MIRT2530945	hsa-miR-3658	CLIP-seq
MIRT2449480	hsa-miR-3662	CLIP-seq
MIRT2530946	hsa-miR-3663-3p	CLIP-seq
MIRT2530947	hsa-miR-3675-3p	CLIP-seq
MIRT2530948	hsa-miR-3677-5p	CLIP-seq
MIRT2530949	hsa-miR-3688-5p	CLIP-seq
MIRT2530950	hsa-miR-3689a-5p	CLIP-seq
MIRT2530951	hsa-miR-3689b	CLIP-seq
MIRT2530952	hsa-miR-3689e	CLIP-seq
MIRT2530953	hsa-miR-3689f	CLIP-seq
MIRT2530954	hsa-miR-370	CLIP-seq
MIRT2530955	hsa-miR-371b-5p	CLIP-seq
MIRT2530956	hsa-miR-376a	CLIP-seq
MIRT2530957	hsa-miR-376b	CLIP-seq
MIRT2530958	hsa-miR-3920	CLIP-seq
MIRT2530959	hsa-miR-3921	CLIP-seq
MIRT2530960	hsa-miR-3974	CLIP-seq
MIRT2530961	hsa-miR-4251	CLIP-seq
MIRT2530962	hsa-miR-4252	CLIP-seq
MIRT989486	hsa-miR-4257	CLIP-seq
MIRT2530963	hsa-miR-4260	CLIP-seq
MIRT2530964	hsa-miR-4262	CLIP-seq
MIRT2530965	hsa-miR-429	CLIP-seq
MIRT2530966	hsa-miR-4291	CLIP-seq
MIRT2530967	hsa-miR-4298	CLIP-seq
MIRT2530968	hsa-miR-4306	CLIP-seq
MIRT2530969	hsa-miR-4324	CLIP-seq
MIRT2530970	hsa-miR-4329	CLIP-seq
MIRT2530971	hsa-miR-433	CLIP-seq
MIRT989489	hsa-miR-4330	CLIP-seq
MIRT2530972	hsa-miR-4426	CLIP-seq
MIRT2530973	hsa-miR-4446-5p	CLIP-seq
MIRT2530974	hsa-miR-4447	CLIP-seq
MIRT2530975	hsa-miR-4470	CLIP-seq
MIRT2530976	hsa-miR-4472	CLIP-seq
MIRT2530977	hsa-miR-4477a	CLIP-seq
MIRT2530978	hsa-miR-448	CLIP-seq
MIRT1993277	hsa-miR-4482	CLIP-seq
MIRT2530979	hsa-miR-4517	CLIP-seq
MIRT2530980	hsa-miR-4525	CLIP-seq
MIRT2530981	hsa-miR-4644	CLIP-seq
MIRT2530982	hsa-miR-4647	CLIP-seq
MIRT2530983	hsa-miR-4651	CLIP-seq
MIRT2530984	hsa-miR-4653-5p	CLIP-seq
MIRT2530985	hsa-miR-4659a-3p	CLIP-seq
MIRT2530986	hsa-miR-4659b-3p	CLIP-seq
MIRT2530987	hsa-miR-4662b	CLIP-seq
MIRT2530988	hsa-miR-4664-5p	CLIP-seq
MIRT2530989	hsa-miR-4665-5p	CLIP-seq
MIRT2530990	hsa-miR-4668-3p	CLIP-seq
MIRT2530991	hsa-miR-4668-5p	CLIP-seq
MIRT2530992	hsa-miR-4670-3p	CLIP-seq
MIRT2530993	hsa-miR-4680-3p	CLIP-seq
MIRT2530994	hsa-miR-4694-3p	CLIP-seq
MIRT2530995	hsa-miR-4698	CLIP-seq
MIRT1993278	hsa-miR-4699-3p	CLIP-seq
MIRT2530996	hsa-miR-4716-5p	CLIP-seq
MIRT2530997	hsa-miR-4717-5p	CLIP-seq
MIRT989491	hsa-miR-4719	CLIP-seq
MIRT2530998	hsa-miR-4723-5p	CLIP-seq
MIRT2530999	hsa-miR-4763-5p	CLIP-seq
MIRT2531000	hsa-miR-4768-5p	CLIP-seq
MIRT2531001	hsa-miR-4778-3p	CLIP-seq
MIRT2531002	hsa-miR-4781-3p	CLIP-seq
MIRT2531003	hsa-miR-4787-5p	CLIP-seq
MIRT2531004	hsa-miR-4793-5p	CLIP-seq
MIRT2531005	hsa-miR-4796-3p	CLIP-seq
MIRT2531006	hsa-miR-483-3p	CLIP-seq
MIRT2531007	hsa-miR-485-3p	CLIP-seq
MIRT2531008	hsa-miR-510	CLIP-seq
MIRT2531009	hsa-miR-512-5p	CLIP-seq
MIRT2531010	hsa-miR-518a-5p	CLIP-seq
MIRT2531011	hsa-miR-520g	CLIP-seq
MIRT2531012	hsa-miR-520h	CLIP-seq
MIRT2531013	hsa-miR-527	CLIP-seq
MIRT2531014	hsa-miR-539	CLIP-seq
MIRT2531015	hsa-miR-545	CLIP-seq
MIRT1993279	hsa-miR-548aa	CLIP-seq
MIRT1993280	hsa-miR-548ac	CLIP-seq
MIRT2531016	hsa-miR-548c-3p	CLIP-seq
MIRT1993281	hsa-miR-548d-3p	CLIP-seq
MIRT2531017	hsa-miR-548p	CLIP-seq
MIRT1993282	hsa-miR-548z	CLIP-seq
MIRT989494	hsa-miR-561	CLIP-seq
MIRT2531018	hsa-miR-587	CLIP-seq
MIRT2531019	hsa-miR-607	CLIP-seq
MIRT2531020	hsa-miR-608	CLIP-seq
MIRT2531021	hsa-miR-625	CLIP-seq
MIRT2531022	hsa-miR-628-3p	CLIP-seq
MIRT989497	hsa-miR-759	CLIP-seq
MIRT2531023	hsa-miR-760	CLIP-seq
MIRT2531024	hsa-miR-767-3p	CLIP-seq
MIRT989498	hsa-miR-877	CLIP-seq
MIRT2531025	hsa-miR-942	CLIP-seq
MIRT2530912	hsa-miR-103b	CLIP-seq
MIRT2530913	hsa-miR-1206	CLIP-seq
MIRT2530914	hsa-miR-1225-5p	CLIP-seq
MIRT2530915	hsa-miR-1251	CLIP-seq
MIRT2530916	hsa-miR-1275	CLIP-seq
MIRT2530917	hsa-miR-1283	CLIP-seq
MIRT2530918	hsa-miR-1295	CLIP-seq
MIRT2530919	hsa-miR-129-5p	CLIP-seq
MIRT2530920	hsa-miR-1302	CLIP-seq
MIRT989477	hsa-miR-1303	CLIP-seq
MIRT2530921	hsa-miR-1305	CLIP-seq
MIRT2530922	hsa-miR-153	CLIP-seq
MIRT2530923	hsa-miR-181a	CLIP-seq
MIRT2530924	hsa-miR-181b	CLIP-seq
MIRT2530925	hsa-miR-181c	CLIP-seq
MIRT2530926	hsa-miR-181d	CLIP-seq
MIRT2680780	hsa-miR-1827	CLIP-seq
MIRT2530927	hsa-miR-185	CLIP-seq
MIRT1993275	hsa-miR-1912	CLIP-seq
MIRT2530928	hsa-miR-1976	CLIP-seq
MIRT2530929	hsa-miR-200b	CLIP-seq
MIRT2530930	hsa-miR-200c	CLIP-seq
MIRT2530931	hsa-miR-216b	CLIP-seq
MIRT2530932	hsa-miR-217	CLIP-seq
MIRT2530933	hsa-miR-2278	CLIP-seq
MIRT2530934	hsa-miR-28-3p	CLIP-seq
MIRT2530935	hsa-miR-29a	CLIP-seq
MIRT2530936	hsa-miR-29b	CLIP-seq
MIRT2530937	hsa-miR-29c	CLIP-seq
MIRT2530938	hsa-miR-302f	CLIP-seq
MIRT1993276	hsa-miR-3130-5p	CLIP-seq
MIRT2530939	hsa-miR-3140-3p	CLIP-seq
MIRT2530940	hsa-miR-3145-3p	CLIP-seq
MIRT2530941	hsa-miR-3148	CLIP-seq
MIRT2449478	hsa-miR-3163	CLIP-seq
MIRT2680781	hsa-miR-3189-3p	CLIP-seq
MIRT2530942	hsa-miR-325	CLIP-seq
MIRT989482	hsa-miR-340	CLIP-seq
MIRT2530943	hsa-miR-342-5p	CLIP-seq
MIRT2680782	hsa-miR-3612	CLIP-seq
MIRT989483	hsa-miR-361-5p	CLIP-seq
MIRT2680783	hsa-miR-362-5p	CLIP-seq
MIRT2449479	hsa-miR-3646	CLIP-seq
MIRT2530944	hsa-miR-3653	CLIP-seq
MIRT2530945	hsa-miR-3658	CLIP-seq
MIRT2449480	hsa-miR-3662	CLIP-seq
MIRT2530946	hsa-miR-3663-3p	CLIP-seq
MIRT2530947	hsa-miR-3675-3p	CLIP-seq
MIRT2530948	hsa-miR-3677-5p	CLIP-seq
MIRT2530949	hsa-miR-3688-5p	CLIP-seq
MIRT2530950	hsa-miR-3689a-5p	CLIP-seq
MIRT2530951	hsa-miR-3689b	CLIP-seq
MIRT2530952	hsa-miR-3689e	CLIP-seq
MIRT2530953	hsa-miR-3689f	CLIP-seq
MIRT2530954	hsa-miR-370	CLIP-seq
MIRT2530955	hsa-miR-371b-5p	CLIP-seq
MIRT2530958	hsa-miR-3920	CLIP-seq
MIRT2530959	hsa-miR-3921	CLIP-seq
MIRT2530960	hsa-miR-3974	CLIP-seq
MIRT2530961	hsa-miR-4251	CLIP-seq
MIRT2530962	hsa-miR-4252	CLIP-seq
MIRT989486	hsa-miR-4257	CLIP-seq
MIRT2530963	hsa-miR-4260	CLIP-seq
MIRT2530964	hsa-miR-4262	CLIP-seq
MIRT2530965	hsa-miR-429	CLIP-seq
MIRT2530966	hsa-miR-4291	CLIP-seq
MIRT2530967	hsa-miR-4298	CLIP-seq
MIRT2530968	hsa-miR-4306	CLIP-seq
MIRT2680784	hsa-miR-432	CLIP-seq
MIRT2530969	hsa-miR-4324	CLIP-seq
MIRT2530970	hsa-miR-4329	CLIP-seq
MIRT2530971	hsa-miR-433	CLIP-seq
MIRT989489	hsa-miR-4330	CLIP-seq
MIRT2530972	hsa-miR-4426	CLIP-seq
MIRT2680785	hsa-miR-4443	CLIP-seq
MIRT2530973	hsa-miR-4446-5p	CLIP-seq
MIRT2530974	hsa-miR-4447	CLIP-seq
MIRT2530975	hsa-miR-4470	CLIP-seq
MIRT2530976	hsa-miR-4472	CLIP-seq
MIRT2530977	hsa-miR-4477a	CLIP-seq
MIRT2530978	hsa-miR-448	CLIP-seq
MIRT1993277	hsa-miR-4482	CLIP-seq
MIRT2530979	hsa-miR-4517	CLIP-seq
MIRT2530980	hsa-miR-4525	CLIP-seq
MIRT2530981	hsa-miR-4644	CLIP-seq
MIRT2530982	hsa-miR-4647	CLIP-seq
MIRT2530983	hsa-miR-4651	CLIP-seq
MIRT2530984	hsa-miR-4653-5p	CLIP-seq
MIRT2530985	hsa-miR-4659a-3p	CLIP-seq
MIRT2530986	hsa-miR-4659b-3p	CLIP-seq
MIRT2530987	hsa-miR-4662b	CLIP-seq
MIRT2530988	hsa-miR-4664-5p	CLIP-seq
MIRT2530989	hsa-miR-4665-5p	CLIP-seq
MIRT2530990	hsa-miR-4668-3p	CLIP-seq
MIRT2530991	hsa-miR-4668-5p	CLIP-seq
MIRT2530992	hsa-miR-4670-3p	CLIP-seq
MIRT2530993	hsa-miR-4680-3p	CLIP-seq
MIRT2530994	hsa-miR-4694-3p	CLIP-seq
MIRT2530995	hsa-miR-4698	CLIP-seq
MIRT1993278	hsa-miR-4699-3p	CLIP-seq
MIRT2530996	hsa-miR-4716-5p	CLIP-seq
MIRT2530997	hsa-miR-4717-5p	CLIP-seq
MIRT989491	hsa-miR-4719	CLIP-seq
MIRT2530998	hsa-miR-4723-5p	CLIP-seq
MIRT2530999	hsa-miR-4763-5p	CLIP-seq
MIRT2531000	hsa-miR-4768-5p	CLIP-seq
MIRT2531001	hsa-miR-4778-3p	CLIP-seq
MIRT2531002	hsa-miR-4781-3p	CLIP-seq
MIRT2531003	hsa-miR-4787-5p	CLIP-seq
MIRT2531004	hsa-miR-4793-5p	CLIP-seq
MIRT2531005	hsa-miR-4796-3p	CLIP-seq
MIRT2531006	hsa-miR-483-3p	CLIP-seq
MIRT2531007	hsa-miR-485-3p	CLIP-seq
MIRT2680786	hsa-miR-500b	CLIP-seq
MIRT2531008	hsa-miR-510	CLIP-seq
MIRT2531009	hsa-miR-512-5p	CLIP-seq
MIRT2531010	hsa-miR-518a-5p	CLIP-seq
MIRT2531011	hsa-miR-520g	CLIP-seq
MIRT2531012	hsa-miR-520h	CLIP-seq
MIRT2531013	hsa-miR-527	CLIP-seq
MIRT2531014	hsa-miR-539	CLIP-seq
MIRT2531015	hsa-miR-545	CLIP-seq
MIRT1993279	hsa-miR-548aa	CLIP-seq
MIRT1993280	hsa-miR-548ac	CLIP-seq
MIRT2531016	hsa-miR-548c-3p	CLIP-seq
MIRT1993281	hsa-miR-548d-3p	CLIP-seq
MIRT2531017	hsa-miR-548p	CLIP-seq
MIRT1993282	hsa-miR-548z	CLIP-seq
MIRT989494	hsa-miR-561	CLIP-seq
MIRT2531018	hsa-miR-587	CLIP-seq
MIRT2531019	hsa-miR-607	CLIP-seq
MIRT2531020	hsa-miR-608	CLIP-seq
MIRT2531021	hsa-miR-625	CLIP-seq
MIRT2531022	hsa-miR-628-3p	CLIP-seq
MIRT2680787	hsa-miR-650	CLIP-seq
MIRT989497	hsa-miR-759	CLIP-seq
MIRT2531023	hsa-miR-760	CLIP-seq
MIRT2531024	hsa-miR-767-3p	CLIP-seq
MIRT989498	hsa-miR-877	CLIP-seq
MIRT2531025	hsa-miR-942	CLIP-seq

Transcription factors

Show/Hide all(33)

Transcription factor	Regulation	Reference
ATF2	Unknown	19670268
ATM	Activation	19502594
EGR1	Repression	9300687
FOS	Activation	10903433
GLI1	Repression	21135115
GLI2	Repression	21135115
HDGF	Activation	19710540
JUN	Activation	10903433
JUN	Unknown	19670268
NFKB1	Activation	19628709;9733827
NFKB1	Repression	16784892
NFKB1	Unknown	10022897;10871852;16317104;7528667
NFKBIA	Repression	9733827
NFYA	Unknown	9261184
NFYB	Unknown	9261184
NFYC	Unknown	9261184
PURA	Repression	10903433
RELA	Activation	19628709;9733827
RELA	Repression	16784892
RELA	Unknown	10871852;16317104
SP1	Activation	22084312
SP1	Unknown	10022897;10871852;9261184;9300785
SREBF1	Activation	18420801
SREBF1	Unknown	12531699;20173757;9300785
SREBF2	Unknown	9300785
STAT1	Unknown	16317104
STAT3	Activation	15223310
STAT3	Repression	16651438;22313388
TFAP2A	Unknown	7528667
TP53	Activation	10101800;11313989
TP53	Unknown	16317104
YBX1	Repression	10903433
YY1	Repression	16784892;17530016

Show/Hide all(51)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001934	Process	Positive regulation of protein phosphorylation	IMP	11096076
GO:0005031	Function	Tumor necrosis factor-activated receptor activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	7536190, 7538907, 10918185, 11003656, 11495919, 11606059, 12724420, 12887920, 15465831, 16498403, 17047155, 17159907, 18328427, 18846110, 21109225, 21382479, 21625644, 21803845, 25241761
GO:0005516	Function	Calmodulin binding	IDA	24914971
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	NAS	7533181
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IMP	21625644
GO:0005886	Component	Plasma membrane	TAS
GO:0006915	Process	Apoptotic process	IDA	9681877
GO:0006919	Process	Activation of cysteine-type endopeptidase activity involved in apoptotic process	TAS
GO:0006924	Process	Activation-induced cell death of T cells	IBA	21873635
GO:0006955	Process	Immune response	IEA
GO:0007165	Process	Signal transduction	TAS	9360929
GO:0009897	Component	External side of plasma membrane	IBA	21873635
GO:0009986	Component	Cell surface	IDA	22891283
GO:0016021	Component	Integral component of membrane	IEA
GO:0016604	Component	Nuclear body	IDA
GO:0019900	Function	Kinase binding	IPI	7538908
GO:0031264	Component	Death-inducing signaling complex	IDA	11101870, 21803845
GO:0031265	Component	CD95 death-inducing signaling complex	IBA	21873635
GO:0031265	Component	CD95 death-inducing signaling complex	IDA	20935634
GO:0032872	Process	Regulation of stress-activated MAPK cascade	IBA	21873635
GO:0032872	Process	Regulation of stress-activated MAPK cascade	IMP	11096076
GO:0033209	Process	Tumor necrosis factor-mediated signaling pathway	IEA
GO:0034198	Process	Cellular response to amino acid starvation	IMP	11096076
GO:0036337	Process	Fas signaling pathway	IMP	11096076
GO:0038023	Function	Signaling receptor activity	NAS	7533181
GO:0042802	Function	Identical protein binding	IPI	7536190, 7538908, 21382479
GO:0042981	Process	Regulation of apoptotic process	NAS	7533181
GO:0042981	Process	Regulation of apoptotic process	TAS
GO:0043065	Process	Positive regulation of apoptotic process	IDA	21625644
GO:0043065	Process	Positive regulation of apoptotic process	IMP	20935634
GO:0043066	Process	Negative regulation of apoptotic process	IBA	21873635
GO:0045121	Component	Membrane raft	IBA	21873635
GO:0045121	Component	Membrane raft	IDA	21382479
GO:0065003	Process	Protein-containing complex assembly	TAS	10875918
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0071260	Process	Cellular response to mechanical stimulus	IEP	19593445
GO:0071455	Process	Cellular response to hyperoxia	IMP	21382479
GO:0097049	Process	Motor neuron apoptotic process	IBA	21873635
GO:0097190	Process	Apoptotic signaling pathway	TAS
GO:0097191	Process	Extrinsic apoptotic signaling pathway	IMP	22891283
GO:0097192	Process	Extrinsic apoptotic signaling pathway in absence of ligand	IBA	21873635
GO:0097527	Process	Necroptotic signaling pathway	IBA	21873635
GO:0097527	Process	Necroptotic signaling pathway	IMP	16507998
GO:1902041	Process	Regulation of extrinsic apoptotic signaling pathway via death domain receptors	TAS
GO:1902042	Process	Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	TAS
GO:2001235	Process	Positive regulation of apoptotic signaling pathway	IMP	11096076
GO:2001269	Process	Positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	IBA	21873635
GO:2001269	Process	Positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	IMP	11096076

MIM	HGNC	e!Ensembl
134637	11920	ENSG00000026103

Protein

UniProt ID

P25445

Protein name

Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95)

Protein function

Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase CASP8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs CASP8 proteolytic activation which initiates the subsequent cascade of caspases

PDB

1DDF , 2NA7 , 3EWT , 3EZQ , 3THM , 3TJE

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00020	TNFR_c6	85 → 127	TNFR/NGFR cysteine-rich region	Domain
PF00020	TNFR_c6	129 → 165	TNFR/NGFR cysteine-rich region	Domain
PF00531	Death	230 → 314	Death domain	Domain

Sequence

MLGIWTLLPLVLTSVARLSSKSVNAQVTDINSKGLELRKTVTTVETQNLEGLHHDGQFCH
KPCPPGERKARDCTVNGDEPDCVPCQEGKEYTDKAHFSSKCRRCRLCDEGHGLEVEINCT
RTQNTKCRCKPNFFCNSTVCEHCDPCTKCEHGIIKECTLTSNTKCKEEGSRSNLGWLCLL
LLPIPLIVWVKRKEVQKTCRKHRKENQGSHESPTLNPETVAINLSDVDLSKYITTIAGVM
TLSQVKGFVRKNGVNEAKIDEIKNDNVQDTAEQKVQLLRNWHQLHGKKEAYDTLIKDLKK
ANLCTLAEKIQTIILKDITSDSENSNFRNEIQSLV

Sequence length

335

Interactions

View interactions

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