FARP2 (FERM, ARH/RhoGEF and pleckstrin domain protein 2)

Gene

• Entrez ID: 9855
• Gene name: FERM, ARH/RhoGEF and pleckstrin domain protein 2
• Gene symbol: FARP2
• Synonyms: FIR, FRG, PLEKHC3
• Chromosome: 2
• Chromosome location: 2q37.3

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IBA	21873635
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IDA	12351724
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	ISS
GO:0005737	Component	Cytoplasm	IDA	12351724
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0007155	Process	Cell adhesion	ISS
GO:0008092	Function	Cytoskeletal protein binding	IEA
GO:0016322	Process	Neuron remodeling	IDA	12351724
GO:0016601	Process	Rac protein signal transduction	IDA	12351724
GO:0022405	Process	Hair cycle process	IEA
GO:0030316	Process	Osteoclast differentiation	ISS
GO:0031532	Process	Actin cytoskeleton reorganization	ISS
GO:0033623	Process	Regulation of integrin activation	ISS
GO:0050790	Process	Regulation of catalytic activity	IEA
GO:0071526	Process	Semaphorin-plexin signaling pathway	ISS
GO:0071800	Process	Podosome assembly	ISS

Other IDs

• MIM: 617586
• HGNC: 16460
• e!Ensembl: ENSG00000006607

Protein

• UniProt ID: O94887
• Protein name: FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3)
• Protein function: Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF09379	FERM_N	48 → 111	FERM N-terminal domain	Domain
  PF00373	FERM_M	127 → 234	FERM central domain	Domain
  PF09380	FERM_C	238 → 328	FERM C-terminal PH-like domain	Domain
  PF08736	FA	333 → 376	FERM adjacent (FA)	Family
  PF00621	RhoGEF	539 → 724	RhoGEF domain	Domain
  PF00169	PH	756 → 852	PH domain	Domain
  PF00169	PH	930 → 1026	PH domain	Domain

• Sequence:

  MGEIEGTYRVLQTAGMRLGAQTPVGVSTLEPGQTLLPRMQEKHLHLRVKLLDNTMEIFDI
  EPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEPMKPIIRQIRRPKNVVLRLA
  VKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAALLTSHLLQSEIGDYDETLD
  REHLKVNEYLPGQQHCLEKILEFHQKHVGQTPAESDFQVLEIARKLEMYGIRFHMASDRE
  GTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRFLIKLHPEVHGPYQDTLEFLL
  GSRDECKNFWKICVEYHTFFRLLDQPKPKAKAVFFSRGSSFRYSGRTQKQLVDYFKDSGM
  KRIPYERRHSKTHTSVRALTADLPKQSISFPEGLRTPASPSSANAFYSLSPSTLVPSGLP
  EFKDSSSSLTDPQVSYVKSPAAERRSGAVAGGPDTPSAQPLGPPALQPGPGLSTKSPQPS
  PSSRKSPLSLSPAFQVPLGPAEQGSSPLLSPVLSDAGGAGMDCEEPRHKRVPADEAYFIV
  KEILATERTYLKDLEVITVWFRSAVVKEDAMPATLMTLLFSNIDPIYEFHRGFLREVEQR
  LALWEGPSKAHTKGSHQRIGDILLRNMRQLKEFTSYFQRHDEVLTELEKATKRCKKLEAV
  YKEFELQKVCYLPLNTFLLKPIQRLLHYRLLLRRLCGHYSPGHHDYADCHDALKAITEVT
  TTLQHILIRLENLQKLTELQRDLVGIENLIAPGREFIREGCLHKLTKKGLQQRMFFLFSD
  MLLYTSKGVAGTSHFRIRGLLPLQGMLVEESDNEWSVPHCFTIYAAQKTIVVAASTRLEK
  EKWMLDLNSAIQAAKSGGDTAPALPGRTVCTRPPRSPNEVSLEQESEDDARGVRSSLEGH
  GQHRANTTMHVCWYRNTSVSRADHSAAVENQLSGYLLRKFKNSHGWQKLWVVFTNFCLFF
  YKTHQDDYPLASLPLLGYSVSIPREADGIHKDYVFKLQFKSHVYFFRAESKYTFERWMEV
  IQGASSSAGRAPSIVQDGPQPSSGLEGMVRGKEE

• Sequence length: 1054