F3 (coagulation factor III, tissue factor)

Gene

• Entrez ID: 2152
• Gene name: Coagulation factor III, tissue factor
• Gene symbol: F3
• Synonyms: CD142, TF, TFA
• Chromosome: 1
• Chromosome location: 1p21.3
• Summary: This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces, for example, on monocytes. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. Platelets and monocytes have been shown to express this coagulation factor under procoagulatory and proinflammatory stimuli, and a major role in HIV-associated coagulopathy has been described. Platelet-dependent monocyte expression of coagulation factor III has been described to be associated with Coronavirus Disease 2019 (COVID-19) severity and mortality. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Aug 2020]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019927	hsa-miR-375	Microarray	20215506
MIRT020315	hsa-miR-130b-3p	Sequencing	20371350
MIRT022817	hsa-miR-124-3p	Microarray	18668037
MIRT028146	hsa-miR-93-5p	Sequencing, PAR-CLIP	20371350
MIRT028146	hsa-miR-93-5p	PAR-CLIP	23592263
MIRT028146	hsa-miR-93-5p	PAR-CLIP	23446348
MIRT028146	hsa-miR-93-5p	PAR-CLIP	21572407
MIRT028146	hsa-miR-93-5p	PAR-CLIP	26701625
MIRT029798	hsa-miR-26b-5p	Microarray	19088304
MIRT477176	hsa-miR-508-3p	PAR-CLIP	23592263
MIRT477176	hsa-miR-508-3p	PAR-CLIP	23446348
MIRT477176	hsa-miR-508-3p	PAR-CLIP	21572407
MIRT477176	hsa-miR-508-3p	PAR-CLIP	20371350
MIRT477176	hsa-miR-508-3p	PAR-CLIP	26701625
MIRT477177	hsa-miR-935	PAR-CLIP	23592263
MIRT477177	hsa-miR-935	PAR-CLIP	23446348
MIRT477177	hsa-miR-935	PAR-CLIP	21572407
MIRT477177	hsa-miR-935	PAR-CLIP	20371350
MIRT477177	hsa-miR-935	PAR-CLIP	26701625
MIRT477178	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT477178	hsa-miR-6876-5p	PAR-CLIP	21572407
MIRT477178	hsa-miR-6876-5p	PAR-CLIP	20371350
MIRT477178	hsa-miR-6876-5p	PAR-CLIP	26701625
MIRT477179	hsa-miR-4476	PAR-CLIP	23592263
MIRT477179	hsa-miR-4476	PAR-CLIP	21572407
MIRT477179	hsa-miR-4476	PAR-CLIP	20371350
MIRT477179	hsa-miR-4476	PAR-CLIP	26701625
MIRT477180	hsa-miR-519c-3p	PAR-CLIP	23592263
MIRT477180	hsa-miR-519c-3p	PAR-CLIP	23446348
MIRT477180	hsa-miR-519c-3p	PAR-CLIP	21572407
MIRT477180	hsa-miR-519c-3p	PAR-CLIP	20371350
MIRT477180	hsa-miR-519c-3p	PAR-CLIP	26701625
MIRT477181	hsa-miR-519b-3p	PAR-CLIP	23592263
MIRT477181	hsa-miR-519b-3p	PAR-CLIP	23446348
MIRT477181	hsa-miR-519b-3p	PAR-CLIP	21572407
MIRT477181	hsa-miR-519b-3p	PAR-CLIP	20371350
MIRT477181	hsa-miR-519b-3p	PAR-CLIP	26701625
MIRT477182	hsa-miR-519a-3p	PAR-CLIP	23592263
MIRT477182	hsa-miR-519a-3p	PAR-CLIP	23446348
MIRT477182	hsa-miR-519a-3p	PAR-CLIP	21572407
MIRT477182	hsa-miR-519a-3p	PAR-CLIP	20371350
MIRT477182	hsa-miR-519a-3p	PAR-CLIP	26701625
MIRT477183	hsa-miR-224-5p	PAR-CLIP	23592263
MIRT477183	hsa-miR-224-5p	PAR-CLIP	23446348
MIRT477183	hsa-miR-224-5p	PAR-CLIP	21572407
MIRT477183	hsa-miR-224-5p	PAR-CLIP	20371350
MIRT477183	hsa-miR-224-5p	PAR-CLIP	26701625
MIRT477184	hsa-miR-4735-3p	PAR-CLIP	23592263
MIRT477184	hsa-miR-4735-3p	PAR-CLIP	21572407
MIRT477184	hsa-miR-4735-3p	PAR-CLIP	20371350
MIRT477184	hsa-miR-4735-3p	PAR-CLIP	26701625
MIRT477185	hsa-miR-18b-5p	PAR-CLIP	23592263
MIRT477185	hsa-miR-18b-5p	PAR-CLIP	21572407
MIRT477185	hsa-miR-18b-5p	PAR-CLIP	20371350
MIRT477185	hsa-miR-18b-5p	PAR-CLIP	26701625
MIRT477186	hsa-miR-18a-5p	PAR-CLIP	23592263
MIRT477186	hsa-miR-18a-5p	PAR-CLIP	21572407
MIRT477186	hsa-miR-18a-5p	PAR-CLIP	20371350
MIRT477186	hsa-miR-18a-5p	PAR-CLIP	26701625
MIRT477187	hsa-miR-4796-3p	PAR-CLIP	23592263
MIRT477187	hsa-miR-4796-3p	PAR-CLIP	23446348
MIRT477187	hsa-miR-4796-3p	PAR-CLIP	21572407
MIRT477187	hsa-miR-4796-3p	PAR-CLIP	20371350
MIRT477187	hsa-miR-4796-3p	PAR-CLIP	26701625
MIRT477188	hsa-miR-548ah-5p	PAR-CLIP	23592263
MIRT477188	hsa-miR-548ah-5p	PAR-CLIP	23446348
MIRT477188	hsa-miR-548ah-5p	PAR-CLIP	21572407
MIRT477188	hsa-miR-548ah-5p	PAR-CLIP	20371350
MIRT477188	hsa-miR-548ah-5p	PAR-CLIP	26701625
MIRT477189	hsa-miR-3609	PAR-CLIP	23592263
MIRT477189	hsa-miR-3609	PAR-CLIP	23446348
MIRT477189	hsa-miR-3609	PAR-CLIP	21572407
MIRT477189	hsa-miR-3609	PAR-CLIP	20371350
MIRT477189	hsa-miR-3609	PAR-CLIP	26701625
MIRT477190	hsa-miR-6835-3p	PAR-CLIP	23592263
MIRT477190	hsa-miR-6835-3p	PAR-CLIP	23446348
MIRT477190	hsa-miR-6835-3p	PAR-CLIP	21572407
MIRT477190	hsa-miR-6835-3p	PAR-CLIP	20371350
MIRT477190	hsa-miR-6835-3p	PAR-CLIP	26701625
MIRT477191	hsa-miR-4422	PAR-CLIP	23592263
MIRT477191	hsa-miR-4422	PAR-CLIP	23446348
MIRT477191	hsa-miR-4422	PAR-CLIP	21572407
MIRT477191	hsa-miR-4422	PAR-CLIP	20371350
MIRT477191	hsa-miR-4422	PAR-CLIP	26701625
MIRT477192	hsa-miR-223-3p	PAR-CLIP	23592263
MIRT477192	hsa-miR-223-3p	PAR-CLIP	23446348
MIRT477192	hsa-miR-223-3p	PAR-CLIP	21572407
MIRT477192	hsa-miR-223-3p	PAR-CLIP	20371350
MIRT477192	hsa-miR-223-3p	PAR-CLIP	26701625
MIRT477193	hsa-miR-20a-5p	PAR-CLIP	23592263
MIRT477193	hsa-miR-20a-5p	PAR-CLIP	23446348
MIRT477193	hsa-miR-20a-5p	PAR-CLIP	21572407
MIRT477193	hsa-miR-20a-5p	PAR-CLIP	20371350
MIRT477193	hsa-miR-20a-5p	PAR-CLIP	26701625
MIRT477194	hsa-miR-106b-5p	PAR-CLIP	23592263
MIRT477194	hsa-miR-106b-5p	PAR-CLIP	23446348
MIRT477194	hsa-miR-106b-5p	PAR-CLIP	21572407
MIRT477194	hsa-miR-106b-5p	PAR-CLIP	20371350
MIRT477194	hsa-miR-106b-5p	PAR-CLIP	26701625
MIRT477195	hsa-miR-519d-3p	PAR-CLIP	23592263
MIRT477195	hsa-miR-519d-3p	PAR-CLIP	23446348
MIRT477195	hsa-miR-519d-3p	PAR-CLIP	21572407
MIRT477195	hsa-miR-519d-3p	PAR-CLIP	20371350
MIRT477195	hsa-miR-519d-3p	PAR-CLIP	26701625
MIRT477196	hsa-miR-20b-5p	PAR-CLIP	23592263
MIRT477196	hsa-miR-20b-5p	PAR-CLIP	23446348
MIRT477196	hsa-miR-20b-5p	PAR-CLIP	21572407
MIRT477196	hsa-miR-20b-5p	PAR-CLIP	20371350
MIRT477196	hsa-miR-20b-5p	PAR-CLIP	26701625
MIRT477197	hsa-miR-526b-3p	PAR-CLIP	23592263
MIRT477197	hsa-miR-526b-3p	PAR-CLIP	23446348
MIRT477197	hsa-miR-526b-3p	PAR-CLIP	21572407
MIRT477197	hsa-miR-526b-3p	PAR-CLIP	20371350
MIRT477197	hsa-miR-526b-3p	PAR-CLIP	26701625
MIRT477198	hsa-miR-17-5p	PAR-CLIP	23592263
MIRT477198	hsa-miR-17-5p	PAR-CLIP	23446348
MIRT477198	hsa-miR-17-5p	PAR-CLIP	21572407
MIRT477198	hsa-miR-17-5p	PAR-CLIP	20371350
MIRT477198	hsa-miR-17-5p	PAR-CLIP	26701625
MIRT477199	hsa-miR-106a-5p	PAR-CLIP	23592263
MIRT477199	hsa-miR-106a-5p	PAR-CLIP	23446348
MIRT477199	hsa-miR-106a-5p	PAR-CLIP	21572407
MIRT477199	hsa-miR-106a-5p	PAR-CLIP	20371350
MIRT477199	hsa-miR-106a-5p	PAR-CLIP	26701625
MIRT763228	hsa-miR-18a-3p	PAR-CLIP	27292025
MIRT765650	hsa-miR-335-5p	PAR-CLIP	27292025
MIRT768400	hsa-miR-4290	PAR-CLIP	27292025
MIRT769193	hsa-miR-4453	PAR-CLIP	27292025
MIRT770229	hsa-miR-4538	PAR-CLIP	27292025
MIRT775102	hsa-miR-5695	PAR-CLIP	27292025

Transcription factors

Transcription factor	Regulation	Reference
EGR1	Unknown	10707957;8576248
JUN	Unknown	11057875
JUND	Unknown	11057875
NFKB1	Unknown	11057875;11157486;19167713;9867853
REL	Unknown	11057875
RELA	Unknown	11057875;11157486;19167713;9867853
SP1	Unknown	10707957;8576248

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001938	Process	Positive regulation of endothelial cell proliferation	IDA	17898544
GO:0002020	Function	Protease binding	IPI	3455766
GO:0002541	Process	Activation of plasma proteins involved in acute inflammatory response	IDA	17469850
GO:0002543	Process	Activation of blood coagulation via clotting cascade	IC	17469850
GO:0004252	Function	Serine-type endopeptidase activity	IDA	24998411
GO:0004896	Function	Cytokine receptor activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	8598903, 8940045, 9414278, 15522303, 15664864, 16959886, 20634491, 25241761, 32296183
GO:0005543	Function	Phospholipid binding	IDA	17469850
GO:0005615	Component	Extracellular space	IDA	19065458
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	TAS
GO:0006919	Process	Activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA	17898544
GO:0007596	Process	Blood coagulation	IDA	8632006, 24998411
GO:0007598	Process	Blood coagulation, extrinsic pathway	TAS
GO:0009986	Component	Cell surface	HDA	19581412
GO:0009986	Component	Cell surface	IDA	17898544
GO:0010628	Process	Positive regulation of gene expression	IMP	22556343
GO:0010641	Process	Positive regulation of platelet-derived growth factor receptor signaling pathway	IDA	17991872
GO:0016021	Component	Integral component of membrane	IBA	21873635
GO:0016485	Process	Protein processing	IDA	24998411
GO:0019221	Process	Cytokine-mediated signaling pathway	IBA	21873635
GO:0030335	Process	Positive regulation of cell migration	TAS	18612547
GO:0031233	Component	Intrinsic component of external side of plasma membrane	IC	17469850
GO:0032757	Process	Positive regulation of interleukin-8 production	IMP	22556343
GO:0045766	Process	Positive regulation of angiogenesis	IDA	17898544
GO:0050927	Process	Positive regulation of positive chemotaxis	IC	17991872
GO:0051897	Process	Positive regulation of protein kinase B signaling	IMP	18612547
GO:0062023	Component	Collagen-containing extracellular matrix	IDA	2704749
GO:1905286	Component	Serine-type peptidase complex	IPI	24998411

Other IDs

• MIM: 134390
• HGNC: 3541
• e!Ensembl: ENSG00000117525

Protein

• UniProt ID: P13726
• Protein name: Tissue factor (TF) (Coagulation factor III) (Thromboplastin) (CD antigen CD142)
• Protein function: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
• PDB: 1AHW, 1BOY, 1DAN, 1FAK, 1J9C, 1JPS, 1NL8, 1O5D, 1TFH, 1UJ3, 1W0Y, 1W2K, 1WQV, 1WSS, 1WTG, 1WUN, 1WV7, 1Z6J, 2A2Q, 2AEI, 2AER, 2B7D, 2B8O, 2C4F, 2CEF, 2CEH, 2CEZ, 2CFJ, 2EC9, 2F9B, 2FIR, 2FLB, 2FLR, 2HFT, 2PUQ, 2ZP0, 2ZWL, 2ZZU, 3ELA, 3TH2, 3TH3, 3TH4, 4IBL, 4M7L, 4YLQ, 4Z6A, 4ZMA, 5W06, 6R2W
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01108	Tissue_fac	17 → 118	Tissue factor	Family
  PF09294	Interfer-bind	138 → 245	Interferon-alpha/beta receptor, fibronectin type III	Domain

• Sequence:

  METPAWPRVPRPETAVARTLLLGWVFAQVAGASGTTNTVAAYNLTWKSTNFKTILEWEPK
  PVNQVYTVQISTKSGDWKSKCFYTTDTECDLTDEIVKDVKQTYLARVFSYPAGNVESTGS
  AGEPLYENSPEFTPYLETNLGQPTIQSFEQVGTKVNVTVEDERTLVRRNNTFLSLRDVFG
  KDLIYTLYYWKSSSSGKKTAKTNTNEFLIDVDKGENYCFSVQAVIPSRTVNRKSTDSPVE
  CMGQEKGEFREIFYIIGAVVFVVIILVIILAISLHKCRKAGVGQSWKENSPLNVS

• Sequence length: 295