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F3 (coagulation factor III, tissue factor)
Gene
Gene SNPs Transcription factors Other IDs
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2152
Gene nameGene Name - the full gene name approved by the HGNC.
Coagulation factor III, tissue factor
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
F3
SynonymsGene synonyms aliases
CD142, TF, TFA
ChromosomeChromosome number
1
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p21.3
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provi
miRNAmiRNA information provided by mirtarbase database.
Gene SNPs Transcription factors Other IDs
miRTarBase ID miRNA Experiments Reference
MIRT019927 hsa-miR-375 Microarray 20215506
MIRT020315 hsa-miR-130b-3p Sequencing 20371350
MIRT022817 hsa-miR-124-3p Microarray 18668037
MIRT028146 hsa-miR-93-5p Sequencing 20371350
MIRT029798 hsa-miR-26b-5p Microarray 19088304
Transcription factors
Gene SNPs Transcription factors Other IDs
Transcription factor Regulation Reference
EGR1 Unknown 10707957;8576248
JUN Unknown 11057875
JUND Unknown 11057875
NFKB1 Unknown 11057875;11157486;19167713;9867853
REL Unknown 11057875
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs Transcription factors Other IDs
GO ID Ontology Definition Evidence Reference
GO:0001938 Process Positive regulation of endothelial cell proliferation IDA 17898544
GO:0002020 Function Protease binding IPI 3455766
GO:0002541 Process Activation of plasma proteins involved in acute inflammatory response IDA 17469850
GO:0002543 Process Activation of blood coagulation via clotting cascade IC 17469850
GO:0004252 Function Serine-type endopeptidase activity IDA 24998411
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs Transcription factors Other IDs
MIM
HGNC
e!Ensembl
Protein
Gene SNPs Transcription factors Other IDs
UniProt ID P13726
Protein name Tissue factor (TF) (Coagulation factor III) (Thromboplastin) (CD antigen CD142)
Protein function Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly a
PDB 1AHW , 1BOY , 1DAN , 1FAK , 1J9C , 1JPS , 1O5D , 1TFH , 1UJ3 , 1W0Y , 1W2K , 1WQV , 1WSS , 1WTG , 1WUN , 1WV7 , 1Z6J , 2A2Q , 2AEI , 2AER , 2B7D , 2B8O , 2C4F , 2CEF , 2CEH , 2CEZ , 2CFJ , 2EC9 , 2F9B , 2FIR , 2FLB , 2FLR , 2HFT , 2PUQ , 2ZP0 , 2ZWL , 2ZZU , 3ELA , 3TH2 , 3TH3 , 3TH4 , 4IBL , 4M7L , 4YLQ , 4Z6A , 4ZMA , 5W06 , 6R2W , 6Z9W , 8CN9 , 8QOD
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01108 Tissue_fac
17 → 118
Tissue factor
 Family
PF09294 Interfer-bind
138 → 245
Interferon-alpha/beta receptor, fibronectin type III
 Domain
Sequence
Sequence length 295
Interactions View interactions

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