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EIF4EBP1 (eukaryotic translation initiation factor 4E binding protein 1)
Gene
Gene SNPs Other IDs
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1978
Gene nameGene Name - the full gene name approved by the HGNC.
Eukaryotic translation initiation factor 4E binding protein 1
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
EIF4EBP1
SynonymsGene synonyms aliases
4E-BP1, 4EBP1, BP-1, PHAS-I
ChromosomeChromosome number
8
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8p11.23
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5` end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]
miRNAmiRNA information provided by mirtarbase database.
Gene SNPs Other IDs
miRTarBase ID miRNA Experiments Reference
MIRT000347 hsa-miR-125b-5p Microarray, qRT-PCR 17891175
MIRT000347 hsa-miR-125b-5p Immunoblot, Immunohistochemistry, In situ hybridization, Luciferase reporter assay, Microarray, qRT-PCR 22071331
MIRT000347 hsa-miR-125b-5p Luciferase reporter assay, qRT-PCR, Western blot 26646586
MIRT021307 hsa-miR-125a-5p Sequencing 20371350
MIRT021307 hsa-miR-125a-5p Luciferase reporter assay, qRT-PCR, Western blot 26646586
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs Other IDs
GO ID Ontology Definition Evidence Reference
GO:0000082 Process G1/S transition of mitotic cell cycle IMP 14673156
GO:0002931 Process Response to ischemia IEA
GO:0005515 Function Protein binding IPI 7651417, 10772338, 12150925, 12150926, 15153109, 16189514, 16271312, 16504179, 17368478, 18337751, 18955708, 19834456, 20224576, 20671708, 20880835, 21191102, 22678294, 24211447, 24722188, 24981860, 25416956, 28514442, 32296183
GO:0005634 Component Nucleus IEA
GO:0005737 Component Cytoplasm IBA 21873635
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs Other IDs
MIM
HGNC
e!Ensembl
Protein
Gene SNPs Other IDs
UniProt ID Q13541
Protein name Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I)
Protein function Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
PDB 1EJ4 , 1EJH , 1WKW , 2JGB , 2JGC , 2V8W , 2V8X , 2V8Y , 3HXG , 3HXI , 3M93 , 3M94 , 3U7X , 4UED , 5BXV , 5EKV , 5NVN , 5WBJ , 6BCU , 6BCX
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05456 eIF_4EBP
1 → 118
Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)
 Family
Sequence
Sequence length 118
Interactions View interactions

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