EIF4EBP1 (eukaryotic translation initiation factor 4E binding protein 1)

Gene

• Entrez ID: 1978
• Gene name: Eukaryotic translation initiation factor 4E binding protein 1
• Gene symbol: EIF4EBP1
• Synonyms: 4E-BP1, 4EBP1, BP-1, PHAS-I
• Chromosome: 8
• Chromosome location: 8p11.23
• Summary: This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subu

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT000347	hsa-miR-125b-5p	Microarray, qRT-PCR	17891175
MIRT021307	hsa-miR-125a-5p	Sequencing	20371350
MIRT022876	hsa-miR-124-3p	Microarray	18668037
MIRT000347	hsa-miR-125b-5p	Immunoblot, Immunohistochemistry, In situ hybridization, Luciferase reporter assay, Microarray, qRT-PCR	22071331
MIRT682577	hsa-miR-508-5p	HITS-CLIP	23706177
MIRT682576	hsa-miR-25-3p	HITS-CLIP	23706177
MIRT682575	hsa-miR-32-5p	HITS-CLIP	23706177
MIRT682574	hsa-miR-363-3p	HITS-CLIP	23706177
MIRT682573	hsa-miR-367-3p	HITS-CLIP	23706177
MIRT682572	hsa-miR-92a-3p	HITS-CLIP	23706177
MIRT682571	hsa-miR-92b-3p	HITS-CLIP	23706177
MIRT682570	hsa-miR-6849-3p	HITS-CLIP	23706177
MIRT682569	hsa-miR-939-3p	HITS-CLIP	23706177
MIRT682568	hsa-miR-766-3p	HITS-CLIP	23706177
MIRT682567	hsa-miR-661	HITS-CLIP	23706177
MIRT682566	hsa-miR-4640-5p	HITS-CLIP	23706177
MIRT682565	hsa-miR-4726-5p	HITS-CLIP	23706177
MIRT682564	hsa-miR-6508-3p	HITS-CLIP	23706177
MIRT682563	hsa-miR-6512-3p	HITS-CLIP	23706177
MIRT682562	hsa-miR-6720-5p	HITS-CLIP	23706177
MIRT682561	hsa-miR-7703	HITS-CLIP	23706177
MIRT682560	hsa-miR-4325	HITS-CLIP	23706177
MIRT615742	hsa-miR-4677-3p	HITS-CLIP	23824327
MIRT615741	hsa-miR-4679	HITS-CLIP	23824327
MIRT624047	hsa-miR-5186	HITS-CLIP	23824327
MIRT615740	hsa-miR-5702	HITS-CLIP	23824327
MIRT615739	hsa-miR-937-5p	HITS-CLIP	23824327
MIRT615738	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT615737	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT615742	hsa-miR-4677-3p	HITS-CLIP	23824327
MIRT615741	hsa-miR-4679	HITS-CLIP	23824327
MIRT624047	hsa-miR-5186	HITS-CLIP	23824327
MIRT615740	hsa-miR-5702	HITS-CLIP	23824327
MIRT615739	hsa-miR-937-5p	HITS-CLIP	23824327
MIRT615738	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT615737	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT615742	hsa-miR-4677-3p	HITS-CLIP	23824327
MIRT615741	hsa-miR-4679	HITS-CLIP	23824327
MIRT624047	hsa-miR-5186	HITS-CLIP	23824327
MIRT615740	hsa-miR-5702	HITS-CLIP	23824327
MIRT615739	hsa-miR-937-5p	HITS-CLIP	23824327
MIRT615738	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT615737	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT615742	hsa-miR-4677-3p	HITS-CLIP	23824327
MIRT615741	hsa-miR-4679	HITS-CLIP	23824327
MIRT615740	hsa-miR-5702	HITS-CLIP	23824327
MIRT615739	hsa-miR-937-5p	HITS-CLIP	23824327
MIRT615738	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT615737	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT363750	hsa-miR-3173-3p	PAR-CLIP	20371350
MIRT363764	hsa-miR-6891-5p	PAR-CLIP	20371350
MIRT363762	hsa-miR-5582-5p	PAR-CLIP	20371350
MIRT567683	hsa-miR-5094	PAR-CLIP	20371350
MIRT363759	hsa-miR-4686	PAR-CLIP	20371350
MIRT363756	hsa-miR-4457	PAR-CLIP	20371350
MIRT567682	hsa-miR-5693	PAR-CLIP	20371350
MIRT567681	hsa-miR-194-3p	PAR-CLIP	20371350
MIRT363767	hsa-miR-93-3p	PAR-CLIP	20371350
MIRT363753	hsa-miR-3692-5p	PAR-CLIP	20371350
MIRT363747	hsa-miR-202-3p	PAR-CLIP	20371350
MIRT567680	hsa-miR-7112-3p	PAR-CLIP	20371350
MIRT567679	hsa-miR-4711-5p	PAR-CLIP	20371350
MIRT363752	hsa-miR-3612	PAR-CLIP	20371350
MIRT363748	hsa-miR-650	PAR-CLIP	20371350
MIRT363765	hsa-miR-7847-3p	PAR-CLIP	20371350
MIRT363763	hsa-miR-6071	PAR-CLIP	20371350
MIRT363754	hsa-miR-4443	PAR-CLIP	20371350
MIRT477545	hsa-miR-6165	PAR-CLIP	23592263
MIRT477544	hsa-miR-4459	PAR-CLIP	23592263
MIRT477543	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT477542	hsa-miR-6894-5p	PAR-CLIP	23592263
MIRT477541	hsa-miR-1273e	PAR-CLIP	23592263
MIRT363746	hsa-miR-138-5p	Luciferase reporter assay	26891291
MIRT363746	hsa-miR-138-5p	Luciferase reporter assay, qRT-PCR	28075468
MIRT363746	hsa-miR-138-5p	Luciferase reporter assay, qRT-PCR	28075468
MIRT021307	hsa-miR-125a-5p	Luciferase reporter assay, qRT-PCR, Western blot	26646586
MIRT021307	hsa-miR-125a-5p	Luciferase reporter assay, qRT-PCR, Western blot	26646586
MIRT000347	hsa-miR-125b-5p	Luciferase reporter assay, qRT-PCR, Western blot	26646586
MIRT000347	hsa-miR-125b-5p	Luciferase reporter assay, qRT-PCR, Western blot	26646586
MIRT682577	hsa-miR-508-5p	HITS-CLIP	23706177
MIRT682576	hsa-miR-25-3p	HITS-CLIP	23706177
MIRT682575	hsa-miR-32-5p	HITS-CLIP	23706177
MIRT682574	hsa-miR-363-3p	HITS-CLIP	23706177
MIRT682573	hsa-miR-367-3p	HITS-CLIP	23706177
MIRT682572	hsa-miR-92a-3p	HITS-CLIP	23706177
MIRT682571	hsa-miR-92b-3p	HITS-CLIP	23706177
MIRT682570	hsa-miR-6849-3p	HITS-CLIP	23706177
MIRT682569	hsa-miR-939-3p	HITS-CLIP	23706177
MIRT682568	hsa-miR-766-3p	HITS-CLIP	23706177
MIRT682567	hsa-miR-661	HITS-CLIP	23706177
MIRT682566	hsa-miR-4640-5p	HITS-CLIP	23706177
MIRT682565	hsa-miR-4726-5p	HITS-CLIP	23706177
MIRT682564	hsa-miR-6508-3p	HITS-CLIP	23706177
MIRT682563	hsa-miR-6512-3p	HITS-CLIP	23706177
MIRT682562	hsa-miR-6720-5p	HITS-CLIP	23706177
MIRT682561	hsa-miR-7703	HITS-CLIP	23706177
MIRT682560	hsa-miR-4325	HITS-CLIP	23706177
MIRT615742	hsa-miR-4677-3p	HITS-CLIP	23824327
MIRT615741	hsa-miR-4679	HITS-CLIP	23824327
MIRT624047	hsa-miR-5186	HITS-CLIP	23824327
MIRT615740	hsa-miR-5702	HITS-CLIP	23824327
MIRT615739	hsa-miR-937-5p	HITS-CLIP	23824327
MIRT615738	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT615737	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT615742	hsa-miR-4677-3p	HITS-CLIP	23824327
MIRT615741	hsa-miR-4679	HITS-CLIP	23824327
MIRT624047	hsa-miR-5186	HITS-CLIP	23824327
MIRT615740	hsa-miR-5702	HITS-CLIP	23824327
MIRT615739	hsa-miR-937-5p	HITS-CLIP	23824327
MIRT615738	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT615737	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT615742	hsa-miR-4677-3p	HITS-CLIP	23824327
MIRT615741	hsa-miR-4679	HITS-CLIP	23824327
MIRT624047	hsa-miR-5186	HITS-CLIP	23824327
MIRT615740	hsa-miR-5702	HITS-CLIP	23824327
MIRT615739	hsa-miR-937-5p	HITS-CLIP	23824327
MIRT615738	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT615737	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT615742	hsa-miR-4677-3p	HITS-CLIP	23824327
MIRT615741	hsa-miR-4679	HITS-CLIP	23824327
MIRT615740	hsa-miR-5702	HITS-CLIP	23824327
MIRT615739	hsa-miR-937-5p	HITS-CLIP	23824327
MIRT615738	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT615737	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT363750	hsa-miR-3173-3p	PAR-CLIP	20371350
MIRT363764	hsa-miR-6891-5p	PAR-CLIP	20371350
MIRT363762	hsa-miR-5582-5p	PAR-CLIP	20371350
MIRT567683	hsa-miR-5094	PAR-CLIP	20371350
MIRT363759	hsa-miR-4686	PAR-CLIP	20371350
MIRT363756	hsa-miR-4457	PAR-CLIP	20371350
MIRT567682	hsa-miR-5693	PAR-CLIP	20371350
MIRT567681	hsa-miR-194-3p	PAR-CLIP	20371350
MIRT363767	hsa-miR-93-3p	PAR-CLIP	20371350
MIRT363753	hsa-miR-3692-5p	PAR-CLIP	20371350
MIRT363747	hsa-miR-202-3p	PAR-CLIP	20371350
MIRT567680	hsa-miR-7112-3p	PAR-CLIP	20371350
MIRT567679	hsa-miR-4711-5p	PAR-CLIP	20371350
MIRT363752	hsa-miR-3612	PAR-CLIP	20371350
MIRT363748	hsa-miR-650	PAR-CLIP	20371350
MIRT363765	hsa-miR-7847-3p	PAR-CLIP	20371350
MIRT363763	hsa-miR-6071	PAR-CLIP	20371350
MIRT363754	hsa-miR-4443	PAR-CLIP	20371350
MIRT477545	hsa-miR-6165	PAR-CLIP	23592263
MIRT477544	hsa-miR-4459	PAR-CLIP	23592263
MIRT477543	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT477542	hsa-miR-6894-5p	PAR-CLIP	23592263
MIRT477541	hsa-miR-1273e	PAR-CLIP	23592263
MIRT958333	hsa-miR-1207-5p	CLIP-seq
MIRT958334	hsa-miR-1252	CLIP-seq
MIRT958335	hsa-miR-1291	CLIP-seq
MIRT958336	hsa-miR-1298	CLIP-seq
MIRT958337	hsa-miR-1343	CLIP-seq
MIRT958338	hsa-miR-1909	CLIP-seq
MIRT958339	hsa-miR-1976	CLIP-seq
MIRT958340	hsa-miR-202	CLIP-seq
MIRT958341	hsa-miR-3127-3p	CLIP-seq
MIRT958342	hsa-miR-3170	CLIP-seq
MIRT958343	hsa-miR-3189-3p	CLIP-seq
MIRT958344	hsa-miR-3202	CLIP-seq
MIRT958345	hsa-miR-328	CLIP-seq
MIRT958346	hsa-miR-342-5p	CLIP-seq
MIRT958347	hsa-miR-3655	CLIP-seq
MIRT958348	hsa-miR-4436b-5p	CLIP-seq
MIRT958349	hsa-miR-4476	CLIP-seq
MIRT958350	hsa-miR-4533	CLIP-seq
MIRT958351	hsa-miR-4651	CLIP-seq
MIRT958352	hsa-miR-4660	CLIP-seq
MIRT958353	hsa-miR-4664-5p	CLIP-seq
MIRT958354	hsa-miR-4736	CLIP-seq
MIRT958355	hsa-miR-4763-3p	CLIP-seq
MIRT958356	hsa-miR-483-3p	CLIP-seq
MIRT958357	hsa-miR-578	CLIP-seq
MIRT958358	hsa-miR-608	CLIP-seq
MIRT958359	hsa-miR-668	CLIP-seq
MIRT958360	hsa-miR-885-3p	CLIP-seq
MIRT1548270	hsa-miR-138	CLIP-seq
MIRT1548271	hsa-miR-4694-5p	CLIP-seq
MIRT1548272	hsa-miR-4779	CLIP-seq
MIRT958336	hsa-miR-1298	CLIP-seq
MIRT1556274	hsa-miR-3652	CLIP-seq
MIRT1556275	hsa-miR-4430	CLIP-seq
MIRT1556276	hsa-miR-4492	CLIP-seq
MIRT1556277	hsa-miR-4498	CLIP-seq
MIRT1556278	hsa-miR-762	CLIP-seq
MIRT2219132	hsa-miR-1238	CLIP-seq
MIRT1548270	hsa-miR-138	CLIP-seq
MIRT2219133	hsa-miR-2110	CLIP-seq
MIRT2219134	hsa-miR-3150a-3p	CLIP-seq
MIRT2219135	hsa-miR-3183	CLIP-seq
MIRT958346	hsa-miR-342-5p	CLIP-seq
MIRT2219136	hsa-miR-3665	CLIP-seq
MIRT2219137	hsa-miR-4271	CLIP-seq
MIRT2219138	hsa-miR-4419a	CLIP-seq
MIRT2219139	hsa-miR-4510	CLIP-seq
MIRT958350	hsa-miR-4533	CLIP-seq
MIRT958351	hsa-miR-4651	CLIP-seq
MIRT958353	hsa-miR-4664-5p	CLIP-seq
MIRT1548271	hsa-miR-4694-5p	CLIP-seq
MIRT2219140	hsa-miR-4716-3p	CLIP-seq
MIRT2219141	hsa-miR-4723-3p	CLIP-seq
MIRT2219142	hsa-miR-4723-5p	CLIP-seq
MIRT2219143	hsa-miR-4725-3p	CLIP-seq
MIRT2219144	hsa-miR-4728-5p	CLIP-seq
MIRT958354	hsa-miR-4736	CLIP-seq
MIRT2219145	hsa-miR-4747-5p	CLIP-seq
MIRT1548272	hsa-miR-4779	CLIP-seq
MIRT2219146	hsa-miR-486-3p	CLIP-seq
MIRT958358	hsa-miR-608	CLIP-seq
MIRT2219147	hsa-miR-635	CLIP-seq
MIRT2219148	hsa-miR-764	CLIP-seq
MIRT958339	hsa-miR-1976	CLIP-seq
MIRT958340	hsa-miR-202	CLIP-seq
MIRT958352	hsa-miR-4660	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000082	Process	G1/S transition of mitotic cell cycle	IMP	14673156
GO:0002931	Process	Response to ischemia	IEA
GO:0005515	Function	Protein binding	IPI	7651417, 10772338, 12150925, 12150926, 15153109, 16189514, 16271312, 16504179, 17368478, 18337751, 18955708, 19834456, 20224576, 20671708, 20880835, 21191102, 22678294, 24211447, 24722188, 24981860, 25416956, 28514442, 32296183
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005829	Component	Cytosol	IDA	23814182
GO:0005829	Component	Cytosol	TAS
GO:0008190	Function	Eukaryotic initiation factor 4E binding	IBA	21873635
GO:0008190	Function	Eukaryotic initiation factor 4E binding	IDA	23814182
GO:0030324	Process	Lung development	IEA
GO:0030371	Function	Translation repressor activity	IDA	22578813
GO:0031333	Process	Negative regulation of protein-containing complex assembly	IEA
GO:0031929	Process	TOR signaling	IDA	12150926, 22578813
GO:0032991	Component	Protein-containing complex	IEA
GO:0045471	Process	Response to ethanol	IEA
GO:0045931	Process	Positive regulation of mitotic cell cycle	IMP	14673156
GO:0045947	Process	Negative regulation of translational initiation	IBA	21873635
GO:0045947	Process	Negative regulation of translational initiation	IDA	22578813
GO:0051721	Function	Protein phosphatase 2A binding	IEA
GO:0071456	Process	Cellular response to hypoxia	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099524	Component	Postsynaptic cytosol	IEA
GO:1990928	Process	Response to amino acid starvation	IEA

Other IDs

• MIM: 602223
• HGNC: 3288
• e!Ensembl: ENSG00000187840

Protein

• UniProt ID: Q13541
• Protein name: Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I)
• Protein function: Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hy
• PDB: 1EJ4, 1EJH, 1WKW, 2JGB, 2JGC, 2V8W, 2V8X, 2V8Y, 3HXG, 3HXI, 3M93, 3M94, 3U7X, 4UED, 5BXV, 5EKV, 5NVN, 5WBJ, 6BCU, 6BCX, 8RCH, 8RCK, 8RCN
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05456	eIF_4EBP	1 → 118	Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)	Family

• Sequence:

  MSGGSSCSQTPSRAIPATRRVVLGDGVQLPPGDYSTTPGGTLFSTTPGGTRIIYDRKFLM
  ECRNSPVTKTPPRDLPTIPGVTSPSSDEPPMEASQSHLRNSPEDKRAGGEESQFEMDI

• Sequence length: 118