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EIF2S3 (eukaryotic translation initiation factor 2 subunit gamma)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1968
Gene nameGene Name - the full gene name approved by the HGNC.
Eukaryotic translation initiation factor 2 subunit gamma
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
EIF2S3
SynonymsGene synonyms aliases
EIF2, EIF2G, EIF2gamma, MEHMO, MRXSBRK, eIF-2gA, eIF2gX
ChromosomeChromosome number
X
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
Xp22.11
SummarySummary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is the largest subunit of a heterotrimeric GTP-binding protein involved in the recruitment of methionyl-tRNA(i) to the 40 S ribosomal subunit. [provided by RefSeq, Jan 2010]
SNPsSNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs751468976 C>A,T Likely-pathogenic Missense variant, coding sequence variant
rs886040855 T>C Pathogenic Missense variant, coding sequence variant
rs886040856 T>G Pathogenic Missense variant, coding sequence variant
rs886040857 TCAA>- Likely-pathogenic, pathogenic Frameshift variant, coding sequence variant
rs1602041478 A>G Likely-pathogenic Coding sequence variant, missense variant
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT025848 hsa-miR-7-5p Microarray 19073608
MIRT027622 hsa-miR-98-5p Microarray 19088304
MIRT030483 hsa-miR-24-3p Microarray 19748357
MIRT049409 hsa-miR-92a-3p CLASH 23622248
MIRT048212 hsa-miR-196a-5p CLASH 23622248
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000049 Function TRNA binding IBA 21873635
GO:0001731 Process Formation of translation preinitiation complex IBA 21873635
GO:0003743 Function Translation initiation factor activity IBA 21873635
GO:0003743 Function Translation initiation factor activity IDA 10900014, 16289705
GO:0003924 Function GTPase activity IEA
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P41091
Protein name Eukaryotic translation initiation factor 2 subunit 3 (EC 3.6.5.3) (Eukaryotic translation initiation factor 2 subunit gamma X) (eIF2-gamma X) (eIF2gX)
Protein function Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:31836389). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S
PDB 6FEC , 6K71 , 6K72 , 6O81 , 6O85 , 6YBV , 6ZMW , 6ZP4 , 7A09 , 7D43 , 7F66 , 7F67 , 7QP6 , 7QP7 , 8OZ0 , 8PHD , 8PHV , 8PJ1 , 8PJ2 , 8PJ3 , 8PJ4 , 8PPL , 8QZZ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00009 GTP_EFTU
39 245
Elongation factor Tu GTP binding domain
Domain
PF03144 GTP_EFTU_D2
276 359
Elongation factor Tu domain 2
Domain
PF09173 eIF2_C
369 459
Initiation factor eIF2 gamma, C terminal
Domain
Sequence
Sequence length 472
Interactions View interactions

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