EGFR (epidermal growth factor receptor)
|
Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
1956 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Epidermal growth factor receptor |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
EGFR |
SynonymsGene synonyms aliases
|
ERBB, ERBB1, ERRP, HER1, NISBD2, NNCIS, PIG61, mENA |
ChromosomeChromosome number
|
7 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
7p11.2 |
SummarySummary of gene provided in NCBI Entrez Gene.
|
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growt |
SNPsSNP information provided by dbSNP.
|
SNP ID |
Visualize variation |
Clinical significance |
Consequence |
rs28929495 |
G>A,C,T |
Pathogenic, likely-pathogenic, not-provided, drug-response |
Missense variant, genic downstream transcript variant, coding sequence variant |
rs121434568 |
T>A,G |
Drug-response, pathogenic, likely-pathogenic |
Genic downstream transcript variant, missense variant, coding sequence variant |
rs121913229 |
G>C |
Uncertain-significance, likely-pathogenic |
Genic downstream transcript variant, missense variant, coding sequence variant |
rs121913231 |
C>T |
Likely-pathogenic |
Genic downstream transcript variant, missense variant, coding sequence variant |
rs121913418 |
G>A,T |
Uncertain-significance, likely-pathogenic |
Genic downstream transcript variant, missense variant, coding sequence variant |
rs121913420 |
G>A |
Likely-pathogenic |
Genic downstream transcript variant, missense variant, coding sequence variant |
rs121913421 |
GGAATTAAGAGAAGC>- |
Drug-response |
Genic downstream transcript variant, inframe deletion, coding sequence variant |
rs121913422 |
AATTAAGAGAAGCAACAT>- |
Drug-response |
Genic downstream transcript variant, inframe indel, coding sequence variant |
rs121913424 |
AATTAAGAGAAGCAACATCT>TC |
Drug-response |
Genic downstream transcript variant, inframe indel, coding sequence variant |
rs121913425 |
AATTAAGAGAAGCAA>- |
Drug-response |
Genic downstream transcript variant, inframe indel, coding sequence variant |
rs121913427 |
G>A,C |
Not-provided, likely-pathogenic |
Genic downstream transcript variant, missense variant, coding sequence variant |
rs121913428 |
G>A,C |
Pathogenic, likely-pathogenic |
Genic downstream transcript variant, missense variant, coding sequence variant |
rs121913430 |
G>A |
Likely-pathogenic |
Genic downstream transcript variant, missense variant, coding sequence variant |
rs121913433 |
A>G |
Likely-pathogenic |
Genic downstream transcript variant, missense variant, coding sequence variant |
rs121913434 |
C>G,T |
Drug-response |
Genic downstream transcript variant, missense variant, coding sequence variant |
rs121913435 |
ATTAAGAGAAG>GC |
Drug-response |
Genic downstream transcript variant, inframe indel, coding sequence variant |
rs121913436 |
TTAAGAGAA>- |
Drug-response |
Genic downstream transcript variant, inframe deletion, coding sequence variant |
rs121913438 |
TAAGAGAAGCAACATCTC>- |
Drug-response |
Genic downstream transcript variant, inframe indel, coding sequence variant |
rs121913440 |
TTAAGAGAAGCAACATCT>- |
Drug-response |
Genic downstream transcript variant, inframe deletion, coding sequence variant |
rs121913442 |
TAAGAGAAGCAACAT>- |
Drug-response |
Genic downstream transcript variant, inframe deletion, coding sequence variant |
rs121913443 |
C>A,T |
Likely-benign, uncertain-significance, likely-pathogenic |
Genic downstream transcript variant, synonymous variant, missense variant, coding sequence variant |
rs121913444 |
T>A,C,G |
Uncertain-significance, drug-response, pathogenic, likely-pathogenic |
Genic downstream transcript variant, missense variant, coding sequence variant |
rs121913446 |
C>T |
Likely-pathogenic |
Genic downstream transcript variant, missense variant, coding sequence variant |
rs121913463 |
TCTCCGAAAGCCAACAAGGAAATC>- |
Drug-response |
Genic downstream transcript variant, inframe deletion, coding sequence variant |
rs121913464 |
C>A |
Likely-pathogenic |
Genic downstream transcript variant, missense variant, coding sequence variant |
rs121913466 |
T>C |
Likely-pathogenic |
Genic downstream transcript variant, missense variant, coding sequence variant |
rs121913467 |
G>A |
Likely-pathogenic |
Genic downstream transcript variant, coding sequence variant, stop gained |
rs139236063 |
G>C,T |
Likely-pathogenic |
Genic downstream transcript variant, missense variant, coding sequence variant |
rs139429793 |
G>A |
Pathogenic |
Missense variant, coding sequence variant |
rs146795390 |
G>A |
Likely-pathogenic |
Genic downstream transcript variant, coding sequence variant, missense variant |
rs149840192 |
C>A,T |
Likely-pathogenic |
Coding sequence variant, intron variant, missense variant |
rs150036236 |
G>A |
Pathogenic |
Coding sequence variant, missense variant, genic downstream transcript variant |
rs397509368 |
TTAAGAGAAGCAA>C |
Drug-response |
Genic downstream transcript variant, coding sequence variant, inframe indel |
rs397517085 |
A>C,G,T |
Drug-response, uncertain-significance |
Missense variant, genic downstream transcript variant, coding sequence variant |
rs397517086 |
AAC>- |
Pathogenic |
Genic downstream transcript variant, coding sequence variant, inframe indel |
rs397517094 |
CAAGGAATTAAGAGAAGC>AAA |
Likely-pathogenic |
Genic downstream transcript variant, inframe deletion, coding sequence variant |
rs397517097 |
T>C |
Likely-pathogenic, uncertain-significance |
Missense variant, genic downstream transcript variant, coding sequence variant |
rs397517098 |
TAAGAGAAG>- |
Likely-pathogenic |
Genic downstream transcript variant, coding sequence variant, inframe indel |
rs397517127 |
G>C,T |
Pathogenic, uncertain-significance |
Missense variant, genic downstream transcript variant, coding sequence variant |
rs483352805 |
G>A |
Drug-response |
Genic downstream transcript variant, missense variant, coding sequence variant |
rs483352808 |
G>A |
Drug-response |
Genic downstream transcript variant, missense variant, coding sequence variant |
rs606231253 |
G>A |
Pathogenic |
Coding sequence variant, missense variant, genic downstream transcript variant |
rs727503014 |
ATCAAGGAATTAAGAGAAGC>GTCAA |
Drug-response |
Coding sequence variant, inframe indel, genic downstream transcript variant |
rs727503015 |
AATTAAGAGAAG>CAC,CCC |
Drug-response |
Coding sequence variant, inframe indel, genic downstream transcript variant |
rs727503016 |
AATTAAGAGAAGCAA>TTC |
Drug-response |
Coding sequence variant, inframe indel, genic downstream transcript variant |
rs727504232 |
ATCTCCGAAAGCCAACAAGGAAAT>- |
Drug-response |
Coding sequence variant, genic downstream transcript variant, inframe deletion |
rs727504233 |
GAATTAAGAGAAGCA>- |
Drug-response |
Coding sequence variant, genic downstream transcript variant, inframe deletion |
rs727504256 |
G>A |
Drug-response |
Coding sequence variant, missense variant, genic downstream transcript variant |
rs727504257 |
ATTAAGAGAAGCAA>GC |
Drug-response |
Coding sequence variant, inframe indel, genic downstream transcript variant |
rs727504258 |
AATTAAGAGAAGCAACATC>T |
Drug-response |
Coding sequence variant, inframe indel, genic downstream transcript variant |
rs727504266 |
GGAATTAAG>- |
Drug-response |
Coding sequence variant, genic downstream transcript variant, inframe deletion |
rs727504278 |
TTAAGAGAAG>C |
Drug-response |
Coding sequence variant, inframe indel, genic downstream transcript variant |
rs727504281 |
GGAATTAAGAGAAG>AATTC |
Drug-response |
Coding sequence variant, inframe indel, genic downstream transcript variant |
rs727504282 |
AATTAAGAGAAGCAACATCTC>TCT |
Drug-response |
Coding sequence variant, inframe indel, genic downstream transcript variant |
rs727504316 |
C>T |
Drug-response |
Coding sequence variant, missense variant, genic downstream transcript variant |
rs727504324 |
CAAGGAATTAAGAGAAGCA>- |
Drug-response |
Coding sequence variant, frameshift variant, genic downstream transcript variant |
rs727504326 |
->AAAATTCCCGTCGCTA |
Drug-response |
Coding sequence variant, frameshift variant, genic downstream transcript variant |
rs727504332 |
GGAATTAAGAGAAGCAA>AATTC |
Drug-response |
Coding sequence variant, inframe indel, genic downstream transcript variant |
rs727504339 |
TTAAGAGAAGCAACATCTC>A,CAAT |
Drug-response |
Coding sequence variant, inframe indel, genic downstream transcript variant |
rs727504395 |
ACATCTCCGAAAGCCAACAAGGAAATC>GAT |
Drug-response |
Coding sequence variant, inframe indel, genic downstream transcript variant |
rs727504402 |
GAATTAAGAGAAGCAAC>AT |
Drug-response |
Coding sequence variant, inframe indel, genic downstream transcript variant |
rs727504414 |
TTAAGAGAAGCAACATCTCCGAAAGC>ACGAGAGA |
Drug-response |
Coding sequence variant, inframe indel, genic downstream transcript variant |
rs727504428 |
CAAGGAATTAAGAGAAGCAAC>AAAGTT |
Drug-response |
Coding sequence variant, inframe indel, genic downstream transcript variant |
rs727504444 |
AATTAAGAGA>C |
Drug-response |
Coding sequence variant, inframe indel, genic downstream transcript variant |
rs769696078 |
G>A |
Likely-pathogenic |
Coding sequence variant, intron variant, missense variant |
rs886037891 |
G>T |
Pathogenic |
Missense variant, coding sequence variant |
rs909905659 |
G>A,T |
Likely-pathogenic |
Genic downstream transcript variant, missense variant, stop gained, coding sequence variant, intron variant |
rs1057519760 |
A>G |
Likely-pathogenic |
Missense variant, genic downstream transcript variant, coding sequence variant |
rs1057519794 |
G>A |
Likely-pathogenic |
Missense variant, genic downstream transcript variant, coding sequence variant |
rs1057519828 |
G>A |
Likely-pathogenic |
Missense variant, coding sequence variant, intron variant |
rs1057519829 |
A>C,G |
Likely-pathogenic |
Missense variant, coding sequence variant, intron variant |
rs1057519830 |
C>T |
Likely-pathogenic |
Missense variant, genic downstream transcript variant, coding sequence variant |
rs1057519848 |
TG>GT |
Likely-pathogenic |
Missense variant, genic downstream transcript variant, coding sequence variant |
rs1057519887 |
GC>AA,AT |
Likely-pathogenic |
Missense variant, coding sequence variant, intron variant |
rs1057519888 |
A>G |
Likely-pathogenic |
Missense variant, coding sequence variant, intron variant |
rs1057520037 |
G>C |
Likely-pathogenic |
Missense variant, genic downstream transcript variant, coding sequence variant |
|
miRNAmiRNA information provided by mirtarbase database.
|
miRTarBase ID |
miRNA |
Experiments |
Reference |
MIRT002289 |
hsa-miR-7-5p |
real-time RT-PCR, Reporter assay, Western blot |
18483236 |
MIRT002289 |
hsa-miR-7-5p |
Luciferase reporter assay |
18483236 |
MIRT002289 |
hsa-miR-7-5p |
Luciferase reporter assay |
18483236 |
MIRT002289 |
hsa-miR-7-5p |
Luciferase reporter assay |
18483236 |
MIRT002289 |
hsa-miR-7-5p |
Western blot |
18483236 |
MIRT006585 |
hsa-miR-128-3p |
Luciferase reporter assay |
18304967 |
MIRT002289 |
hsa-miR-7-5p |
Luciferase reporter assay |
19033458 |
MIRT002289 |
hsa-miR-7-5p |
Luciferase reporter assay |
19029026 |
MIRT002289 |
hsa-miR-7-5p |
Luciferase reporter assay |
18483236 |
MIRT006585 |
hsa-miR-128-3p |
Review |
20130964 |
MIRT003325 |
hsa-miR-145-5p |
Review |
20026422 |
MIRT004730 |
hsa-miR-146a-5p |
qRT-PCR, Western blot |
20124483 |
MIRT001470 |
hsa-miR-16-5p |
pSILAC |
18668040 |
MIRT001370 |
hsa-miR-1-3p |
pSILAC |
18668040 |
MIRT002289 |
hsa-miR-7-5p |
Luciferase reporter assay, qRT-PCR, Western blot |
19073608 |
MIRT002289 |
hsa-miR-7-5p |
Luciferase reporter assay, qRT-PCR, Western blot |
19073608 |
MIRT002289 |
hsa-miR-7-5p |
Luciferase reporter assay, qRT-PCR, Western blot |
19073608 |
MIRT002289 |
hsa-miR-7-5p |
Luciferase reporter assay, qRT-PCR, Western blot |
19073608 |
MIRT002289 |
hsa-miR-7-5p |
Luciferase reporter assay, qRT-PCR, Western blot |
19073608 |
MIRT002289 |
hsa-miR-7-5p |
Luciferase reporter assay, qRT-PCR, Western blot |
19073608 |
MIRT005807 |
hsa-miR-21-5p |
Luciferase reporter assay, Microarray, Western blot |
20864407 |
MIRT002289 |
hsa-miR-7-5p |
Luciferase reporter assay, Microarray, Western blot |
20864407 |
MIRT006330 |
hsa-miR-542-5p |
Luciferase reporter assay, qRT-PCR, Western blot |
22426479 |
MIRT004730 |
hsa-miR-146a-5p |
Luciferase reporter assay, Western blot |
21632853 |
MIRT004730 |
hsa-miR-146a-5p |
Luciferase reporter assay, Western blot |
21632853 |
MIRT006330 |
hsa-miR-542-5p |
Luciferase reporter assay, qRT-PCR, Western blot |
22426479 |
MIRT004730 |
hsa-miR-146a-5p |
Luciferase reporter assay, qRT-PCR, Western blot |
22161865 |
MIRT004730 |
hsa-miR-146a-5p |
Luciferase reporter assay, Western blot |
21632853 |
MIRT006330 |
hsa-miR-542-5p |
Luciferase reporter assay, qRT-PCR, Western blot |
22426479 |
MIRT004730 |
hsa-miR-146a-5p |
Luciferase reporter assay, qRT-PCR, Western blot |
22161865 |
MIRT003325 |
hsa-miR-145-5p |
Microarray, qRT-PCR, Western blot |
21289483 |
MIRT007032 |
hsa-miR-133a-3p |
Luciferase reporter assay |
23069713 |
MIRT007069 |
hsa-miR-133b |
Flow, In situ hybridization, Luciferase reporter assay, qRT-PCR, Western blot |
22883469 |
MIRT007360 |
hsa-miR-27a-3p |
Luciferase reporter assay |
23559009 |
MIRT018378 |
hsa-miR-335-5p |
Microarray |
18185580 |
MIRT020911 |
hsa-miR-155-5p |
Proteomics |
18668040 |
MIRT004730 |
hsa-miR-146a-5p |
Western blot |
19190326 |
MIRT001370 |
hsa-miR-1-3p |
Proteomics;Other |
18668040 |
MIRT002289 |
hsa-miR-7-5p |
Microarray |
17612493 |
MIRT002289 |
hsa-miR-7-5p |
Reporter assay;Western blot;qRT-PCR;Other |
18483236 |
MIRT002289 |
hsa-miR-7-5p |
Reporter assay;Western blot;qRT-PCR;Microarray;Other |
19073608 |
MIRT028600 |
hsa-miR-30a-5p |
Proteomics |
18668040 |
MIRT005807 |
hsa-miR-21-5p |
Western blot;Other |
20048743 |
MIRT001470 |
hsa-miR-16-5p |
Proteomics;Other |
18668040 |
MIRT002289 |
hsa-miR-7-5p |
Western blot |
22853714 |
MIRT004353 |
hsa-miR-128-3p |
Western blot |
22853714 |
MIRT035541 |
hsa-let-7a-5p |
Luciferase reporter assay |
23032975 |
MIRT036702 |
hsa-miR-301b-3p |
CLASH |
23622248 |
MIRT007069 |
hsa-miR-133b |
Luciferase reporter assay, Western blot |
22407299 |
MIRT007069 |
hsa-miR-133b |
Luciferase reporter assay, Western blot |
22407299 |
MIRT007032 |
hsa-miR-133a-3p |
Luciferase reporter assay, Western blot |
22407299 |
MIRT007032 |
hsa-miR-133a-3p |
Luciferase reporter assay, Western blot |
22407299 |
MIRT002289 |
hsa-miR-7-5p |
Immunohistochemistry, In situ hybridization, qRT-PCR, Western blot |
24816687 |
MIRT007032 |
hsa-miR-133a-3p |
Luciferase reporter assay, qRT-PCR |
24816813 |
MIRT007360 |
hsa-miR-27a-3p |
Luciferase reporter assay, qRT-PCR, Western blot |
23650389 |
MIRT007360 |
hsa-miR-27a-3p |
Luciferase reporter assay, qRT-PCR, Western blot |
23650389 |
MIRT007360 |
hsa-miR-27a-3p |
Luciferase reporter assay, qRT-PCR, Western blot |
23650389 |
MIRT007360 |
hsa-miR-27a-3p |
Luciferase reporter assay, qRT-PCR, Western blot |
23650389 |
MIRT007032 |
hsa-miR-133a-3p |
Flow, Luciferase reporter assay, qRT-PCR, Western blot |
23786162 |
MIRT002289 |
hsa-miR-7-5p |
Luciferase reporter assay, Microarray, qRT-PCR, Western blot |
23115635 |
MIRT002289 |
hsa-miR-7-5p |
Luciferase reporter assay, Microarray, qRT-PCR, Western blot |
24573489 |
MIRT002289 |
hsa-miR-7-5p |
Luciferase reporter assay, Microarray, qRT-PCR, Western blot |
24573489 |
MIRT002289 |
hsa-miR-7-5p |
Luciferase reporter assay, Microarray, qRT-PCR, Western blot |
24573489 |
MIRT054243 |
hsa-miR-574-3p |
Luciferase reporter assay, Microarray, qRT-PCR, Western blot |
23554959 |
MIRT004730 |
hsa-miR-146a-5p |
Western blot, qRT-PCR |
23555954 |
MIRT054487 |
hsa-miR-219a-5p |
Luciferase reporter assay, Microarray, Western blot, qRT-PCR |
23690991 |
MIRT054487 |
hsa-miR-219a-5p |
Luciferase reporter assay, Microarray, Western blot, qRT-PCR |
23690991 |
MIRT054661 |
hsa-miR-302b-3p |
Luciferase reporter assay, qRT-PCR, Western blot |
24083596 |
MIRT054661 |
hsa-miR-302b-3p |
Luciferase reporter assay, qRT-PCR, Western blot |
24083596 |
MIRT004730 |
hsa-miR-146a-5p |
Luciferase reporter assay, QRTPCR, Western blot |
24839931 |
MIRT054888 |
hsa-miR-125a-5p |
qRT-PCR, Western blot |
24484870 |
MIRT002289 |
hsa-miR-7-5p |
Luciferase reporter assay |
23319046 |
MIRT002289 |
hsa-miR-7-5p |
Luciferase reporter assay |
23319046 |
MIRT002289 |
hsa-miR-7-5p |
Flow, qRT-PCR, Western blot |
24134702 |
MIRT002289 |
hsa-miR-7-5p |
Flow, qRT-PCR, Western blot |
24134702 |
MIRT002289 |
hsa-miR-7-5p |
Flow, qRT-PCR, Western blot |
24134702 |
MIRT438024 |
hsa-miR-218-5p |
Luciferase reporter assay |
24368849 |
MIRT002289 |
hsa-miR-7-5p |
Flow, qRT-PCR, Western blot |
24134702 |
MIRT002289 |
hsa-miR-7-5p |
Flow, qRT-PCR, Western blot |
24134702 |
MIRT002289 |
hsa-miR-7-5p |
Flow, qRT-PCR, Western blot |
24134702 |
MIRT438024 |
hsa-miR-218-5p |
Luciferase reporter assay |
24368849 |
MIRT438024 |
hsa-miR-218-5p |
HITS-CLIP |
23212916 |
MIRT438024 |
hsa-miR-218-5p |
HITS-CLIP |
23212916 |
MIRT002289 |
hsa-miR-7-5p |
Luciferase reporter assay, qRT-PCR, Western blot |
25475098 |
MIRT002289 |
hsa-miR-7-5p |
Luciferase reporter assay, qRT-PCR, Western blot |
25475098 |
MIRT002289 |
hsa-miR-7-5p |
Luciferase reporter assay, qRT-PCR, Western blot |
25475098 |
MIRT002289 |
hsa-miR-7-5p |
Luciferase reporter assay, qRT-PCR, Western blot |
25475098 |
MIRT007069 |
hsa-miR-133b |
Luciferase reporter assay, Western blot |
26617770 |
MIRT007069 |
hsa-miR-133b |
Luciferase reporter assay, Western blot |
26617770 |
MIRT731611 |
hsa-miR-2861 |
Luciferase reporter assay, Western blot |
27364926 |
MIRT731611 |
hsa-miR-2861 |
Luciferase reporter assay, Western blot |
27364926 |
MIRT007032 |
hsa-miR-133a-3p |
Luciferase reporter assay, Western blot |
26134491 |
MIRT007032 |
hsa-miR-133a-3p |
Luciferase reporter assay, Western blot |
26134491 |
MIRT731713 |
hsa-miR-132-3p |
Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot |
26452132 |
MIRT731713 |
hsa-miR-132-3p |
Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot |
26452132 |
MIRT731713 |
hsa-miR-132-3p |
Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot |
26452132 |
MIRT731713 |
hsa-miR-132-3p |
Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot |
26452132 |
MIRT732238 |
hsa-miR-875-5p |
Luciferase reporter assay, Western blot |
27302926 |
MIRT732238 |
hsa-miR-875-5p |
Luciferase reporter assay, Western blot |
27302926 |
MIRT732244 |
hsa-miR-7-1-3p |
Microarray, qRT-PCR, Western blot |
27448964 |
MIRT732244 |
hsa-miR-7-1-3p |
Microarray, qRT-PCR, Western blot |
27448964 |
MIRT004730 |
hsa-miR-146a-5p |
Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot |
27818285 |
MIRT732238 |
hsa-miR-875-5p |
Immunofluorescence, Luciferase reporter assay, qRT-PCR, Western blot |
28274892 |
MIRT737367 |
hsa-miR-3622b-5p |
Luciferase reporter assay |
27611943 |
MIRT737367 |
hsa-miR-3622b-5p |
Luciferase reporter assay |
27611943 |
MIRT737367 |
hsa-miR-3622b-5p |
Luciferase reporter assay |
27611943 |
MIRT737367 |
hsa-miR-3622b-5p |
Luciferase reporter assay |
27611943 |
MIRT737367 |
hsa-miR-3622b-5p |
Luciferase reporter assay |
27611943 |
MIRT737367 |
hsa-miR-3622b-5p |
Luciferase reporter assay |
27611943 |
MIRT438024 |
hsa-miR-218-5p |
Luciferase reporter assay, qRT-PCR, Western blot |
27057632 |
MIRT438024 |
hsa-miR-218-5p |
Luciferase reporter assay, qRT-PCR, Western blot |
27057632 |
MIRT438024 |
hsa-miR-218-5p |
Luciferase reporter assay, qRT-PCR, Western blot |
27057632 |
MIRT734664 |
hsa-miR-133a-5p |
Western blot |
27465833 |
MIRT737349 |
hsa-miR-137 |
Luciferase reporter assay, Western blot |
28386374 |
MIRT737349 |
hsa-miR-137 |
Luciferase reporter assay, Western blot |
28386374 |
MIRT020911 |
hsa-miR-155-5p |
Immunofluorescence, Luciferase reporter assay, Microarray, qRT-PCR, Western blotting |
33474615 |
MIRT732647 |
hsa-miR-608 |
qRT-PCR |
33523578 |
MIRT733293 |
hsa-miR-128-2-5p |
Immunohistochemistry (IHC), qRT-PCR |
31638205 |
MIRT005807 |
hsa-miR-21-3p |
qRT-PCR |
34208765 |
MIRT007360 |
hsa-miR-27a-3p |
qRT-PCR |
34208765 |
MIRT733417 |
hsa-miR-181a-5p |
qRT-PCR |
34208765 |
MIRT733444 |
hsa-miR-200b-3p |
Luciferase reporter assay, qRT-PCR, Western blotting |
32708220 |
MIRT054487 |
hsa-miR-219a-5p |
Immunofluorescence, qRT-PCR, Western blotting |
34113391 |
MIRT733741 |
hsa-miR-646 |
Luciferase reporter assay, Microarray, qRT-PCR, Western blotting |
33335643 |
MIRT004730 |
hsa-miR-146a-5p |
Luciferase reporter assay, qRT-PCR, Western blotting |
33317606 |
MIRT734078 |
hsa-miR-557 |
Luciferase reporter assay, Microarray, qRT-PCR, Western blotting |
31933947 |
MIRT734109 |
hsa-miR-138-5p |
Luciferase reporter assay, Western blotting, Immunohistochemistry (IHC), qRT-PCR, Flow cytometry |
33209893 |
MIRT007032 |
hsa-miR-133a-3p |
Luciferase reporter assay, qRT-PCR, Western blotting |
32764884 |
MIRT734189 |
hsa-miR-634 |
ELISA, Immunofluorescence, Luciferase reporter assay, qRT-PCR, Western blotting |
33294587 |
MIRT734191 |
hsa-miR-3934-5p |
FACS, Microarray, Western blotting |
33605506 |
MIRT004730 |
hsa-miR-146a-5p |
Immunofluorescence, Immunohistochemistry (IHC), Luciferase reporter assay, qRT-PCR, Western blotting |
33317606 |
MIRT734664 |
hsa-miR-133a-5p |
Luciferase reporter assay |
31736422 |
MIRT734684 |
hsa-miR-21-3p |
Microarray, ELISA |
31727077 |
MIRT734685 |
hsa-miR-146a-3p |
Microarray, ELISA |
31727077 |
MIRT734686 |
hsa-miR-146b-3p |
Microarray, ELISA |
31727077 |
MIRT054243 |
hsa-miR-574-3p |
qRT-PCR |
33194623 |
MIRT006330 |
hsa-miR-542-5p |
qRT-PCR, Flow cytometry |
33173276 |
MIRT007069 |
hsa-miR-133b |
Immunohistochemistry (IHC), qRT-PCR, ELISA |
33211633 |
MIRT736365 |
hsa-miR-486-3p |
Luciferase reporter assay, Western blotting, Immunohistochemistry (IHC), qRT-PCR |
32313144 |
MIRT736523 |
hsa-miR-193a-3p |
Luciferase reporter assay, Western blotting |
34288281 |
MIRT002289 |
hsa-miR-7-5p |
Western blotting, qRT-PCR |
32592373 |
MIRT054888 |
hsa-miR-125a-5p |
Western blotting, qRT-PCR |
34081797 |
MIRT736883 |
hsa-miR-145-3p |
Western blotting, qRT-PCR |
34081797 |
MIRT736883 |
hsa-miR-145-3p |
qRT-PCR |
31554377 |
MIRT054888 |
hsa-miR-125a-5p |
qRT-PCR, ELISA |
31759360 |
MIRT736974 |
hsa-miR-802 |
Luciferase reporter assay, Western blotting, Immunohistochemistry (IHC), Translational profiling, in vitro cullelar assays, qRT-PCR, in vivo gain/loss-of-function experiments |
32210368 |
MIRT736982 |
hsa-miR-4328 |
Microarray, Immunohistochemistry (IHC) |
32170146 |
MIRT736523 |
hsa-miR-193a-3p |
Luciferase reporter assay, Western blotting, Flow cytometry |
34288281 |
MIRT737297 |
hsa-miR-9-3p |
Luciferase reporter assay, Western blotting, qRT-PCR |
32772818 |
MIRT737349 |
hsa-miR-137 |
Western blotting, Microarray, qRT-PCR, Flow cytometry, ELISA |
32627038 |
MIRT737365 |
hsa-miR-200c-3p |
Western blotting, RNA-seq, qRT-PCR |
32417760 |
MIRT737367 |
hsa-miR-3622b-5p |
Luciferase reporter assay, Western blotting, RNA-seq |
32371581 |
MIRT007360 |
hsa-miR-27a-3p |
Luciferase reporter assay, Western blotting, qRT-PCR |
32039029 |
MIRT756070 |
hsa-miR-377-3p |
Luciferase reporter assay, qRT-PCR |
34668101 |
MIRT756387 |
hsa-miR-370-3p |
Luciferase reporter assay, Western blotting, qRT-PCR, Immunoprecipitaion (IP) |
34618022 |
MIRT954740 |
hsa-miR-103a |
CLIP-seq |
|
MIRT954741 |
hsa-miR-107 |
CLIP-seq |
|
MIRT954742 |
hsa-miR-1183 |
CLIP-seq |
|
MIRT954743 |
hsa-miR-1275 |
CLIP-seq |
|
MIRT954744 |
hsa-miR-1323 |
CLIP-seq |
|
MIRT954745 |
hsa-miR-2277-3p |
CLIP-seq |
|
MIRT954746 |
hsa-miR-2278 |
CLIP-seq |
|
MIRT954747 |
hsa-miR-3120-3p |
CLIP-seq |
|
MIRT954748 |
hsa-miR-3129-3p |
CLIP-seq |
|
MIRT954749 |
hsa-miR-3144-5p |
CLIP-seq |
|
MIRT954750 |
hsa-miR-3150a-3p |
CLIP-seq |
|
MIRT954751 |
hsa-miR-3170 |
CLIP-seq |
|
MIRT954752 |
hsa-miR-3175 |
CLIP-seq |
|
MIRT954753 |
hsa-miR-3191 |
CLIP-seq |
|
MIRT954754 |
hsa-miR-342-5p |
CLIP-seq |
|
MIRT954755 |
hsa-miR-3647-3p |
CLIP-seq |
|
MIRT954756 |
hsa-miR-3929 |
CLIP-seq |
|
MIRT954757 |
hsa-miR-3942-3p |
CLIP-seq |
|
MIRT954758 |
hsa-miR-4260 |
CLIP-seq |
|
MIRT954759 |
hsa-miR-4261 |
CLIP-seq |
|
MIRT954760 |
hsa-miR-433 |
CLIP-seq |
|
MIRT954761 |
hsa-miR-4419b |
CLIP-seq |
|
MIRT954762 |
hsa-miR-4428 |
CLIP-seq |
|
MIRT954763 |
hsa-miR-4478 |
CLIP-seq |
|
MIRT954764 |
hsa-miR-4509 |
CLIP-seq |
|
MIRT954765 |
hsa-miR-451b |
CLIP-seq |
|
MIRT954766 |
hsa-miR-4651 |
CLIP-seq |
|
MIRT954767 |
hsa-miR-4652-5p |
CLIP-seq |
|
MIRT954768 |
hsa-miR-4664-5p |
CLIP-seq |
|
MIRT954769 |
hsa-miR-4665-5p |
CLIP-seq |
|
MIRT954770 |
hsa-miR-4682 |
CLIP-seq |
|
MIRT954771 |
hsa-miR-4688 |
CLIP-seq |
|
MIRT954772 |
hsa-miR-4696 |
CLIP-seq |
|
MIRT954773 |
hsa-miR-4735-5p |
CLIP-seq |
|
MIRT954774 |
hsa-miR-4775 |
CLIP-seq |
|
MIRT954775 |
hsa-miR-4803 |
CLIP-seq |
|
MIRT954776 |
hsa-miR-548o |
CLIP-seq |
|
MIRT954777 |
hsa-miR-590-3p |
CLIP-seq |
|
MIRT954778 |
hsa-miR-607 |
CLIP-seq |
|
MIRT954779 |
hsa-miR-875-3p |
CLIP-seq |
|
MIRT954780 |
hsa-miR-939 |
CLIP-seq |
|
MIRT954781 |
hsa-miR-4436a |
CLIP-seq |
|
MIRT1982758 |
hsa-miR-105 |
CLIP-seq |
|
MIRT1982759 |
hsa-miR-128 |
CLIP-seq |
|
MIRT1982760 |
hsa-miR-133a |
CLIP-seq |
|
MIRT954746 |
hsa-miR-2278 |
CLIP-seq |
|
MIRT1982761 |
hsa-miR-27a |
CLIP-seq |
|
MIRT1982762 |
hsa-miR-27b |
CLIP-seq |
|
MIRT1982763 |
hsa-miR-3136-5p |
CLIP-seq |
|
MIRT1982764 |
hsa-miR-3674 |
CLIP-seq |
|
MIRT954757 |
hsa-miR-3942-3p |
CLIP-seq |
|
MIRT954762 |
hsa-miR-4428 |
CLIP-seq |
|
MIRT1982765 |
hsa-miR-4439 |
CLIP-seq |
|
MIRT1982766 |
hsa-miR-4502 |
CLIP-seq |
|
MIRT1982767 |
hsa-miR-4513 |
CLIP-seq |
|
MIRT1982768 |
hsa-miR-4728-3p |
CLIP-seq |
|
MIRT1982769 |
hsa-miR-579 |
CLIP-seq |
|
MIRT1982770 |
hsa-miR-622 |
CLIP-seq |
|
MIRT1982758 |
hsa-miR-105 |
CLIP-seq |
|
MIRT1982759 |
hsa-miR-128 |
CLIP-seq |
|
MIRT2217637 |
hsa-miR-1587 |
CLIP-seq |
|
MIRT1982761 |
hsa-miR-27a |
CLIP-seq |
|
MIRT1982762 |
hsa-miR-27b |
CLIP-seq |
|
MIRT2217638 |
hsa-miR-299-3p |
CLIP-seq |
|
MIRT2217639 |
hsa-miR-3147 |
CLIP-seq |
|
MIRT2217640 |
hsa-miR-3652 |
CLIP-seq |
|
MIRT2217641 |
hsa-miR-3977 |
CLIP-seq |
|
MIRT2217642 |
hsa-miR-4253 |
CLIP-seq |
|
MIRT2217643 |
hsa-miR-4265 |
CLIP-seq |
|
MIRT2217644 |
hsa-miR-4296 |
CLIP-seq |
|
MIRT2217645 |
hsa-miR-4322 |
CLIP-seq |
|
MIRT2217646 |
hsa-miR-4417 |
CLIP-seq |
|
MIRT2217647 |
hsa-miR-4425 |
CLIP-seq |
|
MIRT2217648 |
hsa-miR-4430 |
CLIP-seq |
|
MIRT2217649 |
hsa-miR-4492 |
CLIP-seq |
|
MIRT2217650 |
hsa-miR-4498 |
CLIP-seq |
|
MIRT2217651 |
hsa-miR-450b-3p |
CLIP-seq |
|
MIRT2217652 |
hsa-miR-4656 |
CLIP-seq |
|
MIRT2217653 |
hsa-miR-4675 |
CLIP-seq |
|
MIRT2217654 |
hsa-miR-4687-3p |
CLIP-seq |
|
MIRT2217655 |
hsa-miR-4709-3p |
CLIP-seq |
|
MIRT2217656 |
hsa-miR-4741 |
CLIP-seq |
|
MIRT2217657 |
hsa-miR-4767 |
CLIP-seq |
|
MIRT2217658 |
hsa-miR-502-5p |
CLIP-seq |
|
MIRT2217659 |
hsa-miR-513a-5p |
CLIP-seq |
|
MIRT2217660 |
hsa-miR-762 |
CLIP-seq |
|
MIRT2217661 |
hsa-miR-769-3p |
CLIP-seq |
|
MIRT2387248 |
hsa-miR-1269 |
CLIP-seq |
|
MIRT2387249 |
hsa-miR-1269b |
CLIP-seq |
|
MIRT2387250 |
hsa-miR-1288 |
CLIP-seq |
|
MIRT2387251 |
hsa-miR-4515 |
CLIP-seq |
|
MIRT2387252 |
hsa-miR-4740-5p |
CLIP-seq |
|
MIRT2387253 |
hsa-miR-4788 |
CLIP-seq |
|
|
Transcription factors
|
|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0000139 |
Component |
Golgi membrane |
IEA |
|
GO:0000165 |
Process |
MAPK cascade |
TAS |
|
GO:0000186 |
Process |
Activation of MAPKK activity |
IEA |
|
GO:0001503 |
Process |
Ossification |
NAS |
12925580 |
GO:0001618 |
Function |
Virus receptor activity |
IEA |
|
GO:0001934 |
Process |
Positive regulation of protein phosphorylation |
IDA |
20551055 |
GO:0001942 |
Process |
Hair follicle development |
IEA |
|
GO:0003682 |
Function |
Chromatin binding |
IDA |
20551055 |
GO:0003690 |
Function |
Double-stranded DNA binding |
NAS |
6325948 |
GO:0004709 |
Function |
MAP kinase kinase kinase activity |
NAS |
15542601 |
GO:0004713 |
Function |
Protein tyrosine kinase activity |
IDA |
17115032, 17599051 |
GO:0004713 |
Function |
Protein tyrosine kinase activity |
IMP |
14702346, 20878056 |
GO:0004713 |
Function |
Protein tyrosine kinase activity |
TAS |
16076471 |
GO:0004714 |
Function |
Transmembrane receptor protein tyrosine kinase activity |
IBA |
21873635 |
GO:0004714 |
Function |
Transmembrane receptor protein tyrosine kinase activity |
TAS |
|
GO:0004888 |
Function |
Transmembrane signaling receptor activity |
IDA |
7736574 |
GO:0005006 |
Function |
Epidermal growth factor-activated receptor activity |
IBA |
21873635 |
GO:0005006 |
Function |
Epidermal growth factor-activated receptor activity |
IDA |
12435727, 17115032 |
GO:0005006 |
Function |
Epidermal growth factor-activated receptor activity |
IMP |
22732145 |
GO:0005006 |
Function |
Epidermal growth factor-activated receptor activity |
NAS |
2790960, 6325948 |
GO:0005178 |
Function |
Integrin binding |
IEA |
|
GO:0005515 |
Function |
Protein binding |
IPI |
2176151, 2790960, 7518560, 7542744, 7657591, 7685104, 7693694, 7797556, 7993895, 8034616, 8305738, 8621392, 8887653, 8940013, 9020117, 9050838, 9135143, 9355745, 9419975, 9506989, 9544989, 9852145, 10026169, 10229072, 10572067, 10805725, 11279102, 11896612, 12070153, 12297049, 1229705 |
GO:0005516 |
Function |
Calmodulin binding |
IEA |
|
GO:0005524 |
Function |
ATP binding |
IEA |
|
GO:0005615 |
Component |
Extracellular space |
NAS |
9103388 |
GO:0005634 |
Component |
Nucleus |
IDA |
12828935, 17115032, 20551055 |
GO:0005737 |
Component |
Cytoplasm |
IDA |
7588596, 12435727, 22298428 |
GO:0005768 |
Component |
Endosome |
IDA |
14702346, 17182860, 22732145 |
GO:0005768 |
Component |
Endosome |
IDA |
16554368 |
GO:0005789 |
Component |
Endoplasmic reticulum membrane |
IEA |
|
GO:0005886 |
Component |
Plasma membrane |
IDA |
15465819, 20462955, 22298428, 22732145 |
GO:0005886 |
Component |
Plasma membrane |
TAS |
|
GO:0005887 |
Component |
Integral component of plasma membrane |
IBA |
21873635 |
GO:0005925 |
Component |
Focal adhesion |
HDA |
21423176 |
GO:0006357 |
Process |
Regulation of transcription by RNA polymerase II |
TAS |
|
GO:0006412 |
Process |
Translation |
IEA |
|
GO:0006970 |
Process |
Response to osmotic stress |
IEA |
|
GO:0007165 |
Process |
Signal transduction |
IDA |
10572067 |
GO:0007165 |
Process |
Signal transduction |
TAS |
|
GO:0007166 |
Process |
Cell surface receptor signaling pathway |
IDA |
7736574 |
GO:0007169 |
Process |
Transmembrane receptor protein tyrosine kinase signaling pathway |
IBA |
21873635 |
GO:0007173 |
Process |
Epidermal growth factor receptor signaling pathway |
IDA |
7736574, 12435727 |
GO:0007173 |
Process |
Epidermal growth factor receptor signaling pathway |
IMP |
20878056 |
GO:0007173 |
Process |
Epidermal growth factor receptor signaling pathway |
TAS |
|
GO:0007202 |
Process |
Activation of phospholipase C activity |
TAS |
12435727 |
GO:0007275 |
Process |
Multicellular organism development |
IBA |
21873635 |
GO:0007494 |
Process |
Midgut development |
IEA |
|
GO:0007611 |
Process |
Learning or memory |
ISS |
|
GO:0007623 |
Process |
Circadian rhythm |
IEA |
|
GO:0008284 |
Process |
Positive regulation of cell population proliferation |
IBA |
21873635 |
GO:0008284 |
Process |
Positive regulation of cell population proliferation |
IDA |
7736574 |
GO:0008284 |
Process |
Positive regulation of cell population proliferation |
IMP |
27057632 |
GO:0009925 |
Component |
Basal plasma membrane |
IBA |
21873635 |
GO:0009986 |
Component |
Cell surface |
IDA |
25666625 |
GO:0010008 |
Component |
Endosome membrane |
IDA |
22719997 |
GO:0010750 |
Process |
Positive regulation of nitric oxide mediated signal transduction |
IDA |
12828935 |
GO:0010960 |
Process |
Magnesium ion homeostasis |
IEA |
|
GO:0014066 |
Process |
Regulation of phosphatidylinositol 3-kinase signaling |
IMP |
26514923 |
GO:0016020 |
Component |
Membrane |
IDA |
12435727 |
GO:0016101 |
Process |
Diterpenoid metabolic process |
IEA |
|
GO:0016323 |
Component |
Basolateral plasma membrane |
IDA |
12646923 |
GO:0016324 |
Component |
Apical plasma membrane |
IEA |
|
GO:0018108 |
Process |
Peptidyl-tyrosine phosphorylation |
IDA |
22732145 |
GO:0019899 |
Function |
Enzyme binding |
IPI |
12009895 |
GO:0019900 |
Function |
Kinase binding |
IPI |
18722344 |
GO:0019901 |
Function |
Protein kinase binding |
IEA |
|
GO:0019903 |
Function |
Protein phosphatase binding |
IPI |
15899872, 28759036 |
GO:0030054 |
Component |
Cell junction |
IDA |
|
GO:0030139 |
Component |
Endocytic vesicle |
IEA |
|
GO:0030154 |
Process |
Cell differentiation |
IBA |
21873635 |
GO:0030235 |
Function |
Nitric-oxide synthase regulator activity |
IDA |
12828935 |
GO:0030307 |
Process |
Positive regulation of cell growth |
IDA |
15467833 |
GO:0030324 |
Process |
Lung development |
IEA |
|
GO:0030335 |
Process |
Positive regulation of cell migration |
IMP |
12435727, 25678558 |
GO:0030665 |
Component |
Clathrin-coated vesicle membrane |
TAS |
|
GO:0031625 |
Function |
Ubiquitin protein ligase binding |
IPI |
23418353 |
GO:0031901 |
Component |
Early endosome membrane |
IDA |
17714434 |
GO:0031965 |
Component |
Nuclear membrane |
IEA |
|
GO:0032930 |
Process |
Positive regulation of superoxide anion generation |
IEA |
|
GO:0032991 |
Component |
Protein-containing complex |
IDA |
20878056 |
GO:0033138 |
Process |
Positive regulation of peptidyl-serine phosphorylation |
IMP |
20878056 |
GO:0033590 |
Process |
Response to cobalamin |
IEA |
|
GO:0033594 |
Process |
Response to hydroxyisoflavone |
IEA |
|
GO:0033674 |
Process |
Positive regulation of kinase activity |
IBA |
21873635 |
GO:0034614 |
Process |
Cellular response to reactive oxygen species |
IMP |
26514923 |
GO:0035690 |
Process |
Cellular response to drug |
IEA |
|
GO:0038083 |
Process |
Peptidyl-tyrosine autophosphorylation |
IMP |
20878056 |
GO:0038083 |
Process |
Peptidyl-tyrosine autophosphorylation |
TAS |
22732145 |
GO:0038128 |
Process |
ERBB2 signaling pathway |
TAS |
|
GO:0042059 |
Process |
Negative regulation of epidermal growth factor receptor signaling pathway |
TAS |
|
GO:0042060 |
Process |
Wound healing |
IEA |
|
GO:0042177 |
Process |
Negative regulation of protein catabolic process |
IDA |
17115032 |
GO:0042327 |
Process |
Positive regulation of phosphorylation |
IDA |
15082764 |
GO:0042698 |
Process |
Ovulation cycle |
IEA |
|
GO:0042743 |
Process |
Hydrogen peroxide metabolic process |
IEA |
|
GO:0042802 |
Function |
Identical protein binding |
IPI |
16777603, 17148612, 18042729, 19563760, 19650109, 20007378, 20029029, 20359299, 21278786, 21480528, 21482778, 22232519, 22579287, 23273428, 23374349, 23436906, 23636329, 24135280, 28988771, 31980649 |
GO:0043006 |
Process |
Activation of phospholipase A2 activity by calcium-mediated signaling |
TAS |
12435727 |
GO:0043066 |
Process |
Negative regulation of apoptotic process |
IBA |
21873635 |
GO:0043066 |
Process |
Negative regulation of apoptotic process |
IMP |
18070883 |
GO:0043235 |
Component |
Receptor complex |
IBA |
21873635 |
GO:0043235 |
Component |
Receptor complex |
IDA |
23382219 |
GO:0043406 |
Process |
Positive regulation of MAP kinase activity |
IDA |
10572067 |
GO:0043586 |
Process |
Tongue development |
IEA |
|
GO:0045121 |
Component |
Membrane raft |
IDA |
12009895 |
GO:0045121 |
Component |
Membrane raft |
ISS |
|
GO:0045202 |
Component |
Synapse |
IEA |
|
GO:0045296 |
Function |
Cadherin binding |
HDA |
25468996 |
GO:0045737 |
Process |
Positive regulation of cyclin-dependent protein serine/threonine kinase activity |
IMP |
18483258 |
GO:0045739 |
Process |
Positive regulation of DNA repair |
IDA |
17115032 |
GO:0045740 |
Process |
Positive regulation of DNA replication |
IDA |
17115032 |
GO:0045746 |
Process |
Negative regulation of Notch signaling pathway |
TAS |
|
GO:0045780 |
Process |
Positive regulation of bone resorption |
IEA |
|
GO:0045893 |
Process |
Positive regulation of transcription, DNA-templated |
IMP |
26514923 |
GO:0045907 |
Process |
Positive regulation of vasoconstriction |
IEA |
|
GO:0045930 |
Process |
Negative regulation of mitotic cell cycle |
IEA |
|
GO:0045944 |
Process |
Positive regulation of transcription by RNA polymerase II |
IDA |
20551055 |
GO:0046328 |
Process |
Regulation of JNK cascade |
IMP |
26514923 |
GO:0046718 |
Process |
Viral entry into host cell |
IEA |
|
GO:0046777 |
Process |
Protein autophosphorylation |
IMP |
18070883 |
GO:0048143 |
Process |
Astrocyte activation |
IEA |
|
GO:0048408 |
Function |
Epidermal growth factor binding |
IBA |
21873635 |
GO:0048471 |
Component |
Perinuclear region of cytoplasm |
IMP |
24854121 |
GO:0048661 |
Process |
Positive regulation of smooth muscle cell proliferation |
IEA |
|
GO:0048812 |
Process |
Neuron projection morphogenesis |
IEA |
|
GO:0050679 |
Process |
Positive regulation of epithelial cell proliferation |
IBA |
21873635 |
GO:0050679 |
Process |
Positive regulation of epithelial cell proliferation |
IDA |
10572067 |
GO:0050729 |
Process |
Positive regulation of inflammatory response |
IEA |
|
GO:0050730 |
Process |
Regulation of peptidyl-tyrosine phosphorylation |
IMP |
12435727 |
GO:0050999 |
Process |
Regulation of nitric-oxide synthase activity |
IDA |
12828935 |
GO:0051015 |
Function |
Actin filament binding |
IDA |
14702346 |
GO:0051117 |
Function |
ATPase binding |
ISS |
|
GO:0051205 |
Process |
Protein insertion into membrane |
TAS |
12435727 |
GO:0051592 |
Process |
Response to calcium ion |
IEA |
|
GO:0051897 |
Process |
Positive regulation of protein kinase B signaling |
IMP |
17655843 |
GO:0051897 |
Process |
Positive regulation of protein kinase B signaling |
TAS |
|
GO:0051968 |
Process |
Positive regulation of synaptic transmission, glutamatergic |
IEA |
|
GO:0061024 |
Process |
Membrane organization |
TAS |
|
GO:0070141 |
Process |
Response to UV-A |
IDA |
18483258 |
GO:0070372 |
Process |
Regulation of ERK1 and ERK2 cascade |
IMP |
26514923 |
GO:0070374 |
Process |
Positive regulation of ERK1 and ERK2 cascade |
IDA |
20551055 |
GO:0070374 |
Process |
Positive regulation of ERK1 and ERK2 cascade |
IMP |
21673316 |
GO:0070435 |
Component |
Shc-EGFR complex |
ISS |
|
GO:0071260 |
Process |
Cellular response to mechanical stimulus |
IEA |
|
GO:0071276 |
Process |
Cellular response to cadmium ion |
IMP |
26514923 |
GO:0071364 |
Process |
Cellular response to epidermal growth factor stimulus |
ISS |
|
GO:0071392 |
Process |
Cellular response to estradiol stimulus |
IDA |
20551055 |
GO:0071549 |
Process |
Cellular response to dexamethasone stimulus |
IEA |
|
GO:0090263 |
Process |
Positive regulation of canonical Wnt signaling pathway |
IMP |
20302655 |
GO:0097421 |
Process |
Liver regeneration |
IEA |
|
GO:0097489 |
Component |
Multivesicular body, internal vesicle lumen |
IDA |
17714434 |
GO:0098609 |
Process |
Cell-cell adhesion |
IMP |
12435727 |
GO:1900020 |
Process |
Positive regulation of protein kinase C activity |
IDA |
22732145 |
GO:1900087 |
Process |
Positive regulation of G1/S transition of mitotic cell cycle |
IMP |
18483258 |
GO:1901185 |
Process |
Negative regulation of ERBB signaling pathway |
TAS |
|
GO:1901224 |
Process |
Positive regulation of NIK/NF-kappaB signaling |
IMP |
26514923 |
GO:1902722 |
Process |
Positive regulation of prolactin secretion |
IEA |
|
GO:1903078 |
Process |
Positive regulation of protein localization to plasma membrane |
IDA |
22732145 |
GO:1903800 |
Process |
Positive regulation of production of miRNAs involved in gene silencing by miRNA |
IMP |
21673316 |
GO:1905208 |
Process |
Negative regulation of cardiocyte differentiation |
IMP |
23069713 |
GO:2000145 |
Process |
Regulation of cell motility |
TAS |
|
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
|
|
Protein
|
UniProt ID |
P00533 |
Protein name |
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) |
Protein function |
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:10805725, PubMed:27153536, PubMed:2790960, PubMed:35538033). Known lig |
PDB |
1IVO
,
1M14
,
1M17
,
1MOX
,
1NQL
,
1XKK
,
1YY9
,
1Z9I
,
2EB2
,
2EB3
,
2GS2
,
2GS6
,
2GS7
,
2ITN
,
2ITO
,
2ITP
,
2ITQ
,
2ITT
,
2ITU
,
2ITV
,
2ITW
,
2ITX
,
2ITY
,
2ITZ
,
2J5E
,
2J5F
,
2J6M
,
2JIT
,
2JIU
,
2JIV
,
2KS1
,
2M0B
,
2M20
,
2N5S
,
2RF9
,
2RFD
,
2RFE
,
2RGP
,
3B2U
,
3B2V
,
3BEL
,
3BUO
,
3C09
,
3G5V
,
3G5Y
,
3GOP
,
3GT8
,
3IKA
,
3LZB
,
3NJP
,
3OB2
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF01030 |
Recep_L_domain |
57 → 168 |
Receptor L domain |
Repeat |
PF00757 |
Furin-like |
177 → 338 |
Furin-like cysteine rich region |
Domain |
PF01030 |
Recep_L_domain |
361 → 481 |
Receptor L domain |
Repeat |
PF14843 |
GF_recep_IV |
505 → 637 |
Growth factor receptor domain IV |
Domain |
PF07714 |
PK_Tyr_Ser-Thr |
712 → 968 |
Protein tyrosine and serine/threonine kinase |
Domain |
|
Sequence |
|
Sequence length |
1210 |
Interactions |
View interactions |
|
|