GeDiPNet: Comprehensive Gene Data - OMIM, HGNC, Ensembl, UniProt, GO, Transcription Factors & miRNA

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EGFR (epidermal growth factor receptor)

Gene

1956

Epidermal growth factor receptor

EGFR

ERBB, ERBB1, ERRP, HER1, NISBD2, PIG61, mENA

7p11.2

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). [provided by RefSeq, Jul 2020]

Show/Hide all(76)

SNP ID	Visualize variation	Clinical significance	Consequence
rs28929495	G>A,C,T	Pathogenic, likely-pathogenic, not-provided, drug-response	Missense variant, genic downstream transcript variant, coding sequence variant
rs121434568	T>A,G	Drug-response, pathogenic, likely-pathogenic	Genic downstream transcript variant, missense variant, coding sequence variant
rs121913229	G>C	Uncertain-significance, likely-pathogenic	Genic downstream transcript variant, missense variant, coding sequence variant
rs121913231	C>T	Likely-pathogenic	Genic downstream transcript variant, missense variant, coding sequence variant
rs121913418	G>A,T	Uncertain-significance, likely-pathogenic	Genic downstream transcript variant, missense variant, coding sequence variant
rs121913420	G>A	Likely-pathogenic	Genic downstream transcript variant, missense variant, coding sequence variant
rs121913421	GGAATTAAGAGAAGC>-	Drug-response	Genic downstream transcript variant, inframe deletion, coding sequence variant
rs121913422	AATTAAGAGAAGCAACAT>-	Drug-response	Genic downstream transcript variant, inframe indel, coding sequence variant
rs121913424	AATTAAGAGAAGCAACATCT>TC	Drug-response	Genic downstream transcript variant, inframe indel, coding sequence variant
rs121913425	AATTAAGAGAAGCAA>-	Drug-response	Genic downstream transcript variant, inframe indel, coding sequence variant
rs121913427	G>A,C	Not-provided, likely-pathogenic	Genic downstream transcript variant, missense variant, coding sequence variant
rs121913428	G>A,C	Pathogenic, likely-pathogenic	Genic downstream transcript variant, missense variant, coding sequence variant
rs121913430	G>A	Likely-pathogenic	Genic downstream transcript variant, missense variant, coding sequence variant
rs121913433	A>G	Likely-pathogenic	Genic downstream transcript variant, missense variant, coding sequence variant
rs121913434	C>G,T	Drug-response	Genic downstream transcript variant, missense variant, coding sequence variant
rs121913435	ATTAAGAGAAG>GC	Drug-response	Genic downstream transcript variant, inframe indel, coding sequence variant
rs121913436	TTAAGAGAA>-	Drug-response	Genic downstream transcript variant, inframe deletion, coding sequence variant
rs121913438	TAAGAGAAGCAACATCTC>-	Drug-response	Genic downstream transcript variant, inframe indel, coding sequence variant
rs121913440	TTAAGAGAAGCAACATCT>-	Drug-response	Genic downstream transcript variant, inframe deletion, coding sequence variant
rs121913442	TAAGAGAAGCAACAT>-	Drug-response	Genic downstream transcript variant, inframe deletion, coding sequence variant
rs121913443	C>A,T	Likely-benign, uncertain-significance, likely-pathogenic	Genic downstream transcript variant, synonymous variant, missense variant, coding sequence variant
rs121913444	T>A,C,G	Uncertain-significance, drug-response, pathogenic, likely-pathogenic	Genic downstream transcript variant, missense variant, coding sequence variant
rs121913446	C>T	Likely-pathogenic	Genic downstream transcript variant, missense variant, coding sequence variant
rs121913463	TCTCCGAAAGCCAACAAGGAAATC>-	Drug-response	Genic downstream transcript variant, inframe deletion, coding sequence variant
rs121913464	C>A	Likely-pathogenic	Genic downstream transcript variant, missense variant, coding sequence variant
rs121913466	T>C	Likely-pathogenic	Genic downstream transcript variant, missense variant, coding sequence variant
rs121913467	G>A	Likely-pathogenic	Genic downstream transcript variant, coding sequence variant, stop gained
rs139236063	G>C,T	Likely-pathogenic	Genic downstream transcript variant, missense variant, coding sequence variant
rs139429793	G>A	Pathogenic	Missense variant, coding sequence variant
rs146795390	G>A	Likely-pathogenic	Genic downstream transcript variant, coding sequence variant, missense variant
rs149840192	C>A,T	Likely-pathogenic	Coding sequence variant, intron variant, missense variant
rs150036236	G>A	Pathogenic	Coding sequence variant, missense variant, genic downstream transcript variant
rs397509368	TTAAGAGAAGCAA>C	Drug-response	Genic downstream transcript variant, coding sequence variant, inframe indel
rs397517085	A>C,G,T	Drug-response, uncertain-significance	Missense variant, genic downstream transcript variant, coding sequence variant
rs397517086	AAC>-	Pathogenic	Genic downstream transcript variant, coding sequence variant, inframe indel
rs397517094	CAAGGAATTAAGAGAAGC>AAA	Likely-pathogenic	Genic downstream transcript variant, inframe deletion, coding sequence variant
rs397517097	T>C	Likely-pathogenic, uncertain-significance	Missense variant, genic downstream transcript variant, coding sequence variant
rs397517098	TAAGAGAAG>-	Likely-pathogenic	Genic downstream transcript variant, coding sequence variant, inframe indel
rs397517127	G>C,T	Pathogenic, uncertain-significance	Missense variant, genic downstream transcript variant, coding sequence variant
rs483352805	G>A	Drug-response	Genic downstream transcript variant, missense variant, coding sequence variant
rs483352808	G>A	Drug-response	Genic downstream transcript variant, missense variant, coding sequence variant
rs606231253	G>A	Pathogenic	Coding sequence variant, missense variant, genic downstream transcript variant
rs727503014	ATCAAGGAATTAAGAGAAGC>GTCAA	Drug-response	Coding sequence variant, inframe indel, genic downstream transcript variant
rs727503015	AATTAAGAGAAG>CAC,CCC	Drug-response	Coding sequence variant, inframe indel, genic downstream transcript variant
rs727503016	AATTAAGAGAAGCAA>TTC	Drug-response	Coding sequence variant, inframe indel, genic downstream transcript variant
rs727504232	ATCTCCGAAAGCCAACAAGGAAAT>-	Drug-response	Coding sequence variant, genic downstream transcript variant, inframe deletion
rs727504233	GAATTAAGAGAAGCA>-	Drug-response	Coding sequence variant, genic downstream transcript variant, inframe deletion
rs727504256	G>A	Drug-response	Coding sequence variant, missense variant, genic downstream transcript variant
rs727504257	ATTAAGAGAAGCAA>GC	Drug-response	Coding sequence variant, inframe indel, genic downstream transcript variant
rs727504258	AATTAAGAGAAGCAACATC>T	Drug-response	Coding sequence variant, inframe indel, genic downstream transcript variant
rs727504266	GGAATTAAG>-	Drug-response	Coding sequence variant, genic downstream transcript variant, inframe deletion
rs727504278	TTAAGAGAAG>C	Drug-response	Coding sequence variant, inframe indel, genic downstream transcript variant
rs727504281	GGAATTAAGAGAAG>AATTC	Drug-response	Coding sequence variant, inframe indel, genic downstream transcript variant
rs727504282	AATTAAGAGAAGCAACATCTC>TCT	Drug-response	Coding sequence variant, inframe indel, genic downstream transcript variant
rs727504316	C>T	Drug-response	Coding sequence variant, missense variant, genic downstream transcript variant
rs727504324	CAAGGAATTAAGAGAAGCA>-	Drug-response	Coding sequence variant, frameshift variant, genic downstream transcript variant
rs727504326	->AAAATTCCCGTCGCTA	Drug-response	Coding sequence variant, frameshift variant, genic downstream transcript variant
rs727504332	GGAATTAAGAGAAGCAA>AATTC	Drug-response	Coding sequence variant, inframe indel, genic downstream transcript variant
rs727504339	TTAAGAGAAGCAACATCTC>A,CAAT	Drug-response	Coding sequence variant, inframe indel, genic downstream transcript variant
rs727504395	ACATCTCCGAAAGCCAACAAGGAAATC>GAT	Drug-response	Coding sequence variant, inframe indel, genic downstream transcript variant
rs727504402	GAATTAAGAGAAGCAAC>AT	Drug-response	Coding sequence variant, inframe indel, genic downstream transcript variant
rs727504414	TTAAGAGAAGCAACATCTCCGAAAGC>ACGAGAGA	Drug-response	Coding sequence variant, inframe indel, genic downstream transcript variant
rs727504428	CAAGGAATTAAGAGAAGCAAC>AAAGTT	Drug-response	Coding sequence variant, inframe indel, genic downstream transcript variant
rs727504444	AATTAAGAGA>C	Drug-response	Coding sequence variant, inframe indel, genic downstream transcript variant
rs769696078	G>A	Likely-pathogenic	Coding sequence variant, intron variant, missense variant
rs886037891	G>T	Pathogenic	Missense variant, coding sequence variant
rs909905659	G>A,T	Likely-pathogenic	Genic downstream transcript variant, missense variant, stop gained, coding sequence variant, intron variant
rs1057519760	A>G	Likely-pathogenic	Missense variant, genic downstream transcript variant, coding sequence variant
rs1057519794	G>A	Likely-pathogenic	Missense variant, genic downstream transcript variant, coding sequence variant
rs1057519828	G>A	Likely-pathogenic	Missense variant, coding sequence variant, intron variant
rs1057519829	A>C,G	Likely-pathogenic	Missense variant, coding sequence variant, intron variant
rs1057519830	C>T	Likely-pathogenic	Missense variant, genic downstream transcript variant, coding sequence variant
rs1057519848	TG>GT	Likely-pathogenic	Missense variant, genic downstream transcript variant, coding sequence variant
rs1057519887	GC>AA,AT	Likely-pathogenic	Missense variant, coding sequence variant, intron variant
rs1057519888	A>G	Likely-pathogenic	Missense variant, coding sequence variant, intron variant
rs1057520037	G>C	Likely-pathogenic	Missense variant, genic downstream transcript variant, coding sequence variant

Show/Hide all(70)

miRTarBase ID	miRNA	Experiments	Reference
MIRT001370	hsa-miR-1-3p	pSILAC, Proteomics;Other	18668040
MIRT001470	hsa-miR-16-5p	pSILAC, Proteomics;Other	18668040
MIRT002289	hsa-miR-7-5p	real-time RT-PCR, Reporter assay, Western blot, Luciferase reporter assay, Reporter assay;Western blot;qRT-PCR;Other	18483236
MIRT002289	hsa-miR-7-5p	Luciferase reporter assay, qRT-PCR, Western blot, Reporter assay;Western blot;qRT-PCR;Microarray;Other	19073608
MIRT002289	hsa-miR-7-5p	Luciferase reporter assay	19029026
MIRT002289	hsa-miR-7-5p	Luciferase reporter assay	19033458
MIRT002289	hsa-miR-7-5p	Luciferase reporter assay, Microarray, Western blot	20864407
MIRT002289	hsa-miR-7-5p	Microarray	17612493
MIRT002289	hsa-miR-7-5p	Western blot	22853714
MIRT002289	hsa-miR-7-5p	Immunohistochemistry, In situ hybridization, qRT-PCR, Western blot	24816687
MIRT002289	hsa-miR-7-5p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	23115635
MIRT002289	hsa-miR-7-5p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	24573489
MIRT002289	hsa-miR-7-5p	Luciferase reporter assay	23319046
MIRT002289	hsa-miR-7-5p	Flow, qRT-PCR, Western blot	24134702
MIRT002289	hsa-miR-7-5p	Luciferase reporter assay, qRT-PCR, Western blot	25475098
MIRT003325	hsa-miR-145-5p	Microarray, qRT-PCR, Western blot	21289483
MIRT004353	hsa-miR-128-3p	Western blot	22853714
MIRT004730	hsa-miR-146a-5p	qRT-PCR, Western blot	20124483
MIRT004730	hsa-miR-146a-5p	Luciferase reporter assay, Western blot	21632853
MIRT004730	hsa-miR-146a-5p	Luciferase reporter assay, qRT-PCR, Western blot	22161865
MIRT004730	hsa-miR-146a-5p	Western blot	19190326
MIRT004730	hsa-miR-146a-5p	Western blot, qRT-PCR	23555954
MIRT004730	hsa-miR-146a-5p	Luciferase reporter assay, QRTPCR, Western blot	24839931
MIRT004730	hsa-miR-146a-5p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	27818285
MIRT005807	hsa-miR-21-5p	Luciferase reporter assay, Microarray, Western blot	20864407
MIRT005807	hsa-miR-21-5p	Western blot;Other	20048743
MIRT006330	hsa-miR-542-5p	Luciferase reporter assay, qRT-PCR, Western blot	22426479
MIRT006585	hsa-miR-128b	qRT-PCR, Western blot, GFP reporter assay, Luciferase reporter assay	18304967
MIRT007032	hsa-miR-133a-3p	Luciferase reporter assay	23069713
MIRT007032	hsa-miR-133a-3p	Luciferase reporter assay, Western blot	22407299
MIRT007032	hsa-miR-133a-3p	Luciferase reporter assay, qRT-PCR	24816813
MIRT007032	hsa-miR-133a-3p	Flow, Luciferase reporter assay, qRT-PCR, Western blot	23786162
MIRT007032	hsa-miR-133a-3p	Luciferase reporter assay, Western blot	26134491
MIRT007069	hsa-miR-133b	Flow, In situ hybridization, Luciferase reporter assay, qRT-PCR, Western blot	22883469
MIRT007069	hsa-miR-133b	Luciferase reporter assay, Western blot	22407299
MIRT007069	hsa-miR-133b	Luciferase reporter assay, Western blot	26617770
MIRT007360	hsa-miR-27a-3p	Luciferase reporter assay	23559009
MIRT007360	hsa-miR-27a-3p	Luciferase reporter assay, qRT-PCR, Western blot	23650389
MIRT018378	hsa-miR-335-5p	Microarray	18185580
MIRT020911	hsa-miR-155-5p	Proteomics	18668040
MIRT028600	hsa-miR-30a-5p	Proteomics	18668040
MIRT035541	hsa-let-7a-5p	Luciferase reporter assay	23032975
MIRT036702	hsa-miR-301b-3p	CLASH	23622248
MIRT054243	hsa-miR-574-3p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	23554959
MIRT054487	hsa-miR-219a-5p	Luciferase reporter assay, Microarray, Western blot, qRT-PCR	23690991
MIRT054661	hsa-miR-302b-3p	Luciferase reporter assay, qRT-PCR, Western blot	24083596
MIRT054888	hsa-miR-125a-5p	qRT-PCR, Western blot	24484870
MIRT438024	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT438024	hsa-miR-218-5p	Luciferase reporter assay	24368849
MIRT438024	hsa-miR-218-5p	Luciferase reporter assay, qRT-PCR, Western blot	27057632
MIRT731611	hsa-miR-2861	Luciferase reporter assay, Western blot	27364926
MIRT731713	hsa-miR-132-3p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	26452132
MIRT732238	hsa-miR-875-5p	Luciferase reporter assay, Western blot	27302926
MIRT732238	hsa-miR-875-5p	Immunofluorescence, Luciferase reporter assay, qRT-PCR, Western blot	28274892
MIRT732244	hsa-miR-7-1-3p	Microarray, qRT-PCR, Western blot	27448964
MIRT732437	hsa-miR-491-5p	Luciferase reporter assay	24747968
MIRT732437	hsa-miR-491-5p	Luciferase reporter assay, qRT-PCR, Western blot	25561284
MIRT732478	hsa-miR-27b-3p	qRT-PCR, Luciferase reporter assay, Western blot	25405368
MIRT733034	hsa-miR-27a-5p	Western blot	27313769
MIRT733343	hsa-miR-125b-5p	Immunohistochemistry, Western blot	26686386
MIRT733556	hsa-miR-3622b-5p	Luciferase reporter assay	27611943
MIRT733725	hsa-miR-520b	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	27997901
MIRT733726	hsa-miR-520e	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	27997901
MIRT733879	hsa-miR-133a-5p	Western blot	27465833
MIRT734820	hsa-miR-146b-5p	Luciferase reporter assay, qRT-PCR, Western blot	25760482
MIRT734955	hsa-miR-1-5p	Luciferase reporter assay	27169691
MIRT735250	hsa-miR-137	Luciferase reporter assay, Western blot	28386374
MIRT735379	hsa-miR-122-5p	Luciferase reporter assay, qRT-PCR, Western blot	28641303
MIRT735444	hsa-miR-200a-3p	Western blot	28057023
MIRT735482	hsa-miR-135a-5p	Luciferase reporter assay, Western blot	27524492

Transcription factors

Show/Hide all(33)

Transcription factor	Regulation	Reference
AR	Activation	11556855;21613411
BCL3	Activation	17881446
BRCA1	Repression	21396117
CREBBP	Unknown	21464950
EGR1	Activation	11830539
ESR1	Unknown	12421825
HDAC1	Repression	22025675
HDAC3	Unknown	21464950
HOXB7	Activation	21690342
JUN	Activation	10803405
JUNB	Activation	10803405
KLF10	Repression	22025675
LRRFIP1	Repression	14522076
MTA1	Activation	11948399
NFKB1	Activation	17881446
NFKB1	Unknown	14678988
NR3C2	Activation	17692454
PGR	Unknown	22542550
PML	Repression	12673202;9819401
PPARG	Repression	15486348
RELA	Activation	17881446
SP1	Repression	18202149
SP1	Unknown	10830317;18575762;19538880;21464950
STAT1	Unknown	10558875;22693070
STAT3	Activation	21590492;23504318
TFAP2A	Unknown	8621697
TP53	Activation	10029407
TSG101	Repression	19154774
VDR	Repression	16087726
VDR	Unknown	15218361
WT1	Repression	9291179
YBX1	Activation	17875215;19648825
YY1	Activation	22580610

Show/Hide all(160)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0000165	Process	MAPK cascade	TAS
GO:0000186	Process	Activation of MAPKK activity	IEA
GO:0001503	Process	Ossification	NAS	12925580
GO:0001618	Function	Virus receptor activity	IEA
GO:0001934	Process	Positive regulation of protein phosphorylation	IDA	20551055
GO:0001942	Process	Hair follicle development	IEA
GO:0003682	Function	Chromatin binding	IDA	20551055
GO:0003690	Function	Double-stranded DNA binding	NAS	6325948
GO:0004709	Function	MAP kinase kinase kinase activity	NAS	15542601
GO:0004713	Function	Protein tyrosine kinase activity	IDA	17115032, 17599051
GO:0004713	Function	Protein tyrosine kinase activity	IMP	14702346, 20878056
GO:0004713	Function	Protein tyrosine kinase activity	TAS	16076471
GO:0004714	Function	Transmembrane receptor protein tyrosine kinase activity	IBA	21873635
GO:0004714	Function	Transmembrane receptor protein tyrosine kinase activity	TAS
GO:0004888	Function	Transmembrane signaling receptor activity	IDA	7736574
GO:0005006	Function	Epidermal growth factor-activated receptor activity	IBA	21873635
GO:0005006	Function	Epidermal growth factor-activated receptor activity	IDA	12435727, 17115032
GO:0005006	Function	Epidermal growth factor-activated receptor activity	IMP	22732145
GO:0005006	Function	Epidermal growth factor-activated receptor activity	NAS	2790960, 6325948
GO:0005178	Function	Integrin binding	IEA
GO:0005515	Function	Protein binding	IPI	2176151, 2790960, 7518560, 7542744, 7657591, 7685104, 7693694, 7797556, 7993895, 8034616, 8305738, 8621392, 8887653, 8940013, 9020117, 9050838, 9135143, 9355745, 9419975, 9506989, 9544989, 9852145, 10026169, 10229072, 10572067, 10805725, 11279102, 11896612, 12070153, 12297049, 1229705
GO:0005516	Function	Calmodulin binding	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005615	Component	Extracellular space	NAS	9103388
GO:0005634	Component	Nucleus	IDA	12828935, 17115032, 20551055
GO:0005737	Component	Cytoplasm	IDA	7588596, 12435727, 22298428
GO:0005768	Component	Endosome	IDA	14702346, 17182860, 22732145
GO:0005768	Component	Endosome	IDA	16554368
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005886	Component	Plasma membrane	IDA	15465819, 20462955, 22298428, 22732145
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006357	Process	Regulation of transcription by RNA polymerase II	TAS
GO:0006412	Process	Translation	IEA
GO:0006970	Process	Response to osmotic stress	IEA
GO:0007165	Process	Signal transduction	IDA	10572067
GO:0007165	Process	Signal transduction	TAS
GO:0007166	Process	Cell surface receptor signaling pathway	IDA	7736574
GO:0007169	Process	Transmembrane receptor protein tyrosine kinase signaling pathway	IBA	21873635
GO:0007173	Process	Epidermal growth factor receptor signaling pathway	IDA	7736574, 12435727
GO:0007173	Process	Epidermal growth factor receptor signaling pathway	IMP	20878056
GO:0007173	Process	Epidermal growth factor receptor signaling pathway	TAS
GO:0007202	Process	Activation of phospholipase C activity	TAS	12435727
GO:0007275	Process	Multicellular organism development	IBA	21873635
GO:0007494	Process	Midgut development	IEA
GO:0007611	Process	Learning or memory	ISS
GO:0007623	Process	Circadian rhythm	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IBA	21873635
GO:0008284	Process	Positive regulation of cell population proliferation	IDA	7736574
GO:0008284	Process	Positive regulation of cell population proliferation	IMP	27057632
GO:0009925	Component	Basal plasma membrane	IBA	21873635
GO:0009986	Component	Cell surface	IDA	25666625
GO:0010008	Component	Endosome membrane	IDA	22719997
GO:0010750	Process	Positive regulation of nitric oxide mediated signal transduction	IDA	12828935
GO:0010960	Process	Magnesium ion homeostasis	IEA
GO:0014066	Process	Regulation of phosphatidylinositol 3-kinase signaling	IMP	26514923
GO:0016020	Component	Membrane	IDA	12435727
GO:0016101	Process	Diterpenoid metabolic process	IEA
GO:0016323	Component	Basolateral plasma membrane	IDA	12646923
GO:0016324	Component	Apical plasma membrane	IEA
GO:0018108	Process	Peptidyl-tyrosine phosphorylation	IDA	22732145
GO:0019899	Function	Enzyme binding	IPI	12009895
GO:0019900	Function	Kinase binding	IPI	18722344
GO:0019901	Function	Protein kinase binding	IEA
GO:0019903	Function	Protein phosphatase binding	IPI	15899872, 28759036
GO:0030054	Component	Cell junction	IDA
GO:0030139	Component	Endocytic vesicle	IEA
GO:0030154	Process	Cell differentiation	IBA	21873635
GO:0030235	Function	Nitric-oxide synthase regulator activity	IDA	12828935
GO:0030307	Process	Positive regulation of cell growth	IDA	15467833
GO:0030324	Process	Lung development	IEA
GO:0030335	Process	Positive regulation of cell migration	IMP	12435727, 25678558
GO:0030665	Component	Clathrin-coated vesicle membrane	TAS
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	23418353
GO:0031901	Component	Early endosome membrane	IDA	17714434
GO:0031965	Component	Nuclear membrane	IEA
GO:0032930	Process	Positive regulation of superoxide anion generation	IEA
GO:0032991	Component	Protein-containing complex	IDA	20878056
GO:0033138	Process	Positive regulation of peptidyl-serine phosphorylation	IMP	20878056
GO:0033590	Process	Response to cobalamin	IEA
GO:0033594	Process	Response to hydroxyisoflavone	IEA
GO:0033674	Process	Positive regulation of kinase activity	IBA	21873635
GO:0034614	Process	Cellular response to reactive oxygen species	IMP	26514923
GO:0035690	Process	Cellular response to drug	IEA
GO:0038083	Process	Peptidyl-tyrosine autophosphorylation	IMP	20878056
GO:0038083	Process	Peptidyl-tyrosine autophosphorylation	TAS	22732145
GO:0038128	Process	ERBB2 signaling pathway	TAS
GO:0042059	Process	Negative regulation of epidermal growth factor receptor signaling pathway	TAS
GO:0042060	Process	Wound healing	IEA
GO:0042177	Process	Negative regulation of protein catabolic process	IDA	17115032
GO:0042327	Process	Positive regulation of phosphorylation	IDA	15082764
GO:0042698	Process	Ovulation cycle	IEA
GO:0042743	Process	Hydrogen peroxide metabolic process	IEA
GO:0042802	Function	Identical protein binding	IPI	16777603, 17148612, 18042729, 19563760, 19650109, 20007378, 20029029, 20359299, 21278786, 21480528, 21482778, 22232519, 22579287, 23273428, 23374349, 23436906, 23636329, 24135280, 28988771, 31980649
GO:0043006	Process	Activation of phospholipase A2 activity by calcium-mediated signaling	TAS	12435727
GO:0043066	Process	Negative regulation of apoptotic process	IBA	21873635
GO:0043066	Process	Negative regulation of apoptotic process	IMP	18070883
GO:0043235	Component	Receptor complex	IBA	21873635
GO:0043235	Component	Receptor complex	IDA	23382219
GO:0043406	Process	Positive regulation of MAP kinase activity	IDA	10572067
GO:0043586	Process	Tongue development	IEA
GO:0045121	Component	Membrane raft	IDA	12009895
GO:0045121	Component	Membrane raft	ISS
GO:0045202	Component	Synapse	IEA
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0045737	Process	Positive regulation of cyclin-dependent protein serine/threonine kinase activity	IMP	18483258
GO:0045739	Process	Positive regulation of DNA repair	IDA	17115032
GO:0045740	Process	Positive regulation of DNA replication	IDA	17115032
GO:0045746	Process	Negative regulation of Notch signaling pathway	TAS
GO:0045780	Process	Positive regulation of bone resorption	IEA
GO:0045893	Process	Positive regulation of transcription, DNA-templated	IMP	26514923
GO:0045907	Process	Positive regulation of vasoconstriction	IEA
GO:0045930	Process	Negative regulation of mitotic cell cycle	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	20551055
GO:0046328	Process	Regulation of JNK cascade	IMP	26514923
GO:0046718	Process	Viral entry into host cell	IEA
GO:0046777	Process	Protein autophosphorylation	IMP	18070883
GO:0048143	Process	Astrocyte activation	IEA
GO:0048408	Function	Epidermal growth factor binding	IBA	21873635
GO:0048471	Component	Perinuclear region of cytoplasm	IMP	24854121
GO:0048661	Process	Positive regulation of smooth muscle cell proliferation	IEA
GO:0048812	Process	Neuron projection morphogenesis	IEA
GO:0050679	Process	Positive regulation of epithelial cell proliferation	IBA	21873635
GO:0050679	Process	Positive regulation of epithelial cell proliferation	IDA	10572067
GO:0050729	Process	Positive regulation of inflammatory response	IEA
GO:0050730	Process	Regulation of peptidyl-tyrosine phosphorylation	IMP	12435727
GO:0050999	Process	Regulation of nitric-oxide synthase activity	IDA	12828935
GO:0051015	Function	Actin filament binding	IDA	14702346
GO:0051117	Function	ATPase binding	ISS
GO:0051205	Process	Protein insertion into membrane	TAS	12435727
GO:0051592	Process	Response to calcium ion	IEA
GO:0051897	Process	Positive regulation of protein kinase B signaling	IMP	17655843
GO:0051897	Process	Positive regulation of protein kinase B signaling	TAS
GO:0051968	Process	Positive regulation of synaptic transmission, glutamatergic	IEA
GO:0061024	Process	Membrane organization	TAS
GO:0070141	Process	Response to UV-A	IDA	18483258
GO:0070372	Process	Regulation of ERK1 and ERK2 cascade	IMP	26514923
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IDA	20551055
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IMP	21673316
GO:0070435	Component	Shc-EGFR complex	ISS
GO:0071260	Process	Cellular response to mechanical stimulus	IEA
GO:0071276	Process	Cellular response to cadmium ion	IMP	26514923
GO:0071364	Process	Cellular response to epidermal growth factor stimulus	ISS
GO:0071392	Process	Cellular response to estradiol stimulus	IDA	20551055
GO:0071549	Process	Cellular response to dexamethasone stimulus	IEA
GO:0090263	Process	Positive regulation of canonical Wnt signaling pathway	IMP	20302655
GO:0097421	Process	Liver regeneration	IEA
GO:0097489	Component	Multivesicular body, internal vesicle lumen	IDA	17714434
GO:0098609	Process	Cell-cell adhesion	IMP	12435727
GO:1900020	Process	Positive regulation of protein kinase C activity	IDA	22732145
GO:1900087	Process	Positive regulation of G1/S transition of mitotic cell cycle	IMP	18483258
GO:1901185	Process	Negative regulation of ERBB signaling pathway	TAS
GO:1901224	Process	Positive regulation of NIK/NF-kappaB signaling	IMP	26514923
GO:1902722	Process	Positive regulation of prolactin secretion	IEA
GO:1903078	Process	Positive regulation of protein localization to plasma membrane	IDA	22732145
GO:1903800	Process	Positive regulation of production of miRNAs involved in gene silencing by miRNA	IMP	21673316
GO:1905208	Process	Negative regulation of cardiocyte differentiation	IMP	23069713
GO:2000145	Process	Regulation of cell motility	TAS

MIM	HGNC	e!Ensembl
131550	3236	ENSG00000146648

Protein

UniProt ID

P00533

Protein name

Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)

Protein function

Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:2790960, PubMed:10805725, PubMed:27153536). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975, PubMed:15611079, PubMed:12297049, PubMed:27153536, PubMed:20837704, PubMed:17909029). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). ; Isoform 2 may act as an antagonist of EGF action.; (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins.

PDB

1DNQ , 1DNR , 1IVO , 1M14 , 1M17 , 1MOX , 1NQL , 1XKK , 1YY9 , 1Z9I , 2EB2 , 2EB3 , 2EXP , 2EXQ , 2GS2 , 2GS6 , 2GS7 , 2ITN , 2ITO , 2ITP , 2ITQ , 2ITT , 2ITU , 2ITV , 2ITW , 2ITX , 2ITY , 2ITZ , 2J5E , 2J5F , 2J6M , 2JIT , 2JIU , 2JIV , 2KS1 , 2M0B , 2M20 , 2N5S , 2RF9 , 2RFD , 2RFE , 2RGP , 3B2U , 3B2V , 3BEL , 3BUO , 3C09 , 3G5V , 3G5Y , 3GOP , 3GT8

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01030	Recep_L_domain	57 → 168	Receptor L domain	Repeat
PF00757	Furin-like	177 → 338	Furin-like cysteine rich region	Domain
PF01030	Recep_L_domain	361 → 481	Receptor L domain	Repeat
PF14843	GF_recep_IV	505 → 637	Growth factor receptor domain IV	Domain
PF07714	PK_Tyr_Ser-Thr	712 → 968	Protein tyrosine and serine/threonine kinase	Domain

Sequence

MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA
VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF
QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC
TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK
NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF
ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL
FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN
LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM
GENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVV
ALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS
GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGI
CLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAA
RNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY
GVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPK
FRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQ
QGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTED
SIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLN
TVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRV
APQSSEFIGA

Sequence length

1210

Interactions

View interactions

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