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DUSP6 (dual specificity phosphatase 6)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1848
Gene nameGene Name - the full gene name approved by the HGNC.
Dual specificity phosphatase 6
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
DUSP6
SynonymsGene synonyms aliases
HH19, MKP3, PYST1
ChromosomeChromosome number
12
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q21.33
SummarySummary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regu
SNPsSNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs139318648 G>A,C Risk-factor Missense variant, intron variant, coding sequence variant
rs143946794 T>C Pathogenic Missense variant, intron variant, coding sequence variant
rs146089505 G>A Risk-factor Missense variant, coding sequence variant
rs587776978 A>T Pathogenic Coding sequence variant, missense variant
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT006481 hsa-miR-181a-5p Luciferase reporter assay, Western blot 17382377
MIRT006481 hsa-miR-181a-5p Luciferase reporter assay, Western blot 17382377
MIRT006481 hsa-miR-181a-5p Luciferase reporter assay, Western blot 17382377
MIRT006481 hsa-miR-181a-5p Luciferase reporter assay, Western blot 17382377
MIRT006481 hsa-miR-181a-5p Luciferase reporter assay, Western blot 17382377
Transcription factors
Transcription factor Regulation Reference
ETS1 Unknown 20097731
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000165 Process MAPK cascade TAS
GO:0000187 Process Activation of MAPK activity TAS
GO:0000188 Process Inactivation of MAPK activity IBA 21873635
GO:0000188 Process Inactivation of MAPK activity IDA 8670865
GO:0004721 Function Phosphoprotein phosphatase activity IBA 21873635
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q16828
Protein name Dual specificity protein phosphatase 6 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PYST1) (Mitogen-activated protein kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3)
Protein function Dual specificity protein phosphatase, which mediates dephosphorylation and inactivation of MAP kinases (PubMed:8670865). Has a specificity for the ERK family (PubMed:8670865). Plays an important role in alleviating chronic postoperative pain (By
PDB 1HZM , 1MKP
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00581 Rhodanese
19 142
Rhodanese-like domain
Domain
PF00782 DSPc
214 346
Dual specificity phosphatase, catalytic domain
Domain
Sequence
Sequence length 381
Interactions View interactions

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