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CXCL8 (C-X-C motif chemokine ligand 8)
Gene
Gene SNPs Transcription factors Other IDs
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3576
Gene nameGene Name - the full gene name approved by the HGNC.
C-X-C motif chemokine ligand 8
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
CXCL8
SynonymsGene synonyms aliases
GCP-1, GCP1, IL8, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1, SCYB8
ChromosomeChromosome number
4
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q13.3
SummarySummary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is commonly referred to as interleukin-8 (IL-8). IL-8 is secreted by mononuclear macrophages, neutrophils, e
miRNAmiRNA information provided by mirtarbase database.
Gene SNPs Transcription factors Other IDs
miRTarBase ID miRNA Experiments Reference
MIRT438087 hsa-miR-93-5p Luciferase reporter assay, qRT-PCR 24433094
MIRT438087 hsa-miR-93-5p Luciferase reporter assay, qRT-PCR 24433094
MIRT731479 hsa-miR-203a-3p qRT-PCR 26304234
MIRT731479 hsa-miR-203a-3p qRT-PCR 26304234
MIRT731479 hsa-miR-203a-3p qRT-PCR 26304234
Transcription factors
Gene SNPs Transcription factors Other IDs
Transcription factor Regulation Reference
ATF4 Unknown 16931790
CEBPB Activation 15085176;15688424
CEBPB Unknown 11120852
DDIT3 Unknown 18772138
DEK Unknown 16829531
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs Transcription factors Other IDs
GO ID Ontology Definition Evidence Reference
GO:0001525 Process Angiogenesis TAS 11483765
GO:0002237 Process Response to molecule of bacterial origin IDA 19912257
GO:0005153 Function Interleukin-8 receptor binding IPI 1840701
GO:0005515 Function Protein binding IPI 10880251, 22904195, 23597562, 24501198, 26829648, 28381538
GO:0005576 Component Extracellular region TAS
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs Transcription factors Other IDs
MIM
HGNC
e!Ensembl
Protein
Gene SNPs Transcription factors Other IDs
UniProt ID P10145
Protein name Interleukin-8 (IL-8) (C-X-C motif chemokine 8) (Chemokine (C-X-C motif) ligand 8) (Emoctakin) (Granulocyte chemotactic protein 1) (GCP-1) (Monocyte-derived neutrophil chemotactic factor) (MDNCF) (Monocyte-derived neutrophil-activating peptide) (MONAP) (Ne
Protein function Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection (PubMed:18692776, PubMed:7636208). Also plays an important role in neutrophil activat
PDB 1ICW , 1IKL , 1IKM , 1IL8 , 1ILP , 1ILQ , 1QE6 , 1ROD , 2IL8 , 3IL8 , 4XDX , 5D14 , 5WDZ , 6LFM , 6LFO , 6N2U , 6WZM , 6XMN , 8IC0 , 8XWN , 8XX6
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00048 IL8
32 → 92
Small cytokines (intecrine/chemokine), interleukin-8 like
 Domain
Sequence
Sequence length 99
Interactions View interactions

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