CTNND1 (catenin delta 1)

Gene

• Entrez ID: 1500
• Gene name: Catenin delta 1
• Gene symbol: CTNND1
• Synonyms: BCDS2, CAS, CTNND, P120CAS, P120CTN, p120, p120(CAS), p120(CTN)
• Chromosome: 11
• Chromosome location: 11q12.1
• Summary: This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined. Read-through transcription also exists between this gene and the neighboring upstream thioredoxin-related transmembrane protein 2 (TMX2) gene. [provided by RefSeq, Dec 2010]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT002658	hsa-miR-124-3p	Microarray	15685193
MIRT002658	hsa-miR-124-3p	Microarray	18668037
MIRT019044	hsa-miR-335-5p	Microarray	18185580
MIRT028638	hsa-miR-30a-5p	Proteomics	18668040
MIRT036283	hsa-miR-1229-3p	CLASH	23622248
MIRT040176	hsa-miR-615-3p	CLASH	23622248
MIRT042823	hsa-miR-324-3p	CLASH	23622248
MIRT043271	hsa-miR-331-3p	CLASH	23622248
MIRT047675	hsa-miR-10a-5p	CLASH	23622248
MIRT053645	hsa-miR-143-3p	Microarray	22942087
MIRT053657	hsa-miR-145-5p	Microarray	22942087
MIRT053657	hsa-miR-145-5p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	25470111
MIRT054276	hsa-miR-29c-3p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	25634213
MIRT181428	hsa-miR-6124	PAR-CLIP	22012620
MIRT181428	hsa-miR-6124	PAR-CLIP	27292025
MIRT181438	hsa-miR-409-3p	PAR-CLIP	22100165
MIRT181438	hsa-miR-409-3p	Luciferase reporter assay	26992637
MIRT181480	hsa-miR-548m	PAR-CLIP	23592263
MIRT333613	hsa-miR-651-3p	PAR-CLIP	22012620
MIRT333613	hsa-miR-651-3p	PAR-CLIP	27292025
MIRT333614	hsa-miR-3148	PAR-CLIP	22100165
MIRT444247	hsa-miR-2355-5p	PAR-CLIP	22100165
MIRT444248	hsa-miR-873-5p	PAR-CLIP	22100165
MIRT444249	hsa-miR-548c-3p	PAR-CLIP	22100165
MIRT449134	hsa-miR-599	PAR-CLIP	22100165
MIRT449135	hsa-miR-1273e	PAR-CLIP	22100165
MIRT449136	hsa-miR-3161	PAR-CLIP	22100165
MIRT478543	hsa-miR-5584-5p	PAR-CLIP	23592263
MIRT478544	hsa-miR-3916	PAR-CLIP	23592263
MIRT478545	hsa-miR-4776-3p	PAR-CLIP	23592263
MIRT478546	hsa-miR-3972	PAR-CLIP	23592263
MIRT478547	hsa-miR-1202	PAR-CLIP	23592263
MIRT478548	hsa-miR-6831-5p	PAR-CLIP	23592263
MIRT478549	hsa-miR-3927-3p	PAR-CLIP	23592263
MIRT478550	hsa-miR-5680	PAR-CLIP	23592263
MIRT478550	hsa-miR-5680	PAR-CLIP	22012620
MIRT478551	hsa-miR-4796-3p	PAR-CLIP	23592263
MIRT478552	hsa-miR-887-5p	PAR-CLIP	23592263
MIRT478552	hsa-miR-887-5p	PAR-CLIP	26701625
MIRT478553	hsa-miR-6780a-5p	PAR-CLIP	23592263
MIRT478553	hsa-miR-6780a-5p	PAR-CLIP	26701625
MIRT478554	hsa-miR-6779-5p	PAR-CLIP	23592263
MIRT478554	hsa-miR-6779-5p	PAR-CLIP	26701625
MIRT478555	hsa-miR-3689c	PAR-CLIP	23592263
MIRT478555	hsa-miR-3689c	PAR-CLIP	26701625
MIRT478556	hsa-miR-3689b-3p	PAR-CLIP	23592263
MIRT478556	hsa-miR-3689b-3p	PAR-CLIP	26701625
MIRT478557	hsa-miR-3689a-3p	PAR-CLIP	23592263
MIRT478557	hsa-miR-3689a-3p	PAR-CLIP	26701625
MIRT478558	hsa-miR-30b-3p	PAR-CLIP	23592263
MIRT478558	hsa-miR-30b-3p	PAR-CLIP	26701625
MIRT478559	hsa-miR-1273h-5p	PAR-CLIP	23592263
MIRT478559	hsa-miR-1273h-5p	PAR-CLIP	26701625
MIRT478560	hsa-miR-6788-5p	PAR-CLIP	23592263
MIRT478560	hsa-miR-6788-5p	PAR-CLIP	26701625
MIRT478561	hsa-miR-30c-2-3p	PAR-CLIP	23592263
MIRT478561	hsa-miR-30c-2-3p	PAR-CLIP	26701625
MIRT478562	hsa-miR-30c-1-3p	PAR-CLIP	23592263
MIRT478562	hsa-miR-30c-1-3p	PAR-CLIP	26701625
MIRT478563	hsa-miR-3978	PAR-CLIP	23592263
MIRT478563	hsa-miR-3978	PAR-CLIP	26701625
MIRT478564	hsa-miR-27b-3p	PAR-CLIP	23592263
MIRT478564	hsa-miR-27b-3p	PAR-CLIP	26701625
MIRT478565	hsa-miR-27a-3p	PAR-CLIP	23592263
MIRT478565	hsa-miR-27a-3p	PAR-CLIP	26701625
MIRT478566	hsa-miR-513a-5p	PAR-CLIP	23592263
MIRT478566	hsa-miR-513a-5p	PAR-CLIP	26701625
MIRT478567	hsa-miR-4425	PAR-CLIP	23592263
MIRT478567	hsa-miR-4425	PAR-CLIP	26701625
MIRT478568	hsa-miR-3134	PAR-CLIP	23592263
MIRT478568	hsa-miR-3134	PAR-CLIP	26701625
MIRT478569	hsa-miR-4534	PAR-CLIP	23592263
MIRT478569	hsa-miR-4534	PAR-CLIP	26701625
MIRT478570	hsa-miR-8082	PAR-CLIP	23592263
MIRT478570	hsa-miR-8082	PAR-CLIP	26701625
MIRT478571	hsa-miR-219a-1-3p	PAR-CLIP	23592263
MIRT478571	hsa-miR-219a-1-3p	PAR-CLIP	26701625
MIRT478572	hsa-miR-605-3p	PAR-CLIP	23592263
MIRT478572	hsa-miR-605-3p	PAR-CLIP	22012620
MIRT478572	hsa-miR-605-3p	PAR-CLIP	26701625
MIRT478572	hsa-miR-605-3p	PAR-CLIP	27292025
MIRT478573	hsa-miR-3185	PAR-CLIP	23592263
MIRT478573	hsa-miR-3185	PAR-CLIP	26701625
MIRT478574	hsa-miR-3688-3p	PAR-CLIP	23592263
MIRT478574	hsa-miR-3688-3p	PAR-CLIP	26701625
MIRT478575	hsa-miR-4259	PAR-CLIP	23592263
MIRT478575	hsa-miR-4259	PAR-CLIP	26701625
MIRT478576	hsa-miR-3714	PAR-CLIP	23592263
MIRT478576	hsa-miR-3714	PAR-CLIP	26701625
MIRT526146	hsa-miR-3162-5p	PAR-CLIP	22012620
MIRT526146	hsa-miR-3162-5p	PAR-CLIP	27292025
MIRT526147	hsa-miR-3159	PAR-CLIP	22012620
MIRT526147	hsa-miR-3159	PAR-CLIP	27292025
MIRT526148	hsa-miR-3154	PAR-CLIP	22012620
MIRT526148	hsa-miR-3154	PAR-CLIP	27292025
MIRT526149	hsa-miR-541-5p	PAR-CLIP	22012620
MIRT526149	hsa-miR-541-5p	PAR-CLIP	27292025
MIRT734779	hsa-miR-98-5p	Luciferase reporter assay	26263183
MIRT747088	hsa-miR-4691-3p	PAR-CLIP	26701625

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005102	Function	Signaling receptor binding	IPI	19332538
GO:0005515	Function	Protein binding	IPI	12370829, 12475979, 15657067, 16354688, 17047063, 20123964, 22846708, 23990464, 24189400, 24658140, 28051089, 28877994, 31980649
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	IDA	20123964
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	17047063
GO:0005829	Component	Cytosol	IMP	20123964
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA	17115030
GO:0005886	Component	Plasma membrane	IMP	20123964
GO:0005886	Component	Plasma membrane	TAS
GO:0005911	Component	Cell-cell junction	IDA	12370829
GO:0005912	Component	Adherens junction	IBA	21873635
GO:0005915	Component	Zonula adherens	IEA
GO:0007043	Process	Cell-cell junction assembly	IBA	21873635
GO:0007420	Process	Brain development	IEA
GO:0016055	Process	Wnt signaling pathway	IEA
GO:0016342	Component	Catenin complex	IDA	28051089
GO:0019901	Function	Protein kinase binding	IEA
GO:0030027	Component	Lamellipodium	IEA
GO:0030426	Component	Growth cone	IEA
GO:0030496	Component	Midbody	IDA	15166316
GO:0034332	Process	Adherens junction organization	TAS
GO:0035635	Process	Entry of bacterium into host cell	TAS
GO:0043197	Component	Dendritic spine	IEA
GO:0044331	Process	Cell-cell adhesion mediated by cadherin	IMP	14610055
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0045296	Function	Cadherin binding	IBA	21873635
GO:0045296	Function	Cadherin binding	IPI	12734196
GO:0050821	Process	Protein stabilization	IMP	14610055
GO:0070062	Component	Extracellular exosome	HDA	19199708
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	IMP	20123964
GO:0098609	Process	Cell-cell adhesion	IBA	21873635
GO:0098685	Component	Schaffer collateral - CA1 synapse	IEA
GO:0098686	Component	Hippocampal mossy fiber to CA3 synapse	IEA
GO:0098831	Component	Presynaptic active zone cytoplasmic component	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099072	Process	Regulation of postsynaptic membrane neurotransmitter receptor levels	IDA	18602475
GO:0099072	Process	Regulation of postsynaptic membrane neurotransmitter receptor levels	IMP	18602475
GO:0099092	Component	Postsynaptic density, intracellular component	IEA

Other IDs

• MIM: 601045
• HGNC: 2515
• e!Ensembl: ENSG00000198561

Protein

• UniProt ID: O60716
• Protein name: Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas))
• Protein function: Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476).
• PDB: 3L6X, 3L6Y
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00514	Arm	397 → 437	Armadillo/beta-catenin-like repeat	Repeat
  PF00514	Arm	440 → 481	Armadillo/beta-catenin-like repeat	Repeat
  PF00514	Arm	701 → 739	Armadillo/beta-catenin-like repeat	Repeat

• Sequence:

  MDDSEVESTASILASVKEQEAQFEKLTRALEEERRHVSAQLERVRVSPQDANPLMANGTL
  TRRHQNGRFVGDADLERQKFSDLKLNGPQDHSHLLYSTIPRMQEPGQIVETYTEEDPEGA
  MSVVSVETSDDGTTRRTETTVKKVVKTVTTRTVQPVAMGPDGLPVDASSVSNNYIQTLGR
  DFRKNGNGGPGPYVGQAGTATLPRNFHYPPDGYSRHYEDGYPGGSDNYGSLSRVTRIEER
  YRPSMEGYRAPSRQDVYGPQPQVRVGGSSVDLHRFHPEPYGLEDDQRSMGYDDLDYGMMS
  DYGTARRTGTPSDPRRRLRSYEDMIGEEVPSDQYYWAPLAQHERGSLASLDSLRKGGPPP
  PNWRQPELPEVIAMLGFRLDAVKSNAAAYLQHLCYRNDKVKTDVRKLKGIPVLVGLLDHP
  KKEVHLGACGALKNISFGRDQDNKIAIKNCDGVPALVRLLRKARDMDLTEVITGTLWNLS
  SHDSIKMEIVDHALHALTDEVIIPHSGWEREPNEDCKPRHIEWESVLTNTAGCLRNVSSE
  RSEARRKLRECDGLVDALIFIVQAEIGQKDSDSKLVENCVCLLRNLSYQVHREIPQAERY
  QEAAPNVANNTGPHAASCFGAKKGKDEWFSRGKKPIEDPANDTVDFPKRTSPARGYELLF
  QPEVVRIYISLLKESKTPAILEASAGAIQNLCAGRWTYGRYIRSALRQEKALSAIADLLT
  NEHERVVKAASGALRNLAVDARNKELIGKHAIPNLVKNLPGGQQNSSWNFSEDTVISILN
  TINEVIAENLEAAKKLRETQGIEKLVLINKSGNRSEKEVRAAALVLQTIWGYKELRKPLE
  KEGWKKSDFQVNLNNASRSQSSHSYDDSTLPLIDRNQKSDKKPDREEIQMSNMGSNTKSL
  DNNYSTPNERGDHNRTLDRSGDLGDMEPLKGTTPLMQDEGQESLEEELDVLVLDDEGGQV
  SYPSMQKI

• Sequence length: 968