CSPG4 (chondroitin sulfate proteoglycan 4)

Gene

• Entrez ID: 1464
• Gene name: Chondroitin sulfate proteoglycan 4
• Gene symbol: CSPG4
• Synonyms: CSPG4A, HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16, NG2
• Chromosome: 15
• Chromosome location: 15q24.2
• Summary: A human melanoma-associated chondroitin sulfate proteoglycan plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. CSPG4 represents an integral membrane chondroitin sulfa

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022345	hsa-miR-124-3p	Microarray	18668037
MIRT912897	hsa-miR-1237	CLIP-seq
MIRT912898	hsa-miR-1248	CLIP-seq
MIRT912899	hsa-miR-1285	CLIP-seq
MIRT912900	hsa-miR-1915	CLIP-seq
MIRT912901	hsa-miR-1972	CLIP-seq
MIRT912902	hsa-miR-296-5p	CLIP-seq
MIRT912903	hsa-miR-3157-3p	CLIP-seq
MIRT912904	hsa-miR-3187-5p	CLIP-seq
MIRT912905	hsa-miR-378g	CLIP-seq
MIRT912906	hsa-miR-4252	CLIP-seq
MIRT912907	hsa-miR-4279	CLIP-seq
MIRT912908	hsa-miR-4310	CLIP-seq
MIRT912909	hsa-miR-4486	CLIP-seq
MIRT912910	hsa-miR-490-3p	CLIP-seq
MIRT912911	hsa-miR-502-5p	CLIP-seq
MIRT912912	hsa-miR-612	CLIP-seq
MIRT912913	hsa-miR-642b	CLIP-seq
MIRT912914	hsa-miR-649	CLIP-seq
MIRT912915	hsa-miR-874	CLIP-seq
MIRT1970749	hsa-miR-1912	CLIP-seq
MIRT1970750	hsa-miR-331-3p	CLIP-seq
MIRT1970751	hsa-miR-4292	CLIP-seq
MIRT1970752	hsa-miR-4308	CLIP-seq
MIRT1970753	hsa-miR-4447	CLIP-seq
MIRT1970754	hsa-miR-4459	CLIP-seq
MIRT1970755	hsa-miR-4472	CLIP-seq
MIRT1970756	hsa-miR-4488	CLIP-seq
MIRT1970757	hsa-miR-4697-5p	CLIP-seq
MIRT1970758	hsa-miR-711	CLIP-seq
MIRT2206525	hsa-miR-1910	CLIP-seq
MIRT912900	hsa-miR-1915	CLIP-seq
MIRT2206526	hsa-miR-361-3p	CLIP-seq
MIRT2206527	hsa-miR-4283	CLIP-seq
MIRT1970751	hsa-miR-4292	CLIP-seq
MIRT1970752	hsa-miR-4308	CLIP-seq
MIRT2206528	hsa-miR-455-3p	CLIP-seq
MIRT2678719	hsa-miR-198	CLIP-seq
MIRT2678720	hsa-miR-3591-3p	CLIP-seq
MIRT2678721	hsa-miR-520a-5p	CLIP-seq
MIRT2678722	hsa-miR-525-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000187	Process	Activation of MAPK activity	IEA
GO:0001525	Process	Angiogenesis	IEA
GO:0001726	Component	Ruffle	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005654	Component	Nucleoplasm	IDA
GO:0005796	Component	Golgi lumen	TAS
GO:0005886	Component	Plasma membrane	IDA
GO:0005887	Component	Integral component of plasma membrane	TAS	8790396
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006929	Process	Substrate-dependent cell migration	IEA
GO:0008283	Process	Cell population proliferation	IEA
GO:0008347	Process	Glial cell migration	IEA
GO:0009986	Component	Cell surface	HDA	19581412
GO:0009986	Component	Cell surface	TAS	10587647
GO:0015026	Function	Coreceptor activity	IEA
GO:0016324	Component	Apical plasma membrane	IEA
GO:0019901	Function	Protein kinase binding	IPI	10587647
GO:0030206	Process	Chondroitin sulfate biosynthetic process	TAS
GO:0030207	Process	Chondroitin sulfate catabolic process	TAS
GO:0030208	Process	Dermatan sulfate biosynthetic process	TAS
GO:0031258	Component	Lamellipodium membrane	IEA
GO:0035556	Process	Intracellular signal transduction	IDA	10587647
GO:0043202	Component	Lysosomal lumen	TAS
GO:0048008	Process	Platelet-derived growth factor receptor signaling pathway	IEA
GO:0048771	Process	Tissue remodeling	IEA
GO:0050731	Process	Positive regulation of peptidyl-tyrosine phosphorylation	IDA	10587647
GO:0062023	Component	Collagen-containing extracellular matrix	HDA	27068509, 28675934
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0097178	Process	Ruffle assembly	IEA

Other IDs

• MIM: 601172
• HGNC: 2466
• e!Ensembl: ENSG00000173546

Protein

• UniProt ID: Q6UVK1
• Protein name: Chondroitin sulfate proteoglycan 4 (Chondroitin sulfate proteoglycan NG2) (Melanoma chondroitin sulfate proteoglycan) (Melanoma-associated chondroitin sulfate proteoglycan)
• Protein function: Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface re
• PDB: 7ML7, 7N8X, 7N9Y
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02210	Laminin_G_2	55 → 178	Laminin G domain	Domain
  PF02210	Laminin_G_2	230 → 363	Laminin G domain	Domain
  PF16184	Cadherin_3	423 → 524		Domain
  PF16184	Cadherin_3	536 → 645		Domain
  PF16184	Cadherin_3	652 → 766		Domain
  PF16184	Cadherin_3	771 → 879		Domain
  PF16184	Cadherin_3	884 → 990		Domain
  PF16184	Cadherin_3	1001 → 1110		Domain
  PF16184	Cadherin_3	1115 → 1218		Domain
  PF16184	Cadherin_3	1221 → 1339		Domain
  PF16184	Cadherin_3	1358 → 1450		Domain
  PF16184	Cadherin_3	1456 → 1563		Domain
  PF16184	Cadherin_3	1572 → 1679		Domain
  PF16184	Cadherin_3	1690 → 1803		Domain
  PF16184	Cadherin_3	1815 → 1924		Domain

• Sequence:

  MQSGPRPPLPAPGLALALTLTMLARLASAASFFGENHLEVPVATALTDIDLQLQFSTSQP
  EALLLLAAGPADHLLLQLYSGRLQVRLVLGQEELRLQTPAETLLSDSIPHTVVLTVVEGW
  ATLSVDGFLNASSAVPGAPLEVPYGLFVGGTGTLGLPYLRGTSRPLRGCLHAATLNGRSL
  LRPLTPDVHEGCAEEFSASDDVALGFSGPHSLAAFPAWGTQDEGTLEFTLTTQSRQAPLA
  FQAGGRRGDFIYVDIFEGHLRAVVEKGQGTVLLHNSVPVADGQPHEVSVHINAHRLEISV
  DQYPTHTSNRGVLSYLEPRGSLLLGGLDAEASRHLQEHRLGLTPEATNASLLGCMEDLSV
  NGQRRGLREALLTRNMAAGCRLEEEEYEDDAYGHYEAFSTLAPEAWPAMELPEPCVPEPG
  LPPVFANFTQLLTISPLVVAEGGTAWLEWRHVQPTLDLMEAELRKSQVLFSVTRGARHGE
  LELDIPGAQARKMFTLLDVVNRKARFIHDGSEDTSDQLVLEVSVTARVPMPSCLRRGQTY
  LLPIQVNPVNDPPHIIFPHGSLMVILEHTQKPLGPEVFQAYDPDSACEGLTFQVLGTSSG
  LPVERRDQPGEPATEFSCRELEAGSLVYVHRGGPAQDLTFRVSDGLQASPPATLKVVAIR
  PAIQIHRSTGLRLAQGSAMPILPANLSVETNAVGQDVSVLFRVTGALQFGELQKQGAGGV
  EGAEWWATQAFHQRDVEQGRVRYLSTDPQHHAYDTVENLALEVQVGQEILSNLSFPVTIQ
  RATVWMLRLEPLHTQNTQQETLTTAHLEATLEEAGPSPPTFHYEVVQAPRKGNLQLQGTR
  LSDGQGFTQDDIQAGRVTYGATARASEAVEDTFRFRVTAPPYFSPLYTFPIHIGGDPDAP
  VLTNVLLVVPEGGEGVLSADHLFVKSLNSASYLYEVMERPRHGRLAWRGTQDKTTMVTSF
  TNEDLLRGRLVYQHDDSETTEDDIPFVATRQGESSGDMAWEEVRGVFRVAIQPVNDHAPV
  QTISRIFHVARGGRRLLTTDDVAFSDADSGFADAQLVLTRKDLLFGSIVAVDEPTRPIYR
  FTQEDLRKRRVLFVHSGADRGWIQLQVSDGQHQATALLEVQASEPYLRVANGSSLVVPQG
  GQGTIDTAVLHLDTNLDIRSGDEVHYHVTAGPRWGQLVRAGQPATAFSQQDLLDGAVLYS
  HNGSLSPRDTMAFSVEAGPVHTDATLQVTIALEGPLAPLKLVRHKKIYVFQGEAAEIRRD
  QLEAAQEAVPPADIVFSVKSPPSAGYLVMVSRGALADEPPSLDPVQSFSQEAVDTGRVLY
  LHSRPEAWSDAFSLDVASGLGAPLEGVLVELEVLPAAIPLEAQNFSVPEGGSLTLAPPLL
  RVSGPYFPTLLGLSLQVLEPPQHGALQKEDGPQARTLSAFSWRMVEEQLIRYVHDGSETL
  TDSFVLMANASEMDRQSHPVAFTVTVLPVNDQPPILTTNTGLQMWEGATAPIPAEALRST
  DGDSGSEDLVYTIEQPSNGRVVLRGAPGTEVRSFTQAQLDGGLVLFSHRGTLDGGFRFRL
  SDGEHTSPGHFFRVTAQKQVLLSLKGSQTLTVCPGSVQPLSSQTLRASSSAGTDPQLLLY
  RVVRGPQLGRLFHAQQDSTGEALVNFTQAEVYAGNILYEHEMPPEPFWEAHDTLELQLSS
  PPARDVAATLAVAVSFEAACPQRPSHLWKNKGLWVPEGQRARITVAALDASNLLASVPSP
  QRSEHDVLFQVTQFPSRGQLLVSEEPLHAGQPHFLQSQLAAGQLVYAHGGGGTQQDGFHF
  RAHLQGPAGASVAGPQTSEAFAITVRDVNERPPQPQASVPLRLTRGSRAPISRAQLSVVD
  PDSAPGEIEYEVQRAPHNGFLSLVGGGLGPVTRFTQADVDSGRLAFVANGSSVAGIFQLS
  MSDGASPPLPMSLAVDILPSAIEVQLRAPLEVPQALGRSSLSQQQLRVVSDREEPEAAYR
  LIQGPQYGHLLVGGRPTSAFSQFQIDQGEVVFAFTNFSSSHDHFRVLALARGVNASAVVN
  VTVRALLHVWAGGPWPQGATLRLDPTVLDAGELANRTGSVPRFRLLEGPRHGRVVRVPRA
  RTEPGGSQLVEQFTQQDLEDGRLGLEVGRPEGRAPGPAGDSLTLELWAQGVPPAVASLDF
  ATEPYNAARPYSVALLSVPEAARTEAGKPESSTPTGEPGPMASSPEPAVAKGGFLSFLEA
  NMFSVIIPMCLVLLLLALILPLLFYLRKRNKTGKHDVQVLTAKPRNGLAGDTETFRKVEP
  GQAIPLTAVPGQGPPPGGQPDPELLQFCRTPNPALKNGQYWV

• Sequence length: 2322