CSNK2A2 (casein kinase 2 alpha 2)

Gene

• Entrez ID: 1459
• Gene name: Casein kinase 2 alpha 2
• Gene symbol: CSNK2A2
• Synonyms: CK2A2, CK2alpha', CSNK2A1
• Chromosome: 16
• Chromosome location: 16q21
• Summary: This gene encodes the alpha`, or alpha 2, catalytic subunit of the protein kinase enzyme, casein kinase 2 (CK2). Casein kinase 2 is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular pr

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024100	hsa-miR-1-3p	Proteomics	18668040
MIRT053052	hsa-miR-1228-3p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	23554909
MIRT053052	hsa-miR-1228-3p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	23554909
MIRT912875	hsa-miR-1289	CLIP-seq
MIRT912876	hsa-miR-3185	CLIP-seq
MIRT912877	hsa-miR-3198	CLIP-seq
MIRT912878	hsa-miR-421	CLIP-seq
MIRT912879	hsa-miR-4294	CLIP-seq
MIRT912880	hsa-miR-4309	CLIP-seq
MIRT912881	hsa-miR-4318	CLIP-seq
MIRT912882	hsa-miR-4709-5p	CLIP-seq
MIRT912883	hsa-miR-4786-3p	CLIP-seq
MIRT912884	hsa-miR-505	CLIP-seq
MIRT912885	hsa-miR-671-5p	CLIP-seq
MIRT2206520	hsa-miR-3160-5p	CLIP-seq
MIRT2206521	hsa-miR-4314	CLIP-seq
MIRT2206522	hsa-miR-544	CLIP-seq
MIRT2509773	hsa-miR-1178	CLIP-seq
MIRT2509774	hsa-miR-1284	CLIP-seq
MIRT2509775	hsa-miR-208a	CLIP-seq
MIRT2509776	hsa-miR-208b	CLIP-seq
MIRT2509777	hsa-miR-2113	CLIP-seq
MIRT2509778	hsa-miR-3148	CLIP-seq
MIRT2509779	hsa-miR-346	CLIP-seq
MIRT2509780	hsa-miR-3688-3p	CLIP-seq
MIRT2509781	hsa-miR-4273	CLIP-seq
MIRT2509782	hsa-miR-4288	CLIP-seq
MIRT2509783	hsa-miR-4677-5p	CLIP-seq
MIRT2509784	hsa-miR-4695-3p	CLIP-seq
MIRT2509785	hsa-miR-4711-3p	CLIP-seq
MIRT2509786	hsa-miR-4715-3p	CLIP-seq
MIRT2509787	hsa-miR-499-5p	CLIP-seq
MIRT2509788	hsa-miR-578	CLIP-seq
MIRT2509789	hsa-miR-592	CLIP-seq
MIRT2509790	hsa-miR-599	CLIP-seq
MIRT2509791	hsa-miR-632	CLIP-seq
MIRT2509792	hsa-miR-659	CLIP-seq
MIRT2509793	hsa-miR-767-3p	CLIP-seq
MIRT2509773	hsa-miR-1178	CLIP-seq
MIRT2509774	hsa-miR-1284	CLIP-seq
MIRT2509775	hsa-miR-208a	CLIP-seq
MIRT2509776	hsa-miR-208b	CLIP-seq
MIRT2509777	hsa-miR-2113	CLIP-seq
MIRT2509778	hsa-miR-3148	CLIP-seq
MIRT2509779	hsa-miR-346	CLIP-seq
MIRT2509780	hsa-miR-3688-3p	CLIP-seq
MIRT2509781	hsa-miR-4273	CLIP-seq
MIRT2509782	hsa-miR-4288	CLIP-seq
MIRT2509783	hsa-miR-4677-5p	CLIP-seq
MIRT2509784	hsa-miR-4695-3p	CLIP-seq
MIRT2509785	hsa-miR-4711-3p	CLIP-seq
MIRT2509786	hsa-miR-4715-3p	CLIP-seq
MIRT2678716	hsa-miR-4796-3p	CLIP-seq
MIRT2509787	hsa-miR-499-5p	CLIP-seq
MIRT2678717	hsa-miR-548t	CLIP-seq
MIRT2509788	hsa-miR-578	CLIP-seq
MIRT2678718	hsa-miR-589	CLIP-seq
MIRT2509789	hsa-miR-592	CLIP-seq
MIRT2509790	hsa-miR-599	CLIP-seq
MIRT2509791	hsa-miR-632	CLIP-seq
MIRT2509792	hsa-miR-659	CLIP-seq
MIRT2509793	hsa-miR-767-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	IEA
GO:0001669	Component	Acrosomal vesicle	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA	21873635
GO:0004674	Function	Protein serine/threonine kinase activity	IGI	28031292
GO:0005515	Function	Protein binding	IPI	10094392, 14667819, 19011756, 21988832, 23455922, 23555304, 25416956, 25519132, 25852190, 26496610, 27705803, 28514442, 31515488, 32296183
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	IDA	21282530
GO:0005654	Component	Nucleoplasm	TAS
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IEA
GO:0005956	Component	Protein kinase CK2 complex	IBA	21873635
GO:0006457	Process	Protein folding	TAS
GO:0006656	Process	Phosphatidylcholine biosynthetic process	TAS
GO:0006915	Process	Apoptotic process	IEA
GO:0007049	Process	Cell cycle	IEA
GO:0007283	Process	Spermatogenesis	IEA
GO:0016055	Process	Wnt signaling pathway	IEA
GO:0016236	Process	Macroautophagy	TAS
GO:0018105	Process	Peptidyl-serine phosphorylation	IBA	21873635
GO:0018105	Process	Peptidyl-serine phosphorylation	IDA	28031292
GO:0018107	Process	Peptidyl-threonine phosphorylation	IBA	21873635
GO:0021987	Process	Cerebral cortex development	IEA
GO:0031519	Component	PcG protein complex	IBA	21873635
GO:0031519	Component	PcG protein complex	IDA	21282530
GO:0047485	Function	Protein N-terminus binding	IPI	11972058
GO:0051726	Process	Regulation of cell cycle	IBA	21873635
GO:0097421	Process	Liver regeneration	IEA
GO:0106310	Function	Protein serine kinase activity	IEA
GO:0106311	Function	Protein threonine kinase activity	IEA
GO:1901796	Process	Regulation of signal transduction by p53 class mediator	TAS
GO:1903146	Process	Regulation of autophagy of mitochondrion	HMP	24912190
GO:1903955	Process	Positive regulation of protein targeting to mitochondrion	HMP	24912190
GO:1905818	Process	Regulation of chromosome separation	IBA	21873635
GO:1905818	Process	Regulation of chromosome separation	IMP	11704824
GO:2000059	Process	Negative regulation of ubiquitin-dependent protein catabolic process	IGI	28031292
GO:2001234	Process	Negative regulation of apoptotic signaling pathway	TAS	28031292

Other IDs

• MIM: 115442
• HGNC: 2459
• e!Ensembl: ENSG00000070770

Protein

• UniProt ID: P19784
• Protein name: Casein kinase II subunit alpha' (CK II alpha') (EC 2.7.11.1)
• Protein function: Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:11239457, PubMed:117048
• PDB: 3E3B, 3OFM, 3U87, 5M4U, 5M56, 5OOI, 5Y9M, 5YF9, 5YWM, 6HMB, 6HMC, 6HMD, 6HMQ, 6L20, 6QY8, 6QY9, 6TE2, 6TEW, 6TGU, 7A1B, 7A1Z, 7A22, 7A2H, 7AT9, 7ATV, 7XYH, 8Q77, 8Q9S, 8QBU, 8QCD, 8QCG, 8QF1
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00069	Pkinase	40 → 325	Protein kinase domain	Domain

• Sequence:

  MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINI
  TNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT
  DFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA
  EFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNY
  DQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALD
  LLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADNAVLSSGLTAAR

• Sequence length: 350