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CSNK2A1 (casein kinase 2 alpha 1)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1457
Gene nameGene Name - the full gene name approved by the HGNC.
Casein kinase 2 alpha 1
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
CSNK2A1
SynonymsGene synonyms aliases
CK2A1, CKII, Cka1, Cka2, OCNDS
ChromosomeChromosome number
20
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
20p13
SummarySummary of gene provided in NCBI Entrez Gene.
Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythm. The kinase exists as a tetramer and is c
SNPsSNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs869312840 T>C Pathogenic Missense variant, coding sequence variant
rs869312845 C>T Likely-pathogenic, pathogenic Missense variant, coding sequence variant, 5 prime UTR variant
rs869312846 A>G Pathogenic Splice donor variant
rs869312848 T>C Pathogenic Missense variant, coding sequence variant
rs869312849 T>C,G Pathogenic Missense variant, coding sequence variant, 5 prime UTR variant
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT007207 hsa-miR-216b-5p Immunoblot, Luciferase reporter assay, qRT-PCR, Western blot 23137536
MIRT007208 hsa-miR-337-3p Immunoblot, Luciferase reporter assay, qRT-PCR, Western blot 23137536
MIRT007209 hsa-miR-760 Immunoblot, Luciferase reporter assay, qRT-PCR, Western blot 23137536
MIRT007210 hsa-miR-186-5p Immunoblot, Luciferase reporter assay, qRT-PCR, Western blot 23137536
MIRT030638 hsa-miR-22-3p Sequencing 20371350
Transcription factors
Transcription factor Regulation Reference
ETS1 Unknown 19027835
NFKB1 Unknown 19027835
RELA Unknown 19027835
SP1 Unknown 19027835
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004674 Function Protein serine/threonine kinase activity IBA 21873635
GO:0004674 Function Protein serine/threonine kinase activity IDA 12700239, 15723517, 16193064, 20625391, 20864032, 23123191, 30699359
GO:0004674 Function Protein serine/threonine kinase activity IGI 28031292
GO:0004674 Function Protein serine/threonine kinase activity IMP 11035045
GO:0004674 Function Protein serine/threonine kinase activity TAS 2174700
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P68400
Protein name Casein kinase II subunit alpha (CK II alpha) (EC 2.7.11.1)
Protein function Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:11239457, PubMed:117048
PDB 1JWH , 1NA7 , 1PJK , 2PVR , 2ZJW , 3AMY , 3AT2 , 3AT3 , 3AT4 , 3AXW , 3BQC , 3C13 , 3FWQ , 3H30 , 3JUH , 3MB6 , 3MB7 , 3NGA , 3NSZ , 3OWJ , 3OWK , 3OWL , 3PE1 , 3PE2 , 3PE4 , 3Q04 , 3Q9W , 3Q9X , 3Q9Y , 3Q9Z , 3QA0 , 3R0T , 3RPS , 3TAX , 3U4U , 3U87 , 3U9C , 3W8L , 3WAR , 3WIK , 3WIL , 3WOW , 4DGL , 4FBX , 4GRB , 4GUB , 4GYW , 4GYY , 4GZ3 , 4IB5 , 4KWP
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase
39 324
Protein kinase domain
Domain
Sequence
Sequence length 391
Interactions View interactions

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