CS (citrate synthase)

Gene

• Entrez ID: 1431
• Gene name: Citrate synthase
• Gene symbol: CS
• Synonyms: -
• Chromosome: 12
• Chromosome location: 12q13.3
• Summary: The protein encoded by this gene is a Krebs tricarboxylic acid cycle enzyme that catalyzes the synthesis of citrate from oxaloacetate and acetyl coenzyme A. The enzyme is found in nearly all cells capable of oxidative metablism. This protein is nuclear encoded and transported into the mitochondrial matrix, where the mature form is found. [provided by RefSeq, Jul 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT023232	hsa-miR-122-5p	PAR-CLIP	23592263
MIRT032306	hsa-let-7b-5p	Proteomics	18668040
MIRT039003	hsa-let-7a-3p	CLASH	23622248
MIRT041479	hsa-miR-193b-3p	CLASH	23622248
MIRT043140	hsa-miR-324-5p	CLASH	23622248
MIRT047152	hsa-miR-183-5p	CLASH	23622248
MIRT050008	hsa-miR-28-5p	CLASH	23622248
MIRT052406	hsa-let-7a-5p	CLASH	23622248
MIRT478740	hsa-miR-6515-5p	PAR-CLIP	23592263
MIRT478741	hsa-miR-4443	PAR-CLIP	23592263
MIRT478742	hsa-miR-6846-5p	PAR-CLIP	23592263
MIRT478743	hsa-miR-6848-5p	PAR-CLIP	23592263
MIRT478744	hsa-miR-4697-5p	PAR-CLIP	23592263
MIRT478745	hsa-miR-4488	PAR-CLIP	23592263
MIRT478746	hsa-miR-1237-5p	PAR-CLIP	23592263
MIRT478747	hsa-miR-6894-5p	PAR-CLIP	23592263
MIRT478748	hsa-miR-765	PAR-CLIP	23592263
MIRT478749	hsa-miR-7154-3p	PAR-CLIP	23592263
MIRT478750	hsa-miR-766-5p	PAR-CLIP	23592263
MIRT478751	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT478752	hsa-miR-4692	PAR-CLIP	23592263
MIRT478753	hsa-miR-4514	PAR-CLIP	23592263
MIRT478754	hsa-miR-4433a-3p	PAR-CLIP	23592263
MIRT478755	hsa-miR-761	PAR-CLIP	23592263
MIRT478756	hsa-miR-3619-5p	PAR-CLIP	23592263
MIRT478757	hsa-miR-214-3p	PAR-CLIP	23592263
MIRT478758	hsa-miR-200b-5p	PAR-CLIP	23592263
MIRT478759	hsa-miR-200a-5p	PAR-CLIP	23592263
MIRT478760	hsa-miR-940	PAR-CLIP	23592263
MIRT478761	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT478762	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT478763	hsa-miR-4433b-3p	PAR-CLIP	23592263
MIRT478764	hsa-miR-6165	PAR-CLIP	23592263
MIRT478765	hsa-miR-4662b	PAR-CLIP	23592263
MIRT478766	hsa-miR-4426	PAR-CLIP	23592263
MIRT478767	hsa-miR-4647	PAR-CLIP	23592263
MIRT737910	hsa-miR-155-5p	PAR-CLIP	26701625
MIRT741960	hsa-miR-365a-3p	PAR-CLIP	26701625
MIRT741970	hsa-miR-365b-3p	PAR-CLIP	26701625
MIRT743747	hsa-miR-4290	PAR-CLIP	26701625
MIRT744045	hsa-miR-4323	PAR-CLIP	26701625
MIRT747052	hsa-miR-4690-3p	PAR-CLIP	26701625
MIRT747457	hsa-miR-4712-5p	PAR-CLIP	26701625
MIRT751180	hsa-miR-5685	PAR-CLIP	26701625
MIRT759742	hsa-miR-770-5p	PAR-CLIP	26701625

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22681889
GO:0004108	Function	Citrate (Si)-synthase activity	IBA	21873635
GO:0004108	Function	Citrate (Si)-synthase activity	IDA	9543345
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005739	Component	Mitochondrion	HDA	20833797
GO:0005739	Component	Mitochondrion	IDA
GO:0005759	Component	Mitochondrial matrix	IBA	21873635
GO:0005759	Component	Mitochondrial matrix	IDA	9543345
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0005975	Process	Carbohydrate metabolic process	IBA	21873635
GO:0005975	Process	Carbohydrate metabolic process	IDA	9543345
GO:0006099	Process	Tricarboxylic acid cycle	IBA	21873635
GO:0006099	Process	Tricarboxylic acid cycle	IEA
GO:0006099	Process	Tricarboxylic acid cycle	TAS
GO:0006101	Process	Citrate metabolic process	IEA
GO:0070062	Component	Extracellular exosome	HDA	20458337

Other IDs

• MIM: 118950
• HGNC: 2422
• e!Ensembl: ENSG00000062485

Protein

• UniProt ID: O75390
• Protein name: Citrate synthase, mitochondrial (EC 2.3.3.1) (Citrate (Si)-synthase)
• PDB: 5UZP, 5UZQ, 5UZR
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00285	Citrate_synt	71 → 450	Citrate synthase, C-terminal domain	Domain

• Sequence:

  MALLTAAARLLGTKNASCLVLAARHASASSTNLKDILADLIPKEQARIKTFRQQHGKTVV
  GQITVDMMYGGMRGMKGLVYETSVLDPDEGIRFRGFSIPECQKLLPKAKGGEEPLPEGLF
  WLLVTGHIPTEEQVSWLSKEWAKRAALPSHVVTMLDNFPTNLHPMSQLSAAVTALNSESN
  FARAYAQGISRTKYWELIYEDSMDLIAKLPCVAAKIYRNLYREGSGIGAIDSNLDWSHNF
  TNMLGYTDHQFTELTRLYLTIHSDHEGGNVSAHTSHLVGSALSDPYLSFAAAMNGLAGPL
  HGLANQEVLVWLTQLQKEVGKDVSDEKLRDYIWNTLNSGRVVPGYGHAVLRKTDPRYTCQ
  REFALKHLPNDPMFKLVAQLYKIVPNVLLEQGKAKNPWPNVDAHSGVLLQYYGMTEMNYY
  TVLFGVSRALGVLAQLIWSRALGFPLERPKSMSTEGLMKFVDSKSG

• Sequence length: 466