CREB5 (cAMP responsive element binding protein 5)

Gene

• Entrez ID: 9586
• Gene name: CAMP responsive element binding protein 5
• Gene symbol: CREB5
• Synonyms: CRE-BPA, CREB-5, CREBPA
• Chromosome: 7
• Chromosome location: 7p15.1-p14.3
• Summary: The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family contain zinc-finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a heterodimer with c-Jun or CRE-BP1, and functions as a CRE-dependent trans-activator. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT006460	hsa-miR-204-5p	Immunofluorescence, Microarray, qRT-PCR, Western blot	22523078
MIRT006462	hsa-miR-211-5p	Immunofluorescence, Microarray, qRT-PCR, Western blot	22523078
MIRT021286	hsa-miR-125a-5p	Sequencing	20371350
MIRT025590	hsa-miR-10a-5p	Sequencing	20371350
MIRT028329	hsa-miR-32-5p	Sequencing	20371350
MIRT320565	hsa-miR-6832-3p	HITS-CLIP	19536157
MIRT437455	hsa-miR-182-5p	Luciferase reporter assay	23249749
MIRT613184	hsa-miR-8485	HITS-CLIP	23824327
MIRT613184	hsa-miR-8485	HITS-CLIP	27418678
MIRT613184	hsa-miR-8485	HITS-CLIP	28735896
MIRT628299	hsa-miR-607	HITS-CLIP	23824327
MIRT628300	hsa-miR-3671	HITS-CLIP	23824327
MIRT628301	hsa-miR-7853-5p	HITS-CLIP	23824327
MIRT628302	hsa-miR-105-5p	HITS-CLIP	23824327
MIRT628303	hsa-miR-1179	HITS-CLIP	23824327
MIRT710358	hsa-miR-384	HITS-CLIP	19536157
MIRT710359	hsa-miR-3685	HITS-CLIP	19536157
MIRT710360	hsa-miR-147a	HITS-CLIP	19536157
MIRT710361	hsa-miR-29b-2-5p	HITS-CLIP	19536157
MIRT710362	hsa-miR-155-3p	HITS-CLIP	19536157
MIRT710363	hsa-miR-6867-5p	HITS-CLIP	19536157
MIRT710364	hsa-miR-644a	HITS-CLIP	19536157
MIRT710365	hsa-miR-3911	HITS-CLIP	19536157
MIRT710366	hsa-miR-1273g-5p	HITS-CLIP	19536157
MIRT710367	hsa-miR-203a-5p	HITS-CLIP	19536157
MIRT710368	hsa-miR-92a-1-5p	HITS-CLIP	19536157
MIRT710369	hsa-miR-374c-3p	HITS-CLIP	19536157
MIRT722856	hsa-miR-3667-3p	HITS-CLIP	19536157
MIRT722857	hsa-miR-6734-3p	HITS-CLIP	19536157
MIRT722858	hsa-miR-323b-3p	HITS-CLIP	19536157
MIRT722859	hsa-miR-5195-5p	HITS-CLIP	19536157
MIRT722860	hsa-miR-651-3p	HITS-CLIP	19536157
MIRT732196	hsa-miR-590-5p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	26978739
MIRT732650	hsa-miR-29c-3p	Luciferase reporter assay, Next Generation Sequencing (NGS), qRT-PCR	28160548
MIRT732733	hsa-miR-449a	Luciferase reporter assay	27138288
MIRT762170	hsa-miR-128-3p	PAR-CLIP	27292025
MIRT763859	hsa-miR-216a-3p	PAR-CLIP	27292025
MIRT766743	hsa-miR-3681-3p	PAR-CLIP	27292025
MIRT770881	hsa-miR-4672	PAR-CLIP	27292025
MIRT778572	hsa-miR-6768-5p	PAR-CLIP	27292025

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0003700	Function	DNA-binding transcription factor activity	IDA	8378084
GO:0005515	Function	Protein binding	IPI	8440710
GO:0005634	Component	Nucleus	IC	8378084
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0035497	Function	CAMP response element binding	IBA	21873635
GO:0045893	Process	Positive regulation of transcription, DNA-templated	IDA	8378084
GO:0046872	Function	Metal ion binding	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

Other IDs

• MIM: 618262
• HGNC: 16844
• e!Ensembl: ENSG00000146592

Protein

• UniProt ID: Q02930
• Protein name: Cyclic AMP-responsive element-binding protein 5 (CREB-5) (cAMP-responsive element-binding protein 5) (cAMP-response element-binding protein A) (CRE-BPa)
• Protein function: Binds to the cAMP response element and activates transcription.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00170	bZIP_1	373 → 436	bZIP transcription factor	Coiled-coil

• Sequence:

  MIYEESKMNLEQERPFVCSAPGCSQRFPTEDHLMIHRHKHEMTLKFPSIKTDNMLSDQTP
  TPTRFLKNCEEVGLFSELDCSLEHEFRKAQEEESSKRNISMHNAVGGAMTGPGTHQLSSA
  RLPNHDTNVVIQQAMPSPQSSSVITQAPSTNRQIGPVPGSLSSLLHLHNRQRQPMPASMP
  GTLPNPTMPGSSAVLMPMERQMSVNSSIMGMQGPNLSNPCASPQVQPMHSEAKMRLKAAL
  THHPAAMSNGNMNTMGHMMEMMGSRQDQTPHHHMHSHPHQHQTLPPHHPYPHQHQHPAHH
  PHPQPHHQQNHPHHHSHSHLHAHPAHHQTSPHPPLHTGNQAQVSPATQQMQPTQTIQPPQ
  PTGGRRRRVVDEDPDERRRKFLERNRAAATRCRQKRKVWVMSLEKKAEELTQTNMQLQNE
  VSMLKNEVAQLKQLLLTHKDCPITAMQKESQGYLSPESSPPASPVPACSQQQVIQHNTIT
  TSSSVSEVVGSSTLSQLTTHRTDLNPIL

• Sequence length: 508