CPT1B (carnitine palmitoyltransferase 1B)

Gene

• Entrez ID: 1375
• Gene name: Carnitine palmitoyltransferase 1B
• Gene symbol: CPT1B
• Synonyms: CPT1-M, CPT1M, CPTI, CPTI-M, M-CPT1, MCCPT1, MCPT1
• Chromosome: 22
• Chromosome location: 22q13.33
• Summary: The protein encoded by this gene, a member of the carnitine/choline acetyltransferase family, is the rate-controlling enzyme of the long-chain fatty acid beta-oxidation pathway in muscle mitochondria. This enzyme is required for the net transport of long-chain fatty acyl-CoAs from the cytoplasm into the mitochondria. Multiple transcript variants encoding different isoforms have been found for this gene, and read-through transcripts are expressed from the upstream locus that include exons from this gene. [provided by RefSeq, Jun 2009]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017237	hsa-miR-335-5p	Microarray	18185580
MIRT036268	hsa-miR-1229-3p	CLASH	23622248
MIRT646343	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT646344	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT646345	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT646346	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT646347	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT646348	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT646349	hsa-miR-623	HITS-CLIP	23824327
MIRT646350	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT646351	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT646352	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT646353	hsa-miR-8063	HITS-CLIP	23824327
MIRT646354	hsa-miR-4698	HITS-CLIP	23824327
MIRT646355	hsa-miR-3938	HITS-CLIP	23824327
MIRT646356	hsa-miR-551b-5p	HITS-CLIP	23824327
MIRT646357	hsa-miR-548c-3p	HITS-CLIP	23824327

Transcription factors

Transcription factor	Regulation	Reference
MEF2C	Activation	15356291
PPARG	Activation	15356291
RXRA	Activation	15356291

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004095	Function	Carnitine O-palmitoyltransferase activity	IBA	21873635
GO:0004095	Function	Carnitine O-palmitoyltransferase activity	IMP	9344464
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005739	Component	Mitochondrion	HDA	20833797
GO:0005739	Component	Mitochondrion	IBA	21873635
GO:0005739	Component	Mitochondrion	IDA	9344464
GO:0005741	Component	Mitochondrial outer membrane	TAS
GO:0006631	Process	Fatty acid metabolic process	IBA	21873635
GO:0006635	Process	Fatty acid beta-oxidation	IEA
GO:0006853	Process	Carnitine shuttle	TAS
GO:0009437	Process	Carnitine metabolic process	IBA	21873635
GO:0009637	Process	Response to blue light	ISS
GO:0015909	Process	Long-chain fatty acid transport	IBA	21873635
GO:0016021	Component	Integral component of membrane	IEA

Other IDs

• MIM: 601987
• HGNC: 2329
• e!Ensembl: ENSG00000205560

Protein

• UniProt ID: Q92523
• Protein name: Carnitine O-palmitoyltransferase 1, muscle isoform (CPT1-M) (EC 2.3.1.21) (Carnitine O-palmitoyltransferase I, muscle isoform) (CPT I) (CPTI-M) (Carnitine palmitoyltransferase 1B) (Carnitine palmitoyltransferase I-like protein)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF16484	CPT_N	1 → 47	Carnitine O-palmitoyltransferase N-terminus	Domain
  PF00755	Carn_acyltransf	173 → 762	Choline/Carnitine o-acyltransferase	Family

• Sequence:

  MAEAHQAVAFQFTVTPDGVDFRLSREALKHVYLSGINSWKKRLIRIKNGILRGVYPGSPT
  SWLVVIMATVGSSFCNVDISLGLVSCIQRCLPQGCGPYQTPQTRALLSMAIFSTGVWVTG
  IFFFRQTLKLLLCYHGWMFEMHGKTSNLTRIWAMCIRLLSSRHPMLYSFQTSLPKLPVPR
  VSATIQRYLESVRPLLDDEEYYRMELLAKEFQDKTAPRLQKYLVLKSWWASNYVSDWWEE
  YIYLRGRSPLMVNSNYYVMDLVLIKNTDVQAARLGNIIHAMIMYRRKLDREEIKPVMALG
  IVPMCSYQMERMFNTTRIPGKDTDVLQHLSDSRHVAVYHKGRFFKLWLYEGARLLKPQDL
  EMQFQRILDDPSPPQPGEEKLAALTAGGRVEWAQARQAFFSSGKNKAALEAIERAAFFVA
  LDEESYSYDPEDEASLSLYGKALLHGNCYNRWFDKSFTLISFKNGQLGLNAEHAWADAPI
  IGHLWEFVLGTDSFHLGYTETGHCLGKPNPALAPPTRLQWDIPKQCQAVIESSYQVAKAL
  ADDVELYCFQFLPFGKGLIKKCRTSPDAFVQIALQLAHFRDRGKFCLTYEASMTRMFREG
  RTETVRSCTSESTAFVQAMMEGSHTKADLRDLFQKAAKKHQNMYRLAMTGAGIDRHLFCL
  YLVSKYLGVSSPFLAEVLSEPWRLSTSQIPQSQIRMFDPEQHPNHLGAGGGFGPVADDGY
  GVSYMIAGENTIFFHISSKFSSSETNAQRFGNHIRKALLDIADLFQVPKAYS

• Sequence length: 772