COL4A1 (collagen type IV alpha 1 chain)

Gene

• Entrez ID: 1282
• Gene name: Collagen type IV alpha 1 chain
• Gene symbol: COL4A1
• Synonyms: BSVD, BSVD1, COL4A1s, PADMAL, RATOR
• Chromosome: 13
• Chromosome location: 13q34
• Summary: This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs75711155	A>C	Likely-benign, conflicting-interpretations-of-pathogenicity	Intron variant
rs113994104	C>A,T	Pathogenic	Missense variant, coding sequence variant
rs113994105	C>T	Pathogenic	Genic downstream transcript variant, missense variant, coding sequence variant
rs113994106	C>T	Pathogenic	Genic downstream transcript variant, missense variant, coding sequence variant
rs113994107	C>T	Pathogenic	Genic downstream transcript variant, missense variant, coding sequence variant
rs113994108	C>T	Pathogenic	Genic downstream transcript variant, missense variant, coding sequence variant
rs113994109	C>T	Pathogenic	Genic downstream transcript variant, missense variant, coding sequence variant
rs113994111	C>T	Pathogenic	Genic downstream transcript variant, missense variant, coding sequence variant
rs113994112	C>T	Pathogenic	Genic downstream transcript variant, missense variant, coding sequence variant
rs113994113	C>G	Pathogenic	Genic downstream transcript variant, missense variant, coding sequence variant
rs113994114	C>G	Pathogenic	Genic downstream transcript variant, missense variant, coding sequence variant
rs121912857	C>G,T	Pathogenic	Genic downstream transcript variant, missense variant, coding sequence variant
rs145172612	G>A	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Missense variant, genic downstream transcript variant, coding sequence variant
rs150129180	G>A	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Missense variant, genic downstream transcript variant, coding sequence variant
rs183563055	G>A	Conflicting-interpretations-of-pathogenicity, likely-benign	Intron variant
rs200786329	G>A	Risk-factor, conflicting-interpretations-of-pathogenicity, benign	Coding sequence variant, missense variant
rs267606743	C>T	Pathogenic	Coding sequence variant, missense variant
rs267606744	C>G	Pathogenic	Coding sequence variant, missense variant
rs281865426	CC>AA	Pathogenic	Coding sequence variant, genic downstream transcript variant, missense variant
rs397514624	G>A,C,T	Risk-factor	Coding sequence variant, genic downstream transcript variant, synonymous variant, missense variant
rs567124920	C>T	Likely-pathogenic	Missense variant, coding sequence variant
rs587777379	C>T	Pathogenic	Genic downstream transcript variant, missense variant, coding sequence variant
rs587780588	C>T	Likely-pathogenic, pathogenic	Genic downstream transcript variant, missense variant, coding sequence variant
rs606231464	G>-,GG	Pathogenic	Genic downstream transcript variant, frameshift variant, coding sequence variant
rs606231465	C>T	Pathogenic	Genic downstream transcript variant, splice acceptor variant
rs672601346	C>T	Pathogenic	Genic downstream transcript variant, missense variant, coding sequence variant
rs672601347	C>G,T	Pathogenic	Genic downstream transcript variant, missense variant, coding sequence variant
rs672601348	G>A,C	Pathogenic	Genic downstream transcript variant, synonymous variant, missense variant, coding sequence variant
rs672601349	C>T	Pathogenic	Genic downstream transcript variant, missense variant, coding sequence variant
rs747585517	G>A	Likely-pathogenic	Genic downstream transcript variant, missense variant, coding sequence variant
rs797044867	C>T	Pathogenic	Missense variant, coding sequence variant, genic downstream transcript variant
rs797045034	C>T	Likely-pathogenic	Missense variant, coding sequence variant, genic downstream transcript variant
rs886041714	C>A	Pathogenic	Missense variant, coding sequence variant, genic downstream transcript variant
rs886041965	C>T	Pathogenic	Missense variant, coding sequence variant, genic downstream transcript variant
rs1057517719	G>A	Likely-pathogenic	Coding sequence variant, missense variant
rs1057518100	C>T	Likely-pathogenic	Genic downstream transcript variant, coding sequence variant, missense variant
rs1057518654	T>C	Likely-pathogenic	Genic downstream transcript variant, coding sequence variant, synonymous variant
rs1057523325	C>T	Likely-pathogenic	Genic downstream transcript variant, coding sequence variant, missense variant
rs1057523354	C>A	Pathogenic, likely-pathogenic	Genic downstream transcript variant, coding sequence variant, missense variant
rs1064794777	C>T	Likely-pathogenic	Genic downstream transcript variant, coding sequence variant, missense variant
rs1064795130	C>A	Likely-pathogenic	Genic downstream transcript variant, coding sequence variant, missense variant
rs1064795935	C>T	Uncertain-significance, likely-pathogenic	Genic downstream transcript variant, coding sequence variant, missense variant
rs1064796811	C>T	Likely-pathogenic	Genic downstream transcript variant, splice acceptor variant
rs1085307568	C>T	Likely-pathogenic	Genic downstream transcript variant, coding sequence variant, missense variant
rs1085307614	C>T	Pathogenic	Genic downstream transcript variant, coding sequence variant, missense variant
rs1085307709	C>T	Pathogenic	Genic downstream transcript variant, coding sequence variant, missense variant
rs1085307816	C>T	Pathogenic	Splice donor variant
rs1085307907	C>T	Likely-pathogenic	Genic downstream transcript variant, coding sequence variant, missense variant
rs1085307967	G>A	Likely-pathogenic	Genic downstream transcript variant, coding sequence variant, missense variant
rs1085307982	C>A	Likely-pathogenic	Genic downstream transcript variant, coding sequence variant, missense variant
rs1131691834	C>T	Likely-pathogenic	Genic downstream transcript variant, coding sequence variant, missense variant
rs1461754052	C>A,T	Likely-pathogenic	Coding sequence variant, missense variant
rs1555302449	C>A	Likely-pathogenic	Genic downstream transcript variant, coding sequence variant, missense variant
rs1555302454	C>T	Likely-pathogenic	Genic downstream transcript variant, coding sequence variant, missense variant
rs1555302645	C>A	Pathogenic	Genic downstream transcript variant, splice donor variant
rs1555302735	C>T	Pathogenic	Genic downstream transcript variant, splice donor variant
rs1555302922	C>A	Pathogenic	Genic downstream transcript variant, coding sequence variant, missense variant
rs1555302942	C>T	Pathogenic	Genic downstream transcript variant, coding sequence variant, missense variant
rs1555303010	C>T	Likely-pathogenic	Genic downstream transcript variant, coding sequence variant, missense variant
rs1555303073	C>T	Pathogenic	Genic downstream transcript variant, coding sequence variant, missense variant
rs1555303720	C>T	Likely-pathogenic	Genic downstream transcript variant, coding sequence variant, missense variant
rs1555305682	->G	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1566349968	C>T	Likely-pathogenic	Genic downstream transcript variant, coding sequence variant, missense variant
rs1566351456	C>T	Likely-pathogenic	Genic downstream transcript variant, coding sequence variant, missense variant
rs1566353677	C>T	Pathogenic	Genic downstream transcript variant, coding sequence variant, missense variant
rs1566370178	C>A	Likely-pathogenic	Coding sequence variant, missense variant
rs1594550371	C>A	Likely-pathogenic	Missense variant, genic downstream transcript variant, coding sequence variant
rs1594555106	C>G	Likely-pathogenic	Missense variant, genic downstream transcript variant, coding sequence variant
rs1594560766	C>G	Likely-pathogenic	Missense variant, genic downstream transcript variant, coding sequence variant
rs1594566006	A>-	Pathogenic	Frameshift variant, coding sequence variant
rs1594566751	T>-	Likely-pathogenic	Stop gained, coding sequence variant
rs1594568948	->T	Pathogenic	Frameshift variant, coding sequence variant
rs1594579579	->G	Pathogenic	Frameshift variant, coding sequence variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT001927	hsa-miR-29c-3p	Luciferase reporter assay, Reporter assay;Other	18390668
MIRT001927	hsa-miR-29c-3p	Sequencing, PAR-CLIP	20371350
MIRT001927	hsa-miR-29c-3p	PAR-CLIP	23592263
MIRT001927	hsa-miR-29c-3p	PAR-CLIP	23446348
MIRT001927	hsa-miR-29c-3p	Luciferase reporter assay	22745231
MIRT001927	hsa-miR-29c-3p	Luciferase reporter assay	27666438
MIRT003221	hsa-miR-29a-3p	Luciferase reporter assay, qRT-PCR, Western blot	20067797
MIRT003221	hsa-miR-29a-3p	PAR-CLIP	23592263
MIRT003221	hsa-miR-29a-3p	PAR-CLIP	23446348
MIRT003221	hsa-miR-29a-3p	PAR-CLIP	20371350
MIRT003221	hsa-miR-29a-3p	Luciferase reporter assay	22745231
MIRT003221	hsa-miR-29a-3p	Luciferase reporter assay	27666438
MIRT005568	hsa-miR-29b-3p	Luciferase reporter assay, qRT-PCR, Western blot	20657750
MIRT005568	hsa-miR-29b-3p	Microarray	22942087
MIRT005568	hsa-miR-29b-3p	PAR-CLIP	23592263
MIRT005568	hsa-miR-29b-3p	PAR-CLIP	23446348
MIRT005568	hsa-miR-29b-3p	PAR-CLIP	20371350
MIRT005568	hsa-miR-29b-3p	Luciferase reporter assay	22745231
MIRT005568	hsa-miR-29b-3p	Luciferase reporter assay	27666438
MIRT006821	hsa-miR-21-5p	Luciferase reporter assay, qRT-PCR	22573493
MIRT022172	hsa-miR-124-3p	Microarray	18668037
MIRT024242	hsa-miR-218-5p	Sequencing	20371350
MIRT024242	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT039089	hsa-miR-769-3p	CLASH	23622248
MIRT040877	hsa-miR-18a-3p	CLASH	23622248
MIRT041389	hsa-miR-193b-3p	CLASH	23622248
MIRT045748	hsa-miR-125a-5p	CLASH	23622248
MIRT048584	hsa-miR-100-5p	CLASH	23622248
MIRT048676	hsa-miR-99a-5p	CLASH	23622248
MIRT049483	hsa-miR-92a-3p	CLASH	23622248
MIRT051073	hsa-miR-16-5p	CLASH	23622248
MIRT054906	hsa-miR-637	qRT-PCR	23362149
MIRT437564	hsa-miR-767-5p	PAR-CLIP	23592263
MIRT437564	hsa-miR-767-5p	PAR-CLIP	23446348
MIRT437564	hsa-miR-767-5p	PAR-CLIP	20371350
MIRT437564	hsa-miR-767-5p	Luciferase reporter assay	22745231
MIRT494153	hsa-miR-6808-3p	PAR-CLIP	23592263
MIRT494153	hsa-miR-6808-3p	PAR-CLIP	23446348
MIRT494153	hsa-miR-6808-3p	PAR-CLIP	20371350
MIRT494154	hsa-miR-5682	PAR-CLIP	23592263
MIRT494154	hsa-miR-5682	PAR-CLIP	23446348
MIRT494154	hsa-miR-5682	PAR-CLIP	20371350
MIRT494155	hsa-miR-542-3p	PAR-CLIP	23592263
MIRT494155	hsa-miR-542-3p	PAR-CLIP	23446348
MIRT494155	hsa-miR-542-3p	PAR-CLIP	20371350
MIRT494156	hsa-miR-4504	PAR-CLIP	23592263
MIRT494156	hsa-miR-4504	PAR-CLIP	23446348
MIRT494156	hsa-miR-4504	PAR-CLIP	20371350
MIRT494157	hsa-miR-3185	PAR-CLIP	23592263
MIRT494157	hsa-miR-3185	PAR-CLIP	23446348
MIRT494157	hsa-miR-3185	PAR-CLIP	20371350
MIRT494158	hsa-miR-6871-3p	PAR-CLIP	23592263
MIRT494158	hsa-miR-6871-3p	PAR-CLIP	23446348
MIRT494158	hsa-miR-6871-3p	PAR-CLIP	20371350
MIRT494159	hsa-miR-4716-5p	PAR-CLIP	23592263
MIRT494159	hsa-miR-4716-5p	PAR-CLIP	23446348
MIRT494159	hsa-miR-4716-5p	PAR-CLIP	20371350
MIRT494160	hsa-miR-562	PAR-CLIP	23592263
MIRT494160	hsa-miR-562	PAR-CLIP	23446348
MIRT494160	hsa-miR-562	PAR-CLIP	20371350
MIRT494161	hsa-miR-7-2-3p	PAR-CLIP	23592263
MIRT494161	hsa-miR-7-2-3p	PAR-CLIP	23446348
MIRT494161	hsa-miR-7-2-3p	PAR-CLIP	20371350
MIRT494162	hsa-miR-7-1-3p	PAR-CLIP	23592263
MIRT494162	hsa-miR-7-1-3p	PAR-CLIP	23446348
MIRT494162	hsa-miR-7-1-3p	PAR-CLIP	20371350
MIRT494163	hsa-miR-5688	PAR-CLIP	23592263
MIRT494163	hsa-miR-5688	PAR-CLIP	23446348
MIRT494163	hsa-miR-5688	PAR-CLIP	20371350
MIRT494164	hsa-miR-495-3p	PAR-CLIP	23592263
MIRT494164	hsa-miR-495-3p	PAR-CLIP	23446348
MIRT494164	hsa-miR-495-3p	PAR-CLIP	20371350
MIRT524405	hsa-miR-758-3p	PAR-CLIP	23446348
MIRT524405	hsa-miR-758-3p	PAR-CLIP	20371350
MIRT704504	hsa-miR-335-3p	HITS-CLIP	23313552
MIRT704505	hsa-miR-1305	HITS-CLIP	23313552
MIRT704506	hsa-miR-498	HITS-CLIP	23313552
MIRT704507	hsa-miR-8070	HITS-CLIP	23313552
MIRT704508	hsa-miR-421	HITS-CLIP	23313552
MIRT704509	hsa-miR-505-3p	HITS-CLIP	23313552
MIRT704510	hsa-miR-7159-5p	HITS-CLIP	23313552
MIRT704511	hsa-miR-4693-5p	HITS-CLIP	23313552
MIRT704512	hsa-miR-4709-5p	HITS-CLIP	23313552
MIRT704513	hsa-miR-4272	HITS-CLIP	23313552
MIRT704514	hsa-miR-892a	HITS-CLIP	23313552
MIRT704515	hsa-miR-4318	HITS-CLIP	23313552
MIRT733609	hsa-miR-140-3p	Luciferase reporter assay, Microarray, Next Generation Sequencing (NGS), Western blot	27502506

Transcription factors

Transcription factor	Regulation	Reference
LMX1B	Unknown	12602071

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001569	Process	Branching involved in blood vessel morphogenesis	IMP	20818663
GO:0005201	Function	Extracellular matrix structural constituent	IBA	21873635
GO:0005201	Function	Extracellular matrix structural constituent	IMP	20818663
GO:0005515	Function	Protein binding	IPI	12011424
GO:0005576	Component	Extracellular region	NAS	14718574
GO:0005576	Component	Extracellular region	TAS
GO:0005587	Component	Collagen type IV trimer	IMP	16107487
GO:0005604	Component	Basement membrane	IBA	21873635
GO:0005604	Component	Basement membrane	IC	23065703
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0007420	Process	Brain development	IMP	16107487
GO:0007528	Process	Neuromuscular junction development	IEA
GO:0030020	Function	Extracellular matrix structural constituent conferring tensile strength	HDA	28344315
GO:0030020	Function	Extracellular matrix structural constituent conferring tensile strength	IMP	16107487
GO:0030020	Function	Extracellular matrix structural constituent conferring tensile strength	RCA	23979707, 25037231, 27068509, 27559042, 28327460, 28675934
GO:0030198	Process	Extracellular matrix organization	IBA	21873635
GO:0030198	Process	Extracellular matrix organization	TAS
GO:0030855	Process	Epithelial cell differentiation	IEA
GO:0031012	Component	Extracellular matrix	IBA	21873635
GO:0038063	Process	Collagen-activated tyrosine kinase receptor signaling pathway	IEA
GO:0048407	Function	Platelet-derived growth factor binding	IDA	8900172
GO:0048514	Process	Blood vessel morphogenesis	IMP	20818663
GO:0061304	Process	Retinal blood vessel morphogenesis	IMP	20818663
GO:0061333	Process	Renal tubule morphogenesis	IMP	18160688
GO:0062023	Component	Collagen-containing extracellular matrix	HDA	23658023, 23979707, 25037231, 27068509, 27559042, 28327460, 28344315, 28675934
GO:0062023	Component	Collagen-containing extracellular matrix	ISS	22261194
GO:0071230	Process	Cellular response to amino acid stimulus	IEA
GO:0071711	Process	Basement membrane organization	IMP	18160688, 19949034, 23065703

Other IDs

• MIM: 120130
• HGNC: 2202
• e!Ensembl: ENSG00000187498

Protein

• UniProt ID: P02462
• Protein name: Collagen alpha-1(IV) chain [Cleaved into: Arresten]
• Protein function: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. ; Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation.
• PDB: 1LI1, 5NAX, 5NAY, 6MPX
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01391	Collagen	37 → 105	Collagen triple helix repeat (20 copies)	Repeat
  PF01391	Collagen	61 → 138	Collagen triple helix repeat (20 copies)	Repeat
  PF01391	Collagen	97 → 162	Collagen triple helix repeat (20 copies)	Repeat
  PF01391	Collagen	167 → 225	Collagen triple helix repeat (20 copies)	Repeat
  PF01391	Collagen	273 → 334	Collagen triple helix repeat (20 copies)	Repeat
  PF01391	Collagen	474 → 533	Collagen triple helix repeat (20 copies)	Repeat
  PF01391	Collagen	539 → 592	Collagen triple helix repeat (20 copies)	Repeat
  PF01391	Collagen	643 → 690	Collagen triple helix repeat (20 copies)	Repeat
  PF01391	Collagen	689 → 737	Collagen triple helix repeat (20 copies)	Repeat
  PF01391	Collagen	736 → 801	Collagen triple helix repeat (20 copies)	Repeat
  PF01391	Collagen	837 → 896	Collagen triple helix repeat (20 copies)	Repeat
  PF01391	Collagen	882 → 941	Collagen triple helix repeat (20 copies)	Repeat
  PF01391	Collagen	943 → 1005	Collagen triple helix repeat (20 copies)	Repeat
  PF01391	Collagen	999 → 1058	Collagen triple helix repeat (20 copies)	Repeat
  PF01391	Collagen	1057 → 1117	Collagen triple helix repeat (20 copies)	Repeat
  PF01391	Collagen	1384 → 1443	Collagen triple helix repeat (20 copies)	Repeat
  PF01413	C4	1446 → 1553	C-terminal tandem repeated domain in type 4 procollagen	Domain
  PF01413	C4	1556 → 1667	C-terminal tandem repeated domain in type 4 procollagen	Domain

• Sequence:

  MGPRLSVWLLLLPAALLLHEEHSRAAAKGGCAGSGCGKCDCHGVKGQKGERGLPGLQGVI
  GFPGMQGPEGPQGPPGQKGDTGEPGLPGTKGTRGPPGASGYPGNPGLPGIPGQDGPPGPP
  GIPGCNGTKGERGPLGPPGLPGFAGNPGPPGLPGMKGDPGEILGHVPGMLLKGERGFPGI
  PGTPGPPGLPGLQGPVGPPGFTGPPGPPGPPGPPGEKGQMGLSFQGPKGDKGDQGVSGPP
  GVPGQAQVQEKGDFATKGEKGQKGEPGFQGMPGVGEKGEPGKPGPRGKPGKDGDKGEKGS
  PGFPGEPGYPGLIGRQGPQGEKGEAGPPGPPGIVIGTGPLGEKGERGYPGTPGPRGEPGP
  KGFPGLPGQPGPPGLPVPGQAGAPGFPGERGEKGDRGFPGTSLPGPSGRDGLPGPPGSPG
  PPGQPGYTNGIVECQPGPPGDQGPPGIPGQPGFIGEIGEKGQKGESCLICDIDGYRGPPG
  PQGPPGEIGFPGQPGAKGDRGLPGRDGVAGVPGPQGTPGLIGQPGAKGEPGEFYFDLRLK
  GDKGDPGFPGQPGMPGRAGSPGRDGHPGLPGPKGSPGSVGLKGERGPPGGVGFPGSRGDT
  GPPGPPGYGPAGPIGDKGQAGFPGGPGSPGLPGPKGEPGKIVPLPGPPGAEGLPGSPGFP
  GPQGDRGFPGTPGRPGLPGEKGAVGQPGIGFPGPPGPKGVDGLPGDMGPPGTPGRPGFNG
  LPGNPGVQGQKGEPGVGLPGLKGLPGLPGIPGTPGEKGSIGVPGVPGEHGAIGPPGLQGI
  RGEPGPPGLPGSVGSPGVPGIGPPGARGPPGGQGPPGLSGPPGIKGEKGFPGFPGLDMPG
  PKGDKGAQGLPGITGQSGLPGLPGQQGAPGIPGFPGSKGEMGVMGTPGQPGSPGPVGAPG
  LPGEKGDHGFPGSSGPRGDPGLKGDKGDVGLPGKPGSMDKVDMGSMKGQKGDQGEKGQIG
  PIGEKGSRGDPGTPGVPGKDGQAGQPGQPGPKGDPGISGTPGAPGLPGPKGSVGGMGLPG
  TPGEKGVPGIPGPQGSPGLPGDKGAKGEKGQAGPPGIGIPGLRGEKGDQGIAGFPGSPGE
  KGEKGSIGIPGMPGSPGLKGSPGSVGYPGSPGLPGEKGDKGLPGLDGIPGVKGEAGLPGT
  PGPTGPAGQKGEPGSDGIPGSAGEKGEPGLPGRGFPGFPGAKGDKGSKGEVGFPGLAGSP
  GIPGSKGEQGFMGPPGPQGQPGLPGSPGHATEGPKGDRGPQGQPGLPGLPGPMGPPGLPG
  IDGVKGDKGNPGWPGAPGVPGPKGDPGFQGMPGIGGSPGITGSKGDMGPPGVPGFQGPKG
  LPGLQGIKGDQGDQGVPGAKGLPGPPGPPGPYDIIKGEPGLPGPEGPPGLKGLQGLPGPK
  GQQGVTGLVGIPGPPGIPGFDGAPGQKGEMGPAGPTGPRGFPGPPGPDGLPGSMGPPGTP
  SVDHGFLVTRHSQTIDDPQCPSGTKILYHGYSLLYVQGNERAHGQDLGTAGSCLRKFSTM
  PFLFCNINNVCNFASRNDYSYWLSTPEPMPMSMAPITGENIRPFISRCAVCEAPAMVMAV
  HSQTIQIPPCPSGWSSLWIGYSFVMHTSAGAEGSGQALASPGSCLEEFRSAPFIECHGRG
  TCNYYANAYSFWLATIERSEMFKKPTPSTLKAGELRTHVSRCQVCMRRT

• Sequence length: 1669