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CDK4 (cyclin dependent kinase 4)

Gene

1019

Cyclin dependent kinase 4

CDK4

CMM3, PSK-J3

12q14.1

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]

Show/Hide all(3)

SNP ID	Visualize variation	Clinical significance	Consequence
rs11547328	G>A,T	Likely-pathogenic, pathogenic	Coding sequence variant, missense variant
rs104894340	C>A,T	Risk-factor, likely-pathogenic, pathogenic	Coding sequence variant, missense variant
rs144890720	T>C	Conflicting-interpretations-of-pathogenicity, likely-benign, uncertain-significance	Missense variant, coding sequence variant

Show/Hide all(217)

miRTarBase ID	miRNA	Experiments	Reference
MIRT000117	hsa-miR-24-3p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot, Reporter assay;Western blot;qRT-PCR;Other	19748357
MIRT000763	hsa-miR-34a-5p	Luciferase reporter assay	19461653
MIRT000763	hsa-miR-34a-5p	Luciferase reporter assay, Western blot, Microarray	17914404
MIRT000763	hsa-miR-34a-5p	qRT-PCR	21240262
MIRT000763	hsa-miR-34a-5p	Western blot	21128241
MIRT000763	hsa-miR-34a-5p	qRT-PCR	24504520
MIRT000764	hsa-miR-34b-5p	Luciferase reporter assay	19461653
MIRT000765	hsa-miR-34c-5p	Luciferase reporter assay	19461653
MIRT000765	hsa-miR-34c-5p	Microarray, Western blot, RTPCR	20924086
MIRT002625	hsa-miR-124-3p	Microarray	15685193
MIRT002625	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT002625	hsa-miR-124-3p	Luciferase reporter assay, Western blot	23761023
MIRT002625	hsa-miR-124-3p	Luciferase reporter assay, Western blot	23404119
MIRT002625	hsa-miR-124-3p	PAR-CLIP	24398324
MIRT002625	hsa-miR-124-3p	PAR-CLIP	23446348
MIRT002625	hsa-miR-124-3p	PAR-CLIP	21572407
MIRT002625	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT002625	hsa-miR-124-3p	Luciferase reporter assay	27323123
MIRT003450	hsa-miR-34b-3p	Microarray, Western blot, RTPCR	20924086
MIRT003636	hsa-miR-302a-3p	Luciferase reporter assay, qRT-PCR, Western blot	18710938
MIRT005879	hsa-miR-145-5p	Luciferase reporter assay, qRT-PCR, Western blot	21092188
MIRT006252	hsa-miR-195-5p	Luciferase reporter assay	22289176
MIRT006252	hsa-miR-195-5p	Luciferase reporter assay, Western blot	23544130
MIRT016137	hsa-miR-449b-5p	Western blot	19833767
MIRT016631	hsa-miR-449a	Western blot	19833767
MIRT021016	hsa-miR-155-5p	Proteomics	18668040
MIRT023403	hsa-miR-122-5p	Reporter assay	21750653
MIRT023403	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT024107	hsa-miR-1-3p	Proteomics;Microarray	18668037
MIRT024107	hsa-miR-1-3p	Luciferase reporter assay, qRT-PCR, Western blot	28159933
MIRT024107	hsa-miR-1-3p	Luciferase reporter assay, qRT-PCR, Western blot	27247259
MIRT039027	hsa-miR-766-3p	CLASH	23622248
MIRT041351	hsa-miR-193b-3p	CLASH	23622248
MIRT044439	hsa-miR-320a	CLASH	23622248
MIRT046412	hsa-miR-15b-5p	CLASH	23622248
MIRT050205	hsa-miR-25-3p	CLASH	23622248
MIRT052933	hsa-miR-206	Luciferase reporter assay, Microarray	24289491
MIRT054384	hsa-miR-545-3p	Luciferase reporter assay, qRT-PCR, Western blot	24505359
MIRT054384	hsa-miR-545-3p	PAR-CLIP	24398324
MIRT054384	hsa-miR-545-3p	PAR-CLIP	23446348
MIRT054384	hsa-miR-545-3p	PAR-CLIP	21572407
MIRT054384	hsa-miR-545-3p	PAR-CLIP	20371350
MIRT054620	hsa-miR-506-3p	Immunohistochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	24604117
MIRT054620	hsa-miR-506-3p	PAR-CLIP	24398324
MIRT054620	hsa-miR-506-3p	PAR-CLIP	23446348
MIRT054620	hsa-miR-506-3p	PAR-CLIP	21572407
MIRT054620	hsa-miR-506-3p	PAR-CLIP	20371350
MIRT437795	hsa-miR-497-5p	Luciferase reporter assay, Western blot	23544130
MIRT437861	hsa-miR-483-3p	Immunoblot, Immunofluorescence, Immunoprecipitaion, Luciferase reporter assay, qRT-PCR	23429262
MIRT438347	hsa-miR-29a-3p	qRT-PCR, Western blot	25889078
MIRT502878	hsa-miR-616-3p	PAR-CLIP	24398324
MIRT502878	hsa-miR-616-3p	PAR-CLIP	23446348
MIRT502878	hsa-miR-616-3p	PAR-CLIP	21572407
MIRT502878	hsa-miR-616-3p	PAR-CLIP	20371350
MIRT502879	hsa-miR-3973	PAR-CLIP	24398324
MIRT502879	hsa-miR-3973	PAR-CLIP	23446348
MIRT502879	hsa-miR-3973	PAR-CLIP	21572407
MIRT502879	hsa-miR-3973	PAR-CLIP	20371350
MIRT502880	hsa-miR-513b-3p	PAR-CLIP	24398324
MIRT502880	hsa-miR-513b-3p	PAR-CLIP	23446348
MIRT502880	hsa-miR-513b-3p	PAR-CLIP	21572407
MIRT502880	hsa-miR-513b-3p	PAR-CLIP	20371350
MIRT502881	hsa-miR-216b-5p	PAR-CLIP	24398324
MIRT502881	hsa-miR-216b-5p	PAR-CLIP	23446348
MIRT502881	hsa-miR-216b-5p	PAR-CLIP	21572407
MIRT502881	hsa-miR-216b-5p	PAR-CLIP	20371350
MIRT502882	hsa-miR-216a-5p	PAR-CLIP	24398324
MIRT502882	hsa-miR-216a-5p	PAR-CLIP	23446348
MIRT502882	hsa-miR-216a-5p	PAR-CLIP	21572407
MIRT502882	hsa-miR-216a-5p	PAR-CLIP	20371350
MIRT502883	hsa-miR-3714	PAR-CLIP	24398324
MIRT502883	hsa-miR-3714	PAR-CLIP	23446348
MIRT502883	hsa-miR-3714	PAR-CLIP	21572407
MIRT502883	hsa-miR-3714	PAR-CLIP	20371350
MIRT502884	hsa-miR-3910	PAR-CLIP	24398324
MIRT502884	hsa-miR-3910	PAR-CLIP	23446348
MIRT502884	hsa-miR-3910	PAR-CLIP	21572407
MIRT502884	hsa-miR-3910	PAR-CLIP	20371350
MIRT502885	hsa-miR-559	PAR-CLIP	24398324
MIRT502885	hsa-miR-559	PAR-CLIP	23446348
MIRT502885	hsa-miR-559	PAR-CLIP	21572407
MIRT502885	hsa-miR-559	PAR-CLIP	20371350
MIRT502886	hsa-miR-548y	PAR-CLIP	24398324
MIRT502886	hsa-miR-548y	PAR-CLIP	23446348
MIRT502886	hsa-miR-548y	PAR-CLIP	21572407
MIRT502886	hsa-miR-548y	PAR-CLIP	20371350
MIRT502887	hsa-miR-548w	PAR-CLIP	24398324
MIRT502887	hsa-miR-548w	PAR-CLIP	23446348
MIRT502887	hsa-miR-548w	PAR-CLIP	21572407
MIRT502887	hsa-miR-548w	PAR-CLIP	20371350
MIRT502888	hsa-miR-548o-5p	PAR-CLIP	24398324
MIRT502888	hsa-miR-548o-5p	PAR-CLIP	23446348
MIRT502888	hsa-miR-548o-5p	PAR-CLIP	21572407
MIRT502888	hsa-miR-548o-5p	PAR-CLIP	20371350
MIRT502889	hsa-miR-548j-5p	PAR-CLIP	24398324
MIRT502889	hsa-miR-548j-5p	PAR-CLIP	23446348
MIRT502889	hsa-miR-548j-5p	PAR-CLIP	21572407
MIRT502889	hsa-miR-548j-5p	PAR-CLIP	20371350
MIRT502890	hsa-miR-548i	PAR-CLIP	24398324
MIRT502890	hsa-miR-548i	PAR-CLIP	23446348
MIRT502890	hsa-miR-548i	PAR-CLIP	21572407
MIRT502890	hsa-miR-548i	PAR-CLIP	20371350
MIRT502891	hsa-miR-548h-5p	PAR-CLIP	24398324
MIRT502891	hsa-miR-548h-5p	PAR-CLIP	23446348
MIRT502891	hsa-miR-548h-5p	PAR-CLIP	21572407
MIRT502891	hsa-miR-548h-5p	PAR-CLIP	20371350
MIRT502892	hsa-miR-548d-5p	PAR-CLIP	24398324
MIRT502892	hsa-miR-548d-5p	PAR-CLIP	23446348
MIRT502892	hsa-miR-548d-5p	PAR-CLIP	21572407
MIRT502892	hsa-miR-548d-5p	PAR-CLIP	20371350
MIRT502893	hsa-miR-548c-5p	PAR-CLIP	24398324
MIRT502893	hsa-miR-548c-5p	PAR-CLIP	23446348
MIRT502893	hsa-miR-548c-5p	PAR-CLIP	21572407
MIRT502893	hsa-miR-548c-5p	PAR-CLIP	20371350
MIRT502894	hsa-miR-548bb-5p	PAR-CLIP	24398324
MIRT502894	hsa-miR-548bb-5p	PAR-CLIP	23446348
MIRT502894	hsa-miR-548bb-5p	PAR-CLIP	21572407
MIRT502894	hsa-miR-548bb-5p	PAR-CLIP	20371350
MIRT502895	hsa-miR-548b-5p	PAR-CLIP	24398324
MIRT502895	hsa-miR-548b-5p	PAR-CLIP	23446348
MIRT502895	hsa-miR-548b-5p	PAR-CLIP	21572407
MIRT502895	hsa-miR-548b-5p	PAR-CLIP	20371350
MIRT502896	hsa-miR-548ay-5p	PAR-CLIP	24398324
MIRT502896	hsa-miR-548ay-5p	PAR-CLIP	23446348
MIRT502896	hsa-miR-548ay-5p	PAR-CLIP	21572407
MIRT502896	hsa-miR-548ay-5p	PAR-CLIP	20371350
MIRT502897	hsa-miR-548au-5p	PAR-CLIP	24398324
MIRT502897	hsa-miR-548au-5p	PAR-CLIP	23446348
MIRT502897	hsa-miR-548au-5p	PAR-CLIP	21572407
MIRT502897	hsa-miR-548au-5p	PAR-CLIP	20371350
MIRT502898	hsa-miR-548as-5p	PAR-CLIP	24398324
MIRT502898	hsa-miR-548as-5p	PAR-CLIP	23446348
MIRT502898	hsa-miR-548as-5p	PAR-CLIP	21572407
MIRT502898	hsa-miR-548as-5p	PAR-CLIP	20371350
MIRT502899	hsa-miR-548ar-5p	PAR-CLIP	24398324
MIRT502899	hsa-miR-548ar-5p	PAR-CLIP	23446348
MIRT502899	hsa-miR-548ar-5p	PAR-CLIP	21572407
MIRT502899	hsa-miR-548ar-5p	PAR-CLIP	20371350
MIRT502900	hsa-miR-548aq-5p	PAR-CLIP	24398324
MIRT502900	hsa-miR-548aq-5p	PAR-CLIP	23446348
MIRT502900	hsa-miR-548aq-5p	PAR-CLIP	21572407
MIRT502900	hsa-miR-548aq-5p	PAR-CLIP	20371350
MIRT502901	hsa-miR-548ap-5p	PAR-CLIP	24398324
MIRT502901	hsa-miR-548ap-5p	PAR-CLIP	23446348
MIRT502901	hsa-miR-548ap-5p	PAR-CLIP	21572407
MIRT502901	hsa-miR-548ap-5p	PAR-CLIP	20371350
MIRT502902	hsa-miR-548ak	PAR-CLIP	24398324
MIRT502902	hsa-miR-548ak	PAR-CLIP	23446348
MIRT502902	hsa-miR-548ak	PAR-CLIP	21572407
MIRT502902	hsa-miR-548ak	PAR-CLIP	20371350
MIRT502903	hsa-miR-548am-5p	PAR-CLIP	24398324
MIRT502903	hsa-miR-548am-5p	PAR-CLIP	23446348
MIRT502903	hsa-miR-548am-5p	PAR-CLIP	21572407
MIRT502903	hsa-miR-548am-5p	PAR-CLIP	20371350
MIRT502904	hsa-miR-548ae-5p	PAR-CLIP	24398324
MIRT502904	hsa-miR-548ae-5p	PAR-CLIP	23446348
MIRT502904	hsa-miR-548ae-5p	PAR-CLIP	21572407
MIRT502904	hsa-miR-548ae-5p	PAR-CLIP	20371350
MIRT502905	hsa-miR-548ad-5p	PAR-CLIP	24398324
MIRT502905	hsa-miR-548ad-5p	PAR-CLIP	23446348
MIRT502905	hsa-miR-548ad-5p	PAR-CLIP	21572407
MIRT502905	hsa-miR-548ad-5p	PAR-CLIP	20371350
MIRT502906	hsa-miR-548ab	PAR-CLIP	24398324
MIRT502906	hsa-miR-548ab	PAR-CLIP	23446348
MIRT502906	hsa-miR-548ab	PAR-CLIP	21572407
MIRT502906	hsa-miR-548ab	PAR-CLIP	20371350
MIRT502907	hsa-miR-548a-5p	PAR-CLIP	24398324
MIRT502907	hsa-miR-548a-5p	PAR-CLIP	23446348
MIRT502907	hsa-miR-548a-5p	PAR-CLIP	21572407
MIRT502907	hsa-miR-548a-5p	PAR-CLIP	20371350
MIRT548928	hsa-miR-20b-3p	PAR-CLIP	21572407
MIRT548929	hsa-miR-3137	PAR-CLIP	21572407
MIRT636643	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT636644	hsa-miR-6805-3p	HITS-CLIP	23824327
MIRT636645	hsa-miR-5691	HITS-CLIP	23824327
MIRT636646	hsa-miR-106a-3p	HITS-CLIP	23824327
MIRT636647	hsa-miR-7641	HITS-CLIP	23824327
MIRT636648	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT636649	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT636650	hsa-miR-431-5p	HITS-CLIP	23824327
MIRT636651	hsa-miR-4430	HITS-CLIP	23824327
MIRT636652	hsa-miR-3652	HITS-CLIP	23824327
MIRT636653	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT636654	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT636655	hsa-miR-3135b	HITS-CLIP	23824327
MIRT636656	hsa-miR-3194-3p	HITS-CLIP	23824327
MIRT636657	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT636658	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT636659	hsa-miR-1267	HITS-CLIP	23824327
MIRT636660	hsa-miR-454-3p	HITS-CLIP	23824327
MIRT636661	hsa-miR-4295	HITS-CLIP	23824327
MIRT636662	hsa-miR-3666	HITS-CLIP	23824327
MIRT636663	hsa-miR-301b-3p	HITS-CLIP	23824327
MIRT636664	hsa-miR-301a-3p	HITS-CLIP	23824327
MIRT636665	hsa-miR-130b-3p	HITS-CLIP	23824327
MIRT636666	hsa-miR-130a-3p	HITS-CLIP	23824327
MIRT672187	hsa-miR-4284	HITS-CLIP	23824327
MIRT672188	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT672189	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT672190	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT672191	hsa-miR-5197-5p	HITS-CLIP	23824327
MIRT678565	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT678566	hsa-miR-640	HITS-CLIP	23824327
MIRT678567	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT678568	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT678569	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT678570	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT678571	hsa-miR-1306-3p	HITS-CLIP	23824327
MIRT678572	hsa-miR-1471	HITS-CLIP	23824327
MIRT678573	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT678574	hsa-miR-764	HITS-CLIP	23824327
MIRT678575	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT731583	hsa-miR-486-5p	Luciferase reporter assay	27049724
MIRT732106	hsa-miR-539-5p	Luciferase reporter assay, qRT-PCR, Western blot	26559153
MIRT732964	hsa-miR-711	Flow, Microarray, qRT-PCR, Western blot	26735582
MIRT734384	hsa-miR-1-5p	Immunofluorescence, Immunohistochemistry, Luciferase reporter assay, qRT-PCR	26036633
MIRT734862	hsa-miR-613	Luciferase reporter assay, Western blot	26744345

Transcription factors

Show/Hide all(14)

Transcription factor	Regulation	Reference
ESR1	Unknown	22179484
IRF1	Repression	22200613
MYC	Activation	22395148
MYC	Unknown	10688915;21384303
NFKB1	Activation	18425349
NR3C1	Repression	9154817
RELA	Activation	18425349
SATB1	Activation	22583549
SOX6	Repression	21084391
SOX9	Activation	20651055
SOX9	Repression	20651055
SP1	Activation	19017637
STAT3	Activation	22218594
TP53	Unknown	17530187

Show/Hide all(60)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000079	Process	Regulation of cyclin-dependent protein serine/threonine kinase activity	IEA
GO:0000082	Process	G1/S transition of mitotic cell cycle	IMP	7603984
GO:0000307	Component	Cyclin-dependent protein kinase holoenzyme complex	IDA	17420273, 18827403
GO:0000785	Component	Chromatin	IDA	18827403
GO:0002088	Process	Lens development in camera-type eye	IEA
GO:0004693	Function	Cyclin-dependent protein serine/threonine kinase activity	IBA	21873635
GO:0004693	Function	Cyclin-dependent protein serine/threonine kinase activity	IDA	8114739
GO:0004693	Function	Cyclin-dependent protein serine/threonine kinase activity	TAS
GO:0005515	Function	Protein binding	IPI	7568034, 8078588, 8259215, 8741839, 8756624, 9106657, 9150368, 9529249, 11896535, 11900540, 14641107, 15107404, 15232106, 15558030, 16169070, 16189514, 16326706, 16327805, 16431923, 16962592, 17053782, 17517622, 17909018, 17955473, 19237555, 19237565, 19447967, 19470470, 20399237, 21
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	IDA	16109376, 18827403, 20399237
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005667	Component	Transcription regulator complex	IEA
GO:0005730	Component	Nucleolus	IDA	18827403
GO:0005829	Component	Cytosol	IDA	18827403
GO:0005829	Component	Cytosol	TAS
GO:0005923	Component	Bicellular tight junction	IEA
GO:0006367	Process	Transcription initiation from RNA polymerase II promoter	TAS
GO:0006468	Process	Protein phosphorylation	IBA	21873635
GO:0006468	Process	Protein phosphorylation	IDA	8114739
GO:0007165	Process	Signal transduction	IEA
GO:0007623	Process	Circadian rhythm	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IMP	7603984
GO:0008353	Function	RNA polymerase II CTD heptapeptide repeat kinase activity	IBA	21873635
GO:0009636	Process	Response to toxic substance	IEA
GO:0010288	Process	Response to lead ion	IEA
GO:0010468	Process	Regulation of gene expression	IMP	17420273
GO:0010971	Process	Positive regulation of G2/M transition of mitotic cell cycle	IDA	19124461
GO:0016538	Function	Cyclin-dependent protein serine/threonine kinase regulator activity	TAS
GO:0016592	Component	Mediator complex	IBA	21873635
GO:0030332	Function	Cyclin binding	IPI	19124461
GO:0031100	Process	Animal organ regeneration	IEA
GO:0031965	Component	Nuclear membrane	IDA	18827403
GO:0032869	Process	Cellular response to insulin stimulus	IEA
GO:0033574	Process	Response to testosterone	IEA
GO:0040014	Process	Regulation of multicellular organism growth	IEA
GO:0042493	Process	Response to drug	IEP	18291362
GO:0043065	Process	Positive regulation of apoptotic process	IEA
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0045727	Process	Positive regulation of translation	IEA
GO:0045787	Process	Positive regulation of cell cycle	TAS
GO:0045793	Process	Positive regulation of cell size	IEA
GO:0046626	Process	Regulation of insulin receptor signaling pathway	IEA
GO:0046890	Process	Regulation of lipid biosynthetic process	IEA
GO:0048146	Process	Positive regulation of fibroblast proliferation	IMP	17420273
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0050994	Process	Regulation of lipid catabolic process	IEA
GO:0051301	Process	Cell division	IEA
GO:0051726	Process	Regulation of cell cycle	IBA	21873635
GO:0055093	Process	Response to hyperoxia	IEA
GO:0060612	Process	Adipose tissue development	IEA
GO:0071157	Process	Negative regulation of cell cycle arrest	IDA	19124461
GO:0071222	Process	Cellular response to lipopolysaccharide	IEA
GO:0071353	Process	Cellular response to interleukin-4	IEA
GO:0097129	Component	Cyclin D2-CDK4 complex	IEA
GO:1904628	Process	Cellular response to phorbol 13-acetate 12-myristate	IEA
GO:1904637	Process	Cellular response to ionomycin	IEA
GO:2000134	Process	Negative regulation of G1/S transition of mitotic cell cycle	TAS

MIM	HGNC	e!Ensembl
123829	1773	ENSG00000135446

Protein

UniProt ID

P11802

Protein name

Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3)

Protein function

Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

PDB

1LD2 , 2W96 , 2W99 , 2W9F , 2W9Z , 3G33 , 5FWK , 5FWL , 5FWM , 5FWP , 6P8E , 6P8F , 6P8G , 6P8H

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	6 → 295	Protein kinase domain	Domain

Sequence

MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL
RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL
MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY
RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG
NPE

Sequence length

303

Interactions

View interactions

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