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CDK4 (cyclin dependent kinase 4)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1019
Gene nameGene Name - the full gene name approved by the HGNC.
Cyclin dependent kinase 4
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
CDK4
SynonymsGene synonyms aliases
CMM3, PSK-J3
ChromosomeChromosome number
12
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q14.1
SummarySummary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for
SNPsSNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs11547328 G>A,T Likely-pathogenic, pathogenic Coding sequence variant, missense variant
rs104894340 C>A,T Risk-factor, likely-pathogenic, pathogenic Coding sequence variant, missense variant
rs144890720 T>C Conflicting-interpretations-of-pathogenicity, likely-benign, uncertain-significance Missense variant, coding sequence variant
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT000765 hsa-miR-34c-5p Review, Luciferase reporter assay 19461653
MIRT000764 hsa-miR-34b-5p Review, Luciferase reporter assay 19461653
MIRT000763 hsa-miR-34a-5p Review, Luciferase reporter assay 19461653
MIRT000763 hsa-miR-34a-5p Review, Luciferase reporter assay, Western blot, Microarray 17914404
MIRT003636 hsa-miR-302a-3p Luciferase reporter assay, qRT-PCR, Western blot 18710938
Transcription factors
Transcription factor Regulation Reference
ESR1 Unknown 22179484
IRF1 Repression 22200613
MYC Activation 22395148
MYC Unknown 10688915;21384303
NFKB1 Activation 18425349
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000079 Process Regulation of cyclin-dependent protein serine/threonine kinase activity IEA
GO:0000082 Process G1/S transition of mitotic cell cycle IMP 7603984
GO:0000307 Component Cyclin-dependent protein kinase holoenzyme complex IDA 17420273, 18827403
GO:0000785 Component Chromatin IDA 18827403
GO:0002088 Process Lens development in camera-type eye IEA
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P11802
Protein name Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3)
Protein function Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociat
PDB 2W96 , 2W99 , 2W9F , 2W9Z , 3G33 , 5FWK , 5FWL , 5FWM , 5FWP , 6P8E , 6P8F , 6P8G , 6P8H , 7SJ3
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase
6 295
Protein kinase domain
Domain
Sequence
Sequence length 303
Interactions View interactions

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