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CCND1 (cyclin D1)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
595
Gene nameGene Name - the full gene name approved by the HGNC.
Cyclin D1
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
CCND1
SynonymsGene synonyms aliases
BCL1, D11S287E, PRAD1, U21B31
ChromosomeChromosome number
11
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11q13.3
SummarySummary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhi
SNPsSNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs9344 G>A Risk-factor Synonymous variant, coding sequence variant
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT001225 hsa-miR-16-5p Western blot 18483394
MIRT001227 hsa-miR-15a-5p qRT-PCR, Luciferase reporter assay, Western blot 19591824
MIRT001227 hsa-miR-15a-5p qRT-PCR, Luciferase reporter assay, Western blot 19591824
MIRT001225 hsa-miR-16-5p qRT-PCR, Luciferase reporter assay, Western blot 19591824
MIRT001225 hsa-miR-16-5p qRT-PCR, Luciferase reporter assay, Western blot 19591824
Transcription factors
Transcription factor Regulation Reference
AHR Unknown 24380854
ATF2 Activation 10464245;10915780
BHLHE41 Repression 18223678
BRCA1 Unknown 12032322
BTG2 Repression 15870875;16849553
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000079 Process Regulation of cyclin-dependent protein serine/threonine kinase activity IBA 21873635
GO:0000082 Process G1/S transition of mitotic cell cycle IDA 19412162
GO:0000082 Process G1/S transition of mitotic cell cycle TAS 18483258
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 16569215, 18417529
GO:0000307 Component Cyclin-dependent protein kinase holoenzyme complex IBA 21873635
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P24385
Protein name G1/S-specific cyclin-D1 (B-cell lymphoma 1 protein) (BCL-1) (BCL-1 oncogene) (PRAD1 oncogene)
Protein function Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition (PubMed:1827756, PubMed:1833066, PubMe
PDB 2W96 , 2W99 , 2W9F , 2W9Z , 5VZU , 6P8E , 6P8F , 6P8G , 6P8H
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00134 Cyclin_N
26 153
Cyclin, N-terminal domain
Domain
PF02984 Cyclin_C
155 282
Cyclin, C-terminal domain
Domain
Sequence
Sequence length 295
Interactions View interactions

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