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CCNA2 (cyclin A2)
Gene
Gene SNPs Transcription factors Other IDs
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
890
Gene nameGene Name - the full gene name approved by the HGNC.
Cyclin A2
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
CCNA2
SynonymsGene synonyms aliases
CCN1, CCNA
ChromosomeChromosome number
4
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q27
SummarySummary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members function as regulators of the cell cycle. This protein binds and activates cyclin-dependent kinase 2 and thus promotes transition through G1/S and G2/M. [provided by RefSeq, Aug 2016]
miRNAmiRNA information provided by mirtarbase database.
Gene SNPs Transcription factors Other IDs
miRTarBase ID miRNA Experiments Reference
MIRT000119 hsa-miR-24-3p Luciferase reporter assay, Microarray, qRT-PCR, Western blot, Reporter assay;Western blot;qRT-PCR;Other 19748357
MIRT003999 hsa-let-7b-5p Immunoblot, Immunofluorescence, Luciferase reporter assay, qRT-PCR 18379589
MIRT004017 hsa-miR-146a-5p Microarray, qRT-PCR, Western blot 19944095
MIRT016556 hsa-miR-193b-3p Microarray 20304954
MIRT021865 hsa-miR-132-3p Western blot;qRT-PCR 21329664
Transcription factors
Gene SNPs Transcription factors Other IDs
Transcription factor Regulation Reference
CREM Repression 9280058
E2F3 Unknown 16909110
E4F1 Repression 15805267
E4F1 Unknown 14645522
ESR1 Activation 17681750
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs Transcription factors Other IDs
GO ID Ontology Definition Evidence Reference
GO:0000079 Process Regulation of cyclin-dependent protein serine/threonine kinase activity IBA 21873635
GO:0000086 Process G2/M transition of mitotic cell cycle IDA 1312467
GO:0000307 Component Cyclin-dependent protein kinase holoenzyme complex IBA 21873635
GO:0000307 Component Cyclin-dependent protein kinase holoenzyme complex IDA 1312467
GO:0001939 Component Female pronucleus IEA
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs Transcription factors Other IDs
MIM
HGNC
e!Ensembl
Protein
Gene SNPs Transcription factors Other IDs
UniProt ID P20248
Protein name Cyclin-A2 (Cyclin-A) (Cyclin A)
Protein function Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.
PDB 1E9H , 1FIN , 1FVV , 1GY3 , 1H1P , 1H1Q , 1H1R , 1H1S , 1H24 , 1H25 , 1H26 , 1H27 , 1H28 , 1JST , 1JSU , 1OGU , 1OI9 , 1OIU , 1OIY , 1OKV , 1OKW , 1OL1 , 1OL2 , 1P5E , 1PKD , 1QMZ , 1URC , 1VYW , 2BKZ , 2BPM , 2C4G , 2C5N , 2C5O , 2C5V , 2C5X , 2C6T , 2CCH , 2CCI , 2CJM , 2I40 , 2IW6 , 2IW8 , 2IW9 , 2UUE , 2UZB , 2UZD , 2UZE , 2UZL , 2V22 , 2WEV , 2WFY
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF16500 Cyclin_N2
28 → 166
N-terminal region of cyclin_N
 Family
PF00134 Cyclin_N
181 → 307
Cyclin, N-terminal domain
 Domain
PF02984 Cyclin_C
309 → 427
Cyclin, C-terminal domain
 Domain
Sequence
Sequence length 432
Interactions View interactions

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