GeDiPNet: Comprehensive Gene Data - OMIM, HGNC, Ensembl, UniProt, GO, Transcription Factors & miRNA

Home
Browse
- Genes
- Diseases
- Pathways
  - Reactome
  - KEGG
Analysis
Help
Links
FAQ
Contact us

CASP8 (caspase 8)

Gene

841

Caspase 8

CASP8

ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5

2q33.1

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large pro

Show/Hide all(2)

SNP ID	Visualize variation	Clinical significance	Consequence
rs17860424	C>T	Pathogenic	Coding sequence variant, missense variant, non coding transcript variant
rs587776665	GT>-	Pathogenic	Downstream transcript variant, genic downstream transcript variant, frameshift variant, non coding transcript variant, coding sequence variant

Show/Hide all(374)

miRTarBase ID	miRNA	Experiments	Reference
MIRT005293	hsa-let-7a-5p	Western blot	18758960
MIRT006278	hsa-miR-19b-1-5p	Luciferase reporter assay	22197821
MIRT006278	hsa-miR-19b-1-5p	Luciferase reporter assay	22197821
MIRT006278	hsa-miR-19b-1-5p	Luciferase reporter assay	22197821
MIRT029158	hsa-miR-26b-5p	Microarray	19088304
MIRT204830	hsa-miR-106b-5p	Luciferase reporter assay	24166509
MIRT204830	hsa-miR-106b-5p	Luciferase reporter assay	24166509
MIRT204830	hsa-miR-106b-5p	Luciferase reporter assay	24166509
MIRT204830	hsa-miR-106b-5p	Luciferase reporter assay	24166509
MIRT204830	hsa-miR-106b-5p	Luciferase reporter assay	24166509
MIRT204830	hsa-miR-106b-5p	Luciferase reporter assay	24166509
MIRT204830	hsa-miR-106b-5p	Luciferase reporter assay	24166509
MIRT204830	hsa-miR-106b-5p	Luciferase reporter assay	24166509
MIRT682669	hsa-miR-6808-5p	HITS-CLIP	23706177
MIRT682668	hsa-miR-6893-5p	HITS-CLIP	23706177
MIRT682667	hsa-miR-940	HITS-CLIP	23706177
MIRT682666	hsa-miR-3929	HITS-CLIP	23706177
MIRT682665	hsa-miR-4419b	HITS-CLIP	23706177
MIRT682664	hsa-miR-4478	HITS-CLIP	23706177
MIRT682663	hsa-miR-4768-3p	HITS-CLIP	23706177
MIRT682662	hsa-miR-6746-5p	HITS-CLIP	23706177
MIRT682661	hsa-miR-4649-3p	HITS-CLIP	23706177
MIRT682660	hsa-miR-1827	HITS-CLIP	23706177
MIRT682659	hsa-miR-485-5p	HITS-CLIP	23706177
MIRT682658	hsa-miR-6884-5p	HITS-CLIP	23706177
MIRT682657	hsa-miR-4722-5p	HITS-CLIP	23706177
MIRT682656	hsa-miR-7160-5p	HITS-CLIP	23706177
MIRT682655	hsa-miR-6735-3p	HITS-CLIP	23706177
MIRT682654	hsa-miR-6771-5p	HITS-CLIP	23706177
MIRT682653	hsa-miR-665	HITS-CLIP	23706177
MIRT527678	hsa-miR-495-3p	PAR-CLIP	22012620
MIRT527677	hsa-miR-5688	PAR-CLIP	22012620
MIRT527676	hsa-miR-29a-3p	PAR-CLIP	22012620
MIRT527675	hsa-miR-29b-3p	PAR-CLIP	22012620
MIRT527674	hsa-miR-29c-3p	PAR-CLIP	22012620
MIRT527673	hsa-miR-6871-3p	PAR-CLIP	22012620
MIRT527672	hsa-miR-767-5p	PAR-CLIP	22012620
MIRT527671	hsa-miR-5682	PAR-CLIP	22012620
MIRT731940	hsa-miR-376a-3p	Luciferase reporter assay, qRT-PCR, Western blot	27979415
MIRT731940	hsa-miR-376a-3p	Luciferase reporter assay, qRT-PCR, Western blot	27979415
MIRT731940	hsa-miR-376a-3p	PAR-CLIP	27292025
MIRT733649	hsa-miR-149-5p	qRT-PCR	34051087
MIRT733649	hsa-miR-149-5p	qRT-PCR	34051087
MIRT735255	hsa-miR-21-3p	Microarray, qRT-PCR	32407273
MIRT736406	hsa-miR-491-3p	qRT-PCR, Flow cytometry	33679688
MIRT682669	hsa-miR-6808-5p	HITS-CLIP	23706177
MIRT682668	hsa-miR-6893-5p	HITS-CLIP	23706177
MIRT682667	hsa-miR-940	HITS-CLIP	23706177
MIRT682666	hsa-miR-3929	HITS-CLIP	23706177
MIRT682665	hsa-miR-4419b	HITS-CLIP	23706177
MIRT682664	hsa-miR-4478	HITS-CLIP	23706177
MIRT682663	hsa-miR-4768-3p	HITS-CLIP	23706177
MIRT682662	hsa-miR-6746-5p	HITS-CLIP	23706177
MIRT682661	hsa-miR-4649-3p	HITS-CLIP	23706177
MIRT682660	hsa-miR-1827	HITS-CLIP	23706177
MIRT682659	hsa-miR-485-5p	HITS-CLIP	23706177
MIRT682658	hsa-miR-6884-5p	HITS-CLIP	23706177
MIRT682657	hsa-miR-4722-5p	HITS-CLIP	23706177
MIRT682656	hsa-miR-7160-5p	HITS-CLIP	23706177
MIRT682655	hsa-miR-6735-3p	HITS-CLIP	23706177
MIRT682654	hsa-miR-6771-5p	HITS-CLIP	23706177
MIRT682653	hsa-miR-665	HITS-CLIP	23706177
MIRT527678	hsa-miR-495-3p	PAR-CLIP	22012620
MIRT527677	hsa-miR-5688	PAR-CLIP	22012620
MIRT527676	hsa-miR-29a-3p	PAR-CLIP	22012620
MIRT527675	hsa-miR-29b-3p	PAR-CLIP	22012620
MIRT527674	hsa-miR-29c-3p	PAR-CLIP	22012620
MIRT527673	hsa-miR-6871-3p	PAR-CLIP	22012620
MIRT527672	hsa-miR-767-5p	PAR-CLIP	22012620
MIRT527671	hsa-miR-5682	PAR-CLIP	22012620
MIRT755543	hsa-miR-181c-5p	Western blotting, qRT-PCR	36676955
MIRT864185	hsa-miR-1184	CLIP-seq
MIRT864186	hsa-miR-1226	CLIP-seq
MIRT864187	hsa-miR-1231	CLIP-seq
MIRT864188	hsa-miR-1273	CLIP-seq
MIRT864189	hsa-miR-1293	CLIP-seq
MIRT864190	hsa-miR-137	CLIP-seq
MIRT864191	hsa-miR-192	CLIP-seq
MIRT864192	hsa-miR-215	CLIP-seq
MIRT864193	hsa-miR-24	CLIP-seq
MIRT864194	hsa-miR-3064-3p	CLIP-seq
MIRT864195	hsa-miR-3122	CLIP-seq
MIRT864196	hsa-miR-3689a-3p	CLIP-seq
MIRT864197	hsa-miR-3689c	CLIP-seq
MIRT864198	hsa-miR-3913-5p	CLIP-seq
MIRT864199	hsa-miR-3940-5p	CLIP-seq
MIRT864200	hsa-miR-4252	CLIP-seq
MIRT864201	hsa-miR-4284	CLIP-seq
MIRT864202	hsa-miR-4418	CLIP-seq
MIRT864203	hsa-miR-4483	CLIP-seq
MIRT864204	hsa-miR-4486	CLIP-seq
MIRT864205	hsa-miR-4490	CLIP-seq
MIRT864206	hsa-miR-4507	CLIP-seq
MIRT864207	hsa-miR-4537	CLIP-seq
MIRT864208	hsa-miR-4649-5p	CLIP-seq
MIRT864209	hsa-miR-4715-3p	CLIP-seq
MIRT864210	hsa-miR-4728-5p	CLIP-seq
MIRT864211	hsa-miR-4746-3p	CLIP-seq
MIRT864212	hsa-miR-4755-3p	CLIP-seq
MIRT864213	hsa-miR-4774-5p	CLIP-seq
MIRT864214	hsa-miR-4792	CLIP-seq
MIRT864215	hsa-miR-4793-3p	CLIP-seq
MIRT864216	hsa-miR-508-5p	CLIP-seq
MIRT864217	hsa-miR-509-3-5p	CLIP-seq
MIRT864218	hsa-miR-509-5p	CLIP-seq
MIRT864219	hsa-miR-548ac	CLIP-seq
MIRT864220	hsa-miR-548ae	CLIP-seq
MIRT864221	hsa-miR-548aj	CLIP-seq
MIRT864222	hsa-miR-548am	CLIP-seq
MIRT864223	hsa-miR-548d-3p	CLIP-seq
MIRT864224	hsa-miR-548x	CLIP-seq
MIRT864225	hsa-miR-548z	CLIP-seq
MIRT864226	hsa-miR-635	CLIP-seq
MIRT864227	hsa-miR-661	CLIP-seq
MIRT864228	hsa-miR-766	CLIP-seq
MIRT864186	hsa-miR-1226	CLIP-seq
MIRT864188	hsa-miR-1273	CLIP-seq
MIRT864189	hsa-miR-1293	CLIP-seq
MIRT864190	hsa-miR-137	CLIP-seq
MIRT864194	hsa-miR-3064-3p	CLIP-seq
MIRT864229	hsa-miR-3120-5p	CLIP-seq
MIRT864195	hsa-miR-3122	CLIP-seq
MIRT864230	hsa-miR-3165	CLIP-seq
MIRT864231	hsa-miR-3613-3p	CLIP-seq
MIRT864196	hsa-miR-3689a-3p	CLIP-seq
MIRT864197	hsa-miR-3689c	CLIP-seq
MIRT864232	hsa-miR-371-5p	CLIP-seq
MIRT864233	hsa-miR-371b-5p	CLIP-seq
MIRT864198	hsa-miR-3913-5p	CLIP-seq
MIRT864200	hsa-miR-4252	CLIP-seq
MIRT864234	hsa-miR-4433	CLIP-seq
MIRT864235	hsa-miR-4459	CLIP-seq
MIRT864203	hsa-miR-4483	CLIP-seq
MIRT864207	hsa-miR-4537	CLIP-seq
MIRT864236	hsa-miR-4683	CLIP-seq
MIRT864209	hsa-miR-4715-3p	CLIP-seq
MIRT864210	hsa-miR-4728-5p	CLIP-seq
MIRT864211	hsa-miR-4746-3p	CLIP-seq
MIRT864237	hsa-miR-4778-5p	CLIP-seq
MIRT864214	hsa-miR-4792	CLIP-seq
MIRT864215	hsa-miR-4793-3p	CLIP-seq
MIRT864238	hsa-miR-495	CLIP-seq
MIRT864216	hsa-miR-508-5p	CLIP-seq
MIRT864239	hsa-miR-543	CLIP-seq
MIRT864219	hsa-miR-548ac	CLIP-seq
MIRT864220	hsa-miR-548ae	CLIP-seq
MIRT864221	hsa-miR-548aj	CLIP-seq
MIRT864222	hsa-miR-548am	CLIP-seq
MIRT864223	hsa-miR-548d-3p	CLIP-seq
MIRT864224	hsa-miR-548x	CLIP-seq
MIRT864225	hsa-miR-548z	CLIP-seq
MIRT864228	hsa-miR-766	CLIP-seq
MIRT864185	hsa-miR-1184	CLIP-seq
MIRT864191	hsa-miR-192	CLIP-seq
MIRT864192	hsa-miR-215	CLIP-seq
MIRT864193	hsa-miR-24	CLIP-seq
MIRT864229	hsa-miR-3120-5p	CLIP-seq
MIRT864231	hsa-miR-3613-3p	CLIP-seq
MIRT864232	hsa-miR-371-5p	CLIP-seq
MIRT864233	hsa-miR-371b-5p	CLIP-seq
MIRT1956164	hsa-miR-3944-5p	CLIP-seq
MIRT864201	hsa-miR-4284	CLIP-seq
MIRT864202	hsa-miR-4418	CLIP-seq
MIRT864207	hsa-miR-4537	CLIP-seq
MIRT1956165	hsa-miR-4658	CLIP-seq
MIRT864211	hsa-miR-4746-3p	CLIP-seq
MIRT1956166	hsa-miR-4758-5p	CLIP-seq
MIRT864237	hsa-miR-4778-5p	CLIP-seq
MIRT864214	hsa-miR-4792	CLIP-seq
MIRT864217	hsa-miR-509-3-5p	CLIP-seq
MIRT864218	hsa-miR-509-5p	CLIP-seq
MIRT864188	hsa-miR-1273	CLIP-seq
MIRT864189	hsa-miR-1293	CLIP-seq
MIRT864193	hsa-miR-24	CLIP-seq
MIRT2193822	hsa-miR-3074-3p	CLIP-seq
MIRT864195	hsa-miR-3122	CLIP-seq
MIRT864230	hsa-miR-3165	CLIP-seq
MIRT2193823	hsa-miR-3653	CLIP-seq
MIRT864196	hsa-miR-3689a-3p	CLIP-seq
MIRT864197	hsa-miR-3689c	CLIP-seq
MIRT864198	hsa-miR-3913-5p	CLIP-seq
MIRT2193824	hsa-miR-3942-5p	CLIP-seq
MIRT864200	hsa-miR-4252	CLIP-seq
MIRT864201	hsa-miR-4284	CLIP-seq
MIRT864234	hsa-miR-4433	CLIP-seq
MIRT864235	hsa-miR-4459	CLIP-seq
MIRT864203	hsa-miR-4483	CLIP-seq
MIRT864204	hsa-miR-4486	CLIP-seq
MIRT864207	hsa-miR-4537	CLIP-seq
MIRT864208	hsa-miR-4649-5p	CLIP-seq
MIRT864236	hsa-miR-4683	CLIP-seq
MIRT2193825	hsa-miR-4703-5p	CLIP-seq
MIRT864210	hsa-miR-4728-5p	CLIP-seq
MIRT864211	hsa-miR-4746-3p	CLIP-seq
MIRT864214	hsa-miR-4792	CLIP-seq
MIRT864215	hsa-miR-4793-3p	CLIP-seq
MIRT2193826	hsa-miR-487a	CLIP-seq
MIRT864216	hsa-miR-508-5p	CLIP-seq
MIRT864226	hsa-miR-635	CLIP-seq
MIRT864227	hsa-miR-661	CLIP-seq
MIRT864228	hsa-miR-766	CLIP-seq
MIRT864229	hsa-miR-3120-5p	CLIP-seq
MIRT864231	hsa-miR-3613-3p	CLIP-seq
MIRT864232	hsa-miR-371-5p	CLIP-seq
MIRT864233	hsa-miR-371b-5p	CLIP-seq
MIRT864237	hsa-miR-4778-5p	CLIP-seq
MIRT2497039	hsa-miR-106a	CLIP-seq
MIRT2497040	hsa-miR-106b	CLIP-seq
MIRT2497041	hsa-miR-10a	CLIP-seq
MIRT2497042	hsa-miR-10b	CLIP-seq
MIRT864185	hsa-miR-1184	CLIP-seq
MIRT2497043	hsa-miR-1224-3p	CLIP-seq
MIRT2497044	hsa-miR-1260	CLIP-seq
MIRT2497045	hsa-miR-1260b	CLIP-seq
MIRT864188	hsa-miR-1273	CLIP-seq
MIRT2497046	hsa-miR-128	CLIP-seq
MIRT2497047	hsa-miR-1280	CLIP-seq
MIRT864189	hsa-miR-1293	CLIP-seq
MIRT2497048	hsa-miR-150	CLIP-seq
MIRT2497049	hsa-miR-17	CLIP-seq
MIRT2497050	hsa-miR-1908	CLIP-seq
MIRT864191	hsa-miR-192	CLIP-seq
MIRT2497051	hsa-miR-20a	CLIP-seq
MIRT2497052	hsa-miR-20b	CLIP-seq
MIRT2497053	hsa-miR-2114	CLIP-seq
MIRT864192	hsa-miR-215	CLIP-seq
MIRT864193	hsa-miR-24	CLIP-seq
MIRT2497054	hsa-miR-302a	CLIP-seq
MIRT2497055	hsa-miR-302b	CLIP-seq
MIRT2497056	hsa-miR-302c	CLIP-seq
MIRT2497057	hsa-miR-302d	CLIP-seq
MIRT2497058	hsa-miR-302e	CLIP-seq
MIRT864229	hsa-miR-3120-5p	CLIP-seq
MIRT864195	hsa-miR-3122	CLIP-seq
MIRT864230	hsa-miR-3165	CLIP-seq
MIRT2497059	hsa-miR-339-5p	CLIP-seq
MIRT864231	hsa-miR-3613-3p	CLIP-seq
MIRT864196	hsa-miR-3689a-3p	CLIP-seq
MIRT864197	hsa-miR-3689c	CLIP-seq
MIRT864232	hsa-miR-371-5p	CLIP-seq
MIRT864233	hsa-miR-371b-5p	CLIP-seq
MIRT2497060	hsa-miR-372	CLIP-seq
MIRT2497061	hsa-miR-373	CLIP-seq
MIRT864198	hsa-miR-3913-5p	CLIP-seq
MIRT2497062	hsa-miR-3934	CLIP-seq
MIRT864199	hsa-miR-3940-5p	CLIP-seq
MIRT1956164	hsa-miR-3944-5p	CLIP-seq
MIRT864200	hsa-miR-4252	CLIP-seq
MIRT864201	hsa-miR-4284	CLIP-seq
MIRT864202	hsa-miR-4418	CLIP-seq
MIRT2497063	hsa-miR-4421	CLIP-seq
MIRT864234	hsa-miR-4433	CLIP-seq
MIRT864235	hsa-miR-4459	CLIP-seq
MIRT864203	hsa-miR-4483	CLIP-seq
MIRT864204	hsa-miR-4486	CLIP-seq
MIRT864206	hsa-miR-4507	CLIP-seq
MIRT864208	hsa-miR-4649-5p	CLIP-seq
MIRT1956165	hsa-miR-4658	CLIP-seq
MIRT2497064	hsa-miR-4662a-5p	CLIP-seq
MIRT2497065	hsa-miR-4676-5p	CLIP-seq
MIRT864236	hsa-miR-4683	CLIP-seq
MIRT2497066	hsa-miR-4684-5p	CLIP-seq
MIRT2497067	hsa-miR-4714-3p	CLIP-seq
MIRT864210	hsa-miR-4728-5p	CLIP-seq
MIRT2497068	hsa-miR-4731-5p	CLIP-seq
MIRT1956166	hsa-miR-4758-5p	CLIP-seq
MIRT864237	hsa-miR-4778-5p	CLIP-seq
MIRT864215	hsa-miR-4793-3p	CLIP-seq
MIRT2497069	hsa-miR-498	CLIP-seq
MIRT864216	hsa-miR-508-5p	CLIP-seq
MIRT864217	hsa-miR-509-3-5p	CLIP-seq
MIRT864218	hsa-miR-509-5p	CLIP-seq
MIRT2497070	hsa-miR-512-3p	CLIP-seq
MIRT2497071	hsa-miR-519d	CLIP-seq
MIRT2497072	hsa-miR-520a-3p	CLIP-seq
MIRT2497073	hsa-miR-520b	CLIP-seq
MIRT2497074	hsa-miR-520c-3p	CLIP-seq
MIRT2497075	hsa-miR-520d-3p	CLIP-seq
MIRT2497076	hsa-miR-520e	CLIP-seq
MIRT2497077	hsa-miR-520g	CLIP-seq
MIRT2497078	hsa-miR-520h	CLIP-seq
MIRT2497079	hsa-miR-532-3p	CLIP-seq
MIRT2497080	hsa-miR-548c-3p	CLIP-seq
MIRT2497081	hsa-miR-575	CLIP-seq
MIRT2497082	hsa-miR-593	CLIP-seq
MIRT864226	hsa-miR-635	CLIP-seq
MIRT864227	hsa-miR-661	CLIP-seq
MIRT2497083	hsa-miR-663	CLIP-seq
MIRT864228	hsa-miR-766	CLIP-seq
MIRT2497084	hsa-miR-93	CLIP-seq
MIRT2497039	hsa-miR-106a	CLIP-seq
MIRT2497040	hsa-miR-106b	CLIP-seq
MIRT2497041	hsa-miR-10a	CLIP-seq
MIRT2497042	hsa-miR-10b	CLIP-seq
MIRT864185	hsa-miR-1184	CLIP-seq
MIRT2497043	hsa-miR-1224-3p	CLIP-seq
MIRT2497044	hsa-miR-1260	CLIP-seq
MIRT2497045	hsa-miR-1260b	CLIP-seq
MIRT864188	hsa-miR-1273	CLIP-seq
MIRT2497046	hsa-miR-128	CLIP-seq
MIRT2497047	hsa-miR-1280	CLIP-seq
MIRT864189	hsa-miR-1293	CLIP-seq
MIRT2497048	hsa-miR-150	CLIP-seq
MIRT2497049	hsa-miR-17	CLIP-seq
MIRT2497050	hsa-miR-1908	CLIP-seq
MIRT864191	hsa-miR-192	CLIP-seq
MIRT2497051	hsa-miR-20a	CLIP-seq
MIRT2497052	hsa-miR-20b	CLIP-seq
MIRT2497053	hsa-miR-2114	CLIP-seq
MIRT864192	hsa-miR-215	CLIP-seq
MIRT864193	hsa-miR-24	CLIP-seq
MIRT2497054	hsa-miR-302a	CLIP-seq
MIRT2497055	hsa-miR-302b	CLIP-seq
MIRT2497056	hsa-miR-302c	CLIP-seq
MIRT2497057	hsa-miR-302d	CLIP-seq
MIRT2497058	hsa-miR-302e	CLIP-seq
MIRT864229	hsa-miR-3120-5p	CLIP-seq
MIRT864195	hsa-miR-3122	CLIP-seq
MIRT864230	hsa-miR-3165	CLIP-seq
MIRT2497059	hsa-miR-339-5p	CLIP-seq
MIRT864231	hsa-miR-3613-3p	CLIP-seq
MIRT864196	hsa-miR-3689a-3p	CLIP-seq
MIRT864197	hsa-miR-3689c	CLIP-seq
MIRT864232	hsa-miR-371-5p	CLIP-seq
MIRT864233	hsa-miR-371b-5p	CLIP-seq
MIRT2497060	hsa-miR-372	CLIP-seq
MIRT2497061	hsa-miR-373	CLIP-seq
MIRT864198	hsa-miR-3913-5p	CLIP-seq
MIRT2497062	hsa-miR-3934	CLIP-seq
MIRT864199	hsa-miR-3940-5p	CLIP-seq
MIRT1956164	hsa-miR-3944-5p	CLIP-seq
MIRT864200	hsa-miR-4252	CLIP-seq
MIRT864201	hsa-miR-4284	CLIP-seq
MIRT864202	hsa-miR-4418	CLIP-seq
MIRT2497063	hsa-miR-4421	CLIP-seq
MIRT864234	hsa-miR-4433	CLIP-seq
MIRT864235	hsa-miR-4459	CLIP-seq
MIRT864203	hsa-miR-4483	CLIP-seq
MIRT864204	hsa-miR-4486	CLIP-seq
MIRT864206	hsa-miR-4507	CLIP-seq
MIRT864208	hsa-miR-4649-5p	CLIP-seq
MIRT1956165	hsa-miR-4658	CLIP-seq
MIRT2497064	hsa-miR-4662a-5p	CLIP-seq
MIRT2497065	hsa-miR-4676-5p	CLIP-seq
MIRT864236	hsa-miR-4683	CLIP-seq
MIRT2497066	hsa-miR-4684-5p	CLIP-seq
MIRT2497067	hsa-miR-4714-3p	CLIP-seq
MIRT864210	hsa-miR-4728-5p	CLIP-seq
MIRT2497068	hsa-miR-4731-5p	CLIP-seq
MIRT1956166	hsa-miR-4758-5p	CLIP-seq
MIRT864237	hsa-miR-4778-5p	CLIP-seq
MIRT864215	hsa-miR-4793-3p	CLIP-seq
MIRT2497069	hsa-miR-498	CLIP-seq
MIRT864216	hsa-miR-508-5p	CLIP-seq
MIRT864217	hsa-miR-509-3-5p	CLIP-seq
MIRT864218	hsa-miR-509-5p	CLIP-seq
MIRT2497070	hsa-miR-512-3p	CLIP-seq
MIRT2497071	hsa-miR-519d	CLIP-seq
MIRT2497072	hsa-miR-520a-3p	CLIP-seq
MIRT2497073	hsa-miR-520b	CLIP-seq
MIRT2497074	hsa-miR-520c-3p	CLIP-seq
MIRT2497075	hsa-miR-520d-3p	CLIP-seq
MIRT2497076	hsa-miR-520e	CLIP-seq
MIRT2497077	hsa-miR-520g	CLIP-seq
MIRT2497078	hsa-miR-520h	CLIP-seq
MIRT2497079	hsa-miR-532-3p	CLIP-seq
MIRT2497080	hsa-miR-548c-3p	CLIP-seq
MIRT2497081	hsa-miR-575	CLIP-seq
MIRT2497082	hsa-miR-593	CLIP-seq
MIRT864226	hsa-miR-635	CLIP-seq
MIRT864227	hsa-miR-661	CLIP-seq
MIRT2497083	hsa-miR-663	CLIP-seq
MIRT864228	hsa-miR-766	CLIP-seq
MIRT2497084	hsa-miR-93	CLIP-seq

Transcription factors

Show/Hide all(5)

Transcription factor	Regulation	Reference
CEBPD	Unknown	24810056
CREB1	Activation	18342014
DNMT1	Repression	20398055
MEN1	Activation	17766243
RUNX3	Activation	15930301

Show/Hide all(91)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001525	Process	Angiogenesis	ISS
GO:0004197	Function	Cysteine-type endopeptidase activity	IDA	16920334, 19240112
GO:0004197	Function	Cysteine-type endopeptidase activity	TAS
GO:0005123	Function	Death receptor binding	IEA
GO:0005164	Function	Tumor necrosis factor receptor binding	IEA
GO:0005515	Function	Protein binding	IPI	9208847, 9334338, 9343261, 9560245, 10442631, 12198154, 12884866, 12887920, 12888622, 14612908, 15069192, 15509781, 16498403, 16936772, 17047155, 17159907, 17170703, 17245429, 17479112, 18086677, 18245485, 18328427, 18485876, 18846110, 19060883, 19176810, 19427028, 19524512, 1952451
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005739	Component	Mitochondrion	TAS	10891503
GO:0005741	Component	Mitochondrial outer membrane	TAS
GO:0005829	Component	Cytosol	IDA	17167422
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	TAS	10891503
GO:0006508	Process	Proteolysis	IDA	12888622
GO:0006915	Process	Apoptotic process	IBA	21873635
GO:0006915	Process	Apoptotic process	IGI	17599062
GO:0006915	Process	Apoptotic process	IMP	22891283
GO:0006919	Process	Activation of cysteine-type endopeptidase activity involved in apoptotic process	IBA	21873635
GO:0006919	Process	Activation of cysteine-type endopeptidase activity involved in apoptotic process	TAS
GO:0007166	Process	Cell surface receptor signaling pathway	TAS
GO:0007507	Process	Heart development	ISS
GO:0008233	Function	Peptidase activity	IDA	19740745
GO:0008233	Function	Peptidase activity	IMP	17047155
GO:0008234	Function	Cysteine-type peptidase activity	TAS	8681376
GO:0008625	Process	Extrinsic apoptotic signaling pathway via death domain receptors	IBA	21873635
GO:0009409	Process	Response to cold	IEA
GO:0010803	Process	Regulation of tumor necrosis factor-mediated signaling pathway	TAS
GO:0030101	Process	Natural killer cell activation	TAS	18309324
GO:0030225	Process	Macrophage differentiation	IBA	21873635
GO:0030225	Process	Macrophage differentiation	TAS	18309324
GO:0031264	Component	Death-inducing signaling complex	IDA	11101870, 21803845
GO:0031265	Component	CD95 death-inducing signaling complex	IDA	11717445
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	15069192
GO:0032025	Process	Response to cobalt ion	IEA
GO:0032355	Process	Response to estradiol	IEA
GO:0032496	Process	Response to lipopolysaccharide	IEA
GO:0032731	Process	Positive regulation of interleukin-1 beta production	IMP	22267217
GO:0032991	Component	Protein-containing complex	IDA	22267217
GO:0034138	Process	Toll-like receptor 3 signaling pathway	TAS
GO:0034612	Process	Response to tumor necrosis factor	IMP	10521396
GO:0035666	Process	TRIF-dependent toll-like receptor signaling pathway	TAS
GO:0035877	Function	Death effector domain binding	IBA	21873635
GO:0035877	Function	Death effector domain binding	IPI	11717445
GO:0036462	Process	TRAIL-activated apoptotic signaling pathway	IDA	21785459
GO:0039650	Process	Suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process	TAS
GO:0042110	Process	T cell activation	TAS	18309324
GO:0042113	Process	B cell activation	TAS	18309324
GO:0042802	Function	Identical protein binding	IPI	16169070, 17170703
GO:0043005	Component	Neuron projection	IEA
GO:0043065	Process	Positive regulation of apoptotic process	ISS
GO:0043123	Process	Positive regulation of I-kappaB kinase/NF-kappaB signaling	IEP	12761501
GO:0043123	Process	Positive regulation of I-kappaB kinase/NF-kappaB signaling	IMP	12884866
GO:0043124	Process	Negative regulation of I-kappaB kinase/NF-kappaB signaling	IMP	17047155
GO:0044297	Component	Cell body	IEA
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0045121	Component	Membrane raft	IEA
GO:0045471	Process	Response to ethanol	IEA
GO:0045651	Process	Positive regulation of macrophage differentiation	IMP	17047155
GO:0045862	Process	Positive regulation of proteolysis	IDA	18387192
GO:0046677	Process	Response to antibiotic	IEA
GO:0051603	Process	Proteolysis involved in cellular protein catabolic process	IMP	10521396
GO:0060544	Process	Regulation of necroptotic process	TAS
GO:0060546	Process	Negative regulation of necroptotic process	IDA	31827280
GO:0060546	Process	Negative regulation of necroptotic process	ISS
GO:0060715	Process	Syncytiotrophoblast cell differentiation involved in labyrinthine layer development	TAS	18309324
GO:0070269	Process	Pyroptosis	ISS
GO:0070423	Process	Nucleotide-binding oligomerization domain containing signaling pathway	TAS
GO:0071260	Process	Cellular response to mechanical stimulus	IEP	19593445
GO:0071407	Process	Cellular response to organic cyclic compound	IEA
GO:0071550	Process	Death-inducing signaling complex assembly	TAS
GO:0097110	Function	Scaffold protein binding	IPI	21785459
GO:0097153	Function	Cysteine-type endopeptidase activity involved in apoptotic process	IBA	21873635
GO:0097153	Function	Cysteine-type endopeptidase activity involved in apoptotic process	IDA	31827280
GO:0097153	Function	Cysteine-type endopeptidase activity involved in apoptotic process	IMP	21737330
GO:0097190	Process	Apoptotic signaling pathway	IMP	11101870
GO:0097190	Process	Apoptotic signaling pathway	TAS
GO:0097191	Process	Extrinsic apoptotic signaling pathway	IDA	21785459
GO:0097194	Process	Execution phase of apoptosis	IMP	21737330
GO:0097194	Process	Execution phase of apoptosis	ISS
GO:0097194	Process	Execution phase of apoptosis	TAS
GO:0097199	Function	Cysteine-type endopeptidase activity involved in apoptotic signaling pathway	IBA	21873635
GO:0097199	Function	Cysteine-type endopeptidase activity involved in apoptotic signaling pathway	IMP	11717445, 21980415
GO:0097200	Function	Cysteine-type endopeptidase activity involved in execution phase of apoptosis	IBA	21873635
GO:0097202	Process	Activation of cysteine-type endopeptidase activity	IDA	18387192
GO:0097264	Process	Self proteolysis	ISS
GO:0097296	Process	Activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	TAS
GO:0097342	Component	Ripoptosome	IDA	21737330
GO:1900740	Process	Positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	TAS
GO:1901216	Process	Positive regulation of neuron death	IEA
GO:1902041	Process	Regulation of extrinsic apoptotic signaling pathway via death domain receptors	TAS
GO:1902042	Process	Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	TAS

MIM	HGNC	e!Ensembl
601763	1509	ENSG00000064012

Protein

UniProt ID

Q14790

Protein name

Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Casp

Protein function

Thiol protease that plays a key role in programmed cell death by acting as a molecular switch for apoptosis, necroptosis and pyroptosis, and is required to prevent tissue damage during embryonic development and adulthood (PubMed:23516580, PubMed

PDB

1F9E , 1I4E , 1QDU , 1QTN , 2C2Z , 2FUN , 2K7Z , 2Y1L , 3H11 , 3KJN , 3KJQ , 4JJ7 , 4PRZ , 4PS1 , 4ZBW , 5H31 , 5H33 , 5JQE , 5L08 , 6AGW , 6PX9 , 7DEE , 7LVJ , 7LVM , 8YBX , 8YD7 , 8YD8 , 8YM4 , 8YM5 , 8YM6 , 8YNI , 8YNK , 8YNL , 8YNM , 8YNN

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01335	DED	3 → 84	Death effector domain	Domain
PF01335	DED	101 → 180	Death effector domain	Domain
PF00656	Peptidase_C14	234 → 476		Domain

Sequence

MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF
KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE
FSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN
NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ
LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC
QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW
YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD

Sequence length

479

Interactions

View interactions

| © 2021, Biomedical Informatics Centre, NIRRH |
ICMR-National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400012
Tel: +91-22-24192104, Fax No: +91-22-24139412