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CASP3 (caspase 3)

Gene

836

Caspase 3

CASP3

CPP32, CPP32B, SCA-1

4q35.1

The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulat

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miRTarBase ID	miRNA	Experiments	Reference
MIRT003574	hsa-miR-98-5p	Review	19815577
MIRT005292	hsa-let-7a-5p	Luciferase reporter assay, Western blot	18758960
MIRT005292	hsa-let-7a-5p	Luciferase reporter assay, Western blot	18758960
MIRT006240	hsa-miR-30d-5p	Luciferase reporter assay, Western blot	22058146
MIRT006240	hsa-miR-30d-5p	Luciferase reporter assay, Western blot	22058146
MIRT006240	hsa-miR-30d-5p	Luciferase reporter assay, Western blot	22058146
MIRT006864	hsa-miR-138-5p	Luciferase reporter assay	22921398
MIRT019884	hsa-miR-375	qRT-PCR;Microarray	20584986
MIRT021992	hsa-miR-128-3p	Sequencing	20371350
MIRT024157	hsa-miR-221-3p	Sequencing	20371350
MIRT029617	hsa-miR-26b-5p	Microarray	19088304
MIRT048249	hsa-miR-196a-5p	CLASH	23622248
MIRT054129	hsa-miR-421	qRT-PCR, Western blot	25041019
MIRT438878	hsa-miR-885-5p	Luciferase reporter assay	23271051
MIRT438878	hsa-miR-885-5p	Luciferase reporter assay	23271051
MIRT438878	hsa-miR-885-5p	Luciferase reporter assay	23271051
MIRT438730	hsa-miR-363-3p	and NCH441"	24805821
MIRT438730	hsa-miR-363-3p	and NCH441"	24805821
MIRT438729	hsa-miR-582-5p	and NCH441"	24805821
MIRT438729	hsa-miR-582-5p	and NCH441"	24805821
MIRT438878	hsa-miR-885-5p	Luciferase reporter assay	23271051
MIRT438878	hsa-miR-885-5p	Luciferase reporter assay	23271051
MIRT438878	hsa-miR-885-5p	Luciferase reporter assay	23271051
MIRT438730	hsa-miR-363-3p	and NCH441"	24805821
MIRT438730	hsa-miR-363-3p	and NCH441"	24805821
MIRT438729	hsa-miR-582-5p	and NCH441"	24805821
MIRT438729	hsa-miR-582-5p	and NCH441"	24805821
MIRT487458	hsa-miR-548n	PAR-CLIP	23592263
MIRT164579	hsa-miR-651-3p	PAR-CLIP	23592263
MIRT487457	hsa-miR-562	PAR-CLIP	23592263
MIRT487456	hsa-miR-888-5p	PAR-CLIP	23592263
MIRT487455	hsa-miR-6076	PAR-CLIP	23592263
MIRT487454	hsa-miR-6797-3p	PAR-CLIP	23592263
MIRT164595	hsa-miR-6124	PAR-CLIP	23592263
MIRT487453	hsa-miR-5011-3p	PAR-CLIP	23592263
MIRT487452	hsa-miR-4666b	PAR-CLIP	23592263
MIRT487451	hsa-miR-3680-3p	PAR-CLIP	23592263
MIRT441002	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT441003	hsa-miR-382-5p	HITS-CLIP	24374217
MIRT728049	hsa-miR-30a-5p	HITS-CLIP	22473208
MIRT728050	hsa-miR-30b-5p	HITS-CLIP	22473208
MIRT437365	hsa-miR-30c-5p	HITS-CLIP	22473208
MIRT006240	hsa-miR-30d-5p	HITS-CLIP	22473208
MIRT728048	hsa-miR-30e-5p	HITS-CLIP	22473208
MIRT441002	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT441003	hsa-miR-382-5p	HITS-CLIP	24374217
MIRT003574	hsa-miR-98-5p	Luciferase reporter assay, qRT-PCR, Western blot	26367177
MIRT054129	hsa-miR-421	Luciferase reporter assay	27016414
MIRT054129	hsa-miR-421	Luciferase reporter assay	27016414
MIRT728048	hsa-miR-30e-5p	Luciferase reporter assay	26895377
MIRT728048	hsa-miR-30e-5p	Luciferase reporter assay	26895377
MIRT356254	hsa-let-7b-3p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	26296645
MIRT732067	hsa-miR-224-5p	Luciferase reporter assay, Western blot	26307684
MIRT732067	hsa-miR-224-5p	Luciferase reporter assay, Western blot	26307684
MIRT054129	hsa-miR-421	Immunofluorescence, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	27016414
MIRT054129	hsa-miR-421	Immunofluorescence, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	27016414
MIRT732590	hsa-miR-133a-3p	Immunofluorescence, qRT-PCR, Western blotting	33639970
MIRT734060	hsa-miR-612	qRT-PCR	33564285
MIRT006864	hsa-miR-138-5p	Luciferase reporter assay, Western blotting, qRT-PCR, Flow cytometry	33856081
MIRT734992	hsa-let-7e-3p	qRT-PCR	33066614
MIRT735171	hsa-miR-7-5p	Microarray, qRT-PCR	33468167
MIRT735254	hsa-miR-30d-3p	Microarray, qRT-PCR	32407273
MIRT006864	hsa-miR-138-5p	Western blotting, qRT-PCR	32388607
MIRT006864	hsa-miR-138-5p	Western blotting, qRT-PCR	32388607
MIRT487458	hsa-miR-548n	PAR-CLIP	23592263
MIRT164579	hsa-miR-651-3p	PAR-CLIP	23592263
MIRT487457	hsa-miR-562	PAR-CLIP	23592263
MIRT487456	hsa-miR-888-5p	PAR-CLIP	23592263
MIRT487455	hsa-miR-6076	PAR-CLIP	23592263
MIRT487454	hsa-miR-6797-3p	PAR-CLIP	23592263
MIRT164595	hsa-miR-6124	PAR-CLIP	23592263
MIRT487453	hsa-miR-5011-3p	PAR-CLIP	23592263
MIRT487452	hsa-miR-4666b	PAR-CLIP	23592263
MIRT487451	hsa-miR-3680-3p	PAR-CLIP	23592263
MIRT755542	hsa-miR-181c-5p	Western blotting, qRT-PCR	36676955
MIRT755862	hsa-miR-107	Luciferase reporter assay, Western blotting, qRT-PCR, Flow cytometry, ELISA	38828010
MIRT755862	hsa-miR-107	Immunoprecipitaion (IP)	36816358
MIRT756319	hsa-miR-29b-1-5p	Western blotting, Immunofluorescence	38934067
MIRT756379	hsa-miR-139-5p	Western blotting	37794118
MIRT864029	hsa-miR-1304	CLIP-seq
MIRT864030	hsa-miR-137	CLIP-seq
MIRT864031	hsa-miR-1825	CLIP-seq
MIRT864032	hsa-miR-197	CLIP-seq
MIRT864033	hsa-miR-3152-5p	CLIP-seq
MIRT864034	hsa-miR-4760-3p	CLIP-seq
MIRT864035	hsa-miR-4789-3p	CLIP-seq
MIRT864036	hsa-miR-891b	CLIP-seq
MIRT864037	hsa-miR-103a	CLIP-seq
MIRT755862	hsa-miR-107	CLIP-seq
MIRT864038	hsa-miR-1184	CLIP-seq
MIRT864039	hsa-miR-1205	CLIP-seq
MIRT864040	hsa-miR-1287	CLIP-seq
MIRT864030	hsa-miR-137	CLIP-seq
MIRT864032	hsa-miR-197	CLIP-seq
MIRT864041	hsa-miR-24	CLIP-seq
MIRT864033	hsa-miR-3152-5p	CLIP-seq
MIRT864042	hsa-miR-3158-5p	CLIP-seq
MIRT864043	hsa-miR-3176	CLIP-seq
MIRT864044	hsa-miR-3202	CLIP-seq
MIRT864045	hsa-miR-3616-3p	CLIP-seq
MIRT864046	hsa-miR-3652	CLIP-seq
MIRT864047	hsa-miR-3658	CLIP-seq
MIRT864048	hsa-miR-3662	CLIP-seq
MIRT864049	hsa-miR-376c	CLIP-seq
MIRT864050	hsa-miR-3922-3p	CLIP-seq
MIRT864051	hsa-miR-4430	CLIP-seq
MIRT864052	hsa-miR-4437	CLIP-seq
MIRT864053	hsa-miR-4533	CLIP-seq
MIRT864054	hsa-miR-455-5p	CLIP-seq
MIRT864055	hsa-miR-4662a-3p	CLIP-seq
MIRT864056	hsa-miR-4693-3p	CLIP-seq
MIRT864057	hsa-miR-4698	CLIP-seq
MIRT864058	hsa-miR-4712-3p	CLIP-seq
MIRT864059	hsa-miR-4721	CLIP-seq
MIRT864060	hsa-miR-4757-5p	CLIP-seq
MIRT864061	hsa-miR-4773	CLIP-seq
MIRT864062	hsa-miR-518d-5p	CLIP-seq
MIRT864063	hsa-miR-519b-5p	CLIP-seq
MIRT864064	hsa-miR-519c-5p	CLIP-seq
MIRT864065	hsa-miR-520c-5p	CLIP-seq
MIRT864066	hsa-miR-526a	CLIP-seq
MIRT864067	hsa-miR-548a-5p	CLIP-seq
MIRT864068	hsa-miR-548ab	CLIP-seq
MIRT864069	hsa-miR-548ak	CLIP-seq
MIRT864070	hsa-miR-548b-5p	CLIP-seq
MIRT864071	hsa-miR-548c-5p	CLIP-seq
MIRT864072	hsa-miR-548d-5p	CLIP-seq
MIRT864073	hsa-miR-548h	CLIP-seq
MIRT864074	hsa-miR-548i	CLIP-seq
MIRT864075	hsa-miR-548j	CLIP-seq
MIRT864076	hsa-miR-548k	CLIP-seq
MIRT864077	hsa-miR-548l	CLIP-seq
MIRT864078	hsa-miR-548w	CLIP-seq
MIRT864079	hsa-miR-548y	CLIP-seq
MIRT864080	hsa-miR-559	CLIP-seq
MIRT864081	hsa-miR-603	CLIP-seq
MIRT864082	hsa-miR-654-3p	CLIP-seq
MIRT1546174	hsa-let-7a	CLIP-seq
MIRT1546175	hsa-let-7b	CLIP-seq
MIRT1546176	hsa-let-7c	CLIP-seq
MIRT1546177	hsa-let-7d	CLIP-seq
MIRT1546178	hsa-let-7e	CLIP-seq
MIRT1546179	hsa-let-7f	CLIP-seq
MIRT1546180	hsa-let-7g	CLIP-seq
MIRT1546181	hsa-let-7i	CLIP-seq
MIRT864029	hsa-miR-1304	CLIP-seq
MIRT1546182	hsa-miR-138	CLIP-seq
MIRT1546183	hsa-miR-140-5p	CLIP-seq
MIRT1546184	hsa-miR-202	CLIP-seq
MIRT1546185	hsa-miR-3545-5p	CLIP-seq
MIRT1546186	hsa-miR-376a	CLIP-seq
MIRT1546187	hsa-miR-376b	CLIP-seq
MIRT1546188	hsa-miR-4458	CLIP-seq
MIRT1546189	hsa-miR-4460	CLIP-seq
MIRT1546190	hsa-miR-4500	CLIP-seq
MIRT1546191	hsa-miR-98	CLIP-seq
MIRT1556132	hsa-miR-369-3p	CLIP-seq
MIRT1556133	hsa-miR-374a	CLIP-seq
MIRT1556134	hsa-miR-374b	CLIP-seq
MIRT1556135	hsa-miR-3942-3p	CLIP-seq
MIRT1556136	hsa-miR-410	CLIP-seq
MIRT756379	hsa-miR-139-5p	CLIP-seq
MIRT864047	hsa-miR-3658	CLIP-seq
MIRT864055	hsa-miR-4662a-3p	CLIP-seq
MIRT1956145	hsa-miR-4666-5p	CLIP-seq
MIRT1956146	hsa-miR-4795-3p	CLIP-seq
MIRT1956147	hsa-miR-5095	CLIP-seq
MIRT1956148	hsa-miR-514	CLIP-seq
MIRT1956149	hsa-miR-514b-3p	CLIP-seq
MIRT1956150	hsa-miR-601	CLIP-seq
MIRT864081	hsa-miR-603	CLIP-seq
MIRT1546182	hsa-miR-138	CLIP-seq
MIRT864034	hsa-miR-4760-3p	CLIP-seq
MIRT864037	hsa-miR-103a	CLIP-seq
MIRT755862	hsa-miR-107	CLIP-seq
MIRT2193795	hsa-miR-1229	CLIP-seq
MIRT2193796	hsa-miR-203	CLIP-seq
MIRT2193797	hsa-miR-2277-3p	CLIP-seq
MIRT2193798	hsa-miR-3614-5p	CLIP-seq
MIRT2193799	hsa-miR-3660	CLIP-seq
MIRT2193800	hsa-miR-3672	CLIP-seq
MIRT2193801	hsa-miR-3977	CLIP-seq
MIRT2193802	hsa-miR-4526	CLIP-seq
MIRT2193803	hsa-miR-4642	CLIP-seq
MIRT2193804	hsa-miR-4676-5p	CLIP-seq
MIRT864058	hsa-miR-4712-3p	CLIP-seq
MIRT864034	hsa-miR-4760-3p	CLIP-seq
MIRT2193805	hsa-miR-550b	CLIP-seq
MIRT2193806	hsa-miR-566	CLIP-seq
MIRT2193807	hsa-miR-575	CLIP-seq
MIRT2193808	hsa-miR-652	CLIP-seq
MIRT864082	hsa-miR-654-3p	CLIP-seq
MIRT2193809	hsa-miR-885-3p	CLIP-seq
MIRT2193810	hsa-miR-890	CLIP-seq
MIRT2193811	hsa-miR-942	CLIP-seq
MIRT2385555	hsa-miR-513b	CLIP-seq
MIRT2427045	hsa-miR-23a	CLIP-seq
MIRT2427046	hsa-miR-23b	CLIP-seq
MIRT2427047	hsa-miR-23c	CLIP-seq
MIRT2427048	hsa-miR-323-3p	CLIP-seq
MIRT2427049	hsa-miR-337-3p	CLIP-seq
MIRT2427050	hsa-miR-382	CLIP-seq
MIRT2427051	hsa-miR-4326	CLIP-seq
MIRT2427052	hsa-miR-4709-5p	CLIP-seq
MIRT2427053	hsa-miR-4794	CLIP-seq
MIRT2427054	hsa-miR-619	CLIP-seq
MIRT2446205	hsa-miR-144	CLIP-seq
MIRT2446206	hsa-miR-30a	CLIP-seq
MIRT2446207	hsa-miR-30b	CLIP-seq
MIRT2446208	hsa-miR-30c	CLIP-seq
MIRT2446209	hsa-miR-30d	CLIP-seq
MIRT2446210	hsa-miR-30e	CLIP-seq
MIRT2496952	hsa-miR-1254	CLIP-seq
MIRT2496953	hsa-miR-1256	CLIP-seq
MIRT2496954	hsa-miR-1283	CLIP-seq
MIRT864040	hsa-miR-1287	CLIP-seq
MIRT1546182	hsa-miR-138	CLIP-seq
MIRT2446205	hsa-miR-144	CLIP-seq
MIRT2496955	hsa-miR-153	CLIP-seq
MIRT2496956	hsa-miR-190	CLIP-seq
MIRT2496957	hsa-miR-190b	CLIP-seq
MIRT2496958	hsa-miR-221	CLIP-seq
MIRT2496959	hsa-miR-222	CLIP-seq
MIRT2193797	hsa-miR-2277-3p	CLIP-seq
MIRT864041	hsa-miR-24	CLIP-seq
MIRT2496960	hsa-miR-29a	CLIP-seq
MIRT2496961	hsa-miR-29b	CLIP-seq
MIRT2496962	hsa-miR-29c	CLIP-seq
MIRT2446206	hsa-miR-30a	CLIP-seq
MIRT2446207	hsa-miR-30b	CLIP-seq
MIRT2446208	hsa-miR-30c	CLIP-seq
MIRT2446209	hsa-miR-30d	CLIP-seq
MIRT2446210	hsa-miR-30e	CLIP-seq
MIRT2496963	hsa-miR-3116	CLIP-seq
MIRT2496964	hsa-miR-3145-3p	CLIP-seq
MIRT864033	hsa-miR-3152-5p	CLIP-seq
MIRT2496965	hsa-miR-3163	CLIP-seq
MIRT864043	hsa-miR-3176	CLIP-seq
MIRT2496966	hsa-miR-320a	CLIP-seq
MIRT2496967	hsa-miR-320b	CLIP-seq
MIRT2496968	hsa-miR-320c	CLIP-seq
MIRT2496969	hsa-miR-320d	CLIP-seq
MIRT2496970	hsa-miR-342-3p	CLIP-seq
MIRT2496971	hsa-miR-3529	CLIP-seq
MIRT2496972	hsa-miR-3607-3p	CLIP-seq
MIRT2496973	hsa-miR-3614-3p	CLIP-seq
MIRT864045	hsa-miR-3616-3p	CLIP-seq
MIRT864046	hsa-miR-3652	CLIP-seq
MIRT2193800	hsa-miR-3672	CLIP-seq
MIRT2496974	hsa-miR-370	CLIP-seq
MIRT2496975	hsa-miR-379	CLIP-seq
MIRT864050	hsa-miR-3922-3p	CLIP-seq
MIRT2496976	hsa-miR-4254	CLIP-seq
MIRT2496977	hsa-miR-4317	CLIP-seq
MIRT2496978	hsa-miR-4429	CLIP-seq
MIRT864051	hsa-miR-4430	CLIP-seq
MIRT864052	hsa-miR-4437	CLIP-seq
MIRT2496979	hsa-miR-4451	CLIP-seq
MIRT2496980	hsa-miR-4532	CLIP-seq
MIRT864054	hsa-miR-455-5p	CLIP-seq
MIRT2496981	hsa-miR-4639-5p	CLIP-seq
MIRT2496982	hsa-miR-4649-3p	CLIP-seq
MIRT2496983	hsa-miR-4650-3p	CLIP-seq
MIRT2496984	hsa-miR-4656	CLIP-seq
MIRT2496985	hsa-miR-4663	CLIP-seq
MIRT2193804	hsa-miR-4676-5p	CLIP-seq
MIRT2496986	hsa-miR-4685-5p	CLIP-seq
MIRT2496987	hsa-miR-4688	CLIP-seq
MIRT864059	hsa-miR-4721	CLIP-seq
MIRT2496988	hsa-miR-4728-3p	CLIP-seq
MIRT864060	hsa-miR-4757-5p	CLIP-seq
MIRT2496989	hsa-miR-4763-5p	CLIP-seq
MIRT2496990	hsa-miR-4768-5p	CLIP-seq
MIRT1956146	hsa-miR-4795-3p	CLIP-seq
MIRT2496991	hsa-miR-491-3p	CLIP-seq
MIRT2496992	hsa-miR-513c	CLIP-seq
MIRT2496993	hsa-miR-514b-5p	CLIP-seq
MIRT864062	hsa-miR-518d-5p	CLIP-seq
MIRT864063	hsa-miR-519b-5p	CLIP-seq
MIRT864064	hsa-miR-519c-5p	CLIP-seq
MIRT864065	hsa-miR-520c-5p	CLIP-seq
MIRT2496994	hsa-miR-520d-5p	CLIP-seq
MIRT2496995	hsa-miR-524-5p	CLIP-seq
MIRT864066	hsa-miR-526a	CLIP-seq
MIRT2496996	hsa-miR-548a-3p	CLIP-seq
MIRT2496997	hsa-miR-548e	CLIP-seq
MIRT2496998	hsa-miR-548f	CLIP-seq
MIRT2496999	hsa-miR-548t	CLIP-seq
MIRT2497000	hsa-miR-548v	CLIP-seq
MIRT2193807	hsa-miR-575	CLIP-seq
MIRT2497001	hsa-miR-586	CLIP-seq
MIRT2497002	hsa-miR-596	CLIP-seq
MIRT2497003	hsa-miR-600	CLIP-seq
MIRT2496952	hsa-miR-1254	CLIP-seq
MIRT2496953	hsa-miR-1256	CLIP-seq
MIRT864040	hsa-miR-1287	CLIP-seq
MIRT1546182	hsa-miR-138	CLIP-seq
MIRT2496955	hsa-miR-153	CLIP-seq
MIRT2496956	hsa-miR-190	CLIP-seq
MIRT2496957	hsa-miR-190b	CLIP-seq
MIRT2193797	hsa-miR-2277-3p	CLIP-seq
MIRT864041	hsa-miR-24	CLIP-seq
MIRT2496960	hsa-miR-29a	CLIP-seq
MIRT2496961	hsa-miR-29b	CLIP-seq
MIRT2496962	hsa-miR-29c	CLIP-seq
MIRT2496963	hsa-miR-3116	CLIP-seq
MIRT2496964	hsa-miR-3145-3p	CLIP-seq
MIRT2496965	hsa-miR-3163	CLIP-seq
MIRT864043	hsa-miR-3176	CLIP-seq
MIRT2496966	hsa-miR-320a	CLIP-seq
MIRT2496967	hsa-miR-320b	CLIP-seq
MIRT2496968	hsa-miR-320c	CLIP-seq
MIRT2496969	hsa-miR-320d	CLIP-seq
MIRT2496970	hsa-miR-342-3p	CLIP-seq
MIRT2496971	hsa-miR-3529	CLIP-seq
MIRT2496972	hsa-miR-3607-3p	CLIP-seq
MIRT2496973	hsa-miR-3614-3p	CLIP-seq
MIRT864045	hsa-miR-3616-3p	CLIP-seq
MIRT864046	hsa-miR-3652	CLIP-seq
MIRT2193800	hsa-miR-3672	CLIP-seq
MIRT2496974	hsa-miR-370	CLIP-seq
MIRT2496975	hsa-miR-379	CLIP-seq
MIRT864050	hsa-miR-3922-3p	CLIP-seq
MIRT2496976	hsa-miR-4254	CLIP-seq
MIRT2496977	hsa-miR-4317	CLIP-seq
MIRT2496978	hsa-miR-4429	CLIP-seq
MIRT864051	hsa-miR-4430	CLIP-seq
MIRT864052	hsa-miR-4437	CLIP-seq
MIRT2496979	hsa-miR-4451	CLIP-seq
MIRT2496980	hsa-miR-4532	CLIP-seq
MIRT864054	hsa-miR-455-5p	CLIP-seq
MIRT2496981	hsa-miR-4639-5p	CLIP-seq
MIRT2496982	hsa-miR-4649-3p	CLIP-seq
MIRT2496983	hsa-miR-4650-3p	CLIP-seq
MIRT2496984	hsa-miR-4656	CLIP-seq
MIRT2496985	hsa-miR-4663	CLIP-seq
MIRT2193804	hsa-miR-4676-5p	CLIP-seq
MIRT2496986	hsa-miR-4685-5p	CLIP-seq
MIRT2496987	hsa-miR-4688	CLIP-seq
MIRT864059	hsa-miR-4721	CLIP-seq
MIRT2496988	hsa-miR-4728-3p	CLIP-seq
MIRT864060	hsa-miR-4757-5p	CLIP-seq
MIRT2496989	hsa-miR-4763-5p	CLIP-seq
MIRT2496990	hsa-miR-4768-5p	CLIP-seq
MIRT1956146	hsa-miR-4795-3p	CLIP-seq
MIRT2496991	hsa-miR-491-3p	CLIP-seq
MIRT2496992	hsa-miR-513c	CLIP-seq
MIRT2496993	hsa-miR-514b-5p	CLIP-seq
MIRT864062	hsa-miR-518d-5p	CLIP-seq
MIRT864063	hsa-miR-519b-5p	CLIP-seq
MIRT864064	hsa-miR-519c-5p	CLIP-seq
MIRT864065	hsa-miR-520c-5p	CLIP-seq
MIRT864066	hsa-miR-526a	CLIP-seq
MIRT2496996	hsa-miR-548a-3p	CLIP-seq
MIRT2496997	hsa-miR-548e	CLIP-seq
MIRT2496998	hsa-miR-548f	CLIP-seq
MIRT2193807	hsa-miR-575	CLIP-seq
MIRT2497001	hsa-miR-586	CLIP-seq
MIRT2497002	hsa-miR-596	CLIP-seq
MIRT2497003	hsa-miR-600	CLIP-seq

Transcription factors

Show/Hide all(10)

Transcription factor	Regulation	Reference
ING1	Activation	15662138
ING4	Activation	19895734
NFKB1	Unknown	20056115
PHF10	Unknown	20530714
PML	Activation	16253165
RELA	Unknown	20056115
RUNX3	Activation	15930301;19290488
SIM2	Activation	21729534
SP1	Unknown	11773055
TP53	Unknown	21859835

Show/Hide all(82)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001554	Process	Luteolysis	IEA
GO:0001666	Process	Response to hypoxia	IEA
GO:0001782	Process	B cell homeostasis	IEA
GO:0002020	Function	Protease binding	IEA
GO:0004190	Function	Aspartic-type endopeptidase activity	IEA
GO:0004197	Function	Cysteine-type endopeptidase activity	IDA	16920334, 19240112, 21726810, 24904167
GO:0004861	Function	Cyclin-dependent protein serine/threonine kinase inhibitor activity	IEA
GO:0005123	Function	Death receptor binding	IEA
GO:0005515	Function	Protein binding	IPI	7596430, 9208847, 9736630, 11257232, 15246877, 16227597, 16501604, 16530191, 17167422, 17544405, 17606900, 17823127, 18723680, 19273858, 21726810, 23150525, 25241761, 28514442, 32296183, 32814053
GO:0005634	Component	Nucleus	IDA	17167422
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005829	Component	Cytosol	IDA	17167422, 17823127, 22253444
GO:0005829	Component	Cytosol	TAS
GO:0006309	Process	Apoptotic DNA fragmentation	TAS
GO:0006508	Process	Proteolysis	IDA	12888622, 17553422
GO:0006915	Process	Apoptotic process	IBA	21873635
GO:0006915	Process	Apoptotic process	IMP	15565177
GO:0006974	Process	Cellular response to DNA damage stimulus	IEA
GO:0007413	Process	Axonal fasciculation	IEA
GO:0007507	Process	Heart development	IEA
GO:0007605	Process	Sensory perception of sound	IEA
GO:0007611	Process	Learning or memory	IEA
GO:0008233	Function	Peptidase activity	IDA	9353287, 17167422, 19740745
GO:0008627	Process	Intrinsic apoptotic signaling pathway in response to osmotic stress	IEA
GO:0009411	Process	Response to UV	IEA
GO:0009749	Process	Response to glucose	IEA
GO:0010165	Process	Response to X-ray	IEA
GO:0016005	Function	Phospholipase A2 activator activity	IEA
GO:0016241	Process	Regulation of macroautophagy	TAS	19549685
GO:0016485	Process	Protein processing	IEA
GO:0019221	Process	Cytokine-mediated signaling pathway	TAS
GO:0021766	Process	Hippocampus development	IEA
GO:0030182	Process	Neuron differentiation	IBA	21873635
GO:0030216	Process	Keratinocyte differentiation	IBA	21873635
GO:0030218	Process	Erythrocyte differentiation	IBA	21873635
GO:0030218	Process	Erythrocyte differentiation	IDA	17167422
GO:0030218	Process	Erythrocyte differentiation	TAS	18309324
GO:0030220	Process	Platelet formation	TAS	18309324
GO:0030889	Process	Negative regulation of B cell proliferation	IEA
GO:0031264	Component	Death-inducing signaling complex	IEA
GO:0031647	Process	Regulation of protein stability	IDA	17553422
GO:0032025	Process	Response to cobalt ion	IEA
GO:0032355	Process	Response to estradiol	IEA
GO:0032496	Process	Response to lipopolysaccharide	IEA
GO:0034349	Process	Glial cell apoptotic process	IEA
GO:0034612	Process	Response to tumor necrosis factor	TAS	10521396
GO:0035094	Process	Response to nicotine	IEA
GO:0035329	Process	Hippo signaling	TAS
GO:0042060	Process	Wound healing	IEA
GO:0042493	Process	Response to drug	IEA
GO:0042542	Process	Response to hydrogen peroxide	IEA
GO:0043025	Component	Neuronal cell body	IEA
GO:0043029	Process	T cell homeostasis	IEA
GO:0043065	Process	Positive regulation of apoptotic process	IBA	21873635
GO:0043066	Process	Negative regulation of apoptotic process	IGI	9353287
GO:0043200	Process	Response to amino acid	IEA
GO:0043525	Process	Positive regulation of neuron apoptotic process	IEA
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0045121	Component	Membrane raft	IEA
GO:0045165	Process	Cell fate commitment	IEA
GO:0045736	Process	Negative regulation of cyclin-dependent protein serine/threonine kinase activity	IEA
GO:0046007	Process	Negative regulation of activated T cell proliferation	IEA
GO:0046677	Process	Response to antibiotic	IEA
GO:0048011	Process	Neurotrophin TRK receptor signaling pathway	IDA	23954828
GO:0051146	Process	Striated muscle cell differentiation	IEA
GO:0051384	Process	Response to glucocorticoid	IEA
GO:0051402	Process	Neuron apoptotic process	IEA
GO:0061713	Process	Anterior neural tube closure	IEA
GO:0071887	Process	Leukocyte apoptotic process	IEA
GO:0072734	Process	Cellular response to staurosporine	IMP	22253444
GO:0097153	Function	Cysteine-type endopeptidase activity involved in apoptotic process	IBA	21873635
GO:0097153	Function	Cysteine-type endopeptidase activity involved in apoptotic process	IDA	23729654
GO:0097153	Function	Cysteine-type endopeptidase activity involved in apoptotic process	IMP	10921886
GO:0097190	Process	Apoptotic signaling pathway	TAS	10521396
GO:0097192	Process	Extrinsic apoptotic signaling pathway in absence of ligand	TAS
GO:0097194	Process	Execution phase of apoptosis	IDA	8689682
GO:0097194	Process	Execution phase of apoptosis	IMP	11350920
GO:0097194	Process	Execution phase of apoptosis	TAS
GO:0097199	Function	Cysteine-type endopeptidase activity involved in apoptotic signaling pathway	IMP	21980415
GO:0097200	Function	Cysteine-type endopeptidase activity involved in execution phase of apoptosis	IMP	17559062, 22253444
GO:1902004	Process	Positive regulation of amyloid-beta formation	IDA	17553422

MIM	HGNC	e!Ensembl
600636	1504	ENSG00000164305

Protein

UniProt ID

P42574

Protein name

Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]

Protein function

Thiol protease that acts as a major effector caspase involved in the execution phase of apoptosis (PubMed:18723680, PubMed:20566630, PubMed:23650375, PubMed:35338844, PubMed:35446120, PubMed:7596430). Following cleavage and activation by initiat

PDB

1CP3 , 1GFW , 1I3O , 1NME , 1NMQ , 1NMS , 1PAU , 1QX3 , 1RE1 , 1RHJ , 1RHK , 1RHM , 1RHQ , 1RHR , 1RHU , 2C1E , 2C2K , 2C2M , 2C2O , 2CDR , 2CJX , 2CJY , 2CNK , 2CNL , 2CNN , 2CNO , 2DKO , 2H5I , 2H5J , 2H65 , 2J30 , 2J31 , 2J32 , 2J33 , 2XYG , 2XYH , 2XYP , 2XZD , 2XZT , 2Y0B , 3DEH , 3DEI , 3DEJ , 3DEK , 3EDQ , 3GJQ , 3GJR , 3GJS , 3GJT , 3H0E , 3ITN

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00656	Peptidase_C14	45 → 275		Domain

Sequence

MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG
MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS
HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD
DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN
RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH

Sequence length

277

Interactions

View interactions

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