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CAMKK2 (calcium/calmodulin dependent protein kinase kinase 2)

Gene

10645

Calcium/calmodulin dependent protein kinase kinase 2

CAMKK2

CAMKK, CAMKKB

12q24.31

The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosph

Show/Hide all(264)

miRTarBase ID	miRNA	Experiments	Reference
MIRT027179	hsa-miR-103a-3p	Sequencing	20371350
MIRT031851	hsa-miR-16-5p	Sequencing	20371350
MIRT048541	hsa-miR-100-5p	CLASH	23622248
MIRT045326	hsa-miR-185-5p	CLASH	23622248
MIRT688870	hsa-miR-6854-5p	HITS-CLIP	23313552
MIRT688869	hsa-miR-5584-5p	HITS-CLIP	23313552
MIRT688868	hsa-miR-6750-5p	HITS-CLIP	23313552
MIRT688867	hsa-miR-6822-5p	HITS-CLIP	23313552
MIRT688866	hsa-miR-9500	HITS-CLIP	23313552
MIRT688865	hsa-miR-1288-5p	HITS-CLIP	23313552
MIRT688864	hsa-miR-4330	HITS-CLIP	23313552
MIRT688863	hsa-miR-3664-3p	HITS-CLIP	23313552
MIRT688862	hsa-miR-1289	HITS-CLIP	23313552
MIRT688861	hsa-miR-4294	HITS-CLIP	23313552
MIRT688860	hsa-miR-8078	HITS-CLIP	23313552
MIRT688859	hsa-miR-7847-3p	HITS-CLIP	23313552
MIRT688858	hsa-miR-3911	HITS-CLIP	23313552
MIRT688857	hsa-miR-644a	HITS-CLIP	23313552
MIRT688856	hsa-miR-5100	HITS-CLIP	23313552
MIRT688855	hsa-miR-579-3p	HITS-CLIP	23313552
MIRT688854	hsa-miR-664b-3p	HITS-CLIP	23313552
MIRT688853	hsa-miR-3198	HITS-CLIP	23313552
MIRT688852	hsa-miR-4309	HITS-CLIP	23313552
MIRT688851	hsa-miR-6818-5p	HITS-CLIP	23313552
MIRT688850	hsa-miR-147a	HITS-CLIP	23313552
MIRT688870	hsa-miR-6854-5p	HITS-CLIP	23313552
MIRT688869	hsa-miR-5584-5p	HITS-CLIP	23313552
MIRT688868	hsa-miR-6750-5p	HITS-CLIP	23313552
MIRT688867	hsa-miR-6822-5p	HITS-CLIP	23313552
MIRT688866	hsa-miR-9500	HITS-CLIP	23313552
MIRT688865	hsa-miR-1288-5p	HITS-CLIP	23313552
MIRT688864	hsa-miR-4330	HITS-CLIP	23313552
MIRT688863	hsa-miR-3664-3p	HITS-CLIP	23313552
MIRT688862	hsa-miR-1289	HITS-CLIP	23313552
MIRT688861	hsa-miR-4294	HITS-CLIP	23313552
MIRT688860	hsa-miR-8078	HITS-CLIP	23313552
MIRT688859	hsa-miR-7847-3p	HITS-CLIP	23313552
MIRT688858	hsa-miR-3911	HITS-CLIP	23313552
MIRT688857	hsa-miR-644a	HITS-CLIP	23313552
MIRT688856	hsa-miR-5100	HITS-CLIP	23313552
MIRT688855	hsa-miR-579-3p	HITS-CLIP	23313552
MIRT688854	hsa-miR-664b-3p	HITS-CLIP	23313552
MIRT688853	hsa-miR-3198	HITS-CLIP	23313552
MIRT688852	hsa-miR-4309	HITS-CLIP	23313552
MIRT688851	hsa-miR-6818-5p	HITS-CLIP	23313552
MIRT688850	hsa-miR-147a	HITS-CLIP	23313552
MIRT860471	hsa-miR-1275	CLIP-seq
MIRT860472	hsa-miR-140-5p	CLIP-seq
MIRT860473	hsa-miR-198	CLIP-seq
MIRT860474	hsa-miR-342-5p	CLIP-seq
MIRT860475	hsa-miR-409-5p	CLIP-seq
MIRT860476	hsa-miR-4447	CLIP-seq
MIRT860477	hsa-miR-4472	CLIP-seq
MIRT860478	hsa-miR-4481	CLIP-seq
MIRT860479	hsa-miR-4525	CLIP-seq
MIRT860480	hsa-miR-4651	CLIP-seq
MIRT860481	hsa-miR-4664-5p	CLIP-seq
MIRT860482	hsa-miR-4665-5p	CLIP-seq
MIRT860483	hsa-miR-4723-5p	CLIP-seq
MIRT860484	hsa-miR-4729	CLIP-seq
MIRT860485	hsa-miR-4745-5p	CLIP-seq
MIRT860486	hsa-miR-4757-3p	CLIP-seq
MIRT860487	hsa-miR-4758-5p	CLIP-seq
MIRT860488	hsa-miR-608	CLIP-seq
MIRT860489	hsa-miR-625	CLIP-seq
MIRT860490	hsa-miR-122	CLIP-seq
MIRT860491	hsa-miR-1587	CLIP-seq
MIRT860492	hsa-miR-4280	CLIP-seq
MIRT860493	hsa-miR-4492	CLIP-seq
MIRT860494	hsa-miR-4498	CLIP-seq
MIRT860495	hsa-miR-4656	CLIP-seq
MIRT860496	hsa-miR-4674	CLIP-seq
MIRT860497	hsa-miR-4675	CLIP-seq
MIRT860498	hsa-miR-4711-3p	CLIP-seq
MIRT860499	hsa-miR-4741	CLIP-seq
MIRT860500	hsa-miR-4778-3p	CLIP-seq
MIRT860501	hsa-miR-635	CLIP-seq
MIRT860502	hsa-miR-762	CLIP-seq
MIRT860503	hsa-miR-1200	CLIP-seq
MIRT860504	hsa-miR-127-5p	CLIP-seq
MIRT860505	hsa-miR-1305	CLIP-seq
MIRT860506	hsa-miR-132	CLIP-seq
MIRT860507	hsa-miR-153	CLIP-seq
MIRT860508	hsa-miR-154	CLIP-seq
MIRT860509	hsa-miR-1913	CLIP-seq
MIRT860510	hsa-miR-1972	CLIP-seq
MIRT860511	hsa-miR-212	CLIP-seq
MIRT860512	hsa-miR-3074-5p	CLIP-seq
MIRT860513	hsa-miR-3159	CLIP-seq
MIRT860514	hsa-miR-3189-5p	CLIP-seq
MIRT860515	hsa-miR-3194-5p	CLIP-seq
MIRT860516	hsa-miR-324-3p	CLIP-seq
MIRT860517	hsa-miR-331-3p	CLIP-seq
MIRT860518	hsa-miR-3690	CLIP-seq
MIRT860519	hsa-miR-380	CLIP-seq
MIRT860520	hsa-miR-411	CLIP-seq
MIRT860521	hsa-miR-421	CLIP-seq
MIRT860522	hsa-miR-4254	CLIP-seq
MIRT860523	hsa-miR-4292	CLIP-seq
MIRT860524	hsa-miR-4313	CLIP-seq
MIRT860525	hsa-miR-4640-5p	CLIP-seq
MIRT860526	hsa-miR-4652-3p	CLIP-seq
MIRT860527	hsa-miR-4684-5p	CLIP-seq
MIRT860528	hsa-miR-4691-3p	CLIP-seq
MIRT860529	hsa-miR-4709-5p	CLIP-seq
MIRT860530	hsa-miR-4717-3p	CLIP-seq
MIRT860531	hsa-miR-4726-5p	CLIP-seq
MIRT860532	hsa-miR-4731-3p	CLIP-seq
MIRT860533	hsa-miR-4733-3p	CLIP-seq
MIRT860534	hsa-miR-4738-3p	CLIP-seq
MIRT860535	hsa-miR-4755-3p	CLIP-seq
MIRT860536	hsa-miR-4758-3p	CLIP-seq
MIRT860537	hsa-miR-4801	CLIP-seq
MIRT860538	hsa-miR-4802-3p	CLIP-seq
MIRT860539	hsa-miR-671-5p	CLIP-seq
MIRT860540	hsa-miR-942	CLIP-seq
MIRT1922654	hsa-miR-299-3p	CLIP-seq
MIRT1922655	hsa-miR-3151	CLIP-seq
MIRT1922656	hsa-miR-3607-5p	CLIP-seq
MIRT1922657	hsa-miR-3692	CLIP-seq
MIRT860476	hsa-miR-4447	CLIP-seq
MIRT860477	hsa-miR-4472	CLIP-seq
MIRT1922658	hsa-miR-4736	CLIP-seq
MIRT1922659	hsa-miR-486-3p	CLIP-seq
MIRT1922660	hsa-miR-491-5p	CLIP-seq
MIRT1955332	hsa-miR-1245b-3p	CLIP-seq
MIRT860504	hsa-miR-127-5p	CLIP-seq
MIRT1955333	hsa-miR-129-5p	CLIP-seq
MIRT1955334	hsa-miR-2355-3p	CLIP-seq
MIRT1955335	hsa-miR-3127-3p	CLIP-seq
MIRT1955336	hsa-miR-3202	CLIP-seq
MIRT1955337	hsa-miR-362-5p	CLIP-seq
MIRT1955338	hsa-miR-4533	CLIP-seq
MIRT1955339	hsa-miR-4646-3p	CLIP-seq
MIRT860530	hsa-miR-4717-3p	CLIP-seq
MIRT1955340	hsa-miR-500b	CLIP-seq
MIRT1955341	hsa-miR-501-5p	CLIP-seq
MIRT1955342	hsa-miR-1184	CLIP-seq
MIRT1955343	hsa-miR-1301	CLIP-seq
MIRT1955335	hsa-miR-3127-3p	CLIP-seq
MIRT1955344	hsa-miR-3148	CLIP-seq
MIRT1955345	hsa-miR-3160-5p	CLIP-seq
MIRT1955346	hsa-miR-3179	CLIP-seq
MIRT860515	hsa-miR-3194-5p	CLIP-seq
MIRT1922657	hsa-miR-3692	CLIP-seq
MIRT1955347	hsa-miR-4461	CLIP-seq
MIRT860534	hsa-miR-4738-3p	CLIP-seq
MIRT1955348	hsa-miR-4797-5p	CLIP-seq
MIRT1955349	hsa-miR-5047	CLIP-seq
MIRT1955350	hsa-miR-627	CLIP-seq
MIRT860539	hsa-miR-671-5p	CLIP-seq
MIRT2193089	hsa-miR-1179	CLIP-seq
MIRT1955342	hsa-miR-1184	CLIP-seq
MIRT2193090	hsa-miR-1207-3p	CLIP-seq
MIRT2193091	hsa-miR-1234	CLIP-seq
MIRT860504	hsa-miR-127-5p	CLIP-seq
MIRT2193092	hsa-miR-1283	CLIP-seq
MIRT2193093	hsa-miR-1299	CLIP-seq
MIRT860505	hsa-miR-1305	CLIP-seq
MIRT2193094	hsa-miR-1323	CLIP-seq
MIRT2193095	hsa-miR-185	CLIP-seq
MIRT860473	hsa-miR-198	CLIP-seq
MIRT2193096	hsa-miR-2355-5p	CLIP-seq
MIRT2193097	hsa-miR-3135b	CLIP-seq
MIRT860513	hsa-miR-3159	CLIP-seq
MIRT2193098	hsa-miR-3190	CLIP-seq
MIRT860515	hsa-miR-3194-5p	CLIP-seq
MIRT2193099	hsa-miR-338-3p	CLIP-seq
MIRT2193100	hsa-miR-3646	CLIP-seq
MIRT2193101	hsa-miR-3662	CLIP-seq
MIRT2193102	hsa-miR-3667-5p	CLIP-seq
MIRT2193103	hsa-miR-378	CLIP-seq
MIRT2193104	hsa-miR-378b	CLIP-seq
MIRT2193105	hsa-miR-378c	CLIP-seq
MIRT2193106	hsa-miR-378d	CLIP-seq
MIRT2193107	hsa-miR-378e	CLIP-seq
MIRT2193108	hsa-miR-378f	CLIP-seq
MIRT2193109	hsa-miR-378h	CLIP-seq
MIRT2193110	hsa-miR-378i	CLIP-seq
MIRT2193111	hsa-miR-3919	CLIP-seq
MIRT2193112	hsa-miR-3938	CLIP-seq
MIRT2193113	hsa-miR-3943	CLIP-seq
MIRT2193114	hsa-miR-422a	CLIP-seq
MIRT2193115	hsa-miR-4267	CLIP-seq
MIRT2193116	hsa-miR-4306	CLIP-seq
MIRT2193117	hsa-miR-4310	CLIP-seq
MIRT860524	hsa-miR-4313	CLIP-seq
MIRT2193118	hsa-miR-4323	CLIP-seq
MIRT2193119	hsa-miR-4638-3p	CLIP-seq
MIRT2193120	hsa-miR-4644	CLIP-seq
MIRT860530	hsa-miR-4717-3p	CLIP-seq
MIRT2193121	hsa-miR-4782-5p	CLIP-seq
MIRT1955348	hsa-miR-4797-5p	CLIP-seq
MIRT2193122	hsa-miR-490-5p	CLIP-seq
MIRT2193123	hsa-miR-494	CLIP-seq
MIRT2193124	hsa-miR-512-3p	CLIP-seq
MIRT2193125	hsa-miR-516b	CLIP-seq
MIRT2193126	hsa-miR-520d-5p	CLIP-seq
MIRT2193127	hsa-miR-524-5p	CLIP-seq
MIRT2193128	hsa-miR-548aa	CLIP-seq
MIRT2193129	hsa-miR-548o	CLIP-seq
MIRT2193130	hsa-miR-598	CLIP-seq
MIRT2193131	hsa-miR-634	CLIP-seq
MIRT2193132	hsa-miR-7	CLIP-seq
MIRT2193133	hsa-miR-766	CLIP-seq
MIRT860518	hsa-miR-3690	CLIP-seq
MIRT860522	hsa-miR-4254	CLIP-seq
MIRT860539	hsa-miR-671-5p	CLIP-seq
MIRT2446145	hsa-miR-1228	CLIP-seq
MIRT2446146	hsa-miR-1253	CLIP-seq
MIRT2446147	hsa-miR-140-3p	CLIP-seq
MIRT2446148	hsa-miR-342-3p	CLIP-seq
MIRT2446149	hsa-miR-4251	CLIP-seq
MIRT2446150	hsa-miR-4329	CLIP-seq
MIRT2496170	hsa-miR-105	CLIP-seq
MIRT2496171	hsa-miR-1256	CLIP-seq
MIRT2496172	hsa-miR-1266	CLIP-seq
MIRT2496173	hsa-miR-29a	CLIP-seq
MIRT2496174	hsa-miR-29b	CLIP-seq
MIRT2496175	hsa-miR-29c	CLIP-seq
MIRT2496176	hsa-miR-3119	CLIP-seq
MIRT2496177	hsa-miR-3140-3p	CLIP-seq
MIRT2496178	hsa-miR-3194-3p	CLIP-seq
MIRT2496179	hsa-miR-3689d	CLIP-seq
MIRT2496180	hsa-miR-4436b-5p	CLIP-seq
MIRT2496181	hsa-miR-4487	CLIP-seq
MIRT2496182	hsa-miR-4518	CLIP-seq
MIRT2496183	hsa-miR-4660	CLIP-seq
MIRT860534	hsa-miR-4738-3p	CLIP-seq
MIRT2496184	hsa-miR-4753-5p	CLIP-seq
MIRT2193123	hsa-miR-494	CLIP-seq
MIRT2496185	hsa-miR-548c-3p	CLIP-seq
MIRT860539	hsa-miR-671-5p	CLIP-seq
MIRT2496186	hsa-miR-873	CLIP-seq
MIRT2496187	hsa-miR-885-3p	CLIP-seq
MIRT1955332	hsa-miR-1245b-3p	CLIP-seq
MIRT2496172	hsa-miR-1266	CLIP-seq
MIRT2677340	hsa-miR-1268	CLIP-seq
MIRT2677341	hsa-miR-1268b	CLIP-seq
MIRT2677342	hsa-miR-133a	CLIP-seq
MIRT2677343	hsa-miR-133b	CLIP-seq
MIRT2677344	hsa-miR-188-3p	CLIP-seq
MIRT2496173	hsa-miR-29a	CLIP-seq
MIRT2496174	hsa-miR-29b	CLIP-seq
MIRT2496175	hsa-miR-29c	CLIP-seq
MIRT2677345	hsa-miR-3115	CLIP-seq
MIRT2496179	hsa-miR-3689d	CLIP-seq
MIRT2677346	hsa-miR-3908	CLIP-seq
MIRT2677347	hsa-miR-3942-5p	CLIP-seq
MIRT2677348	hsa-miR-4281	CLIP-seq
MIRT2496180	hsa-miR-4436b-5p	CLIP-seq
MIRT2496182	hsa-miR-4518	CLIP-seq
MIRT2677349	hsa-miR-4703-5p	CLIP-seq
MIRT860534	hsa-miR-4738-3p	CLIP-seq
MIRT2496184	hsa-miR-4753-5p	CLIP-seq
MIRT2677350	hsa-miR-4766-3p	CLIP-seq
MIRT2496185	hsa-miR-548c-3p	CLIP-seq
MIRT2677351	hsa-miR-556-5p	CLIP-seq
MIRT2677352	hsa-miR-585	CLIP-seq
MIRT2677353	hsa-miR-610	CLIP-seq
MIRT2677354	hsa-miR-621	CLIP-seq
MIRT860539	hsa-miR-671-5p	CLIP-seq
MIRT2193132	hsa-miR-7	CLIP-seq
MIRT2496186	hsa-miR-873	CLIP-seq

Show/Hide all(21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000165	Process	MAPK cascade	TAS	11395482
GO:0001934	Process	Positive regulation of protein phosphorylation	IMP	26103054
GO:0004683	Function	Calmodulin-dependent protein kinase activity	IEA
GO:0004713	Function	Protein tyrosine kinase activity	TAS	11395482
GO:0005509	Function	Calcium ion binding	IDA	11395482
GO:0005516	Function	Calmodulin binding	TAS	11395482
GO:0005524	Function	ATP binding	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IMP	26103054
GO:0005829	Component	Cytosol	TAS
GO:0006468	Process	Protein phosphorylation	IDA	11395482
GO:0018108	Process	Peptidyl-tyrosine phosphorylation	IEA
GO:0019722	Process	Calcium-mediated signaling	TAS	11395482
GO:0034614	Process	Cellular response to reactive oxygen species	TAS	26103054
GO:0043005	Component	Neuron projection	IEA
GO:0045859	Process	Regulation of protein kinase activity	TAS	11395482
GO:0045893	Process	Positive regulation of transcription, DNA-templated	TAS	11395482
GO:0046777	Process	Protein autophosphorylation	IDA	11395482
GO:0061762	Process	CAMKK-AMPK signaling cascade	IMP	26103054
GO:1903599	Process	Positive regulation of autophagy of mitochondrion	IC	26103054

MIM	HGNC	e!Ensembl
615002	1470	ENSG00000110931

Protein

UniProt ID

Q96RR4

Protein name

Calcium/calmodulin-dependent protein kinase kinase 2 (CaM-KK 2) (CaM-kinase kinase 2) (CaMKK 2) (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-KK beta) (CaM-kinase kinase beta) (CaMKK beta)

Protein function

Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D

PDB

2ZV2 , 5UY6 , 5UYJ , 5VT1 , 5YV8 , 5YV9 , 5YVA , 5YVB , 5YVC , 6BKU , 6BLE , 6BQL , 6BQP , 6BQQ , 6BRC , 6CMJ , 6EF5 , 6EWW , 6FEL , 6Y3O , 6Y4K , 6Y6B , 6Y8A , 8TUC

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	165 → 446	Protein kinase domain	Domain

Sequence

MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP
GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR
CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK
LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL
KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI
EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS
ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK
DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS
LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTRECESLSELKEARQRRQP
PGHRPAPRGGGGSALVRGSPCVESCWAPAPGSPARMHPLRPEEAMEPE

Sequence length

588

Interactions

View interactions

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