GeDiPNet: Comprehensive Gene Data - OMIM, HGNC, Ensembl, UniProt, GO, Transcription Factors & miRNA

Home
Browse
- Genes
- Diseases
- Pathways
  - Reactome
  - KEGG
Analysis
Help
Links
FAQ
Contact us

CALM3 (calmodulin 3)

Gene

808

Calmodulin 3

CALM3

CALM, CAM1, CAM2, CAMB, CPVT6, CaM, CaMIII, HEL-S-72, LQT16, PHKD, PHKD3

19q13.32

This gene encodes a member of a family of proteins that binds calcium and functions as a enzymatic co-factor. Activity of this protein is important in the regulation of the cell cycle and cytokinesis. Multiple alternatively spliced transcript variants have been observed at this gene. [provided by RefSeq, Aug 2016]

Show/Hide all(196)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004467	hsa-miR-1-3p	Proteomics	18668040
MIRT004467	hsa-miR-1-3p	Luciferase reporter assay	19188439
MIRT025949	hsa-miR-7-5p	Microarray	19073608
MIRT025949	hsa-miR-7-5p	PAR-CLIP	23592263
MIRT025949	hsa-miR-7-5p	PAR-CLIP	24398324
MIRT025949	hsa-miR-7-5p	PAR-CLIP	23446348
MIRT025949	hsa-miR-7-5p	PAR-CLIP	21572407
MIRT025949	hsa-miR-7-5p	PAR-CLIP	20371350
MIRT025949	hsa-miR-7-5p	PAR-CLIP	26701625
MIRT044685	hsa-miR-320a	CLASH	23622248
MIRT046170	hsa-miR-27b-3p	CLASH	23622248
MIRT082502	hsa-miR-490-5p	PAR-CLIP	23592263
MIRT082502	hsa-miR-490-5p	PAR-CLIP	24398324
MIRT082502	hsa-miR-490-5p	PAR-CLIP	23446348
MIRT082502	hsa-miR-490-5p	PAR-CLIP	21572407
MIRT082502	hsa-miR-490-5p	PAR-CLIP	20371350
MIRT082502	hsa-miR-490-5p	PAR-CLIP	26701625
MIRT082503	hsa-miR-432-3p	PAR-CLIP	23592263
MIRT082503	hsa-miR-432-3p	PAR-CLIP	24398324
MIRT082503	hsa-miR-432-3p	PAR-CLIP	23446348
MIRT082503	hsa-miR-432-3p	PAR-CLIP	21572407
MIRT082503	hsa-miR-432-3p	PAR-CLIP	20371350
MIRT082503	hsa-miR-432-3p	PAR-CLIP	26701625
MIRT082504	hsa-miR-641	PAR-CLIP	23592263
MIRT082504	hsa-miR-641	PAR-CLIP	24398324
MIRT082504	hsa-miR-641	PAR-CLIP	23446348
MIRT082504	hsa-miR-641	PAR-CLIP	21572407
MIRT082504	hsa-miR-641	PAR-CLIP	20371350
MIRT082504	hsa-miR-641	PAR-CLIP	26701625
MIRT082505	hsa-miR-1972	PAR-CLIP	23592263
MIRT082505	hsa-miR-1972	PAR-CLIP	24398324
MIRT082505	hsa-miR-1972	PAR-CLIP	23446348
MIRT082505	hsa-miR-1972	PAR-CLIP	21572407
MIRT082505	hsa-miR-1972	PAR-CLIP	20371350
MIRT082505	hsa-miR-1972	PAR-CLIP	26701625
MIRT082506	hsa-miR-3142	PAR-CLIP	23592263
MIRT082506	hsa-miR-3142	PAR-CLIP	24398324
MIRT082506	hsa-miR-3142	PAR-CLIP	23446348
MIRT082506	hsa-miR-3142	PAR-CLIP	21572407
MIRT082506	hsa-miR-3142	PAR-CLIP	20371350
MIRT082506	hsa-miR-3142	PAR-CLIP	26701625
MIRT082507	hsa-miR-3617-5p	PAR-CLIP	23592263
MIRT082507	hsa-miR-3617-5p	PAR-CLIP	24398324
MIRT082507	hsa-miR-3617-5p	PAR-CLIP	23446348
MIRT082507	hsa-miR-3617-5p	PAR-CLIP	21572407
MIRT082507	hsa-miR-3617-5p	PAR-CLIP	20371350
MIRT082507	hsa-miR-3617-5p	PAR-CLIP	26701625
MIRT082508	hsa-miR-4650-5p	PAR-CLIP	23592263
MIRT082508	hsa-miR-4650-5p	PAR-CLIP	24398324
MIRT082508	hsa-miR-4650-5p	PAR-CLIP	23446348
MIRT082508	hsa-miR-4650-5p	PAR-CLIP	21572407
MIRT082508	hsa-miR-4650-5p	PAR-CLIP	20371350
MIRT082508	hsa-miR-4650-5p	PAR-CLIP	26701625
MIRT082510	hsa-miR-1245b-5p	PAR-CLIP	23592263
MIRT082510	hsa-miR-1245b-5p	PAR-CLIP	24398324
MIRT082510	hsa-miR-1245b-5p	PAR-CLIP	23446348
MIRT082510	hsa-miR-1245b-5p	PAR-CLIP	21572407
MIRT082510	hsa-miR-1245b-5p	PAR-CLIP	20371350
MIRT082510	hsa-miR-1245b-5p	PAR-CLIP	26701625
MIRT082511	hsa-miR-4802-3p	PAR-CLIP	23592263
MIRT082511	hsa-miR-4802-3p	PAR-CLIP	24398324
MIRT082511	hsa-miR-4802-3p	PAR-CLIP	23446348
MIRT082511	hsa-miR-4802-3p	PAR-CLIP	21572407
MIRT082511	hsa-miR-4802-3p	PAR-CLIP	20371350
MIRT082511	hsa-miR-4802-3p	PAR-CLIP	26701625
MIRT082513	hsa-miR-6077	PAR-CLIP	23592263
MIRT082513	hsa-miR-6077	PAR-CLIP	24398324
MIRT082513	hsa-miR-6077	PAR-CLIP	23446348
MIRT082513	hsa-miR-6077	PAR-CLIP	21572407
MIRT082513	hsa-miR-6077	PAR-CLIP	20371350
MIRT082513	hsa-miR-6077	PAR-CLIP	26701625
MIRT082514	hsa-miR-29a-3p	PAR-CLIP	23592263
MIRT082515	hsa-miR-29b-3p	PAR-CLIP	23592263
MIRT082516	hsa-miR-29c-3p	PAR-CLIP	23592263
MIRT082518	hsa-miR-4304	PAR-CLIP	23592263
MIRT082519	hsa-miR-3622b-5p	PAR-CLIP	23446348
MIRT082519	hsa-miR-3622b-5p	PAR-CLIP	26701625
MIRT082520	hsa-miR-4678	PAR-CLIP	23592263
MIRT082521	hsa-miR-4733-3p	PAR-CLIP	23592263
MIRT082523	hsa-miR-5187-5p	PAR-CLIP	23592263
MIRT082524	hsa-miR-5682	PAR-CLIP	23592263
MIRT082527	hsa-miR-6728-5p	PAR-CLIP	23592263
MIRT082532	hsa-miR-570-3p	PAR-CLIP	23592263
MIRT082533	hsa-miR-4742-3p	PAR-CLIP	23592263
MIRT235376	hsa-miR-196a-5p	PAR-CLIP	23592263
MIRT235379	hsa-miR-196b-5p	PAR-CLIP	23592263
MIRT253002	hsa-miR-185-5p	PAR-CLIP	23446348
MIRT253002	hsa-miR-185-5p	PAR-CLIP	26701625
MIRT253003	hsa-miR-423-5p	PAR-CLIP	23446348
MIRT253003	hsa-miR-423-5p	PAR-CLIP	26701625
MIRT253005	hsa-miR-510-5p	PAR-CLIP	23446348
MIRT253005	hsa-miR-510-5p	PAR-CLIP	26701625
MIRT253007	hsa-miR-3184-5p	PAR-CLIP	23446348
MIRT253007	hsa-miR-3184-5p	PAR-CLIP	26701625
MIRT253008	hsa-miR-4306	PAR-CLIP	23446348
MIRT253008	hsa-miR-4306	PAR-CLIP	26701625
MIRT253009	hsa-miR-4253	PAR-CLIP	23446348
MIRT253009	hsa-miR-4253	PAR-CLIP	26701625
MIRT253011	hsa-miR-4644	PAR-CLIP	23446348
MIRT253011	hsa-miR-4644	PAR-CLIP	26701625
MIRT253012	hsa-miR-4688	PAR-CLIP	23446348
MIRT253012	hsa-miR-4688	PAR-CLIP	26701625
MIRT253013	hsa-miR-6734-5p	PAR-CLIP	23446348
MIRT253013	hsa-miR-6734-5p	PAR-CLIP	26701625
MIRT253014	hsa-miR-6743-5p	PAR-CLIP	23446348
MIRT253014	hsa-miR-6743-5p	PAR-CLIP	26701625
MIRT253015	hsa-miR-6862-5p	PAR-CLIP	23446348
MIRT253015	hsa-miR-6862-5p	PAR-CLIP	26701625
MIRT348502	hsa-miR-143-3p	PAR-CLIP	23446348
MIRT348502	hsa-miR-143-3p	PAR-CLIP	26701625
MIRT348508	hsa-miR-4770	PAR-CLIP	23446348
MIRT348508	hsa-miR-4770	PAR-CLIP	26701625
MIRT348509	hsa-miR-6088	PAR-CLIP	23446348
MIRT348509	hsa-miR-6088	PAR-CLIP	26701625
MIRT376288	hsa-miR-6871-3p	PAR-CLIP	23592263
MIRT480168	hsa-miR-3978	PAR-CLIP	23592263
MIRT480169	hsa-miR-6124	PAR-CLIP	23592263
MIRT480170	hsa-miR-3148	PAR-CLIP	23592263
MIRT480171	hsa-miR-1208	PAR-CLIP	23592263
MIRT480172	hsa-miR-6760-3p	PAR-CLIP	23592263
MIRT480173	hsa-miR-6079	PAR-CLIP	23592263
MIRT480173	hsa-miR-6079	PAR-CLIP	24398324
MIRT480173	hsa-miR-6079	PAR-CLIP	23446348
MIRT480173	hsa-miR-6079	PAR-CLIP	21572407
MIRT480173	hsa-miR-6079	PAR-CLIP	20371350
MIRT480173	hsa-miR-6079	PAR-CLIP	26701625
MIRT480174	hsa-miR-1193	PAR-CLIP	23592263
MIRT480174	hsa-miR-1193	PAR-CLIP	24398324
MIRT480174	hsa-miR-1193	PAR-CLIP	23446348
MIRT480174	hsa-miR-1193	PAR-CLIP	21572407
MIRT480174	hsa-miR-1193	PAR-CLIP	20371350
MIRT494387	hsa-miR-585-5p	PAR-CLIP	23592263
MIRT494388	hsa-miR-589-3p	PAR-CLIP	23592263
MIRT494389	hsa-miR-4699-3p	PAR-CLIP	23592263
MIRT494390	hsa-miR-4773	PAR-CLIP	23592263
MIRT513256	hsa-miR-4260	PAR-CLIP	23446348
MIRT513256	hsa-miR-4260	PAR-CLIP	26701625
MIRT513258	hsa-miR-5192	PAR-CLIP	23446348
MIRT513258	hsa-miR-5192	PAR-CLIP	26701625
MIRT513259	hsa-miR-6738-5p	PAR-CLIP	23446348
MIRT513259	hsa-miR-6738-5p	PAR-CLIP	26701625
MIRT513260	hsa-miR-5194	PAR-CLIP	23446348
MIRT513260	hsa-miR-5194	PAR-CLIP	26701625
MIRT513261	hsa-miR-1914-3p	PAR-CLIP	23446348
MIRT513261	hsa-miR-1914-3p	PAR-CLIP	26701625
MIRT736008	hsa-miR-1207-5p	PAR-CLIP	26701625
MIRT736106	hsa-miR-122-5p	PAR-CLIP	26701625
MIRT736300	hsa-miR-1237-5p	PAR-CLIP	26701625
MIRT736534	hsa-miR-1253	PAR-CLIP	26701625
MIRT736700	hsa-miR-1266-5p	PAR-CLIP	26701625
MIRT736952	hsa-miR-1276	PAR-CLIP	26701625
MIRT738085	hsa-miR-1827	PAR-CLIP	26701625
MIRT738340	hsa-miR-1909-3p	PAR-CLIP	26701625
MIRT738924	hsa-miR-211-3p	PAR-CLIP	26701625
MIRT740895	hsa-miR-3185	PAR-CLIP	26701625
MIRT741345	hsa-miR-335-5p	PAR-CLIP	26701625
MIRT741661	hsa-miR-3616-3p	PAR-CLIP	26701625
MIRT741950	hsa-miR-3659	PAR-CLIP	26701625
MIRT742039	hsa-miR-3665	PAR-CLIP	26701625
MIRT743000	hsa-miR-3925-5p	PAR-CLIP	26701625
MIRT743550	hsa-miR-4270	PAR-CLIP	26701625
MIRT744301	hsa-miR-4428	PAR-CLIP	26701625
MIRT744517	hsa-miR-4441	PAR-CLIP	26701625
MIRT745222	hsa-miR-4488	PAR-CLIP	26701625
MIRT745696	hsa-miR-4514	PAR-CLIP	26701625
MIRT745773	hsa-miR-4518	PAR-CLIP	26701625
MIRT746496	hsa-miR-4649-5p	PAR-CLIP	26701625
MIRT747104	hsa-miR-4692	PAR-CLIP	26701625
MIRT747139	hsa-miR-4693-3p	PAR-CLIP	26701625
MIRT747226	hsa-miR-4697-5p	PAR-CLIP	26701625
MIRT747376	hsa-miR-4709-3p	PAR-CLIP	26701625
MIRT747441	hsa-miR-4711-5p	PAR-CLIP	26701625
MIRT747988	hsa-miR-4736	PAR-CLIP	26701625
MIRT748517	hsa-miR-4763-3p	PAR-CLIP	26701625
MIRT748812	hsa-miR-4783-5p	PAR-CLIP	26701625
MIRT749092	hsa-miR-486-3p	PAR-CLIP	26701625
MIRT750080	hsa-miR-5197-3p	PAR-CLIP	26701625
MIRT750359	hsa-miR-541-3p	PAR-CLIP	26701625
MIRT750523	hsa-miR-548aj-5p	PAR-CLIP	26701625
MIRT750712	hsa-miR-548f-5p	PAR-CLIP	26701625
MIRT750723	hsa-miR-548g-5p	PAR-CLIP	26701625
MIRT750825	hsa-miR-548x-5p	PAR-CLIP	26701625
MIRT751107	hsa-miR-564	PAR-CLIP	26701625
MIRT751331	hsa-miR-5700	PAR-CLIP	26701625
MIRT753430	hsa-miR-654-5p	PAR-CLIP	26701625
MIRT753780	hsa-miR-6721-5p	PAR-CLIP	26701625
MIRT753853	hsa-miR-6722-3p	PAR-CLIP	26701625
MIRT753959	hsa-miR-6729-5p	PAR-CLIP	26701625
MIRT754692	hsa-miR-6754-5p	PAR-CLIP	26701625
MIRT756554	hsa-miR-6808-5p	PAR-CLIP	26701625
MIRT757426	hsa-miR-6846-5p	PAR-CLIP	26701625
MIRT757500	hsa-miR-6848-5p	PAR-CLIP	26701625
MIRT758698	hsa-miR-6893-5p	PAR-CLIP	26701625
MIRT759075	hsa-miR-7112-3p	PAR-CLIP	26701625
MIRT760795	hsa-miR-940	PAR-CLIP	26701625
MIRT760872	hsa-miR-9500	PAR-CLIP	26701625

Show/Hide all(66)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000086	Process	G2/M transition of mitotic cell cycle	IEA
GO:0000922	Component	Spindle pole	IDA	16760425
GO:0001975	Process	Response to amphetamine	IEA
GO:0002027	Process	Regulation of heart rate	IMP	23040497
GO:0005509	Function	Calcium ion binding	IBA	21873635
GO:0005509	Function	Calcium ion binding	IDA	7607248, 8631777, 11807546, 23040497, 27516456, 31454269
GO:0005513	Process	Detection of calcium ion	IMP	23040497
GO:0005515	Function	Protein binding	IPI	3111527, 10692436, 15140941, 16760425, 19855925, 21299499
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005737	Component	Cytoplasm	TAS	10899953
GO:0005813	Component	Centrosome	IDA	16760425
GO:0005876	Component	Spindle microtubule	IDA	16760425
GO:0005886	Component	Plasma membrane	TAS	10899953
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS	10899953
GO:0007190	Process	Activation of adenylate cyclase activity	IEA
GO:0008076	Component	Voltage-gated potassium channel complex	IEA
GO:0008179	Function	Adenylate cyclase binding	IPI	11807546
GO:0010800	Process	Positive regulation of peptidyl-threonine phosphorylation	TAS	20668654
GO:0010801	Process	Negative regulation of peptidyl-threonine phosphorylation	TAS	20668654
GO:0010856	Function	Adenylate cyclase activator activity	IDA	11807546
GO:0010880	Process	Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IDA	20226167
GO:0010881	Process	Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	IC
GO:0019901	Function	Protein kinase binding	IPI	20668654
GO:0019904	Function	Protein domain specific binding	IPI	11984006
GO:0021762	Process	Substantia nigra development	HEP	22926577
GO:0030017	Component	Sarcomere	IDA	20226167
GO:0030234	Function	Enzyme regulator activity	IBA	21873635
GO:0030235	Function	Nitric-oxide synthase regulator activity	IEA
GO:0030426	Component	Growth cone	IEA
GO:0030672	Component	Synaptic vesicle membrane	IEA
GO:0031432	Function	Titin binding	IPI	7607248
GO:0031800	Function	Type 3 metabotropic glutamate receptor binding	IEA
GO:0031954	Process	Positive regulation of protein autophosphorylation	TAS	20668654
GO:0031966	Component	Mitochondrial membrane	IEA
GO:0031982	Component	Vesicle	HDA	19190083
GO:0031997	Function	N-terminal myristoylation domain binding	IPI	15632291
GO:0032465	Process	Regulation of cytokinesis	IMP	16760425
GO:0032516	Process	Positive regulation of phosphoprotein phosphatase activity	IDA	8631777
GO:0032991	Component	Protein-containing complex	IDA	19855925
GO:0034704	Component	Calcium channel complex	IDA	23040497
GO:0035307	Process	Positive regulation of protein dephosphorylation	IDA	8631777
GO:0043209	Component	Myelin sheath	IEA
GO:0043388	Process	Positive regulation of DNA binding	IEA
GO:0043539	Function	Protein serine/threonine kinase activator activity	TAS	20668654
GO:0043548	Function	Phosphatidylinositol 3-kinase binding	IEA
GO:0044325	Function	Ion channel binding	IPI	21167176, 23040497
GO:0048306	Function	Calcium-dependent protein binding	IEA
GO:0050998	Function	Nitric-oxide synthase binding	IEA
GO:0051000	Process	Positive regulation of nitric-oxide synthase activity	IEA
GO:0051343	Process	Positive regulation of cyclic-nucleotide phosphodiesterase activity	IDA	8631777
GO:0051412	Process	Response to corticosterone	IEA
GO:0051592	Process	Response to calcium ion	IDA	7607248
GO:0055117	Process	Regulation of cardiac muscle contraction	IMP	23040497
GO:0060315	Process	Negative regulation of ryanodine-sensitive calcium-release channel activity	ISS
GO:0060316	Process	Positive regulation of ryanodine-sensitive calcium-release channel activity	IBA	21873635
GO:0060316	Process	Positive regulation of ryanodine-sensitive calcium-release channel activity	IDA	20226167
GO:0071902	Process	Positive regulation of protein serine/threonine kinase activity	TAS	20668654
GO:0072542	Function	Protein phosphatase activator activity	IDA	8631777
GO:0090151	Process	Establishment of protein localization to mitochondrial membrane	IEA
GO:0097718	Function	Disordered domain specific binding	IPI	19855925
GO:0098901	Process	Regulation of cardiac muscle cell action potential	IMP	31454269
GO:1900242	Process	Regulation of synaptic vesicle endocytosis	IEA
GO:1901842	Process	Negative regulation of high voltage-gated calcium channel activity	IMP	31454269
GO:1901844	Process	Regulation of cell communication by electrical coupling involved in cardiac conduction	IC
GO:1902494	Component	Catalytic complex	IDA	11807546
GO:2000300	Process	Regulation of synaptic vesicle exocytosis	IEA

MIM	HGNC	e!Ensembl
114183	1449	ENSG00000160014

Protein

UniProt ID

P0DP24

Protein name

Calmodulin-2

Protein function

PDB

3O77 , 3O78 , 5COC , 5J03 , 5NIN , 5VMS , 5WSU , 5WSV , 6PLM , 6S5T , 6SZ5 , 6XXF , 6Y4O

UniProt ID

P0DP25

Protein name

Calmodulin-3

Protein function

Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Is a regulator of voltage-dependent L-type calcium channels (PubMed:31454269). Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.

PDB

5COC , 5J03 , 6K67 , 7BYL , 7BYM , 7BYN , 7CR3 , 7CR4 , 7CR7

UniProt ID

P0DP23

Protein name

Calmodulin-1

Protein function

Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Is a regulator of voltage-dependent L-type calcium channels (PubMed:31454269). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696). Forms a potassium channel complex with KCNQ1 and regulates electrophysiological activity of the channel via calcium-binding (PubMed:25441029). Acts as a sensor to modulate the endomplasmic reticulum contacts with other organelles mediated by VMP1:ATP2A2 (PubMed:28890335). ; (Microbial infection) Required for Legionella pneumophila SidJ glutamylase activity.

PDB

1AJI , 1CDL , 1CLL , 1CTR , 1IWQ , 1J7O , 1J7P , 1K90 , 1K93 , 1L7Z , 1LVC , 1NKF , 1PK0 , 1S26 , 1SK6 , 1SW8 , 1UP5 , 1WRZ , 1XFU , 1XFV , 1XFW , 1XFX , 1XFY , 1XFZ , 1Y6W , 1YR5 , 1YRT , 1YRU , 1ZOT , 1ZUZ , 2BE6 , 2F3Y , 2F3Z , 2HF5 , 2I08 , 2JZI , 2K0E , 2K0F , 2K0J , 2K61 , 2KNE , 2KUG , 2KUH , 2L53 , 2L7L , 2LGF , 2LL6 , 2LL7 , 2LQC , 2LQP , 2LV6

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13499	EF-hand_7	10 → 74	EF-hand domain pair	Domain
PF13499	EF-hand_7	83 → 147	EF-hand domain pair	Domain

Sequence

MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG
NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE
EVDEMIREADIDGDGQVNYEEFVQMMTAK

Sequence length

149

Interactions

View interactions

| © 2021, Biomedical Informatics Centre, NIRRH |
ICMR-National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400012
Tel: +91-22-24192104, Fax No: +91-22-24139412