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CALM2 (calmodulin 2)

Gene

805

Calmodulin 2

CALM2

CALM, CALML2, CAM1, CAM3, CAMC, CAMII, CAMIII, LQT15, PHKD, PHKD2, caM

2p21

This gene is a member of the calmodulin gene family. There are three distinct calmodulin genes dispersed throughout the genome that encode the identical protein, but differ at the nucleotide level. Calmodulin is a calcium binding protein that plays a role in signaling pathways, cell cycle progression and proliferation. Several infants with severe forms of long-QT syndrome (LQTS) who displayed life-threatening ventricular arrhythmias together with delayed neurodevelopment and epilepsy were found to have mutations in either this gene or another member of the calmodulin gene family (PMID:23388215). Mutations in this gene have also been identified in patients with less severe forms of LQTS (PMID:24917665), while mutations in another calmodulin gene family member have been associated with catecholaminergic polymorphic ventricular tachycardia (CPVT)(PMID:23040497), a rare disorder thought to be the cause of a significant fraction of sudden cardiac deaths in young individuals. Pseudogenes of this gene are found on chromosomes 10, 13, and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]

Show/Hide all(142)

miRTarBase ID	miRNA	Experiments	Reference
MIRT005904	hsa-miR-1-3p	qRT-PCR	21169019
MIRT005904	hsa-miR-1-3p	Proteomics	18668040
MIRT005904	hsa-miR-1-3p	PAR-CLIP	23592263
MIRT040483	hsa-miR-598-3p	CLASH	23622248
MIRT302859	hsa-miR-1261	PAR-CLIP	23592263
MIRT302859	hsa-miR-1261	PAR-CLIP	20371350
MIRT302872	hsa-miR-3613-3p	PAR-CLIP	23592263
MIRT302872	hsa-miR-3613-3p	PAR-CLIP	21572407
MIRT302872	hsa-miR-3613-3p	PAR-CLIP	20371350
MIRT353404	hsa-let-7c-3p	PAR-CLIP	23446348
MIRT353404	hsa-let-7c-3p	PAR-CLIP	20371350
MIRT480175	hsa-miR-3680-3p	PAR-CLIP	23592263
MIRT480175	hsa-miR-3680-3p	PAR-CLIP	23446348
MIRT480175	hsa-miR-3680-3p	PAR-CLIP	20371350
MIRT480175	hsa-miR-3680-3p	HITS-CLIP	21572407
MIRT480176	hsa-miR-557	PAR-CLIP	23592263
MIRT480176	hsa-miR-557	PAR-CLIP	23446348
MIRT480176	hsa-miR-557	PAR-CLIP	20371350
MIRT480176	hsa-miR-557	HITS-CLIP	21572407
MIRT480177	hsa-miR-507	PAR-CLIP	23592263
MIRT480177	hsa-miR-507	PAR-CLIP	23446348
MIRT480177	hsa-miR-507	PAR-CLIP	20371350
MIRT480177	hsa-miR-507	HITS-CLIP	21572407
MIRT480178	hsa-miR-450b-5p	PAR-CLIP	23592263
MIRT480178	hsa-miR-450b-5p	PAR-CLIP	23446348
MIRT480178	hsa-miR-450b-5p	PAR-CLIP	20371350
MIRT480178	hsa-miR-450b-5p	HITS-CLIP	21572407
MIRT480179	hsa-miR-106a-3p	PAR-CLIP	23592263
MIRT480179	hsa-miR-106a-3p	PAR-CLIP	23446348
MIRT480179	hsa-miR-106a-3p	PAR-CLIP	20371350
MIRT480179	hsa-miR-106a-3p	HITS-CLIP	21572407
MIRT480180	hsa-miR-655-3p	PAR-CLIP	23592263
MIRT480180	hsa-miR-655-3p	PAR-CLIP	20371350
MIRT480181	hsa-miR-374c-5p	PAR-CLIP	23592263
MIRT480181	hsa-miR-374c-5p	PAR-CLIP	20371350
MIRT480182	hsa-miR-19b-2-5p	PAR-CLIP	23592263
MIRT480182	hsa-miR-19b-2-5p	PAR-CLIP	20371350
MIRT480182	hsa-miR-19b-2-5p	HITS-CLIP	21572407
MIRT480183	hsa-miR-19b-1-5p	PAR-CLIP	23592263
MIRT480183	hsa-miR-19b-1-5p	PAR-CLIP	20371350
MIRT480183	hsa-miR-19b-1-5p	HITS-CLIP	21572407
MIRT480184	hsa-miR-19a-5p	PAR-CLIP	23592263
MIRT480184	hsa-miR-19a-5p	PAR-CLIP	20371350
MIRT480184	hsa-miR-19a-5p	HITS-CLIP	21572407
MIRT480185	hsa-miR-1911-5p	PAR-CLIP	23592263
MIRT480185	hsa-miR-1911-5p	PAR-CLIP	21572407
MIRT480185	hsa-miR-1911-5p	PAR-CLIP	20371350
MIRT480186	hsa-miR-4530	PAR-CLIP	23592263
MIRT480186	hsa-miR-4530	PAR-CLIP	21572407
MIRT480186	hsa-miR-4530	PAR-CLIP	20371350
MIRT480187	hsa-miR-369-3p	PAR-CLIP	23592263
MIRT480187	hsa-miR-369-3p	PAR-CLIP	20371350
MIRT480188	hsa-miR-4280	PAR-CLIP	23592263
MIRT480188	hsa-miR-4280	PAR-CLIP	21572407
MIRT480188	hsa-miR-4280	PAR-CLIP	20371350
MIRT480189	hsa-miR-7851-3p	PAR-CLIP	23592263
MIRT480189	hsa-miR-7851-3p	PAR-CLIP	21572407
MIRT480189	hsa-miR-7851-3p	PAR-CLIP	20371350
MIRT480190	hsa-miR-619-3p	PAR-CLIP	23592263
MIRT480190	hsa-miR-619-3p	PAR-CLIP	21572407
MIRT480190	hsa-miR-619-3p	PAR-CLIP	20371350
MIRT480191	hsa-miR-634	PAR-CLIP	23592263
MIRT480191	hsa-miR-634	PAR-CLIP	21572407
MIRT480191	hsa-miR-634	PAR-CLIP	20371350
MIRT485724	hsa-miR-8055	PAR-CLIP	23592263
MIRT485726	hsa-miR-1304-5p	PAR-CLIP	23592263
MIRT485726	hsa-miR-1304-5p	PAR-CLIP	27292025
MIRT485727	hsa-miR-550b-2-5p	PAR-CLIP	23592263
MIRT485727	hsa-miR-550b-2-5p	PAR-CLIP	27292025
MIRT485728	hsa-miR-6765-5p	PAR-CLIP	23592263
MIRT485728	hsa-miR-6765-5p	PAR-CLIP	27292025
MIRT485729	hsa-miR-6505-5p	PAR-CLIP	23592263
MIRT485730	hsa-miR-1227-3p	PAR-CLIP	23592263
MIRT485730	hsa-miR-1227-3p	PAR-CLIP	27292025
MIRT485731	hsa-miR-1290	PAR-CLIP	23592263
MIRT485732	hsa-miR-876-5p	PAR-CLIP	23592263
MIRT485733	hsa-miR-3167	PAR-CLIP	23592263
MIRT485734	hsa-miR-1827	PAR-CLIP	23592263
MIRT485734	hsa-miR-1827	PAR-CLIP	27292025
MIRT485735	hsa-miR-1246	PAR-CLIP	23592263
MIRT485736	hsa-miR-890	PAR-CLIP	23592263
MIRT485737	hsa-miR-206	PAR-CLIP	23592263
MIRT485738	hsa-miR-613	PAR-CLIP	23592263
MIRT507897	hsa-miR-653-5p	PAR-CLIP	23446348
MIRT507897	hsa-miR-653-5p	PAR-CLIP	20371350
MIRT507897	hsa-miR-653-5p	HITS-CLIP	21572407
MIRT507898	hsa-miR-943	PAR-CLIP	23446348
MIRT507898	hsa-miR-943	PAR-CLIP	20371350
MIRT507898	hsa-miR-943	HITS-CLIP	21572407
MIRT507899	hsa-miR-4439	PAR-CLIP	23446348
MIRT507899	hsa-miR-4439	PAR-CLIP	20371350
MIRT507899	hsa-miR-4439	HITS-CLIP	21572407
MIRT507900	hsa-miR-3136-5p	PAR-CLIP	23446348
MIRT507900	hsa-miR-3136-5p	PAR-CLIP	20371350
MIRT507900	hsa-miR-3136-5p	HITS-CLIP	21572407
MIRT507901	hsa-miR-4671-3p	PAR-CLIP	23446348
MIRT507901	hsa-miR-4671-3p	PAR-CLIP	20371350
MIRT507901	hsa-miR-4671-3p	HITS-CLIP	21572407
MIRT507902	hsa-miR-891b	PAR-CLIP	23446348
MIRT507902	hsa-miR-891b	PAR-CLIP	20371350
MIRT507902	hsa-miR-891b	HITS-CLIP	21572407
MIRT507903	hsa-miR-1279	PAR-CLIP	23446348
MIRT507903	hsa-miR-1279	PAR-CLIP	20371350
MIRT507903	hsa-miR-1279	HITS-CLIP	21572407
MIRT507904	hsa-miR-5580-3p	PAR-CLIP	23446348
MIRT507904	hsa-miR-5580-3p	PAR-CLIP	20371350
MIRT507904	hsa-miR-5580-3p	HITS-CLIP	21572407
MIRT507905	hsa-miR-454-3p	PAR-CLIP	23446348
MIRT507905	hsa-miR-454-3p	PAR-CLIP	20371350
MIRT507905	hsa-miR-454-3p	HITS-CLIP	21572407
MIRT507906	hsa-miR-4295	PAR-CLIP	23446348
MIRT507906	hsa-miR-4295	PAR-CLIP	20371350
MIRT507906	hsa-miR-4295	HITS-CLIP	21572407
MIRT507907	hsa-miR-301b-3p	PAR-CLIP	23446348
MIRT507907	hsa-miR-301b-3p	PAR-CLIP	20371350
MIRT507907	hsa-miR-301b-3p	HITS-CLIP	21572407
MIRT507908	hsa-miR-301a-3p	PAR-CLIP	23446348
MIRT507908	hsa-miR-301a-3p	PAR-CLIP	20371350
MIRT507908	hsa-miR-301a-3p	HITS-CLIP	21572407
MIRT507909	hsa-miR-130b-3p	PAR-CLIP	23446348
MIRT507909	hsa-miR-130b-3p	PAR-CLIP	20371350
MIRT507909	hsa-miR-130b-3p	HITS-CLIP	21572407
MIRT507910	hsa-miR-3666	PAR-CLIP	23446348
MIRT507910	hsa-miR-3666	PAR-CLIP	20371350
MIRT507910	hsa-miR-3666	HITS-CLIP	21572407
MIRT507911	hsa-miR-130a-3p	PAR-CLIP	23446348
MIRT507911	hsa-miR-130a-3p	PAR-CLIP	20371350
MIRT507911	hsa-miR-130a-3p	HITS-CLIP	21572407
MIRT514025	hsa-miR-302c-5p	PAR-CLIP	23446348
MIRT514025	hsa-miR-302c-5p	PAR-CLIP	20371350
MIRT514026	hsa-miR-493-5p	PAR-CLIP	23446348
MIRT514026	hsa-miR-493-5p	PAR-CLIP	20371350
MIRT514027	hsa-let-7g-3p	PAR-CLIP	23446348
MIRT514027	hsa-let-7g-3p	PAR-CLIP	20371350
MIRT514028	hsa-let-7a-2-3p	PAR-CLIP	23446348
MIRT514028	hsa-let-7a-2-3p	PAR-CLIP	20371350
MIRT514029	hsa-miR-548an	PAR-CLIP	23446348
MIRT514029	hsa-miR-548an	PAR-CLIP	20371350
MIRT572192	hsa-miR-7856-5p	PAR-CLIP	20371350
MIRT572192	hsa-miR-7856-5p	PAR-CLIP	27292025
MIRT774871	hsa-miR-5590-5p	PAR-CLIP	27292025
MIRT779315	hsa-miR-6792-5p	PAR-CLIP	27292025

Show/Hide all(47)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000922	Component	Spindle pole	IDA	16760425
GO:0002027	Process	Regulation of heart rate	IMP	23040497
GO:0005509	Function	Calcium ion binding	IBA	21873635
GO:0005509	Function	Calcium ion binding	IDA	7607248, 8631777, 11807546, 23040497, 26164367, 26969752, 27516456
GO:0005513	Process	Detection of calcium ion	IMP	23040497
GO:0005515	Function	Protein binding	IPI	3111527, 10692436, 15140941, 16760425, 19855925, 21299499
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005737	Component	Cytoplasm	IDA	27165696
GO:0005737	Component	Cytoplasm	TAS	10899953
GO:0005813	Component	Centrosome	IDA	16760425
GO:0005876	Component	Spindle microtubule	IDA	16760425
GO:0005886	Component	Plasma membrane	TAS	10899953
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS	10899953
GO:0008179	Function	Adenylate cyclase binding	IPI	11807546
GO:0010800	Process	Positive regulation of peptidyl-threonine phosphorylation	TAS	20668654
GO:0010801	Process	Negative regulation of peptidyl-threonine phosphorylation	TAS	20668654
GO:0010856	Function	Adenylate cyclase activator activity	IDA	11807546
GO:0010880	Process	Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IDA	20226167
GO:0010881	Process	Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	IC
GO:0019855	Function	Calcium channel inhibitor activity	IDA	26969752
GO:0019901	Function	Protein kinase binding	IPI	20668654
GO:0019904	Function	Protein domain specific binding	IPI	11984006
GO:0021762	Process	Substantia nigra development	HEP	22926577
GO:0030017	Component	Sarcomere	IDA	20226167
GO:0030234	Function	Enzyme regulator activity	IBA	21873635
GO:0031432	Function	Titin binding	IPI	7607248
GO:0031954	Process	Positive regulation of protein autophosphorylation	TAS	20668654
GO:0031982	Component	Vesicle	HDA	19190083
GO:0031997	Function	N-terminal myristoylation domain binding	IPI	15632291
GO:0032465	Process	Regulation of cytokinesis	IMP	16760425
GO:0032516	Process	Positive regulation of phosphoprotein phosphatase activity	IDA	8631777
GO:0032991	Component	Protein-containing complex	IDA	19855925
GO:0034704	Component	Calcium channel complex	IDA	23040497
GO:0035307	Process	Positive regulation of protein dephosphorylation	IDA	8631777
GO:0043539	Function	Protein serine/threonine kinase activator activity	TAS	20668654
GO:0044325	Function	Ion channel binding	IPI	21167176, 23040497
GO:0051343	Process	Positive regulation of cyclic-nucleotide phosphodiesterase activity	IDA	8631777
GO:0051592	Process	Response to calcium ion	IDA	7607248
GO:0055117	Process	Regulation of cardiac muscle contraction	IMP	23040497
GO:0060314	Process	Regulation of ryanodine-sensitive calcium-release channel activity	IBA	21873635
GO:0060315	Process	Negative regulation of ryanodine-sensitive calcium-release channel activity	IDA	26164367
GO:0060316	Process	Positive regulation of ryanodine-sensitive calcium-release channel activity	IDA	20226167
GO:0071902	Process	Positive regulation of protein serine/threonine kinase activity	TAS	20668654
GO:0072542	Function	Protein phosphatase activator activity	IDA	8631777
GO:0097718	Function	Disordered domain specific binding	IPI	19855925
GO:1901844	Process	Regulation of cell communication by electrical coupling involved in cardiac conduction	IC
GO:1902494	Component	Catalytic complex	IDA	11807546

MIM	HGNC	e!Ensembl
114182	1445	ENSG00000143933

Protein

UniProt ID

P0DP24

Protein name

Calmodulin-2

Protein function

PDB

3O77 , 3O78 , 5COC , 5J03 , 5NIN , 5VMS , 5WSU , 5WSV , 6PLM , 6S5T , 6SZ5 , 6XXF , 6Y4O

UniProt ID

P0DP25

Protein name

Calmodulin-3

Protein function

Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Is a regulator of voltage-dependent L-type calcium channels (PubMed:31454269). Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.

PDB

5COC , 5J03 , 6K67 , 7BYL , 7BYM , 7BYN , 7CR3 , 7CR4 , 7CR7

UniProt ID

P0DP23

Protein name

Calmodulin-1

Protein function

Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Is a regulator of voltage-dependent L-type calcium channels (PubMed:31454269). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696). Forms a potassium channel complex with KCNQ1 and regulates electrophysiological activity of the channel via calcium-binding (PubMed:25441029). Acts as a sensor to modulate the endomplasmic reticulum contacts with other organelles mediated by VMP1:ATP2A2 (PubMed:28890335). ; (Microbial infection) Required for Legionella pneumophila SidJ glutamylase activity.

PDB

1AJI , 1CDL , 1CLL , 1CTR , 1IWQ , 1J7O , 1J7P , 1K90 , 1K93 , 1L7Z , 1LVC , 1NKF , 1PK0 , 1S26 , 1SK6 , 1SW8 , 1UP5 , 1WRZ , 1XFU , 1XFV , 1XFW , 1XFX , 1XFY , 1XFZ , 1Y6W , 1YR5 , 1YRT , 1YRU , 1ZOT , 1ZUZ , 2BE6 , 2F3Y , 2F3Z , 2HF5 , 2I08 , 2JZI , 2K0E , 2K0F , 2K0J , 2K61 , 2KNE , 2KUG , 2KUH , 2L53 , 2L7L , 2LGF , 2LL6 , 2LL7 , 2LQC , 2LQP , 2LV6

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13499	EF-hand_7	10 → 74	EF-hand domain pair	Domain
PF13499	EF-hand_7	83 → 147	EF-hand domain pair	Domain

Sequence

MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG
NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE
EVDEMIREADIDGDGQVNYEEFVQMMTAK

Sequence length

149

Interactions

View interactions

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