GeDiPNet: Comprehensive Gene Data - OMIM, HGNC, Ensembl, UniProt, GO, Transcription Factors & miRNA

Home
Browse
- Genes
- Diseases
- Pathways
  - Reactome
  - KEGG
Analysis
Help
Links
FAQ
Contact us

CALM1 (calmodulin 1)

Gene

801

Calmodulin 1

CALM1

CALML2, CAM2, CAM3, CAMB, CAMC, CAMI, CAMIII, CPVT4, DD132, LQT14, PHKD, caM

14q32.11

This gene encodes one of three calmodulin proteins which are members of the EF-hand calcium-binding protein family. Calcium-induced activation of calmodulin regulates and modulates the function of cardiac ion channels. Two pseudogenes have been identified on chromosome 7 and X. Multiple transcript variants encoding different isoforms have been found for this gene.A missense mutation in the CALM1 gene has been associated with ventricular tachycardia.[provided by RefSeq, May 2020]

Show/Hide all(131)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024054	hsa-miR-1-3p	Proteomics;Microarray	18668037
MIRT024054	hsa-miR-1-3p	Proteomics	18668040
MIRT053626	hsa-let-7f-5p	Microarray	22942087
MIRT071460	hsa-miR-129-5p	PAR-CLIP	23446348
MIRT071460	hsa-miR-129-5p	PAR-CLIP	21572407
MIRT071460	hsa-miR-129-5p	PAR-CLIP	20371350
MIRT071461	hsa-miR-450b-5p	PAR-CLIP	23446348
MIRT071461	hsa-miR-450b-5p	PAR-CLIP	21572407
MIRT071461	hsa-miR-450b-5p	PAR-CLIP	20371350
MIRT071480	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT071481	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT071490	hsa-miR-579-3p	PAR-CLIP	21572407
MIRT071491	hsa-miR-595	PAR-CLIP	21572407
MIRT071492	hsa-miR-548c-3p	PAR-CLIP	23446348
MIRT071492	hsa-miR-548c-3p	PAR-CLIP	21572407
MIRT071492	hsa-miR-548c-3p	PAR-CLIP	20371350
MIRT071493	hsa-miR-648	PAR-CLIP	21572407
MIRT071494	hsa-miR-664a-3p	PAR-CLIP	21572407
MIRT071497	hsa-miR-4760-3p	PAR-CLIP	21572407
MIRT071499	hsa-miR-664b-3p	PAR-CLIP	21572407
MIRT071500	hsa-miR-548aw	PAR-CLIP	21572407
MIRT071501	hsa-let-7c-3p	PAR-CLIP	23446348
MIRT071501	hsa-let-7c-3p	PAR-CLIP	21572407
MIRT071501	hsa-let-7c-3p	PAR-CLIP	20371350
MIRT071502	hsa-miR-340-5p	PAR-CLIP	20371350
MIRT071503	hsa-miR-3123	PAR-CLIP	23446348
MIRT071503	hsa-miR-3123	PAR-CLIP	21572407
MIRT071503	hsa-miR-3123	PAR-CLIP	20371350
MIRT071504	hsa-miR-4311	PAR-CLIP	23446348
MIRT071504	hsa-miR-4311	PAR-CLIP	21572407
MIRT071504	hsa-miR-4311	PAR-CLIP	20371350
MIRT071507	hsa-miR-4729	PAR-CLIP	23446348
MIRT071507	hsa-miR-4729	PAR-CLIP	21572407
MIRT071507	hsa-miR-4729	PAR-CLIP	20371350
MIRT071515	hsa-miR-539-5p	HITS-CLIP	24374217
MIRT114796	hsa-miR-586	PAR-CLIP	23446348
MIRT114796	hsa-miR-586	PAR-CLIP	21572407
MIRT114796	hsa-miR-586	PAR-CLIP	20371350
MIRT191923	hsa-miR-196a-5p	PAR-CLIP	21572407
MIRT191924	hsa-miR-196b-5p	PAR-CLIP	21572407
MIRT191943	hsa-miR-495-5p	PAR-CLIP	23446348
MIRT191943	hsa-miR-495-5p	PAR-CLIP	20371350
MIRT191944	hsa-miR-1305	PAR-CLIP	23446348
MIRT191944	hsa-miR-1305	PAR-CLIP	20371350
MIRT191945	hsa-miR-1250-3p	PAR-CLIP	23446348
MIRT191945	hsa-miR-1250-3p	PAR-CLIP	20371350
MIRT280390	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT405875	hsa-miR-548a-3p	PAR-CLIP	21572407
MIRT405876	hsa-miR-548e-3p	PAR-CLIP	21572407
MIRT405877	hsa-miR-548f-3p	PAR-CLIP	21572407
MIRT405879	hsa-miR-548ar-3p	PAR-CLIP	21572407
MIRT405880	hsa-miR-548az-3p	PAR-CLIP	21572407
MIRT441025	hsa-miR-493-3p	HITS-CLIP	24374217
MIRT441026	hsa-miR-142-3p	HITS-CLIP	22473208
MIRT507912	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT507912	hsa-miR-6867-5p	PAR-CLIP	20371350
MIRT507913	hsa-miR-382-5p	PAR-CLIP	23446348
MIRT507913	hsa-miR-382-5p	PAR-CLIP	20371350
MIRT512183	hsa-miR-3680-3p	PAR-CLIP	23446348
MIRT512183	hsa-miR-3680-3p	PAR-CLIP	21572407
MIRT512183	hsa-miR-3680-3p	PAR-CLIP	20371350
MIRT512184	hsa-miR-557	PAR-CLIP	23446348
MIRT512184	hsa-miR-557	PAR-CLIP	21572407
MIRT512184	hsa-miR-557	PAR-CLIP	20371350
MIRT512185	hsa-miR-507	PAR-CLIP	23446348
MIRT512185	hsa-miR-507	PAR-CLIP	21572407
MIRT512185	hsa-miR-507	PAR-CLIP	20371350
MIRT512186	hsa-miR-4696	PAR-CLIP	23446348
MIRT512186	hsa-miR-4696	PAR-CLIP	21572407
MIRT512186	hsa-miR-4696	PAR-CLIP	20371350
MIRT524572	hsa-miR-3163	PAR-CLIP	23446348
MIRT524572	hsa-miR-3163	PAR-CLIP	21572407
MIRT524572	hsa-miR-3163	PAR-CLIP	20371350
MIRT524573	hsa-miR-583	PAR-CLIP	23446348
MIRT524573	hsa-miR-583	PAR-CLIP	21572407
MIRT524573	hsa-miR-583	PAR-CLIP	20371350
MIRT524574	hsa-miR-1276	PAR-CLIP	23446348
MIRT524574	hsa-miR-1276	PAR-CLIP	21572407
MIRT524574	hsa-miR-1276	PAR-CLIP	20371350
MIRT524575	hsa-miR-142-5p	PAR-CLIP	23446348
MIRT524575	hsa-miR-142-5p	PAR-CLIP	21572407
MIRT524575	hsa-miR-142-5p	PAR-CLIP	20371350
MIRT524576	hsa-miR-5590-3p	PAR-CLIP	23446348
MIRT524576	hsa-miR-5590-3p	PAR-CLIP	21572407
MIRT524576	hsa-miR-5590-3p	PAR-CLIP	20371350
MIRT524577	hsa-miR-4659b-3p	PAR-CLIP	23446348
MIRT524577	hsa-miR-4659b-3p	PAR-CLIP	27292025
MIRT524578	hsa-miR-4659a-3p	PAR-CLIP	23446348
MIRT524578	hsa-miR-4659a-3p	PAR-CLIP	27292025
MIRT538736	hsa-miR-4639-5p	PAR-CLIP	22012620
MIRT538737	hsa-miR-502-5p	PAR-CLIP	22012620
MIRT538738	hsa-miR-5589-3p	PAR-CLIP	22012620
MIRT538739	hsa-miR-1915-5p	PAR-CLIP	22012620
MIRT538740	hsa-miR-6841-3p	PAR-CLIP	22012620
MIRT538741	hsa-miR-4662a-3p	PAR-CLIP	22012620
MIRT538742	hsa-miR-3591-3p	PAR-CLIP	22012620
MIRT538743	hsa-miR-21-3p	PAR-CLIP	22012620
MIRT549060	hsa-miR-5696	PAR-CLIP	21572407
MIRT549061	hsa-miR-1468-3p	PAR-CLIP	21572407
MIRT549062	hsa-miR-548x-5p	PAR-CLIP	21572407
MIRT549063	hsa-miR-548g-5p	PAR-CLIP	21572407
MIRT549064	hsa-miR-548f-5p	PAR-CLIP	21572407
MIRT549065	hsa-miR-548aj-5p	PAR-CLIP	21572407
MIRT558970	hsa-miR-1324	PAR-CLIP	21572407
MIRT558971	hsa-miR-382-3p	PAR-CLIP	21572407
MIRT558972	hsa-miR-4538	PAR-CLIP	21572407
MIRT558973	hsa-miR-4453	PAR-CLIP	21572407
MIRT558974	hsa-miR-6882-5p	PAR-CLIP	21572407
MIRT558975	hsa-miR-570-5p	PAR-CLIP	21572407
MIRT558976	hsa-miR-548ba	PAR-CLIP	21572407
MIRT558977	hsa-miR-548ai	PAR-CLIP	21572407
MIRT558978	hsa-miR-548ag	PAR-CLIP	21572407
MIRT558979	hsa-miR-5582-3p	PAR-CLIP	21572407
MIRT765008	hsa-miR-3148	PAR-CLIP	27292025
MIRT770848	hsa-miR-4668-5p	PAR-CLIP	27292025
MIRT772233	hsa-miR-4777-5p	PAR-CLIP	27292025
MIRT773592	hsa-miR-518d-5p	PAR-CLIP	27292025
MIRT773595	hsa-miR-518e-5p	PAR-CLIP	27292025
MIRT773598	hsa-miR-518f-5p	PAR-CLIP	27292025
MIRT773686	hsa-miR-519a-5p	PAR-CLIP	27292025
MIRT773700	hsa-miR-519b-5p	PAR-CLIP	27292025
MIRT773714	hsa-miR-519c-5p	PAR-CLIP	27292025
MIRT773795	hsa-miR-520c-5p	PAR-CLIP	27292025
MIRT773858	hsa-miR-520g-5p	PAR-CLIP	27292025
MIRT773893	hsa-miR-522-5p	PAR-CLIP	27292025
MIRT773896	hsa-miR-523-5p	PAR-CLIP	27292025
MIRT773909	hsa-miR-526a	PAR-CLIP	27292025
MIRT776111	hsa-miR-625-5p	PAR-CLIP	27292025
MIRT779347	hsa-miR-6795-5p	PAR-CLIP	27292025
MIRT780714	hsa-miR-6873-5p	PAR-CLIP	27292025
MIRT781070	hsa-miR-6887-5p	PAR-CLIP	27292025

Show/Hide all(81)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000086	Process	G2/M transition of mitotic cell cycle	IEA
GO:0000165	Process	MAPK cascade	TAS
GO:0000922	Component	Spindle pole	IDA	16760425
GO:0001975	Process	Response to amphetamine	IEA
GO:0002027	Process	Regulation of heart rate	IMP	23040497
GO:0002576	Process	Platelet degranulation	TAS
GO:0005509	Function	Calcium ion binding	IBA	21873635
GO:0005509	Function	Calcium ion binding	IDA	7607248, 8631777, 11807546, 23040497, 26164367, 26969752, 27516456, 27564677, 31454269
GO:0005513	Process	Detection of calcium ion	IMP	23040497
GO:0005515	Function	Protein binding	IPI	3111527, 10692436, 15140941, 16127172, 16760425, 19855925, 21299499, 30021165, 30287853
GO:0005576	Component	Extracellular region	TAS
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	27165696
GO:0005737	Component	Cytoplasm	TAS	10899953
GO:0005813	Component	Centrosome	IDA	16760425
GO:0005829	Component	Cytosol	TAS
GO:0005876	Component	Spindle microtubule	IDA	16760425
GO:0005886	Component	Plasma membrane	TAS	10899953
GO:0005980	Process	Glycogen catabolic process	TAS
GO:0006936	Process	Muscle contraction	TAS
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS	10899953
GO:0007190	Process	Activation of adenylate cyclase activity	IEA
GO:0007223	Process	Wnt signaling pathway, calcium modulating pathway	TAS
GO:0008076	Component	Voltage-gated potassium channel complex	IEA
GO:0008179	Function	Adenylate cyclase binding	IPI	11807546
GO:0010800	Process	Positive regulation of peptidyl-threonine phosphorylation	TAS	20668654
GO:0010801	Process	Negative regulation of peptidyl-threonine phosphorylation	TAS	20668654
GO:0010856	Function	Adenylate cyclase activator activity	IDA	11807546
GO:0010880	Process	Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IDA	20226167
GO:0010881	Process	Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	IC
GO:0016032	Process	Viral process	IEA
GO:0019855	Function	Calcium channel inhibitor activity	IDA	26969752
GO:0019901	Function	Protein kinase binding	IPI	20668654
GO:0019904	Function	Protein domain specific binding	IPI	11984006
GO:0021762	Process	Substantia nigra development	HEP	22926577
GO:0022400	Process	Regulation of rhodopsin mediated signaling pathway	TAS
GO:0030017	Component	Sarcomere	IDA	20226167
GO:0030234	Function	Enzyme regulator activity	IBA	21873635
GO:0030235	Function	Nitric-oxide synthase regulator activity	IEA
GO:0030426	Component	Growth cone	IEA
GO:0030672	Component	Synaptic vesicle membrane	IEA
GO:0031432	Function	Titin binding	IPI	7607248
GO:0031800	Function	Type 3 metabotropic glutamate receptor binding	IEA
GO:0031954	Process	Positive regulation of protein autophosphorylation	TAS	20668654
GO:0031966	Component	Mitochondrial membrane	IEA
GO:0031982	Component	Vesicle	HDA	19190083
GO:0031997	Function	N-terminal myristoylation domain binding	IPI	15632291
GO:0032465	Process	Regulation of cytokinesis	IMP	16760425
GO:0032516	Process	Positive regulation of phosphoprotein phosphatase activity	IDA	8631777
GO:0032991	Component	Protein-containing complex	IDA	19855925
GO:0034704	Component	Calcium channel complex	IDA	23040497
GO:0035307	Process	Positive regulation of protein dephosphorylation	IDA	8631777
GO:0038095	Process	Fc-epsilon receptor signaling pathway	TAS
GO:0043209	Component	Myelin sheath	IEA
GO:0043388	Process	Positive regulation of DNA binding	IEA
GO:0043539	Function	Protein serine/threonine kinase activator activity	TAS	20668654
GO:0043548	Function	Phosphatidylinositol 3-kinase binding	IEA
GO:0043647	Process	Inositol phosphate metabolic process	TAS
GO:0044325	Function	Ion channel binding	IPI	21167176, 23040497, 27564677
GO:0048306	Function	Calcium-dependent protein binding	IEA
GO:0050998	Function	Nitric-oxide synthase binding	IEA
GO:0050999	Process	Regulation of nitric-oxide synthase activity	TAS
GO:0051000	Process	Positive regulation of nitric-oxide synthase activity	IEA
GO:0051343	Process	Positive regulation of cyclic-nucleotide phosphodiesterase activity	IDA	8631777
GO:0051412	Process	Response to corticosterone	IEA
GO:0051592	Process	Response to calcium ion	IDA	7607248
GO:0055117	Process	Regulation of cardiac muscle contraction	IMP	23040497
GO:0060314	Process	Regulation of ryanodine-sensitive calcium-release channel activity	IDA	22067155
GO:0060315	Process	Negative regulation of ryanodine-sensitive calcium-release channel activity	IDA	26164367
GO:0060316	Process	Positive regulation of ryanodine-sensitive calcium-release channel activity	IDA	20226167
GO:0071902	Process	Positive regulation of protein serine/threonine kinase activity	TAS	20668654
GO:0072542	Function	Protein phosphatase activator activity	IDA	8631777
GO:0090151	Process	Establishment of protein localization to mitochondrial membrane	IEA
GO:0097718	Function	Disordered domain specific binding	IPI	19855925
GO:0098901	Process	Regulation of cardiac muscle cell action potential	IMP	31454269
GO:1900242	Process	Regulation of synaptic vesicle endocytosis	IEA
GO:1901842	Process	Negative regulation of high voltage-gated calcium channel activity	IMP	31454269
GO:1901844	Process	Regulation of cell communication by electrical coupling involved in cardiac conduction	IC
GO:1902494	Component	Catalytic complex	IDA	11807546
GO:2000300	Process	Regulation of synaptic vesicle exocytosis	IEA

MIM	HGNC	e!Ensembl
114180	1442	ENSG00000198668

Protein

UniProt ID

P0DP24

Protein name

Calmodulin-2

Protein function

PDB

3O77 , 3O78 , 5COC , 5J03 , 5NIN , 5VMS , 5WSU , 5WSV , 6PLM , 6S5T , 6SZ5 , 6XXF , 6Y4O

UniProt ID

P0DP25

Protein name

Calmodulin-3

Protein function

Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Is a regulator of voltage-dependent L-type calcium channels (PubMed:31454269). Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.

PDB

5COC , 5J03 , 6K67 , 7BYL , 7BYM , 7BYN , 7CR3 , 7CR4 , 7CR7

UniProt ID

P0DP23

Protein name

Calmodulin-1

Protein function

Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Is a regulator of voltage-dependent L-type calcium channels (PubMed:31454269). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696). Forms a potassium channel complex with KCNQ1 and regulates electrophysiological activity of the channel via calcium-binding (PubMed:25441029). Acts as a sensor to modulate the endomplasmic reticulum contacts with other organelles mediated by VMP1:ATP2A2 (PubMed:28890335). ; (Microbial infection) Required for Legionella pneumophila SidJ glutamylase activity.

PDB

1AJI , 1CDL , 1CLL , 1CTR , 1IWQ , 1J7O , 1J7P , 1K90 , 1K93 , 1L7Z , 1LVC , 1NKF , 1PK0 , 1S26 , 1SK6 , 1SW8 , 1UP5 , 1WRZ , 1XFU , 1XFV , 1XFW , 1XFX , 1XFY , 1XFZ , 1Y6W , 1YR5 , 1YRT , 1YRU , 1ZOT , 1ZUZ , 2BE6 , 2F3Y , 2F3Z , 2HF5 , 2I08 , 2JZI , 2K0E , 2K0F , 2K0J , 2K61 , 2KNE , 2KUG , 2KUH , 2L53 , 2L7L , 2LGF , 2LL6 , 2LL7 , 2LQC , 2LQP , 2LV6

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13499	EF-hand_7	10 → 74	EF-hand domain pair	Domain
PF13499	EF-hand_7	83 → 147	EF-hand domain pair	Domain

Sequence

MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG
NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE
EVDEMIREADIDGDGQVNYEEFVQMMTAK

Sequence length

149

Interactions

View interactions

| © 2021, Biomedical Informatics Centre, NIRRH |
ICMR-National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400012
Tel: +91-22-24192104, Fax No: +91-22-24139412